Understanding of cytokines and targeted therapy in macrophage activation syndrome.

Abstract:

:Macrophage activation syndrome (MAS) is a potentially life-threatening complication of systemic autoinflammatory/autoimmune diseases, generally systemic juvenile idiopathic arthritis and adult-onset Still's disease. It is characterized by an excessive proliferation of macrophages and T lymphocytes. Recent research revealed that cytokine storm with elevated pro-inflammatory cytokines, including IFN-γ, IL-18, and IL-6, may be central to the pathogenesis of MAS. Though the mainstream of MAS treatment remains corticosteroids and cyclosporine, targeted therapies with anti-cytokine biologics are reported to be promising for controlling systemic inflammation in MAS.

journal_name

Semin Arthritis Rheum

authors

Tang S,Li S,Zheng S,Ding Y,Zhu D,Sun C,Hu Y,Qiao J,Fang H

doi

10.1016/j.semarthrit.2020.12.007

subject

Has Abstract

pub_date

2020-12-24 00:00:00

pages

198-210

issue

1

eissn

0049-0172

issn

1532-866X

pii

S0049-0172(20)30315-2

journal_volume

51

pub_type

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