Great Desire for Extended Life and Health amongst the American Public.

abstract：:Different genes have their protein products localized in various subcellular compartments. The diversity in protein localization may serve as a gene characteristic, revealing gene essentiality from a subcellular perspective. To measure this diversity, we introduced a Subcellular Diversity Index (SDI) based on the Gene...

journal_title：Frontiers in genetics

authors： Jia K,Zhou Y,Cui Q

更新日期：2020-01-21 00:00:00

abstract：:The prevalence of obesity continues to increase particularly in developed countries. To establish the primary mechanisms involved, relevant animal models which track the developmental pathway to obesity are required. This need is emphasized by the substantial rise in the number of overweight and obese children, of whi...

journal_title：Frontiers in genetics

authors： Symonds ME,Sebert S,Budge H

更新日期：2011-05-31 00:00:00

abstract：:Various patterns of multi-phenotype associations (MPAs) exist in the results of Genome Wide Association Studies (GWAS) involving different topologies of single nucleotide polymorphism (SNP)-phenotype associations. These can provide interesting information about the different impacts of a gene on closely related phenot...

journal_title：Frontiers in genetics

authors： Weighill D,Jones P,Bleker C,Ranjan P,Shah M,Zhao N,Martin M,DiFazio S,Macaya-Sanz D,Schmutz J,Sreedasyam A,Tschaplinski T,Tuskan G,Jacobson D

更新日期：2019-05-10 00:00:00

abstract：:Human exposure to mercury is a serious problem of public health in Amazon. As in other vulnerable populations throughout the world, Amazonian riverine populations are chronically exposed to this metal and some symptoms of mercury intoxication were already detected in these populations. However, studies on the genetic ...

journal_title：Frontiers in genetics

authors： Arrifano GPF,Martín-Doimeadios RCR,Jiménez-Moreno M,Fernández-Trujillo S,Augusto-Oliveira M,Souza-Monteiro JR,Macchi BM,Alvarez-Leite JI,do Nascimento JLM,Amador MT,Santos S,Ribeiro-Dos-Santos Â,Silva-Pereira LC,Oriá RB,Cresp

更新日期：2018-07-27 00:00:00

abstract：:The termites evolved eusociality and complex societies before the ants, but have been studied much less. The recent publication of the first two termite genomes provides a unique comparative opportunity, particularly because the sequenced termites represent opposite ends of the social complexity spectrum. Zootermopsis...

journal_title：Frontiers in genetics

authors： Korb J,Poulsen M,Hu H,Li C,Boomsma JJ,Zhang G,Liebig J

更新日期：2015-03-04 00:00:00

abstract：UNLABELLED:The PIMMS (Pragmatic Insertional Mutation Mapping System) pipeline has been developed for simple conditionally essential genome discovery experiments in bacteria. Capable of using raw sequence data files alongside a FASTA sequence of the reference genome and GFF file, PIMMS will generate a tabulated output o...

journal_title：Frontiers in genetics

authors： Blanchard AM,Leigh JA,Egan SA,Emes RD

更新日期：2015-04-09 00:00:00

abstract：:Analysis of the relationships among wild species of section Moutan in the plant genus Paeonia has traditionally been problematic. Interspecies relationships cannot be effectively determined using phenotypic traits alone or through analysis of nuclear or chloroplast DNA fragments. Elucidation of complete chloroplast ge...

journal_title：Frontiers in genetics

authors： Wu L,Nie L,Xu Z,Li P,Wang Y,He C,Song J,Yao H

更新日期：2020-09-18 00:00:00

abstract：:Vitamin D receptor (VDR) gene polymorphisms were reported to influence blood lead levels (BLL) and the response of subjects to the symptoms of lead toxicity. However, no studies have been conducted in the Saudi Arabian population which has unique ethnicity and socio-demographic features. This study examined the polymo...

journal_title：Frontiers in genetics

authors： Shaik AP,Alsaeed AH,Faiyaz-Ul-Haque M,Alsaeed MA,Alyousef AA,Bammidi VK,Shaik AS

更新日期：2019-04-26 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects about 1% of the world's population. The etiology of RA remains unknown. It is considered to occur in the presence of genetic and environmental factors. An increasing body of evidence pinpoints that epigenetic modifications play an important role i...

journal_title：Frontiers in genetics

authors： Nemtsova MV,Zaletaev DV,Bure IV,Mikhaylenko DS,Kuznetsova EB,Alekseeva EA,Beloukhova MI,Deviatkin AA,Lukashev AN,Zamyatnin AA Jr

更新日期：2019-06-14 00:00:00

abstract：:RNA-binding proteins (RBPs) are a kind of gene regulatory factor that presents a significant biological effect in the initiation and development of various tumors, including bladder cancer (BLCA). However, the RBP-based prognosis signature for BLCA has not been investigated. In this study, we attempted to develop an R...

journal_title：Frontiers in genetics

authors： Wu Y,Liu Y,He A,Guan B,He S,Zhang C,Kang Z,Gong Y,Li X,Zhou L

更新日期：2020-08-28 00:00:00

abstract：:Circular RNAs (circRNAs), expressed abundantly and universally in various eukaryotes, are involved in growth and development of animals. Our previous study on circRNA sequencing revealed that circSVIL, an exonic circular, expressed differentially among skeletal muscle at 11 embryo age (E11), 16 embryo age (E16), and 1...

journal_title：Frontiers in genetics

authors： Ouyang H,Chen X,Li W,Li Z,Nie Q,Zhang X

更新日期：2018-05-16 00:00:00

abstract：:Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine...

journal_title：Frontiers in genetics

authors： Wu T,Wang Y,Shi W,Zhang BQ,Raelson J,Yao YM,Wu HD,Xu ZX,Marois-Blanchet FC,Ledoux J,Blunck R,Sheng JZ,Hu SJ,Luo H,Wu J

更新日期：2020-11-27 00:00:00

abstract：Background:Despite recent advance in immune therapy, great heterogeneity exists in the outcomes of colorectal cancer (CRC) patients. In this study, we aimed to analyze the immune-related gene (IRG) expression profiles from three independent public databases and develop an effective signature to forecast patient's progn...

journal_title：Frontiers in genetics

authors： Dai S,Xu S,Ye Y,Ding K

更新日期：2020-12-04 00:00:00

abstract：:Functional annotation of the genome is important to understand the phenotypic complexity of various species. The road toward functional annotation involves several challenges ranging from experiments on individual molecules to large-scale analysis of high-throughput sequencing (HTS) data. HTS data is typically a resul...

journal_title：Frontiers in genetics

authors： Pundhir S,Poirazi P,Gorodkin J

更新日期：2015-05-19 00:00:00

abstract：:Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by the cell in several crucial biological processes including gene transcription and DNA methylation. The homeostasis of H3K36 methylation is...

journal_title：Frontiers in genetics

authors： Zaghi M,Broccoli V,Sessa A

更新日期：2020-01-09 00:00:00

abstract：:Goats (Capra hircus) are an economically important livestock species providing meat and milk across the globe. They are of particular importance in tropical agri-systems contributing to sustainable agriculture, alleviation of poverty, social cohesion, and utilisation of marginal grazing. There are excellent genetic an...

journal_title：Frontiers in genetics

authors： Muriuki C,Bush SJ,Salavati M,McCulloch MEB,Lisowski ZM,Agaba M,Djikeng A,Hume DA,Clark EL

更新日期：2019-11-04 00:00:00

abstract：:Background: Milroy disease (MD) is rare and autosomal dominant resulting from mutations of the vascular endothelial growth factor receptor-3 (VEGFR-3 or FLT4), which leads to dysgenesis of the lymphatic system. Methods: Here we report a Chinese MD family with 2 affected members of two generations. We identified the mu...

journal_title：Frontiers in genetics

authors： Zhang S,Chen X,Yuan L,Wang S,Moli D,Liu S,Wu Y

更新日期：2019-03-19 00:00:00

abstract：:Our understanding of the mechanisms governing the response to DNA damage in higher eucaryotes crucially depends on our ability to dissect the temporal and spatial organization of the cellular machinery responsible for maintaining genomic integrity. To achieve this goal, we need experimental tools to inflict DNA lesion...

journal_title：Frontiers in genetics

authors： Ferrando-May E,Tomas M,Blumhardt P,Stöckl M,Fuchs M,Leitenstorfer A

更新日期：2013-07-16 00:00:00

abstract：:In light of the complex nature of multiple sclerosis (MS) and the recently estimated contribution of low-frequency variants into disease, decoding its genetic risk components requires novel variant prioritization strategies. We selected, by reviewing MS Genome Wide Association Studies (GWAS), 107 candidate loci marked...

journal_title：Frontiers in genetics

authors： Ziliotto N,Marchetti G,Scapoli C,Bovolenta M,Meneghetti S,Benazzo A,Lunghi B,Balestra D,Laino LA,Bozzini N,Guidi I,Salvi F,Straudi S,Gemmati D,Menegatti E,Zamboni P,Bernardi F

更新日期：2019-06-26 00:00:00

abstract：:ZNF143, a human homolog of the transcriptional activator Staf, is a C2H2-type protein consisting of seven zinc finger domains. As a transcription factor (TF), ZNF143 is sequence specifically binding to chromatin and activates the expression of protein-coding and non-coding genes on a genome scale. Although it is ubiqu...

journal_title：Frontiers in genetics

authors： Ye B,Yang G,Li Y,Zhang C,Wang Q,Yu G

更新日期：2020-04-07 00:00:00

abstract：:Members of the Cryptococcus complex, includes Cryptococcus neoformans (most common fungal infection of the brain) and Cryptococcus gattii (high-impact emerging pathogen worldwide). Currently, the fungal multilocus sequence typing database (Fungal MLST Database) constitutes a valuable data repository of the genes used ...

journal_title：Frontiers in genetics

authors： Muñoz M,Camargo M,Ramírez JD

更新日期：2018-04-24 00:00:00

abstract：:Searching for the Multiple Longest Common Subsequences (MLCS) of multiple sequences is a classical NP-hard problem, which has been used in many applications. One of the most effective exact approaches for the MLCS problem is based on dominant point graph, which is a kind of directed acyclic graph (DAG). However, the t...

journal_title：Frontiers in genetics

authors： Peng Z,Wang Y

更新日期：2017-08-09 00:00:00

abstract：:While substantial progress has been made in finding genetic variants associated with nicotine dependence (ND), a large proportion of the genetic variants remain undiscovered. The current research focuses have shifted toward uncovering rare variants, gene-gene/gene-environment interactions, and structural variations pr...

journal_title：Frontiers in genetics

authors： Zhang X,Lan T,Wang T,Xue W,Tong X,Ma T,Liu G,Lu Q

更新日期：2019-05-17 00:00:00

abstract：:It is critical for patients who cannot undergo eradicable surgery to predict the risk of lung cancer recurrence and metastasis; therefore, the physicians can design the appropriate adjuvant therapy plan. However, traditional circulating tumor cell (CTC) detection or next-generation sequencing (NGS)-based methods are u...

journal_title：Frontiers in genetics

authors： Wu Z,Wang L,Li C,Cai Y,Liang Y,Mo X,Lu Q,Dong L,Liu Y

更新日期：2020-08-25 00:00:00

abstract：:Postpartum depression (PPD) affects up to 19% of women, negatively impacting maternal and infant health. Reductions in plasma oxytocin levels have been associated with PPD and heritability studies have established a genetic contribution. Epigenetic regulation of the oxytocin receptor gene (OXTR) has been demonstrated ...

journal_title：Frontiers in genetics

authors： Bell AF,Carter CS,Steer CD,Golding J,Davis JM,Steffen AD,Rubin LH,Lillard TS,Gregory SP,Harris JC,Connelly JJ

更新日期：2015-07-21 00:00:00

abstract：:Understanding the processes that cause speciation is a key aim of evolutionary biology. Lineages or biomes that exhibit recent and rapid diversification are ideal model systems for determining these processes. Species rich biomes reported to be of relatively recent origin, i.e., since the beginning of the Miocene, inc...

journal_title：Frontiers in genetics

authors： Madriñán S,Cortés AJ,Richardson JE

更新日期：2013-10-09 00:00:00

abstract：:Innate immune response is triggered by pathogen components, like lipopolysaccharides (LPS) of gram-negative bacteria. LPS initiates Toll-like receptor 4 (TLR4) signaling, which involves mitogen activated protein kinases (MAPK) and nuclear factor kappa B (NFκB) in different pathway branches and ultimately induces infla...

journal_title：Frontiers in genetics

authors： Ostareck DH,Ostareck-Lederer A

更新日期：2019-02-04 00:00:00

abstract：:Aspirin exacerbated respiratory disease (AERD) is a set of diseases of the unified airway, and its physiopathology is related to disruption of the metabolism of arachidonic acid (AA). Genetic association studies in AERD had explored single nucleotide polymorphism (SNPs) in several genes related to many mechanisms (AA ...

journal_title：Frontiers in genetics

authors： Pavón-Romero GF,Pérez-Rubio G,Ramírez-Jiménez F,Ambrocio-Ortiz E,Bañuelos-Ortiz E,Alvarado-Franco N,Xochipa-Ruiz KE,Hernández-Juárez E,Flores-García BA,Camarena ÁE,Terán LM,Falfán-Valencia R

更新日期：2018-09-11 00:00:00

abstract：:Multidrug resistant bacteria are a serious worldwide problem, especially carbapenem-resistant Enterobacteriaceae (such as Klebsiella pneumoniae and Escherichia coli), Acinetobacter baumannii and Pseudomonas aeruginosa. Since the emergence of extensive and pan-drug resistant bacteria there are few antibiotics left to t...

journal_title：Frontiers in genetics

authors： Parmeciano Di Noto G,Molina MC,Quiroga C

更新日期：2019-02-22 00:00:00

abstract：:Lin28 is a developmentally regulated RNA-binding protein that plays important roles in diverse physiological and pathological processes including oncogenesis and brain synaptic function. These pleiotropic roles of Lin28 are mechanistically linked both to its ability to directly stimulate translation of genes involved ...

journal_title：Frontiers in genetics

authors： Kallen AN,Ma J,Huang Y

更新日期：2012-11-16 00:00:00