Platelet-activating factor and edema surrounding meningiomas.

Abstract:

OBJECT:The purpose of this study was to evaluate the involvement of platelet-activating factor (PAF) in the formation of edema surrounding meningiomas. METHODS:Volumes of tumor and peritumoral edema were calculated based on three-dimensional reconstructed magnetic resonance images in 31 patients with intracranial meningiomas. The authors measured tumor concentrations of PAF and localized PAF and leukocytes in the tumors by using immunohistochemical studies. A significant positive correlation was found between peritumoral edema and PAF concentration. Both PAF and leukocyte common antigen were localized to the interstitial tissue of the tumor. Edema production was related to the degree of leukocyte infiltration in meningiomas. CONCLUSIONS:It appears that PAF, which may arise from infiltrating leukocytes, is important to the development of peritumoral edema in patients with meningioma.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Hirashima Y,Hayashi N,Fukuda O,Ito H,Endo S,Takaku A

doi

10.3171/jns.1998.88.2.0304

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

304-7

issue

2

eissn

0022-3085

issn

1933-0693

journal_volume

88

pub_type

杂志文章
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