The Co-existence of ADHD With Autism in Saudi Children: An Analysis Using Next-Generation DNA Sequencing.

abstract：:Clear cell renal cell carcinoma (ccRCC) is one of the most common histological subtypes of renal cancer, with a poor prognosis. Our study aimed to identify a biomarker that is significantly associated with ccRCC prognosis and novel immunotherapeutic targets, as well as some novel molecular drugs for ccRCC. Based on th...

journal_title：Frontiers in genetics

authors： Xiao GF,Yan X,Chen Z,Zhang RJ,Liu TZ,Hu WL

更新日期：2020-08-18 00:00:00

abstract：:Among people of European descent, the ability to digest lactose into adulthood arose via strong positive selection of a highly advantageous allele encompassing the lactase gene. Lactose-tolerant and intolerant individuals may have different disease risks due to the shared genetics of their haplotype block. Therefore, ...

journal_title：Frontiers in genetics

authors： Joslin SEK,Durbin-Johnson BP,Britton M,Settles ML,Korf I,Lemay DG

更新日期：2020-10-29 00:00:00

abstract：:Autoimmune encephalitis (AE) is a severe neurological disease. The brain of the AE patient is attacked by a dysregulated immune system, which is caused by the excessive production of autoantibodies against neuronal receptors and synaptic proteins. AE is also characterized by the uncontrolled B lymphocyte infiltration ...

journal_title：Frontiers in genetics

authors： Tsai MH,Lin CH,Tsai KW,Lin MH,Ho CJ,Lu YT,Weng KP,Lin Y,Lin PH,Li SC

更新日期：2019-11-22 00:00:00

abstract：:In recent years, studies have shown that phytopathogenic fungi possess the ability of cross-kingdom regulation of host plants through small RNAs (sRNAs). Magnaporthe oryzae, a causative agent of rice blast, introduces disease by penetrating the rice tissues through appressoria. However, little is known about the trans...

journal_title：Frontiers in genetics

authors： Zhang H,Liu S,Chang H,Zhan M,Qin QM,Zhang B,Li Z,Liu Y

更新日期：2019-03-29 00:00:00

abstract：:The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease (CVD), and have also been associated with longevity. We sought to identify novel loci for HDL that could potentially provide new insights into biological regulation of...

journal_title：Frontiers in genetics

authors： Feitosa MF,Wojczynski MK,Straka R,Kammerer CM,Lee JH,Kraja AT,Christensen K,Newman AB,Province MA,Borecki IB

更新日期：2014-06-03 00:00:00

abstract：CONTEXT:The effect of weight loss by diet alone or diet in conjunction with exercise on low-grade inflammation in non-obese (overweight) individuals is not known. OBJECTIVE:Test the hypothesis that 24 weeks of moderate calorie restriction (CR; 25%) by diet only or with aerobic exercise would reduce markers of systemic...

journal_title：Frontiers in genetics

authors： Tam CS,Covington JD,Ravussin E,Redman LM,Pennington CALERIE Team.

更新日期：2012-04-19 00:00:00

abstract：:In the last few years, the role of non-coding regulatory elements and their involvement in human disease have received great attention. Among the non-coding regulatory sequences, enhancers are particularly important for the proper establishment of cell type-specific gene-expression programs. Furthermore, the disruptio...

journal_title：Frontiers in genetics

authors： Sánchez-Gaya V,Mariner-Faulí M,Rada-Iglesias A

更新日期：2020-07-20 00:00:00

abstract：:The emergence of eusociality ("true sociality") in several insect lineages represents one of the most successful evolutionary adaptations in the animal kingdom in terms of species richness and global biomass. In contrast to solitary insects, eusocial insects evolved a set of unique behavioral and physiological traits ...

journal_title：Frontiers in genetics

authors： Søvik E,Bloch G,Ben-Shahar Y

更新日期：2015-05-27 00:00:00

abstract：:Plants are subjected to strong fluctuations in light intensity in their natural growth environment, caused both by unpredictable changes due to weather conditions and movement of clouds and upper canopy leaves and predictable changes during day-night cycle. The mechanisms of long-term acclimation to fluctuating light ...

journal_title：Frontiers in genetics

authors： Niedermaier S,Schneider T,Bahl MO,Matsubara S,Huesgen PF

更新日期：2020-03-05 00:00:00

abstract：:Next generation sequencing (NGS) technologies, primarily based on massively parallel sequencing, have touched and radically changed almost all aspects of research worldwide. These technologies have allowed for the rapid analysis, to date, of the genomes of more than 2,000 different species. In humans, NGS has arguably...

journal_title：Frontiers in genetics

authors： Peters BA,Liu J,Drmanac R

更新日期：2015-01-14 00:00:00

abstract：:Objective: Schizophrenia is thought to be a neurodevelopmental disorder. As a key regulator in the development of the central nervous system, transcription factor 4 (TCF4) has been shown to be involved in the pathogenesis of schizophrenia. The aim of our study was to assay the association of TCF4 single nucleotide pol...

journal_title：Frontiers in genetics

authors： Yin J,Zhu D,Li Y,Lv D,Yu H,Liang C,Luo X,Xu X,Fu J,Yan H,Dai Z,Zhou X,Wen X,Xiong S,Lin Z,Lin J,Zhao B,Wang Y,Li K,Ma G

更新日期：2019-05-28 00:00:00

abstract：:In spite of the significant advancements in the treatment modalities, 30% of advanced stage ovarian cancer (OC) patients do not respond to the standard chemotherapeutic regimen and most of the responders finally relapse over time due to the escalation of multidrug resistance (MDR) Phenomenon. Our present study evaluat...

journal_title：Frontiers in genetics

authors： Haque A,Sait KHW,Alam Q,Alam MZ,Anfinan N,Wali AWN,Rasool M

更新日期：2020-05-26 00:00:00

abstract：:Severe hypercholesterolemia (HC) is defined as an elevation of total cholesterol (TC) due to the increase in LDL cholesterol (LDL-C) >95th percentile or 190 mg/dl. The high values of LDL-C, especially when it is maintained over time, is considered a risk factor for the development of atherosclerotic cardiovascular dis...

journal_title：Frontiers in genetics

authors： Jarauta E,Bea-Sanz AM,Marco-Benedi V,Lamiquiz-Moneo I

更新日期：2020-12-03 00:00:00

abstract：:The prophase of meiosis I ensures the correct segregation of chromosomes to each daughter cell. This includes the pairing, synapsis, and recombination of homologous chromosomes. A subset of chromosomal abnormalities, including translocation and inversion, disturbs these processes, resulting in the failure to complete ...

journal_title：Frontiers in genetics

authors： Kurahashi H,Kogo H,Tsutsumi M,Inagaki H,Ohye T

更新日期：2012-06-18 00:00:00

abstract：:The goal of this review is to discuss how behavioral tests in mice relate to the pathological and neuropsychological features seen in human Alzheimer's disease (AD), and present a comprehensive analysis of the temporal progression of behavioral impairments in commonly used AD mouse models that contain mutations in amy...

journal_title：Frontiers in genetics

authors： Webster SJ,Bachstetter AD,Nelson PT,Schmitt FA,Van Eldik LJ

更新日期：2014-04-23 00:00:00

abstract：:It is time to review all the available data and find the distinctive characteristics of actin that make it such an important cell molecule. The presented double-stranded organization of filamentous actin cannot explain the strong polymorphism of actin fibrils. In this work, we performed bioinformatics analysis of a se...

journal_title：Frontiers in genetics

authors： Glyakina AV,Galzitskaya OV

更新日期：2020-12-10 00:00:00

abstract：:While substantial progress has been made in finding genetic variants associated with nicotine dependence (ND), a large proportion of the genetic variants remain undiscovered. The current research focuses have shifted toward uncovering rare variants, gene-gene/gene-environment interactions, and structural variations pr...

journal_title：Frontiers in genetics

authors： Zhang X,Lan T,Wang T,Xue W,Tong X,Ma T,Liu G,Lu Q

更新日期：2019-05-17 00:00:00

abstract：:An increasing number of studies have shown that long intergenic non-coding RNAs (lincRNAs) are a very important class of non-coding RNAs that plays a vital role in many biological processes. Adipose tissue is an important place for storing energy, but few studies on lincRNAs were related to pig subcutaneous fat develo...

journal_title：Frontiers in genetics

authors： Shi G,Chen L,Chen G,Zou C,Li J,Li M,Fang C,Li C

更新日期：2019-03-04 00:00:00

abstract：:Posttraumatic Stress Disorder (PTSD) is a complex illness, frequently co-morbid with depression, caused by both genetics, and the environment. Alcohol Use Disorder (AUD), which also co-occurs with depression, is often co-morbid with PTSD. To date, very few genes have been identified for PTSD and even less for PTSD com...

journal_title：Frontiers in genetics

authors： Lim PH,Shi G,Wang T,Jenz ST,Mulligan MK,Redei EE,Chen H

更新日期：2018-11-27 00:00:00

abstract：:The interaction of miRNA and lncRNA is known to be important for gene regulations. However, the number of known lncRNA-miRNA interactions is still very limited and there are limited computational tools available for predicting new ones. Considering that lncRNAs and miRNAs share internal patterns in the partnership bet...

journal_title：Frontiers in genetics

authors： Huang YA,Huang ZA,You ZH,Zhu Z,Huang WZ,Guo JX,Yu CQ

更新日期：2019-08-29 00:00:00

abstract：:Cardiovascular diseases are one of the prime reasons for disability and death worldwide. Diseases and conditions, such as hypoxia, pressure overload, infection, and hyperglycemia, might initiate cardiac remodeling and dysfunction by inducing hypertrophy or apoptosis in cardiomyocytes and by promoting proliferation in ...

journal_title：Frontiers in genetics

authors： Dai B,Wang F,Nie X,Du H,Zhao Y,Yin Z,Li H,Fan J,Wen Z,Wang DW,Chen C

更新日期：2020-11-20 00:00:00

abstract：:Expanded newborn screening for inborn errors of metabolism (IEMs) by tandem mass spectrometry (MS/MS) could simultaneously analyze more than 40 metabolites and identify about 50 kinds of IEMs. Next generation sequencing (NGS) targeting hundreds of IMEs-associated genes as a follow-up test in expanded newborn screening...

journal_title：Frontiers in genetics

authors： Wang T,Ma J,Zhang Q,Gao A,Wang Q,Li H,Xiang J,Wang B

更新日期：2019-10-29 00:00:00

abstract：:ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein-coding and non-coding genes on a genome scale. Although it is ubiqu...

journal_title：Frontiers in genetics

authors： Ye B,Yang G,Li Y,Zhang C,Wang Q,Yu G

更新日期：2020-04-07 00:00:00

abstract：:Cell viability and gene expression profiles are altered in cellular models of neurodegenerative disorders such as Huntington's Disease (HD). Using the yeast model system, we show that the SUMO-targeted ubiquitin ligase (STUbL) Slx5 reduces the toxicity and abnormal transcriptional activity associated with a mutant, ag...

journal_title：Frontiers in genetics

authors： Ohkuni K,Pasupala N,Peek J,Holloway GL,Sclar GD,Levy-Myers R,Baker RE,Basrai MA,Kerscher O

更新日期：2018-09-18 00:00:00

abstract：:Alternative splicing (AS) can enhance transcript diversity dramatically and play an important role in stress adaptation. Limited researches of AS have been reported in the Pacific white shrimp (Litopenaeus vannamei), which is an important aquaculture species in the world. Here, we performed a genome-wide identificatio...

journal_title：Frontiers in genetics

authors： Zhang X,Yuan J,Zhang X,Liu C,Xiang J,Li F

更新日期：2019-09-12 00:00:00

abstract：:Extracting inherent valuable knowledge from omics big data remains as a daunting problem in bioinformatics and computational biology. Deep learning, as an emerging branch from machine learning, has exhibited unprecedented performance in quite a few applications from academia and industry. We highlight the difference a...

journal_title：Frontiers in genetics

authors： Tang B,Pan Z,Yin K,Khateeb A

更新日期：2019-03-26 00:00:00

abstract：:A within-breed genome-wide association study (GWAS) is useful when identifying the QTL that segregates in a breed. However, an across-breed meta-analysis can be used to increase the power of identification and precise localization of QTL that segregate in multiple breeds. Precise localization will allow including QTL ...

journal_title：Frontiers in genetics

authors： Marete AG,Guldbrandtsen B,Lund MS,Fritz S,Sahana G,Boichard D

更新日期：2018-11-06 00:00:00

abstract：:This article reviews research results and ideas presented at a special symposium at the International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 in San Francisco. Five researchers presented their results related to infection and Alzheimer's disease (AD). Prof. Itzhaki presented her wor...

journal_title：Frontiers in genetics

authors： Fülöp T,Itzhaki RF,Balin BJ,Miklossy J,Barron AE

更新日期：2018-09-10 00:00:00

abstract：:The epithelial-mesenchymal transition (EMT) describes a reversible switch from an epithelial-like to a mesenchymal-like phenotype. It is essential for the development of the normal epithelium and also contributes to the invasive properties of carcinomas. At the molecular level, the EMT transition is characterized by a...

journal_title：Frontiers in genetics

authors： Kim JE,Leung E,Baguley BC,Finlay GJ

更新日期：2013-05-31 00:00:00

abstract：:Human malnutrition due to micronutrient deficiencies, particularly with regards to Zinc (Zn) and Selenium (Se), affects millions of people around the world, and the enrichment of staple foods through biofortification has been successfully used to fight hidden hunger. Rice (Oryza sativa L.) is one of the staple foods m...

journal_title：Frontiers in genetics

authors： Roda FA,Marques I,Batista-Santos P,Esquível MG,Ndayiragije A,Lidon FC,Swamy BPM,Ramalho JC,Ribeiro-Barros AI

更新日期：2020-07-07 00:00:00