Anemia in children and adolescents with hypothyroidism.

Abstract:

:In a review of 17 adolescents and children (excluding newborns) with definite clinical signs, symptoms, and laboratory findings of hypothyroidism, 11 patients (65%) had anemia. The mean corpuscular volume (MCV) of the red blood cells was either macrocytic or normocytic. The hemoglobin did not correlate with the serum thyroxine level. Anemia occurred only in those patients with heights below the third percentile, but there was no similar correlation with weights. Of the 10 patients who had radiographs for bone age, all showed severe delay (47 to 103 months) and had heights below the third percentile. Nine of these patients were anemic, but the severity of the anemia did not correlate with the delay in bone age. Neither microcytic anemia nor pernicious anemia, noted in many adult hypothyroid patients, was found in the children and adolescents with hypothyroidism studied here. The "uncomplicated" anemia secondary to hypothyroidism responded to thyroid replacement therapy alone. Anemia can be the most prominent feature of hypothyroidism. In patients with mild to moderate anemia of unknown origin, especially those with fall-off in linear growth and increased MCV, hypothyroidism should be considered in the differential diagnosis of the anemia.

journal_name

Clin Pediatr (Phila)

journal_title

Clinical pediatrics

authors

Chu JY,Monteleone JA,Peden VH,Graviss ER,Vernava AM

doi

10.1177/000992288102001102

subject

Has Abstract

pub_date

1981-11-01 00:00:00

pages

696-9

issue

11

eissn

0009-9228

issn

1938-2707

journal_volume

20

pub_type

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