Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: relationships and prognostic value.

Abstract:

:Consecutive paraffin sections of 105 astrocytomas and 15 oligoastrocytomas were examined for expression of p53, MIB-1 (Ki-67), and proliferating cell nuclear antigen (PCNA). The tumors had been examined previously for genetic abnormalities and by flow cytometry. Regardless of the tumor's stage and grade and the patient's age and gender, p53 expression was found in 40% of tumors. Although p53 expression was associated with a loss on chromosome 17p and was more frequent in aneuploid tumors, it had no association with survival time. The MIB-1 and PCNA labeling indices increased with increasing tumor grade but showed no association with other clinicopathological parameters. In individual tumors, there was poor concordance between any of the variables (MIB-1, PCNA, and p53). Results for p53 and MIB-1 were similar for both astrocytomas and oligoastrocytomas. The MIB-1 and PCNA values appeared to have prognostic utility in univariate analysis but not after adjusting for patient age and tumor grade. The poor concordance between MIB-1 and PCNA in individual tumors indicates that any one means of assessing proliferative potential in gliomas may not be reliable.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Cunningham JM,Kimmel DW,Scheithauer BW,O'Fallon JR,Novotny PJ,Jenkins RB

doi

10.3171/jns.1997.86.1.0121

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

121-30

issue

1

eissn

0022-3085

issn

1933-0693

journal_volume

86

pub_type

杂志文章
  • A leap forward in the endovascular management of acute basilar artery occlusion since the appearance of stent retrievers: a single-center comparative study.

    abstract::OBJECTIVE Contrary to acute ischemic stroke involving the anterior circulation, no randomized trial has yet demonstrated the safety and effectiveness of endovascular management in acute basilar artery occlusion (BAO). Recently developed thrombectomy devices, such as stentrievers and aspiration systems, have helped in ...

    journal_title:Journal of neurosurgery

    pub_type: 评论,杂志文章

    doi:10.3171/2016.2.JNS151983

    authors: Fahed R,Di Maria F,Rosso C,Sourour N,Degos V,Deltour S,Baronnet-Chauvet F,Léger A,Crozier S,Gabrieli J,Samson Y,Chiras J,Clarençon F

    更新日期:2017-05-01 00:00:00

  • Atretic cephalocele: the tip of the iceberg.

    abstract::Atretic cephalocele appears as an unimportant and benign lesion. This malformation consists of meningeal and vestigial tissues (arachnoid, glial, or central nervous system rests). The authors report the findings in 16 cases (seven parietal and nine occipital) of rudimentary cephaloceles. Twelve patients presented with...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.2.0230

    authors: Martinez-Lage JF,Sola J,Casas C,Poza M,Almagro MJ,Girona DG

    更新日期:1992-08-01 00:00:00

  • Chiari malformation with compression of the medulla oblongata by the vertebral arteries. Case report.

    abstract::A unique case is reported of Chiari malformation and compression of the medulla oblongata by both vertebral arteries. A 39-year-old woman complained of unsteady giant and motor weakness of the legs, and magnetic resonance imaging revealed the malformation and compression. Vascular decompression of the vertebral arteri...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1992.77.2.0307

    authors: Kobayashi T,Ogawa A,Kameyama M,Uenohara H,Yoshimoto T

    更新日期:1992-08-01 00:00:00

  • The role of endoscopic third ventriculostomy in the treatment of triventricular hydrocephalus seen in children with achondroplasia.

    abstract::The authors of this paper describe two patients with achondroplasia in whom triventricular hydrocephalus has been successfully treated using endoscopic third ventriculostomy (ETV). The authors performed ETVs in two children with achondroplasia involving a moderate macrocranium and enlarged lateral and third ventricles...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2005.103.3.0260

    authors: Etus V,Ceylan S

    更新日期:2005-09-01 00:00:00

  • Effects of intracranial meningioma location, size, and surgery on neurocognitive functions: a 3-year prospective study.

    abstract::OBJECT Current recommendations stress the need for cognitive parameters to be integrated in the evaluation of outcomes for intracranial meningioma surgery. The aim of this prospective study was to examine neurocognitive function in meningioma patients pre- and postoperatively. METHODS Patients with skull base (anterio...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2015.6.JNS1549

    authors: Liouta E,Koutsarnakis C,Liakos F,Stranjalis G

    更新日期:2016-06-01 00:00:00

  • History of neurosurgery at University of Toronto: the St. Michael's story.

    abstract::In this paper, the authors describe the history of neurosurgery at St. Michael's Hospital, University of Toronto. St. Michael's has long been regarded as one of the top teaching and research hospitals in Canada. A detailed literature review of published and unpublished works was performed to formulate a succinct but i...

    journal_title:Journal of neurosurgery

    pub_type: 历史文章,杂志文章

    doi:10.3171/2016.9.JNS161119

    authors: Alotaibi NM,Guha D,Ahuja CS,Spears J,Muller PJ,Tucker WS,Hudson AR,Macdonald RL

    更新日期:2017-12-01 00:00:00

  • Intracranial desmoplastic small round cell tumor presenting as a suprasellar mass.

    abstract::Desmoplastic small round cell tumors (DSRCTs) are rare, aggressive neoplasms that typically arise from abdominal and pelvic peritoneum in young adults. Other primary sites are uncommon, and an intracranial origin is exceptionally rare. Here the authors report the first case of a DSRCT presenting as a primary suprasell...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.10.JNS132490

    authors: Thondam SK,du Plessis D,Cuthbertson DJ,Das KS,Javadpour M,MacFarlane IA,Leggate J,Haylock B,Daousi C

    更新日期:2015-04-01 00:00:00

  • Traumatic lumbosacral meningocele. Case report.

    abstract::A case of traumatic avulsion of the L-5 and S-1 nerve roots is described. Surgical intervention was undertaken and long-term functional recovery obtained. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1977.46.4.0536

    authors: Barberá J,Broseta J,Argüelles F,Barcia-Salorio JL

    更新日期:1977-04-01 00:00:00

  • Diagnosis of superior sagittal sinus thrombosis by computerized tomography. Report of two cases.

    abstract::Superior sagittal sinus thrombosis was diagnosed on computerized tomography (CT) scanning and was subsequently confirmed by angiography in two patients. Small ventricles and filling defects occurring within the sinus (the empty triangle sign) appeared to be highly suggestive of superior sagittal sinus thrombosis, and ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.61.6.1129

    authors: d'Avella D,Russo A,Santoro G,Pandolfo N,Cafarelli F,De Blasi F,del Vivo RE

    更新日期:1984-12-01 00:00:00

  • Factors influencing the complication rate of subduroperitoneal shunt placement for the treatment of subdural hematomas in infants.

    abstract:OBJECT:In this study the authors' goal was to identify the complication rate of subduroperitoneal (SDP) shunts for the treatment of subdural hematomas (SDHs) in infants and to determine the influences on and predictive factors for these complications. METHODS:The authors present a case series spanning the years 1994 t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2007.106.3.172

    authors: Kurschel S,Puget S,Bourgeois M,Zerah M,Ofner P,Renier D

    更新日期:2007-03-01 00:00:00

  • Pyrogenic cytokine interleukin-6 expression by a chordoid meningioma in an adult with a systemic inflammatory syndrome. Case report and review of the literature.

    abstract::Chordoid meningioma is a rare meningothelial tumor characterized by chordoma-like histological features with lymphoplasmacellular infiltration. This tumor is often seen in children, but not in adults, with a systemic inflammatory syndrome (iron-resistant microcytic anemia and/or dysgammaglobulinemia) and very rarely w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2005.103.3.0555

    authors: Denaro L,Di Rocco F,Gessi M,Lauriola L,Lauretti L,Pallini R,Fernandez E,Maira G

    更新日期:2005-09-01 00:00:00

  • Failure of prophylactically administered phenytoin to prevent early posttraumatic seizures.

    abstract::A randomized double-blind placebo-controlled study was carried out to determine whether phenytoin administered soon after injury lessens the incidence of epilepsy in the 1st week after severe head trauma. In this study, 244 patients were randomized into either a phenytoin or placebo group. The patients in the phenytoi...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3171/jns.1983.58.2.0231

    authors: Young B,Rapp RP,Norton JA,Haack D,Tibbs PA,Bean JR

    更新日期:1983-02-01 00:00:00

  • Risk factors and analysis of long-term headache in sporadic vestibular schwannoma: a multicenter cross-sectional study.

    abstract:OBJECT:The primary goals of this study were: 1) to examine the influence of disease and treatment on headache in patients with sporadic vestibular schwannoma (VS); and 2) to identify clinical predictors of long-term headache disability. METHODS:This was a cross-sectional observational study with international multicen...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2014.12.JNS142109

    authors: Carlson ML,Tveiten ØV,Driscoll CL,Boes CJ,Sullan MJ,Goplen FK,Lund-Johansen M,Link MJ

    更新日期:2015-11-01 00:00:00

  • Neurological and neuropsychological outcome after resection of craniopharyngiomas.

    abstract:OBJECTIVE:Craniopharyngiomas are rare and benign tumors of the sellar and/or parasellar region. Primary treatment involves resection followed by adjuvant radiotherapy. While the grade of resection was frequently analyzed following surgery, the neurological outcome and especially neuropsychological deficits and quality ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.10.JNS181557

    authors: Giese H,Haenig B,Haenig A,Unterberg A,Zweckberger K

    更新日期:2019-04-19 00:00:00

  • Hemorrhage from moyamoya-like vessels associated with a cerebral arteriovenous malformation. Case report.

    abstract::The authors describe a case of subarachnoid hemorrhage from moyamoya-like vessels associated with an arteriovenous malformation (AVM) in a 44-year-old Hispanic man who presented with severe headache. The AVM was located in the left parietal lobe and the ipsilateral middle cerebral artery was occluded. Although the pat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.5.0869

    authors: Fassett DR,Schloesser PE,Couldwell WT

    更新日期:2004-11-01 00:00:00

  • Immunobiology of primary intracranial tumors. Part 10: Therapeutic efficacy of interferon in the treatment of recurrent gliomas.

    abstract::Human lymphoblastoid alpha-interferon was administered intravenously or intramuscularly to 19 patients with recurrent gliomas. Each patient had previously undergone surgery and radiation therapy. The treatment course consisted of 8 weeks of therapy with an escalating daily dosage and number of days of treatment per we...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.5.0719

    authors: Mahaley MS Jr,Urso MB,Whaley RA,Blue M,Williams TE,Guaspari A,Selker RG

    更新日期:1985-11-01 00:00:00

  • A retrospective analysis of reasons for reoperation following initially successful peripheral nerve stimulation.

    abstract:OBJECT:The authors investigated the causes for surgical reexploration in patients with complex regional pain syndrome Type II who received initial relief of pain from implantation of a peripheral nerve stimulator (PNS). METHODS:The authors reviewed the charts of 11 consecutive patients who underwent a total of 27 PNS-...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2007.106.3.388

    authors: Ishizuka K,Oaklander AL,Chiocca EA

    更新日期:2007-03-01 00:00:00

  • Tentorial edge traumatic aneurysm of the superior cerebellar artery. Case report.

    abstract::The authors report an unusual case of a traumatic aneurysm of the right superior cerebellar artery (SCA). A 22-year-old woman presented with continuous headaches that appeared 15 days after she experienced closed head trauma as a result of a cycling accident. Computerized tomography scanning performed 3 months later s...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1997.87.6.0950

    authors: Proust F,Callonec F,Bellow F,Laquerriere A,Hannequin D,Fréger P

    更新日期:1997-12-01 00:00:00

  • Shunts in normal-pressure hydrocephalus: do we place too many or too few?

    abstract:OBJECT:The average 65-year-old patient with moderate dementia can look forward to only 1.4 quality-adjusted life years (QALYs), that is, longevity times quality of life. Some of these patients suffer from normal-pressure hydrocephalus (NPH) and respond dramatically to shunt insertion. Currently, however, NPH cannot be ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.105.6.815

    authors: Stein SC,Burnett MG,Sonnad SS

    更新日期:2006-12-01 00:00:00

  • Synergistic effect of basic fibroblast growth factor and methylprednisolone on neurological function after experimental spinal cord injury.

    abstract::The authors evaluated the effects of exogenous basic fibroblast growth factor (bFGF) in combination with intravenous methylprednisolone on neurological function and cord angiogenesis in a model of spinal cord injury. Cord injury was produced by extradural clip compression through a T-1 laminectomy. Rats were randomize...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.83.1.0105

    authors: Baffour R,Achanta K,Kaufman J,Berman J,Garb JL,Rhee S,Friedmann P

    更新日期:1995-07-01 00:00:00

  • Quality of life in patients with intracranial gliomas: the impact of modern image-guided surgery.

    abstract:OBJECT:Outcome following brain tumor operations is often assessed by health professionals using various gross function scales. However, surprisingly little is known about how modern glioma surgery affects quality of life (QOL) as reported by the patients themselves. In the present study the authors aimed to assess chan...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2011.1.JNS101657

    authors: Jakola AS,Unsgård G,Solheim O

    更新日期:2011-06-01 00:00:00

  • Iniencephaly: neuroradiological and surgical features. Case report and review of the literature.

    abstract::Iniencephaly is a rare congenital anomaly characterized by spina bifida of the cervical vertebrae, fixed retroflexion of the head on the cervical spine, and occipital bone defect. There are only five reports of surviving patients with iniencephaly. The authors report the case of a newborn who presented with iniencepha...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1998.89.2.0317

    authors: Erdinçler P,Kaynar MY,Canbaz B,Koçer N,Kuday C,Ciplak N

    更新日期:1998-08-01 00:00:00

  • Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions.

    abstract::Mean hemispheric cerebral blood flow (CBF) and intracranial pressure (ICP) were measured in 19 severely head-injured patients treated with barbiturate coma. The CBF was calculated from the clearance of tracer substance monitored by extracranial scintillation detectors after intravenous administration of xenon-133. In ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.68.3.0424

    authors: Nordström CH,Messeter K,Sundbärg G,Schalén W,Werner M,Ryding E

    更新日期:1988-03-01 00:00:00

  • Blood flow and autoregulation in rat pituitary gland.

    abstract::The authors describe an experimental model that allows dynamic studies of blood flow in the pituitary gland. Twenty-eight male Wistar rats were anesthetized and the pituitary gland was exposed using a parapharyngeal approach. Teflon-coated platinum wire electrodes were placed in the adenohypophysis near the midline an...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.63.1.0116

    authors: Kemeny AA,Jakubowski JA,Jefferson AA,Pasztor E

    更新日期:1985-07-01 00:00:00

  • Quantification of thermal asymmetry. Part 2: Application in low-back pain and sciatica.

    abstract::Temperature differences between the lower extremities were measured using a computerized thermometric scanning system in order to compare the degree of thermal asymmetry in 144 patients with low-back pain. The patients displayed highly significant thermal asymmetries, with the involved limb being cooler (p less than 0...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1988.69.4.0556

    authors: Uematsu S,Jankel WR,Edwin DH,Kim W,Kozikowski J,Rosenbaum A,Long DM

    更新日期:1988-10-01 00:00:00

  • Desmopressin administration and rebleeding in subarachnoid hemorrhage: analysis of an observational prospective database.

    abstract::OBJECTIVERebleeding remains a frequent and catastrophic event leading to poor outcome after subarachnoid hemorrhage (SAH). Reduced platelet function after the initial bleed is associated with higher risk of early rebleeding. Desmopressin (DDAVP) is a well-known hemostatic agent, and recent guidelines already suggest i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.7.JNS17990

    authors: Francoeur CL,Roh D,Schmidt JM,Mayer SA,Falo MC,Agarwal S,Connolly ES,Claassen J,Elkind MSV,Park S

    更新日期:2018-01-01 00:00:00

  • Symptomatic C1-2 fusion failure due to a fracture of the lateral C-1 posterior arch in a patient with rheumatoid arthritis. Case report and review of the literature.

    abstract::The authors report a case in which the lateral C-1 arch fractured in a patient with rheumatoid arthritis and an intact fusion mass; this patient had previously undergone a C1-2 Brooks-type fusion. This unique complication occurred secondary to continued resorption of the C1-2 rheumatoid pannus. Two years after occipit...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.2001.94.1.0137

    authors: Ecker RD,Dekutoski MB,Ebersold MJ

    更新日期:2001-01-01 00:00:00

  • Spontaneous intracranial meningioma bleeding: clinicopathological features and outcome.

    abstract:OBJECT:The aim of this study was to determine the clinicopathological features of patients with intracranial bleeding from unsuspected meningioma and to relate these data to surgery-related outcome. METHODS:The authors report on two cases in which hemorrhage of an unsuspected meningioma occurred in the tentorial ridge...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.2005.103.3.0473

    authors: Bosnjak R,Derham C,Popović M,Ravnik J

    更新日期:2005-09-01 00:00:00

  • American views of Sir Victor Horsley in the era of Cushing.

    abstract::Sir Victor Horsley was a pioneering British neurosurgeon known for his numerous neurosurgical, scientific, and sociopolitical contributions. Although word of these surgical and scientific achievements quickly spread throughout Europe and North America in the late 19th century, much of modern neurosurgery's view of Hor...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.8.JNS171438

    authors: Lehner KR,Schulder M

    更新日期:2018-03-01 00:00:00

  • Management and outcome of hemorrhage after Gamma Knife surgery for arteriovenous malformations of the brain.

    abstract:OBJECT:Appropriate management of hemorrhage after Gamma Knife surgery (GKS) for arteriovenous malformations (AVMs) of the brain is poorly understood, although a certain proportion of patients suffer from hemorrhage. METHODS:Among 500 patients observed for 1 to 183 months (median 70 months) after GKS, 32 patients (6.4%...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/sup.2006.105.7.52

    authors: Maruyama K,Shin M,Tago M,Kurita H,Kawahara N,Morita A,Saito N

    更新日期:2006-12-01 00:00:00