Gamma Knife surgery of vestibular schwannomas: longitudinal changes in vestibular function and measurement of the Dizziness Handicap Inventory.

Abstract:

OBJECT:Gamma Knife surgery (GKS) is one of the methods available to treat vestibular schwannomas (VSs), in addition to microsurgical resection; however, clear information regarding balance function outcomes and the impact of treatment on patients' quality of life over time remains an important clinical need. The purpose of this study was to assess the longitudinal balance outcomes and Dizziness Handicap Inventory (DHI) following GKS for VSs. METHODS:This was a prospective clinical study of balance outcomes in all patients with VSs treated in the Acoustic Neuroma and Skull Base Surgery Program at a tertiary referral center by the senior author and the Gamma Knife team between June 2000 and May 2008. The main outcome measures included preoperative vestibular testing and postoperative caloric testing performed at 6-month intervals to determine vestibular function. The DHI questionnaires were administered retrospectively to assess the impact of GKS on self-perceived disability. RESULTS:Between June 2000 and May 2008, 55 sporadic VSs were treated. There was a >or= 60-month follow-up available in 27 of these patients, >or= 48 months in 32, >or= 36 months in 38, >or= 24 months in 43, >or= 12 months in 51, and >or= 6 months in 54 (1 patient was excluded from the analysis because the follow-up was < 6 months). Various patterns of changes in vestibular function were observed in either positive or negative directions. A significant difference in total DHI score was seen only in the elderly (> 65 years old) patients pre-GKS compared with post-GKS (t = 1.34, p = 0.05). CONCLUSIONS:Longitudinal changes in vestibular function occur over time, with the largest changes seen in the first 6 months after treatment. Potential for clinical intervention, such as vestibular rehabilitation therapy, exists during this interval; however, larger cohorts must be studied to determine the timing and efficacy of this intervention. The statistically significant improvement in the DHI score in the patient cohort > 65 years old treated with GKS suggests that this group may benefit from this option when considering the symptom of dizziness.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Wackym PA,Hannley MT,Runge-Samuelson CL,Jensen J,Zhu YR

doi

10.3171/JNS/2008/109/12/S21

subject

Has Abstract

pub_date

2008-12-01 00:00:00

pages

137-43

eissn

0022-3085

issn

1933-0693

journal_volume

109 Suppl

pub_type

杂志文章
  • Acoustic neurinoma presenting as subarachnoid hemorrhage. Case report.

    abstract::A case of an acoustic neurinoma presenting as a subarachnoid hemorrhage is described. This is the second such case in the literature. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.49.4.0602

    authors: Gleeson RK,Butzer JF,Grin OD Jr

    更新日期:1978-10-01 00:00:00

  • The role of cerebral blood volume changes in brain specific-gravity measurements.

    abstract::Cerebral blood volume (CBV) was calculated in gerbils from specific-gravity (SG) changes between normal and saline-perfused brains. Furthermore, changes in CBV were investigated during ischemia using carbon-14-labeled dextran (MW 70,000) as an intravascular marker. Both data were used to evaluate the possible error du...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.5.0704

    authors: Picozzi P,Todd NV,Crockard AH

    更新日期:1985-05-01 00:00:00

  • Revascularization of the extracranial vertebral artery at any level without cross-clamping.

    abstract::Hemodynamic insufficiency resulting from extracranial vertebral artery stenosis or occlusion is believed to be the major cause of vertebrobasilar transient ischemic attacks. The major difficulties in treating this disorder have been exposure of the vertebral artery distal to the stenosis and the risk of vertebral arte...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.3.0334

    authors: Senter HJ,Bittar SM,Long ET

    更新日期:1985-03-01 00:00:00

  • Falcine sinus and occipital encephalocele: a magnetic resonance venography study.

    abstract:OBJECT:Occipital encephaloceles are relatively frequently encountered. Many investigators have addressed the embryogenesis of these formations, but the dural system has never before been studied. In this retrospective analysis the authors sought to gain a better understanding of the origins of these defects. METHODS:T...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1998.89.5.0738

    authors: Bartels RH,Merx JL,van Overbeeke JJ

    更新日期:1998-11-01 00:00:00

  • The Barrow Ruptured Aneurysm Trial: 3-year results.

    abstract:OBJECT:The authors report the 3-year results of the Barrow Ruptured Aneurysm Trial (BRAT). The objective of this ongoing randomized trial is to compare the safety and efficacy of microsurgical clip occlusion and endovascular coil embolization for the treatment of acutely ruptured cerebral aneurysms and to compare funct...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,随机对照试验

    doi:10.3171/2013.3.JNS12683

    authors: Spetzler RF,McDougall CG,Albuquerque FC,Zabramski JM,Hills NK,Partovi S,Nakaji P,Wallace RC

    更新日期:2013-07-01 00:00:00

  • Meningiomas causing spontaneous intracranial hematomas.

    abstract::Four cases of spontaneous intracranial hematomas caused by unsuspected meningiomas are reported. Nine previous cases were found in the literature and the entire series of 13 cases is reviewed. Because of their unusual clinical presentation, these cases were not diagnosed correctly prior to radiological studies. Hypert...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1976.45.4.0437

    authors: Modesti LM,Binet EF,Collins GH

    更新日期:1976-10-01 00:00:00

  • Diffuse bilateral cerebral astrocytomas with atypical neuroimaging studies.

    abstract::The authors describe the clinical behavior of eight patients with cerebral astrocytomas, in whom computerized tomography (CT) or magnetic resonance (MR) imaging of the brain was characterized by diffuse bilateral cerebral hemisphere tissue density abnormalities and minimal focal mass effect. Five patients were newly d...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1994.81.6.0817

    authors: Rogers LR,Weinstein MA,Estes ML,Cairncross JG,Strachan T

    更新日期:1994-12-01 00:00:00

  • Flow diversion treatment of complex bifurcation aneurysms beyond the circle of Willis: complications, aneurysm sac occlusion, reabsorption, recurrence, and jailed branch modification at follow-up.

    abstract:OBJECTIVE:The purpose of this study is to present the authors' medium-term results, with special emphasis on complications, occlusion rate of the aneurysm sac (digital subtraction angiography [DSA] and MRI), and the fate of cortical branches and perforating arteries covered ("jailed") by the flow diverter (FD) stent. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.7.JNS18654

    authors: Michelozzi C,Darcourt J,Guenego A,Januel AC,Tall P,Gawlitza M,Bonneville F,Cognard C

    更新日期:2018-12-21 00:00:00

  • Endoscopic transorbital surgery for Meckel's cave and middle cranial fossa tumors: surgical technique and early results.

    abstract::OBJECTIVETumors involving Meckel's cave remain extremely challenging because of the surrounding complex neurovascular structures and deep-seated location. The authors investigated a new minimal-access technique using the endoscopic transorbital approach (eTOA) through the superior eyelid crease to Meckel's cave and mi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.6.JNS181099

    authors: Jeon C,Hong CK,Woo KI,Hong SD,Nam DH,Lee JI,Choi JW,Seol HJ,Kong DS

    更新日期:2018-11-01 00:00:00

  • The neurophysiology and effect of deep brain stimulation in a patient with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism.

    abstract::Parkinsonism caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) exposure was first identified in intravenous drug users. This neurotoxicant has since been used extensively in nonhuman primates to induce an experimental model of Parkinson disease (PD). In this study, the authors examined the intraoperative p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.8.JNS08882

    authors: Christine CW,Langston JW,Turner RS,Starr PA

    更新日期:2009-02-01 00:00:00

  • Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value.

    abstract::Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patien...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1997.86.1.0121

    authors: Cunningham JM,Kimmel DW,Scheithauer BW,O'Fallon JR,Novotny PJ,Jenkins RB

    更新日期:1997-01-01 00:00:00

  • Pituitary hyperplasia causing complete bitemporal hemianopia with resolution following surgical decompression: case report.

    abstract::In this report, the authors demonstrated that idiopathic pituitary hyperplasia (PH) can cause complete bitemporal hemianopia and amenorrhea, even in the setting of mild anatomical compression of the optic chiasm and normal pituitary function. Furthermore, complete resolution of symptoms can be achieved with surgical d...

    journal_title:Journal of neurosurgery

    pub_type:

    doi:10.3171/2020.5.JNS20448

    authors: Raviv N,Amin A,Kenning TJ,Pinheiro-Neto CD,Jones D,Sharma V,Peris-Celda M

    更新日期:2020-08-14 00:00:00

  • Diffuse axonal injury in mild traumatic brain injury: a diffusion tensor imaging study.

    abstract:OBJECT:Diffuse axonal injury (DAI) is a major complication of traumatic brain injury (TBI) that leads to functional and psychological deficits. Although DAI is frequently underdiagnosed by conventional imaging modalities, it can be demonstrated using diffusion tensor imaging. The aim of this study was to assess the pre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.2.0298

    authors: Inglese M,Makani S,Johnson G,Cohen BA,Silver JA,Gonen O,Grossman RI

    更新日期:2005-08-01 00:00:00

  • Iatrogenic failure of a ventriculoperitoneal shunt. Case report.

    abstract::A previous undescribed cause of ventriculoperitoneal shunt malfunction is presented. Limitation of abdominal excursion by a spica cast used to correct congenital hip dislocation reduced cerebrospinal fluid flow through a shunt. This easily correctable cause of "shunt failure" nearly resulted in replacement of a workin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.46.6.0830

    authors: Gerber AM

    更新日期:1977-06-01 00:00:00

  • Ganglioglioma presenting as a vascular lesion in a 10-year-old boy. Case report.

    abstract::The authors present the case of a 10-year-old boy admitted for evaluation of a generalized seizure and a history of headaches. Computerized tomography (CT) and gadolinium-enhanced magnetic resonance (MR) imaging demonstrated a large nonhomogeneous contrast-enhancing mass of the left frontal lobe, with a large cystic c...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1993.79.6.0920

    authors: Baltuch GH,Farmer JP,Meagher-Villemure K,O'Gorman AM,Montes JL

    更新日期:1993-12-01 00:00:00

  • Symptoms of pituitary apoplexy rapidly reversed with bromocriptine. Case report.

    abstract::Macroprolactinomas rarely present with apoplexy. The authors describe a patient with a macroprolactinoma who presented with apoplexy and rapid progression of a third nerve palsy. The patient was managed expectantly with bromocriptine, and within 48 hours, the patient's third nerve palsy had completely resolved. The au...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.85.6.1153

    authors: Brisman MH,Katz G,Post KD

    更新日期:1996-12-01 00:00:00

  • Resection and brain brachytherapy with permanent iodine-125 sources for brain metastasis.

    abstract::OBJECTIVE Stereotactic radiosurgery (SRS) with or without whole-brain radiotherapy can be used to achieve local control (> 90%) for small brain metastases after resection. However, many brain metastases are unsuitable for SRS because of their size or previous treatment, and whole-brain radiotherapy is associated with ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2016.4.JNS152530

    authors: Raleigh DR,Seymour ZA,Tomlin B,Theodosopoulos PV,Berger MS,Aghi MK,Geneser SE,Krishnamurthy D,Fogh SE,Sneed PK,McDermott MW

    更新日期:2017-06-01 00:00:00

  • Cavernous angioma of the geniculate ganglion.

    abstract::Intracranial extraaxial cavernous angiomas are rare vascular malformations. Their occurrence at the geniculate ganglion of the facial nerve within the temporal bone is exceptional. The authors describe a 35-year-old man who developed a slowly progressing facial palsy. Initial cranial MR imaging showed no pathological ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/JNS/2008/109/11/0893

    authors: Capelle HH,Nakamura M,Lenarz T,Brandis A,Haubitz B,Krauss JK

    更新日期:2008-11-01 00:00:00

  • Temporal bone neoplasms: a report on 20 surgically treated cases.

    abstract::The surgical resection of neoplasms involving the petrous bone and surrounding areas in 20 patients is reported. Technical advances described include the total resection of several tumors previously considered inoperable due to involvement of dura and brain, petrous internal carotid artery (ICA), the vein of Labbé, an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.76.4.0578

    authors: Sekhar LN,Pomeranz S,Janecka IP,Hirsch B,Ramasastry S

    更新日期:1992-04-01 00:00:00

  • Window anatomy for neurosurgical approaches. Laboratory investigation.

    abstract:OBJECT:Knowledge of the cranium projections of the gyral structures is essential to reduce the surgical complications and to perform minimally invasive interventions in daily neurosurgical practice. Thus, in this study the authors aimed to provide detailed information on cranial projections of the eloquent cortical are...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2008.10.JNS08159

    authors: Kendir S,Acar HI,Comert A,Ozdemir M,Kahilogullari G,Elhan A,Ugur HC

    更新日期:2009-08-01 00:00:00

  • Brain invasion and the risk of seizures in patients with meningioma.

    abstract:OBJECTIVE:Identification of risk factors for perioperative epilepsy remains crucial in the care of patients with meningioma. Moreover, associations of brain invasion with clinical and radiological variables have been largely unexplored. The authors hypothesized that invasion of the cortex and subsequent increased edema...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.11.JNS172265

    authors: Hess K,Spille DC,Adeli A,Sporns PB,Brokinkel C,Grauer O,Mawrin C,Stummer W,Paulus W,Brokinkel B

    更新日期:2018-04-27 00:00:00

  • Descriptive epidemiology of pituitary tumors in the United States, 2004-2009.

    abstract:OBJECT:Pituitary tumors are abnormal growths that develop in the pituitary gland. The Central Brain Tumor Registry of the United States (CBTRUS) contains the largest aggregation of population-based data on the incidence of primary CNS tumors in the US. These data were used to determine the incidence of tumors of the pi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.5.JNS131819

    authors: Gittleman H,Ostrom QT,Farah PD,Ondracek A,Chen Y,Wolinsky Y,Kruchko C,Singer J,Kshettry VR,Laws ER,Sloan AE,Selman WR,Barnholtz-Sloan JS

    更新日期:2014-09-01 00:00:00

  • Grafting of perfused adrenal medullary tissue into the caudate nucleus of patients with Parkinson's disease. Clinica Puerta de Hierro Neural Transplantation Group.

    abstract::The authors report results obtained in 20 severely affected patients with Parkinson's disease (Grade IV or V) who received an autotransplant of perfused adrenal medullary tissue. This study seems to indicate that these autoimplants can improve the parkinsonian symptomatology and induce amelioration in the patients' pe...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.2.0234

    authors: López-Lozano JJ,Bravo G,Abascal J

    更新日期:1991-08-01 00:00:00

  • Evaluation of a bispecific biological drug designed to simultaneously target glioblastoma and its neovasculature in the brain.

    abstract:OBJECT:The authors of this study aimed to genetically design a bispecific targeted toxin that would simultaneously target overexpressed markers on glioma as well as the tumor vasculature, to mutate certain amino acids to reduce the immunogenicity of this new drug, and to determine whether the drug was able to effective...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.11.JNS101214

    authors: Oh S,Tsai AK,Ohlfest JR,Panoskaltsis-Mortari A,Vallera DA

    更新日期:2011-06-01 00:00:00

  • No effect of enoxaparin on outcome of aneurysmal subarachnoid hemorrhage: a randomized, double-blind, placebo-controlled clinical trial.

    abstract:OBJECT:From the moment an intracranial aneurysm ruptures, cerebral blood flow is impaired, and this impairment mainly determines the outcome in patients who survive after the initial bleeding. The exact mechanism of impairment is unknown, but activation of coagulation and fibrinolysis correlate with clinical condition ...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3171/jns.2003.99.6.0953

    authors: Siironen J,Juvela S,Varis J,Porras M,Poussa K,Ilveskero S,Hernesniemi J,Lassila R

    更新日期:2003-12-01 00:00:00

  • Unilateral septal technique for transsphenoidal microsurgical approach to the sella turcica. Technical note.

    abstract::A modification of the transseptal, transsphenoidal appraoch to the sella turcica is described; it consists of a unilateral separation of the nasal mucosa from the nasal septum. Experience with the technique in 215 cases has indicated that it is a useful, practical appraoch. The advantages are that the septum is spared...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1978.49.1.0138

    authors: Tindall GT,Collins WF Jr,Kirchner JA

    更新日期:1978-07-01 00:00:00

  • Intraoperative neurophysiological monitoring of extracranial-intracranial bypass procedures.

    abstract:OBJECT:Intraoperative neurophysiological monitoring (IONM) represents an established tool in neurosurgery to increase patient safety. Its application, however, is controversial. Its use has been described as helpful in avoiding neurological deterioration during intracranial aneurysm surgery. Its impact on extracranial-...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2013.4.JNS122205

    authors: Dengler J,Cabraja M,Faust K,Picht T,Kombos T,Vajkoczy P

    更新日期:2013-07-01 00:00:00

  • A tentorial sling in microvascular decompression for trigeminal neuralgia. Technical note.

    abstract::The key to the successful microvascular decompression of the trigeminal nerve is the maintenance of the separation between the trigeminal nerve and the offending vessel. The authors describe a technique whereby a dural sling is fashioned from the tentorium cerebelli (the anatomy of which is briefly reviewed), which is...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.84.1.0127

    authors: Melvill RL,Baxter BL

    更新日期:1996-01-01 00:00:00

  • Volumetric quantification of cement leakage following percutaneous vertebroplasty in metastatic and osteoporotic vertebrae.

    abstract:OBJECT:The goal of this study was to quantify volumetrically cement fill and leakage in patients with osteoporotic and metastatic vertebral lesions undergoing percutaneous vertebroplasty and to establish whether these factors have any clinical significance at follow up. METHODS:Digital computerized tomography data wer...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2003.99.1.0056

    authors: Mousavi P,Roth S,Finkelstein J,Cheung G,Whyne C

    更新日期:2003-07-01 00:00:00

  • Treatment of spontaneous carotid-cavernous fistula in Ehlers-Danlos syndrome by transvenous occlusion with Guglielmi detachable coils. Case report and review of the literature.

    abstract::The authors report on a young woman with Ehlers-Danlos syndrome (EDS) Type IV in whom a spontaneous direct carotid-cavernous fistula (CCF) was treated by transvenous occlusion with regular and fiber-coated Guglielmi detachable coils. To the authors' knowledge, this is the first time this approach has been used in a pa...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.2000.93.4.0689

    authors: Kanner AA,Maimon S,Rappaport ZH

    更新日期:2000-10-01 00:00:00