Interleukin-2 and autologous lymphokine-activated killer cells in the treatment of malignant glioma. Preliminary report.

Abstract:

:Nine patients with malignant glioma were treated with the lymphokine interleukin-2 (IL-2) or with lymphokine-activated killer (LAK) cells, and one patient received combination therapy with both LAK cells and IL-2. The LAK cells were generated by culturing recombinant IL-2 with peripheral blood lymphocytes obtained from brain-tumor patients. Escalating doses of LAK cells (10(8) to 10(10] or IL-2 (10(4) to 10(6) U) were administered intraoperatively by direct injection into the brain tissue surrounding the cavity left by debulking the tumor. There were no signs of systemic or neural toxicity following treatment. The selective killing of the tumor by LAK cells used for these treatments was demonstrated by a chromium release microcytotoxicity assay which showed in vitro the ability of the LAK cells to lyse glioma cells but not normal cells.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Jacobs SK,Wilson DJ,Kornblith PL,Grimm EA

doi

10.3171/jns.1986.64.5.0743

subject

Has Abstract

pub_date

1986-05-01 00:00:00

pages

743-9

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

64

pub_type

临床试验,杂志文章
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    abstract::The outcome following decompressive laminectomy and spinal irradiation has been evaluated in 104 consecutive patients with epidural metastatic neoplasia, using broad criteria for successful outcome. Of patients so treated, 33% were benefited, while 23% became worse. Both tumor histology and the preoperative neurologic...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.52.1.0047

    authors: Dunn RC Jr,Kelly WA,Wohns RN,Howe JF

    更新日期:1980-01-01 00:00:00

  • Comparison of spinal cord gray matter and white matter softness: measurement by pipette aspiration method.

    abstract:OBJECT:Although the gray matter of the spinal cord has been thought to be softer than the white matter, there is no evidence to support this belief. Because the spinal cord is extremely soft, it has been difficult to measure the mechanical properties of the gray and white matter. The modulis of elasticity of the gray a...

    journal_title:Journal of neurosurgery

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    doi:10.3171/spi.2001.95.2.0221

    authors: Ozawa H,Matsumoto T,Ohashi T,Sato M,Kokubun S

    更新日期:2001-10-01 00:00:00

  • Evolution of the graded repair of CSF leaks and skull base defects in endonasal endoscopic tumor surgery: trends in repair failure and meningitis rates in 509 patients.

    abstract:Objective:The authors previously described a graded approach to skull base repair following endonasal microscopic or endoscope-assisted tumor surgery. In this paper they review their experience with skull base reconstruction in the endoscopic era. Methods:A retrospective review of a single-institution endonasal endosc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.11.JNS172141

    authors: Conger A,Zhao F,Wang X,Eisenberg A,Griffiths C,Esposito F,Carrau RL,Barkhoudarian G,Kelly DF

    更新日期:2018-05-11 00:00:00

  • Spontaneous involution of a large pineal region hemorrhagic cyst in an infant. Case report.

    abstract::The authors report the case of a newborn presenting at birth with macrocephaly and a large pineal region hemorrhagic cyst without neurological deficit. No neurosurgical intervention was performed, and subsequent imaging studies demonstrated complete involution of the cyst. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2006.104.4.275

    authors: Nimmagadda A,Sandberg DI,Ragheb J

    更新日期:2006-04-01 00:00:00

  • Painful supernumerary phantom arm following motor cortex stimulation for central poststroke pain. Case report.

    abstract::In this report, the authors describe a case in which the patient began to experience a supernumerary phantom arm after she received motor cortex stimulation for central pain. The patient had a history of right thalamocapsular stroke. It is speculated that the motor cortex activation triggered a response in the patient...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.91.1.0121

    authors: Canavero S,Bonicalzi V,Castellano G,Perozzo P,Massa-Micon B

    更新日期:1999-07-01 00:00:00

  • Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury.

    abstract:OBJECT:Although traumatic brain injury (TBI) is the leading cause of death and morbidity in young adults, no effective pharmaceutical treatment is available. By inhibiting glycogen synthase kinase-3 (GSK-3) and histone deacetylases (HDACs), respectively, lithium and valproate (VPA) have beneficial effects in diverse ne...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.6.JNS13135

    authors: Yu F,Wang Z,Tanaka M,Chiu CT,Leeds P,Zhang Y,Chuang DM

    更新日期:2013-09-01 00:00:00

  • Tenascin-C-coated platinum coils for acceleration of organization of cavities and reduction of lumen size in a rat aneurysm model.

    abstract:OBJECT:Detachable platinum coils are widely used in the endovascular treatment of intracranial aneurysms. The use of coil placement produces a higher incidence of aneurysm recurrence compared with surgical clipping. To reduce the incidence of recurrence by promoting clot organization, the authors designed a platinum co...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.4.0681

    authors: Toma N,Imanaka-Yoshida K,Takeuchi T,Matsushima S,Iwata H,Yoshida T,Taki W

    更新日期:2005-10-01 00:00:00

  • Role of gamma knife surgery for intracranial atypical (WHO grade II) meningiomas.

    abstract:OBJECT:Atypical meningioma often recurs even after resection. As a salvage modality, radiotherapy or stereotactic radiosurgery (SRS) is attempted for this aggressive tumor. This retrospective study was performed to evaluate the efficacy of SRS that involved Gamma Knife surgery (GKS) for atypical meningioma. METHODS:Th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.8.JNS13343

    authors: Hanakita S,Koga T,Igaki H,Murakami N,Oya S,Shin M,Saito N

    更新日期:2013-12-01 00:00:00

  • Platelet-activating factor and edema surrounding meningiomas.

    abstract:OBJECT:The purpose of this study was to evaluate the involvement of platelet-activating factor (PAF) in the formation of edema surrounding meningiomas. METHODS:Volumes of tumor and peritumoral edema were calculated based on three-dimensional reconstructed magnetic resonance images in 31 patients with intracranial meni...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.88.2.0304

    authors: Hirashima Y,Hayashi N,Fukuda O,Ito H,Endo S,Takaku A

    更新日期:1998-02-01 00:00:00

  • Reinforcement with gauze wrapping for ruptured aneurysms of the middle cerebral artery.

    abstract::A 2- to 15-year follow-up study is presented of a series of 35 consecutive patients treated for ruptured aneurysms of the middle cerebral artery by reinforcement with gauze wrapping. Only one patient suffered early recurrent hemorrhage in the postoperative period, and none had a late hemorrhage. The procedure carried ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.47.6.0828

    authors: Taylor JC,Choudhury AR

    更新日期:1977-12-01 00:00:00

  • Carcinoembryonic antigen production associated with an osteolytic meningioma. Case report.

    abstract::An elevated serum carcinoembryonic antigen (CEA) without evidence of neoplasia was noted in an 84-year-old woman. She subsequently developed a lytic skull lesion, which at surgery proved to be an atypical meningioma. Immunohistochemical analysis demonstrated that this tumor was producing CEA. This aggressive meningiom...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.3.0489

    authors: Partington MD,Scheithauer BW,Piepgras DG

    更新日期:1995-03-01 00:00:00

  • The facial nerve in medial acoustic neuromas.

    abstract:OBJECT:Functional results after surgery for acoustic neuromas that have little or no growth within the internal auditory canal are controversial, because these medial tumors can grow to a considerable size within the cerebellopontine angle (CPA) before symptoms occur. METHODS:A prospective study was designed to evalua...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2002.97.5.1083

    authors: Strauss C

    更新日期:2002-11-01 00:00:00

  • Traumatic subarachnoid hemorrhage on the computerized tomography scan obtained at admission: a multicenter assessment of the accuracy of diagnosis and the potential impact on patient outcome.

    abstract:OBJECT:The goal of this study was fourfold: 1) to determine the incidence of traumatic subarachnoid hemorrhage (tSAH) in patients with traumatic brain injury (TBI); 2) to verify agreement in the diagnosis of tSAH in a multicenter study; 3) to assess the incidence of tSAH on the outcome of the patient; and 4) to establi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/jns.2003.98.1.0037

    authors: Mattioli C,Beretta L,Gerevini S,Veglia F,Citerio G,Cormio M,Stocchetti N

    更新日期:2003-01-01 00:00:00

  • Targeting the cranial nerve: microradiosurgery for trigeminal neuralgia with CISS and 3D-flash MR imaging sequences.

    abstract:OBJECT:The authors undertook a study to identify magnetic resonance (MR) imaging techniques that can be used reliably during gamma knife surgery (GKS) to identify the trigeminal nerve, surrounding vasculature, and areas of compression. METHODS:Preoperative visualization of the trigeminal nerve and surrounding vasculat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.102.s_supplement.0107

    authors: Zerris VA,Noren GC,Shucart WA,Rogg J,Friehs GM

    更新日期:2005-01-01 00:00:00

  • Different aspects of dysexecutive syndrome in patients with moyamoya disease and its clinical subtypes.

    abstract::OBJECTIVE Dysexecutive syndrome is common in patients with moyamoya disease (MMD), a chronic cerebrovascular disease that is characterized by stenosis of the bilateral internal carotid arteries and progressive collateral revascularization, and MMD can be classified as ischemic or hemorrhagic according to the disease p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.7.JNS142666

    authors: Fang L,Huang J,Zhang Q,Chan RC,Wang R,Wan W

    更新日期:2016-08-01 00:00:00

  • Role of monoamines in experimental spinal cord injury in rats. Relationship between Na+-K+-ATPase and lipid peroxidation.

    abstract::A spinal cord injury was produced in Wistar rats by extradural compression of the cord with a Sugita aneurysm clip for 5 seconds. During a 2-week observation period following the injury, the tissue norepinephrine (NE), dopamine (DA), and serotonin (5-HT) concentrations decreased uniformly at and below the injured site...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.5.0743

    authors: Kurihara M

    更新日期:1985-05-01 00:00:00

  • Panventriculomegaly with a wide foramen of Magendie and large cisterna magna.

    abstract::OBJECT The authors' goal in this paper is to provide the first clinical, radiological, and genetic studies of panventriculomegaly (PaVM) defined by a wide foramen of Magendie and large cisterna magna. METHODS Clinical and brain imaging data from 28 PaVM patients (including 10 patients from 5 families) were retrospecti...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.6.JNS15162

    authors: Kageyama H,Miyajima M,Ogino I,Nakajima M,Shimoji K,Fukai R,Miyake N,Nishiyama K,Matsumoto N,Arai H

    更新日期:2016-06-01 00:00:00

  • Epidemiology of venous thromboembolism in 9489 patients with malignant glioma.

    abstract:OBJECT:The authors sought to define the incidence of symptomatic venous thromboembolism (VTE) in patients harboring malignant gliomas. METHODS:The authors conducted a retrospective analysis of data obtained in all cases of malignant glioma diagnosed in California during a 6-year period; the occurrence of a VTE was ide...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2007.106.4.601

    authors: Semrad TJ,O'Donnell R,Wun T,Chew H,Harvey D,Zhou H,White RH

    更新日期:2007-04-01 00:00:00

  • Operating room waste: disposable supply utilization in neurosurgical procedures.

    abstract::OBJECTIVE Disposable supplies constitute a large portion of operating room (OR) costs and are often left over at the end of a surgical case. Despite financial and environmental implications of such waste, there has been little evaluation of OR supply utilization. The goal of this study was to quantify the utilization ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.2.JNS152442

    authors: Zygourakis CC,Yoon S,Valencia V,Boscardin C,Moriates C,Gonzales R,Lawton MT

    更新日期:2017-02-01 00:00:00

  • Adult rhombencephalosynapsis. Case report.

    abstract::Rhombencephalosynapsis (RS) is a relatively rare developmental disorder of the cerebellum in which the cerebellar hemispheres are fused across the midline without being separated by a cleft or the vermis. The condition may be associated with hydrocephalus and other intracranial and extracranial abnormalities. The auth...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.2.0323

    authors: Guyot LL,Kazmierczak CD,Michael DB

    更新日期:2000-08-01 00:00:00

  • Changes in gamma-aminobutyric acid and somatostatin in epileptic cortex associated with low-grade gliomas.

    abstract::The role of specific neuronal populations in epileptic foci was studied by comparing epileptic and non-epileptic cortex removed from patients with low-grade gliomas. Epileptic and nearby (within 1 to 2 cm) non-epileptic temporal lobe neocortex was identified using electrocorticography. Cortical specimens taken from fo...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.2.0209

    authors: Haglund MM,Berger MS,Kunkel DD,Franck JE,Ghatan S,Ojemann GA

    更新日期:1992-08-01 00:00:00

  • A dose-response study of dexamethasone in a model of spinal cord compression caused by epidural tumor.

    abstract::In order to assess the clinical and biological effects of glucocorticoids in the therapy of epidural spinal cord compression, the T8-10 epidural space of 50 rats was implanted with Walker 256 tumor. The rats were studied 10 to 20 days later when they became paraparetic. The regional blood-spinal cord transport constan...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1989.70.6.0920

    authors: Delattre JY,Arbit E,Thaler HT,Rosenblum MK,Posner JB

    更新日期:1989-06-01 00:00:00

  • Association between a black band on the inner membrane of a chronic subdural hematoma on T2*-weighted magnetic resonance images and enlargement of the hematoma.

    abstract:OBJECT:The cause and indication for enlargement of chronic subdural hematomas (CSDHs) have remained unresolved. The authors observed a black band on the inner membrane of a CSDH on T2*-weighted magnetic resonance (MR) images obtained in patients with symptoms. After surgical treatment, the band disappeared. The T2*-wei...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.5.0824

    authors: Imaizumi T,Horita Y,Honma T,Niwa J

    更新日期:2003-11-01 00:00:00

  • Extracorporeal membrane oxygenation combined with endovascular embolization for management of neonatal high-output cardiac failure secondary to intracranial arteriovenous fistula. Case report.

    abstract::The authors describe a novel approach to the management of high-output heart failure secondary to an intracranial high-flow dural arteriovenous fistula (DAVF) by using extracorporeal membrane oxygenation (ECMO). To the best of the authors' knowledge, this represents the first report of an embolization performed in con...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2004.100.2.0197

    authors: Burry M,Reig AS,Beierle EA,Chen MK,Mericle RA

    更新日期:2004-02-01 00:00:00

  • Short-term preoperative treatment of macroprolactinomas by dopamine agonists.

    abstract::During a period of 3 years, 25 patients with intra- and extrasellar macroprolactinomas were pretreated with dopamine agonists for a period of 2 to 6 1/2 weeks prior to transsphenoidal microsurgical tumor resection. Dopamine agonists were administered orally to 17 patients, intramuscularly to three patients, and both o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.6.0807

    authors: Fahlbusch R,Buchfelder M,Schrell U

    更新日期:1987-12-01 00:00:00

  • Neurological manifestations of pediatric achondroplasia.

    abstract::The neurological and neuroradiological manifestations of pediatric achondroplasia are analyzed on the basis of 10 cases. In addition to the classical symptomatology of an enlarging head, with or without increased intracranial pressure, several patients presented symptoms related to a small foramen magnum. Respiratory ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.54.1.0049

    authors: Yamada H,Nakamura S,Tajima M,Kageyama N

    更新日期:1981-01-01 00:00:00

  • Posterior subtemporal transtentorial approach to intraparenchymal lesions of the anteromedial region of the superior cerebellum.

    abstract:OBJECT:To overcome the limitations associated with surgical approaches that have been described for accessing intraparenchymal lesions of the anteromedial region of the superior cerebellum, the authors used a posterior subtemporal transtentorial approach to remove tumors in this region. In this paper they describe the ...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.2005.103.5.0783

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    更新日期:2005-11-01 00:00:00

  • Harvey W. Cushing and cerebrovascular surgery: Part II, Vascular malformations.

    abstract::The surgical treatment of cerebrovascular malformations intrigued early neurosurgeons. Cushing defined vascular malformations as tumors arising from cerebral blood vessels. He successfully resected the first arteriovenous malformation 3 years after it had been irradiated. In the absence of angiography, the pathoanatom...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/jns.2004.101.3.0553

    authors: Cohen-Gadol AA,Spencer DD

    更新日期:2004-09-01 00:00:00

  • Computerized tomography, magnetic resonance imaging, and positron emission tomography in the study of brain trauma. Preliminary observations.

    abstract::Results of computerized tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), xenon-133 measurement of cerebral blood flow (CBF), and neuropsychological assessments are described in three head-injured patients. The patients were selected because they presented with intracranial hemorrh...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.5.0760

    authors: Langfitt TW,Obrist WD,Alavi A,Grossman RI,Zimmerman R,Jaggi J,Uzzell B,Reivich M,Patton DR

    更新日期:1986-05-01 00:00:00

  • Analysis of treatment failure after radiosurgery for arteriovenous malformations.

    abstract:OBJECT:The aim of this study was to evaluate the causes of treatment failure in patients with arteriovenous malformations (AVMs) who underwent radiosurgery, which is increasingly used as a treatment method for selected, surgically high-risk AVMs. Unfortunately, radiosurgical treatment fails in a small but significant p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.89.1.0104

    authors: Ellis TL,Friedman WA,Bova FJ,Kubilis PS,Buatti JM

    更新日期:1998-07-01 00:00:00