Genome-Wide Analysis of Alternative Splicing Provides Insights Into Stress Response of the Pacific White Shrimp Litopenaeus vanname.

abstract：:The interaction of miRNA and lncRNA is known to be important for gene regulations. However, the number of known lncRNA-miRNA interactions is still very limited and there are limited computational tools available for predicting new ones. Considering that lncRNAs and miRNAs share internal patterns in the partnership bet...

journal_title：Frontiers in genetics

authors： Huang YA,Huang ZA,You ZH,Zhu Z,Huang WZ,Guo JX,Yu CQ

更新日期：2019-08-29 00:00:00

abstract：BACKGROUND:Schizophrenia is a complex psychiatric disorder with a lifetime morbidity rate of 0.5-1.0%. The pathophysiology of schizophrenia still remains obscure. Accumulating evidence indicates that DNA methylation, which is the addition of a methyl group to the cytosine in a CpG dinucleotide, might play an important ...

journal_title：Frontiers in genetics

authors： Numata S,Ye T,Herman M,Lipska BK

更新日期：2014-08-26 00:00:00

abstract：:Both natural and artificial selection are among the main driving forces shaping genetic variation across the genome of livestock species. Selection typically leaves signatures in the genome, which are often characterized by high genetic differentiation across breeds and/or a strong reduction in genetic diversity in re...

journal_title：Frontiers in genetics

authors： Onzima RB,Upadhyay MR,Doekes HP,Brito LF,Bosse M,Kanis E,Groenen MAM,Crooijmans RPMA

更新日期：2018-08-14 00:00:00

abstract：:Recent studies have revealed that the RNA N6-methyladenosine (m6A) modification plays a critical role in a variety of biological processes and associated with multiple diseases including cancers. Till this day, transcriptome-wide m6A RNA methylation sites have been identified by high-throughput sequencing technique co...

journal_title：Frontiers in genetics

authors： Tang Y,Chen K,Wu X,Wei Z,Zhang SY,Song B,Zhang SW,Huang Y,Meng J

更新日期：2019-04-03 00:00:00

abstract：:Complex traits are manifestations of intricate gene interaction networks. Evolution of complex traits revolves around the genetic variation in such networks. Genomics has increased our ability to investigate the complex gene interaction networks, and characterize the extent of genetic variation in these networks. Immu...

journal_title：Frontiers in genetics

authors： Wertheim B

更新日期：2015-06-19 00:00:00

abstract：:Poultry feed constitutes the largest cost in poultry production, estimated to be up to 70% of the total cost. Moreover, there is pressure on the poultry industry to increase production to meet the protein demand of humans and simultaneously reduce emissions to protect the environment. Therefore, improving feed efficie...

journal_title：Frontiers in genetics

authors： Ye S,Chen ZT,Zheng R,Diao S,Teng J,Yuan X,Zhang H,Chen Z,Zhang X,Li J,Zhang Z

更新日期：2020-04-03 00:00:00

abstract：:Nuclear factor Y (NF-Y) is a heterotrimeric transcription factor with the ability to bind to a CCAAT box in nearly all eukaryotes. However, the function of NF-Y in the life-history traits of insects is unclear. Here, we identified three NF-Y subunits, NlNF-YA, NlNF-YB, and NlNF-YC, in the wing-dimorphic brown planthop...

journal_title：Frontiers in genetics

authors： Chen HH,Liu YL,Liu XY,Zhang JL,Xu HJ

更新日期：2020-11-03 00:00:00

abstract：:Purpose: To explore a method for the early, rapid and accurate diagnosis of Wolfram syndrome 1 (WS1) and further enrich the spectrum of WFS1 mutations in the Chinese population. Methods: We analyzed 279 patients with unexplained optic atrophy using next-generation sequencing. All patients underwent detailed clinical e...

journal_title：Frontiers in genetics

authors： Wang DD,Hu FY,Gao FJ,Zhang SH,Xu P,Tian GH,Wu JH

更新日期：2019-11-26 00:00:00

abstract：:Recent advances in genomics and proteomics generated a large amount of trans regulatory data such as those mediated by RNA binding proteins (RBPs) and microRNAs. Since many trans regulators target 3' UTR of mRNA transcripts, it is likely that there would be interactions, i.e., competitive or cooperative effect, among ...

journal_title：Frontiers in genetics

authors： Liu Y,Pan C,Kong D,Luo J,Zhang Z

更新日期：2020-09-08 00:00:00

abstract：:Olfactory receptors (ORs) are a type of GTP-binding protein-coupled receptor (GPCR). These receptors are responsible for mediating the sense of smell through their interaction with odor ligands. OR-odorant interactions marks the first step in the process that leads to olfaction. Computational studies on model OR struc...

journal_title：Frontiers in genetics

authors： Lai PC,Crasto CJ

更新日期：2012-05-03 00:00:00

abstract：:Studies in rats and mice have established that maternal nutrition induces epigenetic modifications, sometimes permanently, that alter gene expression in the fetus, which in turn leads to phenotypic changes. However, limited data is available on the influence of maternal diet on epigenetic modifications and gene expres...

journal_title：Frontiers in genetics

authors： Lan X,Cretney EC,Kropp J,Khateeb K,Berg MA,Peñagaricano F,Magness R,Radunz AE,Khatib H

更新日期：2013-04-05 00:00:00

abstract：:The Xichuan black-bone chicken, which is a rare local chicken species in China, is an important genetic resource of black-bone chickens. Tyrosine can affect melanin production, but the molecular mechanism underlying tyrosine-induced melanin deposition in Xichuan black-bone chickens is poorly understood. Here, the blac...

journal_title：Frontiers in genetics

authors： Li D,Wang X,Fu Y,Zhang C,Cao Y,Wang J,Zhang Y,Li Y,Chen Y,Li Z,Li W,Jiang R,Sun G,Tian Y,Li G,Kang X

更新日期：2019-05-15 00:00:00

abstract：:Genome-wide Association Studies (GWAS) result in millions of summary statistics ("z-scores") for single nucleotide polymorphism (SNP) associations with phenotypes. These rich datasets afford deep insights into the nature and extent of genetic contributions to complex phenotypes such as psychiatric disorders, which are...

journal_title：Frontiers in genetics

authors： Holland D,Wang Y,Thompson WK,Schork A,Chen CH,Lo MT,Witoelar A,Schizophrenia Working Group of the Psychiatric Genomics Consortium.,Enhancing Neuro Imaging Genetics through Meta Analysis Consortium.,Werge T,O'Donovan M,Andreassen OA

更新日期：2016-02-16 00:00:00

abstract：Background:This study searched for immune-related long noncoding RNAs (lncRNAs) to predict the prognosis of patients with cervical cancer. Method:We obtained immunologically relevant lncRNA expression profiles and clinical follow-up data from cervical cancer patients from The Cancer Genome Atlas database and the Molec...

journal_title：Frontiers in genetics

authors： Chen Q,Hu L,Huang D,Chen K,Qiu X,Qiu B

更新日期：2020-10-14 00:00:00

abstract：:People want to live long, healthy lives. Previous surveys suggest very limited interest in much longer lifespans, but we show that stipulating good health changes responses to favor longer lives by an order of magnitude. Advances in aging research hold out hope for greatly slowed aging with associated good health. Und...

journal_title：Frontiers in genetics

authors： Donner Y,Fortney K,Calimport SR,Pfleger K,Shah M,Betts-LaCroix J

更新日期：2016-01-20 00:00:00

abstract：:In the last 40 years, the Asian tiger mosquito Aedes albopictus, indigenous to East Asia, has colonized every continent except Antarctica. Its spread is a major public health concern, given that this species is a competent vector for numerous arboviruses, including those causing dengue, chikungunya, West Nile, and the...

journal_title：Frontiers in genetics

authors： Battaglia V,Gabrieli P,Brandini S,Capodiferro MR,Javier PA,Chen XG,Achilli A,Semino O,Gomulski LM,Malacrida AR,Gasperi G,Torroni A,Olivieri A

更新日期：2016-11-23 00:00:00

abstract：:Trauma is a leading cause of morbidity and mortality. It is unclear why some trauma victims follow a complicated clinical course and die, while others, with apparently similar injury characteristics, do not. Interpatient genomic differences, in the form of single nucleotide polymorphisms (SNPs), have been associated p...

journal_title：Frontiers in genetics

authors： Schimunek L,Namas RA,Yin J,Barclay D,Liu D,El-Dehaibi F,Abboud A,Cohen M,Zamora R,Billiar TR,Vodovotz Y

更新日期：2019-11-08 00:00:00

abstract：:Background: Porcine respiratory and reproductive syndrome virus (PRRSV) is a single-stranded RNA virus member that infects pigs and causes losses to the commercial industry reaching upward of a billion dollars annually in combined direct and indirect costs. The virus can be separated into etiologies that contain multi...

journal_title：Frontiers in genetics

authors： Fleming DS,Miller LC

更新日期：2019-08-02 00:00:00

abstract：:Recently, a consanguineous family was identified in Israel with three children affected by Infantile Nystagmus and Foveal Hypoplasia, following an autosomal recessive mode of inheritance. A homozygous stop mutation c.1861C > T; p.Q621∗ in the aryl hydrocarbon receptor (AHR) gene (AHR; MIM 600253) was identified that c...

journal_title：Frontiers in genetics

authors： Borovok N,Weiss C,Sharkia R,Reichenstein M,Wissinger B,Azem A,Mahajnah M

更新日期：2020-09-24 00:00:00

abstract：:The principles and function of chromatin and nuclear architecture have been extensively studied in model organisms, such as Drosophila melanogaster. However, little is known about the role of these epigenetic processes in transcriptional regulation in other insects including mosquitoes, which are major disease vectors...

journal_title：Frontiers in genetics

authors： Lezcano ÓM,Sánchez-Polo M,Ruiz JL,Gómez-Díaz E

更新日期：2020-12-07 00:00:00

abstract：:Plant Glycine-rich proteins (GRP), a superfamily with a glycine-rich domain, play an important role in various stresses such as high or low temperature stress and drought stress. GRP genes have been studied in many plants, but seldom in Chinese cabbage (Brassica rapa L. ssp. pekinensis). In this study, a total of 64 G...

journal_title：Frontiers in genetics

authors： Lu X,Cheng Y,Gao M,Li M,Xu X

更新日期：2020-07-23 00:00:00

abstract：:The primary function of leaves is to provide an interface between plants and their environment for gas exchange, light exposure and thermoregulation. Leaves have, therefore a central contribution to plant fitness by allowing an efficient absorption of sunlight energy through photosynthesis to ensure an optimal growth....

journal_title：Frontiers in genetics

authors： Fritz MA,Rosa S,Sicard A

更新日期：2018-10-24 00:00:00

abstract：:Over millions of years, vertebrate species populated vast environments spanning the globe. Among the most challenging habitats encountered were those with limited availability of oxygen, yet many animal and human populations inhabit and perform life cycle functions and/or daily activities in varying degrees of hypoxia...

journal_title：Frontiers in genetics

authors： Pamenter ME,Hall JE,Tanabe Y,Simonson TS

更新日期：2020-07-22 00:00:00

abstract：:Background: Although there is evidence that the CYP3A4*22 variant should be considered in tacrolimus dosing in renal transplantation, its impact beyond tacrolimus dose requirements remains controversial. Methods: In a cohort of 121 kidney transplant recipients, we analyzed the CYP3A4*1B, CYP3A4*22, and CYP3A5*3 allele...

journal_title：Frontiers in genetics

authors： Abdel-Kahaar E,Winter S,Tremmel R,Schaeffeler E,Olbricht CJ,Wieland E,Schwab M,Shipkova M,Jaeger SU

更新日期：2019-09-26 00:00:00

abstract：:A complete and compelling evolutionary explanation for the origin of human menopause is wanting. Menopause onset is defined clinically as the final menses, confirmed after 1 year without menstruation. The theory proposed herein explains at multiple levels - ultimately genetic but involving (1) behavioral, (2) life his...

journal_title：Frontiers in genetics

authors： Takahashi M,Singh RS,Stone J

更新日期：2017-01-06 00:00:00

abstract：:In the world of high-throughput sequencing there are numerous challenges to effective data quality control. There are no single quality metrics which are appropriate in all conditions. Here we detail the different open source software used at the Exeter Sequencing Service to provide generic quality control information...

journal_title：Frontiers in genetics

authors： Paszkiewicz KH,Farbos A,O'Neill P,Moore K

更新日期：2014-05-27 00:00:00

abstract：:Filamentous pathogens, such as phytopathogenic oomycetes and fungi, secrete a remarkable diversity of apoplastic effector proteins to facilitate infection, many of which are able to induce cell death in plants. Over the past decades, over 177 apoplastic cell death-inducing proteins (CDIPs) have been identified in fila...

journal_title：Frontiers in genetics

authors： Li Y,Han Y,Qu M,Chen J,Chen X,Geng X,Wang Z,Chen S

更新日期：2020-06-26 00:00:00

abstract：:Apomixis, an asexual mode of reproduction through seeds, has immense scope for crop improvement due to its ability to fix hybrid vigor. In C. ciliaris, a predominantly apomictically reproducing range grass, apomixis is genetically controlled by an apospory-specific-genomic-region (ASGR) which is enriched with retrotra...

journal_title：Frontiers in genetics

authors： Rathore P,Raina SN,Kumar S,Bhat V

更新日期：2020-07-22 00:00:00

abstract：:Plants are subjected to strong fluctuations in light intensity in their natural growth environment, caused both by unpredictable changes due to weather conditions and movement of clouds and upper canopy leaves and predictable changes during day-night cycle. The mechanisms of long-term acclimation to fluctuating light ...

journal_title：Frontiers in genetics

authors： Niedermaier S,Schneider T,Bahl MO,Matsubara S,Huesgen PF

更新日期：2020-03-05 00:00:00

abstract：:Genomic breed composition (GBC) of an individual animal refers to the partition of its genome according to the inheritance from its ancestors or ancestral breeds. For crossbred or composite animals, knowing their GBC is useful to estimate heterosis, to characterize their actual inheritance from foundation breeds, and ...

journal_title：Frontiers in genetics

authors： Wu XL,Li Z,Wang Y,He J,Rosa GJM,Ferretti R,Genho J,Tait RG Jr,Parham J,Schultz T,Bauck S

更新日期：2020-10-30 00:00:00