Understanding of cytokines and targeted therapy in macrophage activation syndrome.

Abstract:

:Macrophage activation syndrome (MAS) is a potentially life-threatening complication of systemic autoinflammatory/autoimmune diseases, generally systemic juvenile idiopathic arthritis and adult-onset Still's disease. It is characterized by an excessive proliferation of macrophages and T lymphocytes. Recent research revealed that cytokine storm with elevated pro-inflammatory cytokines, including IFN-γ, IL-18, and IL-6, may be central to the pathogenesis of MAS. Though the mainstream of MAS treatment remains corticosteroids and cyclosporine, targeted therapies with anti-cytokine biologics are reported to be promising for controlling systemic inflammation in MAS.

journal_name

Semin Arthritis Rheum

authors

Tang S,Li S,Zheng S,Ding Y,Zhu D,Sun C,Hu Y,Qiao J,Fang H

doi

10.1016/j.semarthrit.2020.12.007

subject

Has Abstract

pub_date

2020-12-24 00:00:00

pages

198-210

issue

1

eissn

0049-0172

issn

1532-866X

pii

S0049-0172(20)30315-2

journal_volume

51

pub_type

杂志文章,评审
  • Assessment of clinical practice guideline methodology for the treatment of knee osteoarthritis with intra-articular hyaluronic acid.

    abstract:INTRODUCTION:Clinical practice guidelines are of increasing importance in the decision making for the treatment of knee osteoarthritis. Inconsistent recommendations regarding the use of intra-articular hyaluronic acid for the treatment of knee osteoarthritis have led to confusion among treating physicians. METHODS:Lit...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2015.04.013

    authors: Altman RD,Schemitsch E,Bedi A

    更新日期:2015-10-01 00:00:00

  • Dermatomyositis presenting with severe subcutaneous edema: five additional cases and review of the literature.

    abstract:OBJECTIVES:Dermatomyositis (DM) constitutes a subset of idiopathic inflammatory myopathies clinically characterized by proximal muscle weakness and skin involvement. Some of the dermatologic manifestations are highly prevalent and characteristic, but others such as generalized or limb edema are truly rare. The aim of t...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2014.04.004

    authors: Milisenda JC,Doti PI,Prieto-González S,Grau JM

    更新日期:2014-10-01 00:00:00

  • Epidemiology of depression and anxiety in patients with psoriatic arthritis: A systematic review and meta-analysis.

    abstract:OBJECTIVE:To conduct a systematic review and meta-analysis of the prevalence, incidence, and medication treatment of depression and anxiety among patients with psoriatic arthritis (PsA). METHODS:We searched Medline, Embase, Cochrane Database of Systematic Reviews, CINAHL and PsycINFO for full-length studies that: util...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2020.02.001

    authors: Zusman EZ,Howren AM,Park JYE,Dutz J,De Vera MA

    更新日期:2020-12-01 00:00:00

  • Disseminated histoplasmosis in systemic lupus erythematosus: case report and review of the literature.

    abstract:OBJECTIVES:To report a patient who developed both central nervous system systemic lupus erythematosus (SLE) and disseminated histoplasmosis and to review the literature regarding histoplasma infection in patients with SLE. METHODS:MEDLINE review of the medical literature published in English. RESULTS:Disseminated his...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/s0049-0172(98)80036-x

    authors: Hansen KE,St Clair EW

    更新日期:1998-12-01 00:00:00

  • Clinical features distinguishing lymphoma development in primary Sjögren's Syndrome--a retrospective cohort study.

    abstract:OBJECTIVE:The objective is to determine the relationship between clinical features and non-Hodgkin lymphoma (NHL) development in primary Sjögren's Syndrome (pSS), taking recently designed disease activity/severity scores into account. METHODS:Medical charts of pSS patients were retrospectively analyzed, scoring first ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2013.03.001

    authors: Risselada AP,Kruize AA,Bijlsma JW

    更新日期:2013-10-01 00:00:00

  • Epidemiological and clinical aspects relating to the variability of rheumatoid arthritis.

    abstract:OBJECTIVE:To review epidemiological studies dealing with the temporal and geographic variability in the occurrence of rheumatoid arthritis (RA) and clinical studies that address the variability of severity and manifestations among populations. METHODS:An extensive search of the literature, including a Medline search, ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/s0049-0172(97)80012-1

    authors: Abdel-Nasser AM,Rasker JJ,Valkenburg HA

    更新日期:1997-10-01 00:00:00

  • Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system.

    abstract:BACKGROUND:Chondroitin sulfates (CS) are involved in articular metabolism and could be used as therapeutic agents in degenerative articular diseases. OBJECTIVES:To review the published reports describing both the metabolism of glycosaminoglycans (GAG) and their involvement in osteoarticular pathophysiology. METHODS:M...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1053/sarh.2000.24874

    authors: Bali JP,Cousse H,Neuzil E

    更新日期:2001-08-01 00:00:00

  • Anti-nuclear antibody development is associated with poor treatment response to biological disease-modifying anti-rheumatic drugs in patients with rheumatoid arthritis.

    abstract:BACKGROUND:It has been well known that TNF-α inhibitor (TNFi) treatment for patients with rheumatoid arthritis (RA) is associated with anti-nuclear antibody (ANA) development. We previously reported that ANA development was associated with poor outcomes of infliximab (IFX) treatment (1). However, no replication studies...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2019.02.003

    authors: Ishikawa Y,Hashimoto M,Ito H,Tanaka M,Yukawa N,Fujii T,Yamamoto W,Mimori T,Terao C

    更新日期:2019-10-01 00:00:00

  • The mediating role of pain and function in the association between stiffness and quality of life in patients with axial spondyloarthritis.

    abstract:OBJECTIVE:The relationship between stiffness and quality of life (QoL) remains unclear. We therefore aimed to examine the role of pain and function in linking stiffness and QoL in patients with axSpA. METHODS:We used cross-sectional data from a registry of axSpA patients in a tertiary referral centre to assess the lin...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2019.02.010

    authors: Kwan YH,Fong W,Cheng GHL,Phang JK,Leung YY,Lui NL,Thumboo J,Østbye T

    更新日期:2019-12-01 00:00:00

  • Presence of comorbidities and prognosis of clinical symptoms in knee and/or hip osteoarthritis: A systematic review and meta-analysis.

    abstract:OBJECTIVE:(i) To determine the association between the presence of comorbidities and severity of pain and physical dysfunction in people with knee and/or hip osteoarthritis; (ii) to explore associations between specific comorbidities (cardiac disease and/or hypertension, diabetes, depression, and back pain) and symptom...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.semarthrit.2017.10.016

    authors: Calders P,Van Ginckel A

    更新日期:2018-06-01 00:00:00

  • Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women.

    abstract:OBJECTIVE:It is unclear whether the association between osteoarthritis (OA) and metabolic syndrome (MetS) varies with the site of the affected joint and the presence of pain. Our aim was to describe the association between MetS and radiographic OA (ROA) affecting the knee or the hand in the presence or absence of concu...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2018.07.007

    authors: Sanchez-Santos MT,Judge A,Gulati M,Spector TD,Hart DJ,Newton JL,Arden NK,Kluzek S

    更新日期:2019-04-01 00:00:00

  • History of knee surgery is associated with higher prevalence of neuropathic pain-like symptoms in patients with severe osteoarthritis of the knee.

    abstract:OBJECTIVE:Neuropathic pain (NP) mechanisms contribute to the pain experience in osteoarthritis (OA). We aimed to characterise the factors that contribute to NP-like symptoms in knee OA patients. PATIENTS AND METHODS:A total of 139 patients with knee OA were recruited from secondary care, and completed a nurse- adminis...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2013.10.001

    authors: Valdes AM,Suokas AK,Doherty SA,Jenkins W,Doherty M

    更新日期:2014-04-01 00:00:00

  • Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness.

    abstract:OBJECTIVES:To discuss the current terminologies used for fibromyalgia syndrome (FMS) and related overlapping conditions, to examine if central sensitivity syndromes (CSS) is the appropriate nosology for these disorders, and to explore the issue of disease versus illness. METHODS:A literature search was performed throu...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2007.09.003

    authors: Yunus MB

    更新日期:2008-06-01 00:00:00

  • Pulmonary disease during the treatment of rheumatoid arthritis with low dose pulse methotrexate.

    abstract::Methotrexate therapy has been effective in the treatment of RA with short term experience suggesting little serious adverse reactions. Our review of 168 patients receiving methotrexate has identified nine patients with probable or possible methotrexate-induced pulmonary toxicity, giving a prevalence of 5% and an incid...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/0049-0172(87)90021-7

    authors: Carson CW,Cannon GW,Egger MJ,Ward JR,Clegg DO

    更新日期:1987-02-01 00:00:00

  • Vascular damage, fibrosis, and chronic inflammation in mechanical back pain problems.

    abstract::Our current hypothesis is that mechanical damage in the spine such as a disc prolapse can lead directly to pain. However, pain arising for this reason is usually of short duration. In many subjects, however, the mechanical problems lead to vascular damage and, in particular, venous obstruction and dilatation with endo...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/0049-0172(89)90020-6

    authors: Jayson MI

    更新日期:1989-05-01 00:00:00

  • Rheumatic syndromes in endocrine disease.

    abstract::It is not widely appreciated that endocrine disease may present primarily as rheumatic syndromes, sometimes spectacular in onset, more commonly insidious and subtle, making their true recognition difficult. The underlying hormonal, biochemical, and metabolic events have understandable reflection in the structure and f...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/0049-0172(79)90002-7

    authors: Bland JH,Frymoyer JW,Newberg AH,Revers R,Norman RJ

    更新日期:1979-08-01 00:00:00

  • Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles.

    abstract::The beneficial effects of the anti-tumor necrosis factor (TNF) monoclonal antibodies infliximab and adalimumab and the soluble receptor fusion protein etanercept in the treatment of rheumatoid arthritis and a variety of other inflammatory disorders have been well described. However, less is known about the propensity ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2005.01.005

    authors: Anderson PJ

    更新日期:2005-04-01 00:00:00

  • Pneumocystis jirovecii pneumonia (PJP) prophylaxis patterns among patients with rheumatic diseases receiving high-risk immunosuppressant drugs.

    abstract:INTRODUCTION/OBJECTIVES:Pneumocystis jirovecii pneumonia (PJP) is a rare but potentially fatal opportunistic infection; however, consensus varies around which conditions or medications confer a level of risk sufficient to justify antibiotic prophylaxis for PJP. We used electronic health record (EHR) data to assess the ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2018.10.018

    authors: Schmajuk G,Jafri K,Evans M,Shiboski S,Gianfrancesco M,Izadi Z,Patterson SL,Aggarwal I,Sarkar U,Dudley RA,Yazdany J

    更新日期:2019-06-01 00:00:00

  • Long-term clinical and radiological magnetic resonance imaging outcome of abscess-associated spontaneous pyogenic vertebral osteomyelitis under conservative management.

    abstract:OBJECTIVES:Management of abscess-associated spontaneous pyogenic vertebral osteomyelitis (PVO) is controversial. The role of magnetic resonance imaging (MRI) in follow-up and its relation with clinical outcome is often unclear. This study evaluates the clinical and MRI outcome of abscess-associated PVO under conservati...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2007.08.007

    authors: Euba G,Narváez JA,Nolla JM,Murillo O,Narváez J,Gómez-Vaquero C,Ariza J

    更新日期:2008-08-01 00:00:00

  • Systematic review on the effectiveness of immunosuppressants and biological therapies in the treatment of autoimmune posterior uveitis.

    abstract:OBJECTIVES:To analyze the effectiveness of immunosuppressants and biological therapies in autoimmune posterior uveitis, chronic anterior uveitis associated with juvenile idiopathic arthritis, and macular edema. METHODS:Systematic review. We conducted a sensitive literature search in Medline (from 1961) and EMBASE (fro...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2010.05.008

    authors: Pato E,Muñoz-Fernández S,Francisco F,Abad MA,Maese J,Ortiz A,Carmona L,Uveitis Working Group from Spanish Society of Rheumatology.

    更新日期:2011-02-01 00:00:00

  • Worldwide trends in the socioeconomic impact and long-term prognosis of rheumatoid arthritis.

    abstract::Rheumatoid arthritis (RA), once considered a benign and nonprogressive disease, is a debilitating condition with serious physical, emotional, and economic consequences. It afflicts approximately 1% of the adult population worldwide; prevalence increases with age, with twice as many women as men affected. In the United...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/0049-0172(91)90046-3

    authors: Markenson JA

    更新日期:1991-10-01 00:00:00

  • Duplex study of the carotid and femoral arteries of patients with rheumatoid arthritis: a controlled study.

    abstract:BACKGROUND:"Ultrasonic biopsy" (U-B) is a noninvasive screening technique to detect early atherosclerotic plaques and arterial wall changes. AIM:To identify atherosclerosis (AS) in the common carotid artery (CCA) and common femoral artery (CFA) of patients with rheumatoid arthritis (RA) and their matched controls. ME...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.semarthrit.2004.11.007

    authors: Abu-Shakra M,Polychuck I,Szendro G,Bolotin A,Jonathan BS,Flusser D,Buskila D,Sukenik S

    更新日期:2005-08-01 00:00:00

  • Primary preventive services in patients with systemic lupus erythematosus: study from a population-based sample in Southeast U.S.

    abstract:OBJECTIVES:Systemic lupus erythematosus (SLE) patients are at risk for complications that can be mitigated by appropriate preventive care. We examined the receipt of immunizations, cancer screening, and cardiovascular risk preventive services in a predominantly Black cohort of SLE patients from the Southeast U.S. To id...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2013.04.003

    authors: Drenkard C,Rask KJ,Easley KA,Bao G,Lim SS

    更新日期:2013-10-01 00:00:00

  • Immune-mediated congenital heart block (CHB): identifying and counseling patients at risk for having children with CHB.

    abstract:OBJECTIVE:To identify patterns of maternal antibodies associated with an increased risk of having a child with congenital heart block (CHB) and to provide a basis for counseling women with a previously affected child. METHODS:This retrospective clinical study of the obstetric histories of 46 Finnish women with a CHB c...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/s0049-0172(98)80042-5

    authors: Julkunen H,Kaaja R,Siren MK,Mack C,McCready S,Holthöfer H,Kurki P,Maddison P

    更新日期:1998-10-01 00:00:00

  • A pooled analysis of the safety of tofacitinib as monotherapy or in combination with background conventional synthetic disease-modifying antirheumatic drugs in a Phase 3 rheumatoid arthritis population.

    abstract:OBJECTIVE:This post-hoc, pooled analysis of Phase 3 studies of tofacitinib examined the safety of tofacitinib 5 and 10 mg twice daily (BID) when used as monotherapy versus combination therapy with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in patients with rheumatoid arthritis (RA). METHOD...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.semarthrit.2018.07.006

    authors: Kivitz AJ,Cohen S,Keystone E,van Vollenhoven RF,Haraoui B,Kaine J,Fan H,Connell CA,Bananis E,Takiya L,Fleischmann R

    更新日期:2018-12-01 00:00:00

  • Trigeminal neuralgia in systemic sclerosis.

    abstract:OBJECTIVES:Although trigeminal neuralgia (TN) has been associated with systemic sclerosis (SSc), there is a paucity of evidence and pathophysiological processes remain unknown. We undertook a nested case-control study to identify associations between TN and SSc in a large multi-centered cohort and identify possible pat...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2021.01.001

    authors: Maltez N,Choi MY,Troyanov Y,Wang M,Jantz M,Fritzler MJ,Baron M,Hudson M,Canadian Scleroderma Research Group.

    更新日期:2021-01-07 00:00:00

  • Switching tumor necrosis factor inhibitors in the treatment of axial spondyloarthritis.

    abstract:OBJECTIVE:To assess the impact of switching tumor necrosis factor (TNF)-alpha inhibitors on patients with axial spondyloarthritis (axSpA). METHODS:PubMed literature searches were conducted using combinations of search terms including ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, switch/switching, dru...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2017.04.005

    authors: Deodhar A,Yu D

    更新日期:2017-12-01 00:00:00

  • Role of collagen hydrolysate in bone and joint disease.

    abstract:OBJECTIVES:To review the current status of collagen hydrolysate in the treatment of osteoarthritis and osteoporosis. METHODS:Review of past and current literature relative to collagen hydrolysate metabolism, and assessment of clinical investigations of therapeutic trials in osteoarthritis and osteoporosis. RESULTS:Hy...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1053/sarh.2000.9622

    authors: Moskowitz RW

    更新日期:2000-10-01 00:00:00

  • ACTH as a treatment for acute crystal-induced arthritis: update on clinical evidence and mechanisms of action.

    abstract:BACKGROUND:ACTH, a member of the melanocortin group of proteins, has long been used in the treatment of gout and is considered as an alternative therapeutic option, especially in difficult-to-treat patients. METHODS:We performed a systematic electronic search (Medline and ScienceDirect) using the keywords gout, treatm...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章,评审

    doi:10.1016/j.semarthrit.2013.09.006

    authors: Daoussis D,Antonopoulos I,Andonopoulos AP

    更新日期:2014-04-01 00:00:00

  • Long-term outcomes of coronary artery bypass grafting versus percutaneous coronary intervention for Takayasu arteritis patients with coronary artery involvement.

    abstract:OBJECTIVE:Coronary artery involvement significantly increases mortality of patients with Takayasu arteritis (TA); however, the optimal revascularization strategy for this condition has not been established. We aimed to compare the long-term outcomes of TA patients with coronary artery involvement treated with coronary ...

    journal_title:Seminars in arthritis and rheumatism

    pub_type: 杂志文章

    doi:10.1016/j.semarthrit.2017.03.009

    authors: Wang X,Dang A,Lv N,Cheng N,Cheng X,Yang Y,Song Y

    更新日期:2017-10-01 00:00:00