Comparative effectiveness analysis of Pipeline device versus coiling in unruptured aneurysms smaller than 10 mm.

Abstract:

OBJECTIVE:Both endovascular coiling and the Pipeline embolization device (PED) have been shown to be safe and clinically effective for treatment of small (< 10 mm) aneurysms. The authors conducted a comparative effectiveness analysis to compare the utility of these treatment methods in terms of health benefits. METHODS:A decision-analytical study was performed with Markov modeling methods to simulate patients with small unruptured aneurysms undergoing endovascular coiling, stent-assisted coiling (SAC), or PED placement for treatment. Input probabilities were derived from prior literature, and 1-way, 2-way, and probabilistic sensitivity analyses were performed to assess model and input parameter uncertainty. RESULTS:The base case calculation for a 50-year-old man reveals PED to have a higher health benefit (17.48 quality-adjusted life years [QALYs]) than coiling (17.44 QALYs) or SAC (17.36 QALYs). PED is the better option in 6020 of the 10,000 iterations in probabilistic sensitivity analysis. When the retreatment rate of PED is lower than 9.53%, and the coiling retreatment is higher than 15.6%, PED is the better strategy. In the 2-way sensitivity analysis varying the retreatment rates from both treatment modalities, when the retreatment rate of PED is approximately 14% lower than the retreatment rate of coiling, PED is the more favorable treatment strategy. Otherwise, coiling is more effective. SAC may be better than PED when the unfavorable outcome risk of SAC is lower than 70% of its reported current value. CONCLUSIONS:With the increasing use of PEDs for treatment of small unruptured aneurysms, the current study indicates that these devices may have higher health benefits due to lower rates of retreatment compared to both simple coiling and stent-assisted techniques. Longer follow-up studies are needed to document the rates of recurrence and retreatment after coiling and PED to assess the cost-effectiveness of these strategies.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Malhotra A,Wu X,Miller T,Matouk CC,Sanelli P,Gandhi D

doi

10.3171/2018.8.JNS181080

subject

Has Abstract

pub_date

2019-01-11 00:00:00

pages

42-50

issue

1

eissn

0022-3085

issn

1933-0693

pii

2018.8.JNS181080

journal_volume

132

pub_type

杂志文章
  • Treatment of intracranial gliomas with bone marrow-derived dendritic cells pulsed with tumor antigens.

    abstract:OBJECT:An approach toward the treatment of intracranial gliomas was developed in a rat experimental model. The authors investigated the ability of "professional" antigen-presenting cells (dendritic cells) to enhance host antitumor immune responses when injected as a vaccine into tumor-bearing animals. METHODS:Dendriti...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.90.6.1115

    authors: Liau LM,Black KL,Prins RM,Sykes SN,DiPatre PL,Cloughesy TF,Becker DP,Bronstein JM

    更新日期:1999-06-01 00:00:00

  • High-dose BCNU with autologous bone marrow rescue for recurrent glioblastoma multiforme.

    abstract::Eleven patients with recurrent malignant glioma were treated with single high doses of BCNU ranging from 600 to 1400 mg/sq m. To prevent the characteristic late myelosuppression observed after conventional doses of BCNU, autologous bone marrow harvested just before drug treatment was infused 24 to 36 hours after thera...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1981.54.4.0455

    authors: Hochberg FH,Parker LM,Takvorian T,Canellos GP,Zervas NT

    更新日期:1981-04-01 00:00:00

  • Variations in pressure-volume index and CSF outflow resistance at different locations in the feline craniospinal axis.

    abstract::Pressure volume index (PVI) and cerebrospinal fluid (CSF) outflow resistance (Ro) were estimated in spontaneously breathing anestheized cats by the bolus injection test under normal conditions and also under abnormal conditions produced by slow infusion of saline into the CSF space. Bolus injections were made separate...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1986.64.2.0298

    authors: Takizawa H,Gabra-Sanders T,Miller JD

    更新日期:1986-02-01 00:00:00

  • CT-guided stereotactic fibrinolysis of spontaneous and hypertensive cerebellar hemorrhage: long-term results.

    abstract::The surgical indication for spontaneous cerebellar hemorrhage is not as controversial as the operative management of intracranial hemorrhage. Timing of the operation is crucial: intervening too early can produce an additional strain on the patient and an increased risk, while waiting too long to evacuate the hematoma ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1990.73.2.0217

    authors: Mohadjer M,Eggert R,May J,Mayfrank L

    更新日期:1990-08-01 00:00:00

  • Neurosurgical management of acromegaly. Results in 82 patients treated between 1972 and 1977.

    abstract::A consecutive series of 82 acromegalic patients who underwent transsphenoidal surgery during a 5-year period is presented. Preoperative and postoperative values for human growth hormone (HGH) were available in 80 cases. Microadenomas were present in 18 patients with a mean preoperative HGH value of 25.2 ng/ml, diffuse...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.50.4.0454

    authors: Laws ER Jr,Piepgras DG,Randall RV,Abboud CF

    更新日期:1979-04-01 00:00:00

  • Intraoperative neurophysiological monitoring of extracranial-intracranial bypass procedures.

    abstract:OBJECT:Intraoperative neurophysiological monitoring (IONM) represents an established tool in neurosurgery to increase patient safety. Its application, however, is controversial. Its use has been described as helpful in avoiding neurological deterioration during intracranial aneurysm surgery. Its impact on extracranial-...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.4.JNS122205

    authors: Dengler J,Cabraja M,Faust K,Picht T,Kombos T,Vajkoczy P

    更新日期:2013-07-01 00:00:00

  • Carcinoembryonic antigen production associated with an osteolytic meningioma. Case report.

    abstract::An elevated serum carcinoembryonic antigen (CEA) without evidence of neoplasia was noted in an 84-year-old woman. She subsequently developed a lytic skull lesion, which at surgery proved to be an atypical meningioma. Immunohistochemical analysis demonstrated that this tumor was producing CEA. This aggressive meningiom...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.3.0489

    authors: Partington MD,Scheithauer BW,Piepgras DG

    更新日期:1995-03-01 00:00:00

  • Intraoperative transdural functional mapping. Technical note.

    abstract::During craniotomy for supratentorial intraparenchymal space-occupying lesions, with the patient either under general anesthesia or awake, a smaller durotomy designed to expose only the region of resection may be desirable because of brain swelling. Similarly, during repeat craniotomy or craniotomy following cerebral i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.80.4.0756

    authors: Silbergeld DL

    更新日期:1994-04-01 00:00:00

  • Shunt surgery in patients with hydrocephalus and white matter changes.

    abstract:OBJECT:Patients with idiopathic normal pressure hydrocephalus (iNPH) often present with impaired gait and cognition together with ventricular enlargement and normal intracranial pressure. Many have vascular risk factors as well as periventricular and deep white matter changes on MR imaging. Abnormal CSF dynamics, that ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,随机对照试验

    doi:10.3171/2010.11.JNS10967

    authors: Tisell M,Tullberg M,Hellström P,Edsbagge M,Högfeldt M,Wikkelsö C

    更新日期:2011-05-01 00:00:00

  • Observer variability in assessing the clinical features of subarachnoid hemorrhage.

    abstract::Clinical assessment of patients with subarachnoid hemorrhage (SAH) is important both in determining management and in predicting outcome. A previous report showed considerable observer inconsistency when patients were graded with either the Hunt and Hess or the Nishioka system. This study evaluates observer variabilit...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1983.58.1.0057

    authors: Lindsay KW,Teasdale GM,Knill-Jones RP

    更新日期:1983-01-01 00:00:00

  • Risk factors and analysis of long-term headache in sporadic vestibular schwannoma: a multicenter cross-sectional study.

    abstract:OBJECT:The primary goals of this study were: 1) to examine the influence of disease and treatment on headache in patients with sporadic vestibular schwannoma (VS); and 2) to identify clinical predictors of long-term headache disability. METHODS:This was a cross-sectional observational study with international multicen...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2014.12.JNS142109

    authors: Carlson ML,Tveiten ØV,Driscoll CL,Boes CJ,Sullan MJ,Goplen FK,Lund-Johansen M,Link MJ

    更新日期:2015-11-01 00:00:00

  • Adverse radiation effect after stereotactic radiosurgery for brain metastases: incidence, time course, and risk factors.

    abstract:OBJECT:The authors sought to determine the incidence, time course, and risk factors for overall adverse radiation effect (ARE) and symptomatic ARE after stereotactic radiosurgery (SRS) for brain metastases. METHODS:All cases of brain metastases treated from 1998 through 2009 with Gamma Knife SRS at UCSF were considere...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS141610

    authors: Sneed PK,Mendez J,Vemer-van den Hoek JG,Seymour ZA,Ma L,Molinaro AM,Fogh SE,Nakamura JL,McDermott MW

    更新日期:2015-08-01 00:00:00

  • Impaired capillary perfusion and brain edema following experimental subarachnoid hemorrhage: a morphometric study.

    abstract::To evaluate microcirculatory disturbance and cerebral edema associated with subarachnoid hemorrhage (SAH), both stereological morphometry on the intraparenchymal capillary network and microgravimetry were performed on a rabbit SAH model. Autologous arterial blood (5 ml) was injected into the cisterna magna, and the an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1990.73.3.0410

    authors: Johshita H,Kassell NF,Sasaki T,Ogawa H

    更新日期:1990-09-01 00:00:00

  • The neuroprotective pharmacology of methylprednisolone.

    abstract::A 24-hour intensive intravenous dosing regimen with the glucocorticoid steroid methylprednisolone has recently been shown to be effective in enhancing neurological recovery in spinal cord-injured patients when initiated within 8 hours after injury. The state of knowledge concerning the neuroprotective pharmacology of ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1992.76.1.0013

    authors: Hall ED

    更新日期:1992-01-01 00:00:00

  • Hemodynamic analysis of the recipient parasylvian cortical arteries for predicting postoperative hyperperfusion during STA-MCA bypass in adult patients with moyamoya disease.

    abstract:OBJECTIVE:Superficial temporal artery-middle cerebral artery (STA-MCA) bypass is a common approach for treating moyamoya disease (MMD); however, the selection of recipient vessels is still controversial, and its relationship with postoperative cerebral hyperperfusion (CHP) has not been revealed. The aim of the study wa...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2019.10.JNS191207

    authors: Zhang J,Li S,Fujimura M,Lau TY,Wu X,Hu M,Zheng H,Xu H,Zhao W,Li X,Chen J

    更新日期:2019-12-27 00:00:00

  • Axonal supercharging technique using reverse end-to-side neurorrhaphy in peripheral nerve repair: an experimental study in the rat model.

    abstract:OBJECT:In an attempt to improve peripheral nerve repair, the influence of the addition of reverse end-to-side neurorrhaphy for an injured peripheral nerve was investigated in the rat sciatic nerve transection model. METHODS:Twelve Sprague-Dawley rats were divided into two groups (six rats in each group). In Group I, t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS-07/10/0821

    authors: Fujiwara T,Matsuda K,Kubo T,Tomita K,Hattori R,Masuoka T,Yano K,Hosokawa K

    更新日期:2007-10-01 00:00:00

  • Gamma Knife surgery of vestibular schwannomas: longitudinal changes in vestibular function and measurement of the Dizziness Handicap Inventory.

    abstract:OBJECT:Gamma Knife surgery (GKS) is one of the methods available to treat vestibular schwannomas (VSs), in addition to microsurgical resection; however, clear information regarding balance function outcomes and the impact of treatment on patients' quality of life over time remains an important clinical need. The purpos...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/12/S21

    authors: Wackym PA,Hannley MT,Runge-Samuelson CL,Jensen J,Zhu YR

    更新日期:2008-12-01 00:00:00

  • Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973-1997.

    abstract:OBJECT:The purpose of this study was to examine patterns of diagnosis and relative survival rates in individuals in whom a primary malignant brain tumor was diagnosed between 1973 and 1997; follow-up review of these patients continued through the end of 1999. METHODS:The study population was composed of 21,493 patient...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.3.0458

    authors: Barnholtz-Sloan JS,Sloan AE,Schwartz AG

    更新日期:2003-09-01 00:00:00

  • Neoplastic cerebral aneurysm from metastatic gestational choriocarcinoma. Case report.

    abstract::This case of metastatic gestational choriocarcinoma presented as intracerebral hemorrhage from an atypical distal middle cerebral artery aneurysm. Operative evacuation of the intracerebral hematoma was undertaken and histopathological examination revealed choriocarcinoma invading the vessel wall. Neoplastic cerebral a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.4.0644

    authors: Pullar M,Blumbergs PC,Phillips GE,Carney PG

    更新日期:1985-10-01 00:00:00

  • Transparaspinal exposure of dumbbell tumors of the spine. Report of two cases.

    abstract::The authors present a surgical technique for resection of dumbbell tumors of the spine. The transparaspinal exposure combines laminectomy and sectioning of the paraspinal muscles through a transverse incision. The procedure allows total tumor resection by means of a single posterior approach in selected patients, thus...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.88.1.0106

    authors: Onesti ST,Ashkenazi E,Michelsen WJ

    更新日期:1998-01-01 00:00:00

  • Radiographic absence of the posterior communicating arteries and the prediction of cognitive dysfunction after carotid endarterectomy.

    abstract:OBJECT:Approximately 25% of patients exhibit cognitive dysfunction 24 hours after carotid endarterectomy (CEA). One of the purported mechanisms of early cognitive dysfunction (eCD) is hypoperfusion due to inadequate collateral circulation during cross-clamping of the carotid artery. The authors assessed whether poor co...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.5.JNS131736

    authors: Sussman ES,Kellner CP,Mergeche JL,Bruce SS,McDowell MM,Heyer EJ,Connolly ES

    更新日期:2014-09-01 00:00:00

  • Risk of early closed reduction in cervical spine subluxation injuries.

    abstract:OBJECT:The authors retrospectively reviewed 121 patients with traumatic cervical spine injuries to determine the risk of neurological deterioration following early closed reduction. METHODS:After excluding minor fractures and injuries without subluxation, the medical records and imaging studies (computerized tomograph...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.1999.90.1.0013

    authors: Grant GA,Mirza SK,Chapman JR,Winn HR,Newell DW,Jones DT,Grady MS

    更新日期:1999-01-01 00:00:00

  • Cerebrovascular effects of hypocapnia during adenosine-induced arterial hypotension.

    abstract::Profound arterial hypotension is a commonly used adjunct in surgery for aneurysms and arteriovenous malformations. Hyperventilation with hypocapnia is also used in these patients to increase brain slackness. Both measures reduce cerebral blood flow (CBF). Of concern is whether CBF is reduced below ischemic thresholds ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.6.0937

    authors: Boarini DJ,Kassell NF,Sprowell JA,Olin JJ,Coester HC

    更新日期:1985-12-01 00:00:00

  • A randomized placebo-controlled double-blind trial of nimodipine after SAH in monkeys. Part 1: Clinical and radiological findings.

    abstract::The authors have developed a method to induce chronic cerebral vasospasm after subarachnoid hemorrhage (SAH) in monkeys. With microsurgical techniques, 33 monkeys had a frontotemporal craniectomy and unilateral opening of the subarachnoid cisterns. Cerebrospinal fluid was drained and a fresh hematoma, obtained from an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.6.1167

    authors: Espinosa F,Weir B,Overton T,Castor W,Grace M,Boisvert D

    更新日期:1984-06-01 00:00:00

  • Motor areas of the frontal cortex in patients with motor eloquent brain lesions.

    abstract::OBJECTIVE Because of its huge clinical potential, the importance of premotor areas for motor function itself and plastic reshaping due to tumors or ischemic brain lesions has received increased attention. Thus, in this study the authors used navigated transcranial magnetic stimulation (nTMS) to investigate whether tum...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.11.JNS152103

    authors: Bulubas L,Sabih J,Wohlschlaeger A,Sollmann N,Hauck T,Ille S,Ringel F,Meyer B,Krieg SM

    更新日期:2016-12-01 00:00:00

  • Emergency balloon occlusion for massive epistaxis due to traumatic carotid-cavernous aneurysm. Case report.

    abstract::A patient with a giant traumatic aneurysm of the right internal carotid artery presented with recurrent massive epistaxis 30 years after a head injury. During an episode of acute hemorrhage, this patient was effectively treated with occlusion of the internal carotid artery circulation by a detachable inflatable balloo...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.1.0142

    authors: Simpson RK Jr,Harper RL,Bryan RN

    更新日期:1988-01-01 00:00:00

  • Subarachnoid-pleural fistula after resection of thoracic tumors.

    abstract:OBJECT:Little has been written about the appropriate diagnosis, investigation, and management of subarachnoid-pleural fistula (SPF). The authors report a series of patients with SPF that developed after resection of spinal tumor and discuss the diagnosis and treatment of this entity. METHODS:Between 1993 and 2002, nin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2004.100.4.0332

    authors: Hentschel SJ,Rhines LD,Wong FC,Gokaslan ZL,McCutcheon IE

    更新日期:2004-04-01 00:00:00

  • Severe posttraumatic craniocervical instability in the very young patient. Report of three cases.

    abstract::Children younger than 3 years of age represent a distinct subpopulation of patients at particular risk for high cervical and craniovertebral injuries. There are few descriptions of survivors of severe craniocervical trauma among the very young, and scarce data exist regarding management after initial emergency stabili...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2004.101.2.0102

    authors: Ghatan S,Newell DW,Grady MS,Mirza SK,Chapman JR,Mann FA,Ellenbogen RG

    更新日期:2004-08-01 00:00:00

  • Comparing the risks of frameless stereotactic biopsy in eloquent and noneloquent regions of the brain: a retrospective review of 284 cases.

    abstract:OBJECT:Frameless stereotactic biopsy has been shown in multiple studies to be a safe and effective tool for the diagnosis of brain lesions. However, no study has directly evaluated its safety in lesions located in eloquent regions in comparison with noneloquent locations. In this study, the authors determine whether an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2009.3.JNS081695

    authors: Air EL,Leach JL,Warnick RE,McPherson CM

    更新日期:2009-10-01 00:00:00

  • Reconstruction of irreparable brachial plexus injuries with reinnervated free-muscle transfer. Case report.

    abstract::The complete avulsion of the brachial plexus is a severe injury usually caused by high-energy trauma. Even with the advent of modern microsurgical techniques, many patients have been rendered severely handicapped following this injury. The authors present a new reconstructive procedure that uses a microsurgical reinne...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.1.0174

    authors: Doi K,Sakai K,Fuchigami Y,Kawai S

    更新日期:1996-07-01 00:00:00