Real-Time MEG Source Localization Using Regional Clustering.

Abstract:

:With its millisecond temporal resolution, Magnetoencephalography (MEG) is well suited for real-time monitoring of brain activity. Real-time feedback allows the adaption of the experiment to the subject's reaction and increases time efficiency by shortening acquisition and off-line analysis. Two formidable challenges exist in real-time analysis: the low signal-to-noise ratio (SNR) and the limited time available for computations. Since the low SNR reduces the number of distinguishable sources, we propose an approach which downsizes the source space based on a cortical atlas and allows to discern the sources in the presence of noise. Each cortical region is represented by a small set of dipoles, which is obtained by a clustering algorithm. Using this approach, we adapted dynamic statistical parametric mapping for real-time source localization. In terms of point spread and crosstalk between regions the proposed clustering technique performs better than selecting spatially evenly distributed dipoles. We conducted real-time source localization on MEG data from an auditory experiment. The results demonstrate that the proposed real-time method localizes sources reliably in the superior temporal gyrus. We conclude that real-time source estimation based on MEG is a feasible, useful addition to the standard on-line processing methods, and enables feedback based on neural activity during the measurements.

journal_name

Brain Topogr

journal_title

Brain topography

authors

Dinh C,Strohmeier D,Luessi M,Güllmar D,Baumgarten D,Haueisen J,Hämäläinen MS

doi

10.1007/s10548-015-0431-9

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

771-84

issue

6

eissn

0896-0267

issn

1573-6792

pii

10.1007/s10548-015-0431-9

journal_volume

28

pub_type

杂志文章
  • MEG-EEG Information Fusion and Electromagnetic Source Imaging: From Theory to Clinical Application in Epilepsy.

    abstract::The purpose of this study is to develop and quantitatively assess whether fusion of EEG and MEG (MEEG) data within the maximum entropy on the mean (MEM) framework increases the spatial accuracy of source localization, by yielding better recovery of the spatial extent and propagation pathway of the underlying generator...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-015-0437-3

    authors: Chowdhury RA,Zerouali Y,Hedrich T,Heers M,Kobayashi E,Lina JM,Grova C

    更新日期:2015-11-01 00:00:00

  • Topology of EEG coherence changes may reflect differential neural network activation in cold and pain perception.

    abstract::Pain perception in the brain can be analyzed by neuroimaging (PET, fMRI) and electrophysiological parameter mapping (EEG, ERP/MEG, MEF). These studies have generally been focused on the localization of cerebral activation. Whether pain can be conceptualized as localized function or best be understood by distributed fu...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/a:1022254505510

    authors: Chen AC,Rappelsberger P,Filz O

    更新日期:1998-01-01 00:00:00

  • Quantified neurophysiology with mapping: statistical inference, exploratory and confirmatory data analysis.

    abstract::Topographic mapping of brain electrical activity has become a commonly used method in the clinical as well as research laboratory. To enhance analytic power and accuracy, mapping applications often involve statistical paradigms for the detection of abnormality or difference. Because mapping studies involve many measur...

    journal_title:Brain topography

    pub_type: 杂志文章,评审

    doi:10.1007/BF01128856

    authors: Duffy FH,Jones K,Bartels P,Albert M,McAnulty GB,Als H

    更新日期:1990-10-01 00:00:00

  • Computation for the implicit components of ERP in attention.

    abstract::EEG reveals brain functions with high temporal resolution. Yet, multiple implicit variables may be involved in limited ERP measures. Special computation techniques are needed to recover these parameters. In the study of attention, we can obtain the ERP in attended (V) and unattended (U) conditions. Usually, the effect...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/a:1025662500837

    authors: Yao D

    更新日期:2003-10-01 00:00:00

  • Functional imaging of brain responses to repetitive sensory stimulation: sources estimated from EEG and SPECT.

    abstract::This study examined the effect of modality of stimulation on two measures of cerebral function: (a) the scalp distribution of sensory evoked potentials and (b) the cerebral distribution of radiolabelled HMPAO. Steady-state stimulation in the auditory, somatosensory or visual modality was presented to six subjects. Sca...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01128854

    authors: Weinberg H,Johnson B,Cohen P,Crisp D,Robertson A

    更新日期:1989-10-01 00:00:00

  • Comparing electrophysiological correlates of word production in immediate and delayed naming through the analysis of word age of acquisition effects.

    abstract::Most EEG studies analysing speech production with event related brain potential (ERP) have adopted silent metalinguistic tasks or delayed or tacit picture naming in order to avoid possible artefacts during motor preparation. A central issue in the interpretation of these results is whether the processes involved in th...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-010-0162-x

    authors: Laganaro M,Perret C

    更新日期:2011-03-01 00:00:00

  • Higher Fasting Plasma Glucose is Associated with Increased Cortical Thinning Over 12 Years: The PATH Through Life Study.

    abstract::Recent evidence suggests that type 2 diabetes (T2D) is associated with accelerated brain ageing, consistent with the observation of increased risk of cognitive impairment and dementia in affected individuals. Even non-diabetic individuals with impaired fasting plasma glucose (IFG) levels have shown increased cerebral ...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-017-0544-4

    authors: Shaw ME,Nettersheim J,Sachdev PS,Anstey KJ,Cherbuin N

    更新日期:2017-05-01 00:00:00

  • A new method of spatio-temporal topographic mapping by correlation coefficient of K-means cluster.

    abstract::It would be of the utmost interest to map correlated sources in the working human brain by Event-Related Potentials (ERPs). This work is to develop a new method to map correlated neural sources based on the time courses of the scalp ERPs waveforms. The ERP data are classified first by k-means cluster analysis, and the...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-006-0017-7

    authors: Li L,Yao D

    更新日期:2007-07-01 00:00:00

  • Brain and human pain: topographic EEG amplitude and coherence mapping.

    abstract::Nineteen young healthy volunteers (8 males and 11 females) participated in an experimental ice-cube cold pressor test to study topographic changes of EEG parameters in response to painful stimulation. EEG was recorded with 19 electrodes and quantified by amplitude and coherence analyses. Mean amplitudes and values for...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01186771

    authors: Chen AC,Rappelsberger P

    更新日期:1994-01-01 00:00:00

  • Advantages and limitations of magnetic source imaging.

    abstract::The term "magnetic source image" (MSI) describes the distribution of neuronal activity in the brain that can be deduced from measurements of the field pattern it produces across the scalp. The signals which provide the basis for an MSI are obtained from the magnetoencephalogram (MEG) which is conventionally recorded w...

    journal_title:Brain topography

    pub_type: 杂志文章,评审

    doi:10.1007/BF01132773

    authors: Williamson SJ,Lü ZL,Karron D,Kaufman L

    更新日期:1991-01-01 00:00:00

  • A Finite-Difference Solution for the EEG Forward Problem in Inhomogeneous Anisotropic Media.

    abstract::Accurate source localization of electroencephalographic (EEG) signals requires detailed information about the geometry and physical properties of head tissues. Indeed, these strongly influence the propagation of neural activity from the brain to the sensors. Finite difference methods (FDMs) are head modelling approach...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-018-0683-2

    authors: Cuartas Morales E,Acosta-Medina CD,Castellanos-Dominguez G,Mantini D

    更新日期:2019-03-01 00:00:00

  • Auditory Magnetoencephalographic Frequency-Tagged Responses Mirror the Ongoing Segmentation Processes Underlying Statistical Learning.

    abstract::Humans are highly sensitive to statistical regularities in their environment. This phenomenon, usually referred as statistical learning, is most often assessed using post-learning behavioural measures that are limited by a lack of sensibility and do not monitor the temporal dynamics of learning. In the present study, ...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-016-0518-y

    authors: Farthouat J,Franco A,Mary A,Delpouve J,Wens V,Op de Beeck M,De Tiège X,Peigneux P

    更新日期:2017-03-01 00:00:00

  • Cognitive Bias by Gender Interaction on N170 Response to Emotional Facial Expressions in Major and Minor Depression.

    abstract::States of depression are considered to relate to a cognitive bias reactivity to emotional events. Moreover, gender effect may influence differences in emotional processing. The current study is to investigate whether there is an interaction of cognitive bias by gender on emotional processing in minor depression (MiD) ...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-015-0444-4

    authors: Wu X,Chen J,Jia T,Ma W,Zhang Y,Deng Z,Yang L

    更新日期:2016-03-01 00:00:00

  • Change in Excitability of Corticospinal Pathway and GABA-Mediated Inhibitory Circuits of Primary Motor Cortex Induced by Contraction of Adjacent Hand Muscle.

    abstract::The present study examined whether the excitability of the corticospinal pathway and the GABA-mediated inhibitory circuits of the primary motor cortex that project onto the corticospinal neurons in the tonically contracting hand muscle are changed by tonic contraction of the adjacent hand muscle. The motor evoked pote...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-016-0499-x

    authors: Jono Y,Iwata Y,Mizusawa H,Hiraoka K

    更新日期:2016-11-01 00:00:00

  • Electrocortical Dynamics in Children with a Language-Learning Impairment Before and After Audiovisual Training.

    abstract::Detecting and discriminating subtle and rapid sound changes in the speech environment is a fundamental prerequisite of language processing, and deficits in this ability have frequently been observed in individuals with language-learning impairments (LLI). One approach to studying associations between dysfunctional aud...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-015-0466-y

    authors: Heim S,Choudhury N,Benasich AA

    更新日期:2016-05-01 00:00:00

  • High and low stimulus-driven conflict engage segregated brain networks, not quantitatively different resources.

    abstract::Task-irrelevant information is constantly present in our environment and may interfere with the processing of the information necessary to achieve goal-directed behavior. While task goals determine which information must be suppressed, the demand for inhibitory control depends on the strength of the interference induc...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-013-0303-0

    authors: Chouiter L,Dieguez S,Annoni JM,Spierer L

    更新日期:2014-03-01 00:00:00

  • A-magnetic optic-mechanical device to quantify finger kinematics for fMRI studies of bimanual coordination.

    abstract::Several fMRI studies have been performed to detect the neural correlates of stable bimanual coordination patterns in humans. Only few of those studies were accompanied by the on-line recording of the relative phase of fingers or hands, but none with high space and time resolutions. Conversely, the high-resolution reco...

    journal_title:Brain topography

    pub_type: 临床试验,杂志文章

    doi:10.1007/s10548-007-0022-5

    authors: De Luca C,Comani S,Di Donato L,Caulo M,Bertollo M,Romani GL

    更新日期:2007-04-01 00:00:00

  • A Comparison of Evoked and Non-evoked Functional Networks.

    abstract::The growing interest in brain networks to study the brain's function in cognition and diseases has produced an increase in methods to extract these networks. Typically, each method yields a different network. Therefore, one may ask what the resulting networks represent. To address this issue we consider electrocortico...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-018-0692-1

    authors: Hebbink J,van Blooijs D,Huiskamp G,Leijten FSS,van Gils SA,Meijer HGE

    更新日期:2019-05-01 00:00:00

  • A four sphere model for calculating the magnetic field associated with spreading cortical depression.

    abstract::In our previous model, we ascertained that the large amplitude waves (LAWs), reported by Barkley and coworkers (1990) in time series magnetoencephalography (MEG) recordings from migraine patients, could be simulated and compared with the recorded signals using a simple plane volume conductor model (Tepley and Wijesing...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01190388

    authors: Wijesinghe RS,Tepley N

    更新日期:1997-04-01 00:00:00

  • Alpha frequency, cognitive load and memory performance.

    abstract::EEG-signals were recorded from subjects as they performed a modified version of Schneider's and Shiffrin's memory search paradigm. The hypothesis was tested whether individual (centre of gravity) alpha frequency, termed IAF, is related to memory performance and/or attentional demands. The results show that memory perf...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01128991

    authors: Klimesch W,Schimke H,Pfurtscheller G

    更新日期:1993-04-01 00:00:00

  • Similarities between simulated spatial spectra of scalp EEG, MEG and structural MRI.

    abstract::Electrical dipoles oriented perpendicular to the cortical surface are the primary source of the scalp EEGs and MEGs. Thus, in particular, gyri and sulci structures on the cortical surface have a definite possibility to influence the EEGs and MEGs. This was examined by comparing the spatial power spectral density (PSD)...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-009-0104-7

    authors: Ramon C,Freeman WJ,Holmes M,Ishimaru A,Haueisen J,Schimpf PH,Rezvanian E

    更新日期:2009-11-01 00:00:00

  • Application of singular value decomposition to topographic analysis of flash-evoked potentials.

    abstract::Singular value decomposition is a robust numerical method for decomposing a matrix of multichannel EEG or EP data into a sharply reduced set of features with corresponding waveform, amplitude, and spatial vectors. In 19 normal subjects aged 19 to 40 years, the three largest features computed by the SVD algorithm accou...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01128847

    authors: Harner RN,Riggio S

    更新日期:1989-10-01 00:00:00

  • Learning to associate auditory and visual stimuli: behavioral and neural mechanisms.

    abstract::The ability to effectively combine sensory inputs across modalities is vital for acquiring a unified percept of events. For example, watching a hammer hit a nail while simultaneously identifying the sound as originating from the event requires the ability to identify spatio-temporal congruencies and statistical regula...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-013-0333-7

    authors: Altieri N,Stevenson RA,Wallace MT,Wenger MJ

    更新日期:2015-05-01 00:00:00

  • Time course of processes underlying picture and word evaluation: an event-related potential approach.

    abstract::A substantial body of research suggests that the cognitive mechanisms for picture and word processes are functionally and anatomically distinct. In spite of significant advancements in the understanding of pictures and words, the electrophysiological activities mediating these processes are not well known. To address ...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-006-0270-9

    authors: Azizian A,Watson TD,Parvaz MA,Squires NK

    更新日期:2006-04-01 00:00:00

  • EEG Artifact Removal in TMS Studies of Cortical Speech Areas.

    abstract::The combination of transcranial magnetic stimulation (TMS) and electroencephalography (EEG) is commonly applied for studying the effective connectivity of neuronal circuits. The stimulation excites neurons, and the resulting TMS-evoked potentials (TEPs) are recorded with EEG. A serious obstacle in this method is the g...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-019-00724-w

    authors: Salo KS,Mutanen TP,Vaalto SMI,Ilmoniemi RJ

    更新日期:2020-01-01 00:00:00

  • Global Brain Involvement in Posterior Cortical Atrophy: Multimodal MR Imaging Investigation.

    abstract::Posterior cortical atrophy (PCA), considered a visual variant of Alzheimer's disease, has similar pathological characteristics yet shows a selective visual manifestation with relative preservation of other cortical areas, at least at early stages of disease. Using a gamut of imaging methods, we aim to evaluate the glo...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-020-00788-z

    authors: Glick-Shames H,Keadan T,Backner Y,Bick A,Levin N

    更新日期:2020-09-01 00:00:00

  • Topographic mapping of the EEG: an examination of accuracy and precision.

    abstract::The accuracy and precision of topographic maps depicting scalp potentials and scalp potentials squared have been examined. Electrode placement was that specified by the International 10-20 System and the methods of interpolation bilinear and bicubic spines. The results indicate that, for these interpolation methods, t...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/BF01129173

    authors: Koles ZJ,Paranjape RB

    更新日期:1988-01-01 00:00:00

  • Chemotherapy-Induced Brain Effects in Small-Cell Lung Cancer Patients: A Multimodal MRI Study.

    abstract::The golden standard of treating Small Cell Lung Cancer (SCLC) entails application of platinum-based chemotherapy, is often accompanied by Prophylactic Cranial Irradiation (PCI), which have been linked to neurotoxic side-effects in cognitive functions. The related existing neuroimaging research mainly focuses on the ef...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-020-00811-3

    authors: Mentzelopoulos A,Gkiatis K,Karanasiou I,Karavasilis E,Papathanasiou M,Efstathopoulos E,Kelekis N,Kouloulias V,Matsopoulos GK

    更新日期:2021-01-05 00:00:00

  • Spatial enhancement of event-related potentials using multiresolution analysis.

    abstract::Multiresolution analysis is a potentially useful tool to enhance the brain's electrical fields (spatial distributions of event-related potentials (ERP)), and to bring out spatial features which may not be seen in the fields before enhancement. For comparing different images (slices from ERP of different subjects or fr...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1023/a:1022209209531

    authors: Wang K,Begleiter H,Porjesz B

    更新日期:1998-04-01 00:00:00

  • Interaction Between Words and Symbolic Gestures as Revealed By N400.

    abstract::What happens if you see a person pronouncing the word "go" after having gestured "stop"? Differently from iconic gestures, that must necessarily be accompanied by verbal language in order to be unambiguously understood, symbolic gestures are so conventionalized that they can be effortlessly understood in the absence o...

    journal_title:Brain topography

    pub_type: 杂志文章

    doi:10.1007/s10548-014-0392-4

    authors: Fabbri-Destro M,Avanzini P,De Stefani E,Innocenti A,Campi C,Gentilucci M

    更新日期:2015-07-01 00:00:00