Emergency Department Treatment of Children With Diarrhea Who Attend Day Care: A Randomized Multidose Trial of a Lactobacillus helveticus and Lactobacillus rhamnosus Combination Probiotic.

Abstract:

BACKGROUND:Benefits associated with probiotic administration to children seeking emergency department care with diarrheal disease are unknown. METHODS:In this 3-site, double-blind, placebo-controlled study, children aged 4 to 48 months with gastroenteritis were randomized to receive 5 days of placebo, low-dose (4 × 10(9) colony forming units per day), or high-dose (8 × 10(9) colony forming units per day) probiotic (Lactobacillus helveticus and Lactobacillus rhamnosus) in a 2:1:1 ratio. The primary outcome was day care absenteeism. RESULTS:The proportion of children missing a day of day care was 63% (39/62) and 61% (37/61) in the placebo and probiotic arms, respectively (95%CI -14.6% to 18.9%). The proportions experiencing unscheduled health care provider visits and intravenous fluid rehydration were 24% (15/62), 7% (4/62), and 30% (18/61), 5% (3/61) in the placebo and probiotic study arms, respectively (P = .52 and P = .65). None of the results differed based on probiotic dose. CONCLUSIONS:The probiotic evaluated did not reduce absenteeism. Since power was suboptimal, further evaluation is required.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Freedman SB,Sherman PM,Willan A,Johnson D,Gouin S,Schuh S,Pediatric Emergency Research Canada (PERC).

doi

10.1177/0009922815569200

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

1158-66

issue

12

eissn

0009-9228

issn

1938-2707

pii

0009922815569200

journal_volume

54

pub_type

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