Abstract:
AIMS:The aims of this study were to detect the infection rates of DNA viruses in liver tissue of biliary atresia and to investigate the effect of perinatal infection of cytomegalovirus in biliary atresia. METHODS:A total of 85 liver biopsies (taken during Kasai portoenterostomy) were tested by fluorescence quantitative polymerase chain reaction for DNA viruses (herpes simplex virus [HSV], Epstein-Barr virus [EBV], varicella zoster virus [VZV], cytomegalovirus [HCMV], and adenovirus). Immunocytochemical detection of CMV-pp65 antigenemia assay was used to detect the presence of viral protein in liver samples. Human intrahepatic biliary epithelial cells was infected by the laboratory strain AD169 of HCMV in vitro. RESULTS:Virus DNA was found in the biopsies (51/85 HCMV, 5/85 ADV, 3/85 EBV). The biopsies of 2 patients were tested positive for 2 viruses simultaneously. They include one case of HCMV in combination with ADV and one case of ASV in combination with EBV. CMV-pp65 antigenemia were distributed in hepatocyte, vascular endothelial cell, and biliary duct endothelial cell. The cytopathic effect and apoptosis were observed after HCMVAD169 infected human intrahepatic biliary epithelial cells at 6 days. CONCLUSION:Human intrahepatic biliary epithelial cell is the target cell of HCMV. The etiology of biliary atresia is probably multifactorial. The perinatal infection of HCMV is one of the important etiologies for biliary atresia in China.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Xu Y,Yu J,Zhang R,Yin Y,Ye J,Tan L,Xia Hdoi
10.1177/0009922811406264subject
Has Abstractpub_date
2012-02-01 00:00:00pages
109-13issue
2eissn
0009-9228issn
1938-2707pii
0009922811406264journal_volume
51pub_type
杂志文章abstract::An adolescent female with occult cystic medial necrosis died following spontaneous aortic rupture. A large saccular aortic aneurysm that had ruptured into the pericardial space was demonstrated by two-dimensional echocardiography and confirmed at surgery. Echocardiographic screening of the patient's family members rev...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288502400408
更新日期:1985-04-01 00:00:00
abstract::Recent studies have indicated possible changes in the incidence of acute mastoiditis. A retrospective review of children discharged with a diagnosis of acute mastoiditis was undertaken to describe the epidemiology, clinical presentation, microbiology, and treatment of acute mastoiditis over past years. Demographic his...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280404300307
更新日期:2004-04-01 00:00:00
abstract:OBJECTIVE:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a major contributor to neonatal hyperbilirubinemia, yet newborn screening for this disorder in the United States is not standard practice. We surveyed pediatric providers regarding a novel newborn G6PD screening program successfully implemented in 2007 at...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922814557786
更新日期:2015-06-01 00:00:00
abstract::Pediatricians are expected to discuss the hazards of passive smoking and provide smoking cessation counseling (SCC) because passive smoking is known to have a direct negative effect on children's health. We conducted a cross-sectional survey of pediatric and medicine- pediatric residents at 2 training programs to iden...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922807308182
更新日期:2008-04-01 00:00:00
abstract::Five children with pyogenic liver abscess were admitted to Institute of Child Health, Kabul during the period 1978 to 1980. All patients were males, and their ages ranged from 4 to 10 years. The clinical picture was characterized by fever, upper abdominal pain, enlarged tender liver with raised right dome of the diaph...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288202100204
更新日期:1982-02-01 00:00:00
abstract::Although common, little is known about the characteristics and management of undifferentiated abdominal pain (UAP) in the pediatric emergency department (ED). This study was a 12-month retrospective study for "abdominal pain" ED visits. Patients without an identifiable diagnosis were categorized as "UAP," while others...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922819867459
更新日期:2019-10-01 00:00:00
abstract::We conducted a retrospective study to identify electrocardiogram (ECG) and echocardiogram utilization among patients presenting for a follow-up cardiology evaluation with innocent heart murmur between 2012 and 2014. The 2014 echocardiogram Appropriate Use Criteria was applied. We observed high rates of ordering ECGs a...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922818787280
更新日期:2018-10-01 00:00:00
abstract::Among 145 patients treated with recombinant human growth hormone (GH), four developed sleep apnea (two obstructive, two mixed) associated with tonsillar and adenoidal hypertrophy in three. These four patients had no local risk factors predisposing to upper airway obstruction (i.e., frequent pharyngitis or sinusitis). ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289703600602
更新日期:1997-06-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Published data regarding outcomes of pediatric behavioral weight management are mainly from research interventions. The authors wished to explore outcomes from a clinical program. METHODS:A retrospective analysis of data from obese adolescents enrolled in the Michigan Pediatric Outpatient Weight E...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922810384845
更新日期:2011-03-01 00:00:00
abstract::Eighty-five infants and children presenting with acute otitis media who had normal tympanic membrane landmarks and mobility within 1 month before entry into the study were studied. These criteria were used in order to avoid including children with prior otitis media with effusion (secretory otitis media). A diagnosis ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288102000901
更新日期:1981-09-01 00:00:00
abstract::One pattern of dysfunctional family interaction is described as a syndrome. Four case histories are presented in which different family members take polar positions on various continua. In one instance the continuum is oral communication, with garrulousness on one side and silence on the other. Another continuum is fa...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288102000408
更新日期:1981-04-01 00:00:00
abstract::An online survey was administered through the American Academy of Pediatrics (AAP) Section of Emergency Medicine Survey Listserv in Fall, 2017. Overall compliance was measured as never using chest X-rays, viral testing, bronchodilators, or systemic steroids. Practice compliance was measured as never using those modali...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922819850462
更新日期:2019-08-01 00:00:00
abstract::Eighty two infants, aged 2-12 months, were prospectively studied for infectious episodes following diphtheria-pertussis-tetanus (DPT) immunization. The occurrence of infectious episodes during the month following vaccination was compared to that during the month prior to its administration. The 3 days following vaccin...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288802701005
更新日期:1988-10-01 00:00:00
abstract::Such a program was used to treat 18 encopretic children; 17 improved and 14 became completely free of soiling. Most encopretic children can be managed by pediatricians and only those children with severe emotional disorders require psychiatric referral. ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992287801700110
更新日期:1978-01-01 00:00:00
abstract::Although copper deficiency is a rare occurrence in the developed world, attention should be given to the proper supplementation of minerals to at-risk pediatric patients. This study presents 3 distinct cases of copper deficiency in hospitalized patients aged 14 months, 6 years, and 12 years. Two patients had short bow...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922812446743
更新日期:2012-08-01 00:00:00
abstract::In a review of 17 adolescents and children (excluding newborns) with definite clinical signs, symptoms, and laboratory findings of hypothyroidism, 11 patients (65%) had anemia. The mean corpuscular volume (MCV) of the red blood cells was either macrocytic or normocytic. The hemoglobin did not correlate with the serum ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288102001102
更新日期:1981-11-01 00:00:00
abstract::We administered a questionnaire to determine changes in parental use and administration of over-the-counter (OTC) drugs after cyanide-laced Extra-Strength Tylenol capsules caused the deaths of at least seven people in Illinois in 1982. Three hundred area parents were studied and divided into three equally sized groups...
journal_title:Clinical pediatrics
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doi:10.1177/000992288402300806
更新日期:1984-08-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992288402300501
更新日期:1984-05-01 00:00:00
abstract::Anonymous self-report surveys of a convenience sample of caregivers accompanying children to the pediatrician for acute or well visits at 4 pediatric practices in the Washington, DC area from July through November 1998 were evaluated. Three hundred seventy-eight (85%) of 443 caregivers approached participated. The 348...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992280404300408
更新日期:2004-05-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922810384847
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVES:Obstructive sleep apnea (OSA) and habitual snoring are highly prevalent childhood conditions and have been associated with a large array of negative health outcomes. Although guidelines were published by the American Academy of Pediatrics (AAP) a decade ago recommending routine screening of sleep-disordered ...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922812464548
更新日期:2012-12-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922815594359
更新日期:2016-03-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289203100109
更新日期:1992-01-01 00:00:00
abstract:OBJECTIVE:Dysfunctional voiding (DV) is an extremely common pediatric complaint. The goal of this study was to examine the relationship between DV and childhood temperament. METHODS:Information about the voiding behaviors and temperaments of 50 children was examined using a case-control model. Caregivers were asked to...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922813492376
更新日期:2013-08-01 00:00:00
abstract::The goal of this study was to determine the value of a certified child life specialist (CCLS) on the patient and staff experiences in an epilepsy monitoring unit (EMU). We integrated a CCLS into the EMU for all children as well as adults with intellectual disability. We surveyed families to determine the impact of chi...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922818769469
更新日期:2018-10-01 00:00:00
abstract::This study assessed the impact of respiratory syncytial virus-confirmed hospitalizations (RSVH) on caregivers of high-risk preterm infants. Caregivers for infants born at 29 to 35 weeks' gestational age and hospitalized for confirmed RSV disease responded to measures of self-rated and perceived infant stress (1-7; 7 =...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922819843639
更新日期:2019-07-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/0009922806297515
更新日期:2007-06-01 00:00:00
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journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992289002900814
更新日期:1990-08-01 00:00:00
abstract::Of 43 youngsters with gonorrhea, 11 were under 10 years of age. These 11 had in common atypical clinical presentation, marital disharmony of the parents, crowded living conditions; some had been abused sexually. Management of gonorrhea in such young children may require a concerted effort by a team of medical, social,...
journal_title:Clinical pediatrics
pub_type: 杂志文章
doi:10.1177/000992287701600709
更新日期:1977-07-01 00:00:00
abstract::The authors administered an abbreviated revision of a previously field-tested, self-administered, brief screening test (the 30-item Drug and Alcohol Problem Quick Screen) to 355 consecutive middle-class adolescent patients seen at a five-pediatrician group practice setting. Ninety-six percent (341) of the subjects com...
journal_title:Clinical pediatrics
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doi:10.1177/000992289002900106
更新日期:1990-01-01 00:00:00