Abstract:
:In a review of 17 adolescents and children (excluding newborns) with definite clinical signs, symptoms, and laboratory findings of hypothyroidism, 11 patients (65%) had anemia. The mean corpuscular volume (MCV) of the red blood cells was either macrocytic or normocytic. The hemoglobin did not correlate with the serum thyroxine level. Anemia occurred only in those patients with heights below the third percentile, but there was no similar correlation with weights. Of the 10 patients who had radiographs for bone age, all showed severe delay (47 to 103 months) and had heights below the third percentile. Nine of these patients were anemic, but the severity of the anemia did not correlate with the delay in bone age. Neither microcytic anemia nor pernicious anemia, noted in many adult hypothyroid patients, was found in the children and adolescents with hypothyroidism studied here. The "uncomplicated" anemia secondary to hypothyroidism responded to thyroid replacement therapy alone. Anemia can be the most prominent feature of hypothyroidism. In patients with mild to moderate anemia of unknown origin, especially those with fall-off in linear growth and increased MCV, hypothyroidism should be considered in the differential diagnosis of the anemia.
journal_name
Clin Pediatr (Phila)journal_title
Clinical pediatricsauthors
Chu JY,Monteleone JA,Peden VH,Graviss ER,Vernava AMdoi
10.1177/000992288102001102subject
Has Abstractpub_date
1981-11-01 00:00:00pages
696-9issue
11eissn
0009-9228issn
1938-2707journal_volume
20pub_type
杂志文章abstract::Eighty-five adolescents (ages 13 to 17), recruited from various metropolitan pediatric outpatient clinics, were administered the Patient Health Questionnaire (PHQ)-2, a two-item depression screener, along with two other well-established measures of depression, the Children's Depression Inventory (CDI) and the Beck Dep...
journal_title:Clinical pediatrics
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