Role of monoamines in experimental spinal cord injury in rats. Relationship between Na+-K+-ATPase and lipid peroxidation.

Abstract:

:A spinal cord injury was produced in Wistar rats by extradural compression of the cord with a Sugita aneurysm clip for 5 seconds. During a 2-week observation period following the injury, the tissue norepinephrine (NE), dopamine (DA), and serotonin (5-HT) concentrations decreased uniformly at and below the injured site. The chemical denervation of NE or 5-HT neurons produced by the intraspinal injection of 6-hydroxydopamine (6-OHDA) or 5,7-dihydroxytryptamine (5,7-DHT) 2 weeks before the injury did not cause a marked difference in the extent of hemorrhagic necrosis of the spinal cord after trauma as compared to control animals without pretreatment. In the rats pretreated with 6-OHDA, NE was decreased to less than 30% of control (non-pretreated) values, and, beginning at 5 days after injury, motor performance (assessed quantitatively with the inclined-plane method) was significantly improved compared to results in the non-pretreated control rats. The rats pretreated with 5,7-DHT showed no change from control animals. Spinal cord samples from non-pretreated control animals obtained at the injury site 30 minutes after the compression injury showed a marked decrease in the activity of synaptosomal Na+-K+-ATPase (adenosine triphosphatase) of about 50%, and an increase in both thiobarbituric acid reaction substance (about 170%) and cyclic guanine monophosphate (about 150%). The NE-denervated rats showed no significant changes in these three parameters. The results indicated that NE released after crush injury may impair the neuronal cell membrane around the lesion site by induction of lipid peroxidation. The possible mechanisms by which released NE may alter membrane function are discussed.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Kurihara M

doi

10.3171/jns.1985.62.5.0743

subject

Has Abstract

pub_date

1985-05-01 00:00:00

pages

743-9

issue

5

eissn

0022-3085

issn

1933-0693

journal_volume

62

pub_type

杂志文章
  • Primary intracranial choriocarcinoma.

    abstract::The authors report four cases of primary intracranial choriocarcinoma, all in young males. There tumors occurred in the pineal region and one in the lateral ventricle. Besides the signs of increased intracranial pressure and ophthalmological disorders, skin pigmentation or eruption was observed in three cases and prec...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.53.3.0369

    authors: Kawakami Y,Yamada O,Tabuchi K,Ohmoto T,Nishimoto A

    更新日期:1980-09-01 00:00:00

  • Treatment of spontaneous intracranial hypotension with percutaneous placement of a fibrin sealant. Report of four cases.

    abstract::Spontaneous intracranial hypotension due to a cerebrospinal fluid (CSF) leak in the spine is an important cause of new, daily persistent headaches. Most patients respond well to conservative treatments including epidural blood patching. Limited options for effective treatment are available for patients in whom these t...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.100.6.1098

    authors: Schievink WI,Maya MM,Moser FM

    更新日期:2004-06-01 00:00:00

  • Reversal of experimental parkinsonism by using selective chemical ablation of the medial globus pallidus.

    abstract:OBJECT:Symptoms from Parkinson's disease improve after surgical ablation of the medial globus pallidus (GPm). Although, in theory, selective chemical ablation of neurons in the GPm could preserve vital structures jeopardized by surgery, the potential of this approach is limited when using traditional techniques of drug...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1999.90.5.0928

    authors: Lieberman DM,Corthesy ME,Cummins A,Oldfield EH

    更新日期:1999-05-01 00:00:00

  • Inverse correlation of epidermal growth factor receptor messenger RNA induction and suppression of anchorage-independent growth by OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in glioblastoma multiforme cell lines.

    abstract:OBJECT:Quantitative and qualitative alterations in the epidermal growth factor receptor (EGFR) commonly occur in many cancers in humans, including malignant gliomas. The aim of the current study was to evaluate molecular and cellular effects of OSI-774, a novel EGFR tyrosine kinase inhibitor, on nine glioblastoma multi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.100.3.0523

    authors: Halatsch ME,Gehrke EE,Vougioukas VI,Bötefür IC,A-Borhani F,Efferth T,Gebhart E,Domhof S,Schmidt U,Buchfelder M

    更新日期:2004-03-01 00:00:00

  • High-resolution ultrasonography and diffusion tensor tractography map normal nerve fascicles in relation to schwannoma tissue prior to resection.

    abstract::The goals of the present study were to demonstrate the ability of high-resolution ultrasonography to delineate normal nerve fascicles within or around peripheral nerve sheath tumors (NSTs). A blinded examiner evaluated 2 patients with symptomatic upper limb NSTs with high-resolution ultrasonography performed in the pe...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2014.2.JNS131975

    authors: Simon NG,Cage T,Narvid J,Noss R,Chin C,Kliot M

    更新日期:2014-05-01 00:00:00

  • Neuroimaging and pathological findings in a child with cerebral sparganosis. Case report.

    abstract::The authors report the case of a 6-year-old boy with cerebral sparganosis due to infection with a plerocercoid tapeworm larva of Spirometra mansoni. Magnetic resonance imaging revealed an area of irregular long T2 signal in the right frontal lobe. When compared with images obtained 2 years earlier, the lesion appeared...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/ped.2006.105.6.470

    authors: Bo G,Xuejian W

    更新日期:2006-12-01 00:00:00

  • Chronic subdural hematoma: evaluation of the clinical significance of postoperative drainage volume.

    abstract:OBJECT:A wide variation in postoperative drainage volumes is observed during treatment of chronic subdural hematoma (CSDH) with twist-drill or burr-hole craniostomy and closed-system drainage. In this study the authors investigate the causes of the variation, the clinical significance thereof, and its influence on trea...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2000.93.5.0796

    authors: Kwon TH,Park YK,Lim DJ,Cho TH,Chung YG,Chung HS,Suh JK

    更新日期:2000-11-01 00:00:00

  • Pressure-volume index as a function of cerebral perfusion pressure. Part 2: The effects of low cerebral perfusion pressure and autoregulation.

    abstract::The pressure-volume index (PVI) was measured in six adult cats while cerebral perfusion pressure (CPP) was reduced from normal levels to below the autoregulatory range by a continuous infusion of adenosine triphosphate. Anesthesia was induced with methohexital and maintained with an N2O:O2 (70%:30%) mixture. Body temp...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.67.3.0377

    authors: Gray WJ,Rosner MJ

    更新日期:1987-09-01 00:00:00

  • Translabyrinthine and transtentorial removal of acoustic nerve tumors. Results in 150 cases.

    abstract::The translabyrinthine route or an extension of it was used to remove 150 acoustic nerve tumors. The mortality was 2% and the morbidity low. Preservation of the facial nerve was achieved in 100% of the small and 80% of the medium-sized tumors, but in only 20% of the large growths. The complications encountered are disc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1980.52.2.0210

    authors: King TT,Morrison AW

    更新日期:1980-02-01 00:00:00

  • Spontaneous regression of a herniated cervical disc in a patient with myelopathy. Case report.

    abstract::The authors present a case of spontaneous regression of a herniated cervical nucleus pulposus in a patient with myelopathy. This 37-year-old woman developed sudden quadriparesis; she had reported no history of trauma. Magnetic resonance (MR) imaging revealed a large disc herniation and increased signal intensity of th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/spi.1999.90.1.0138

    authors: Song JH,Park HK,Shin KM

    更新日期:1999-01-01 00:00:00

  • Prophylactic phenytoin in severe head injuries.

    abstract::We are reporting a retrospective study of 62 patients whose head injury was sufficiently severe to cause a high probability of posttraumatic epilepsy. Of 50 patients treated with phenytoin, 10% developed epilepsy of late onset. Twelve patients not treated with phenytoin but who had head injuries of equal magnitude had...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1979.51.4.0507

    authors: Wohns RN,Wyler AR

    更新日期:1979-10-01 00:00:00

  • Optochiasmal arachnoiditis following muslin wrapping of ruptured anterior communicating artery aneurysms.

    abstract::Optochiasmal arachnoiditis has been reported following treatment of ruptured intracranial aneurysms, particularly arising from the anterior communicating artery. It has been suggested that the accompanying loss of vision is due to a muslin-induced optic neuropathy. This paper considers five cases of this condition; th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1991.75.3.0393

    authors: McFadzean RM,Hadley DM,McIlwaine GG

    更新日期:1991-09-01 00:00:00

  • Longitudinal anterior-to-posterior shift of collateral channels in patients with moyamoya disease: an implication for its hemorrhagic onset.

    abstract:OBJECTIVE:This study aimed to assess longitudinal changes in the collateral channels originating from the lenticulostriate artery (LSA), posterior communicating artery (PCoA), and anterior and posterior choroidal arteries (AChA and PChA, respectively) during disease progression and/or aging. The impact of collateral ch...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2017.9.JNS172231

    authors: Yamamoto S,Hori S,Kashiwazaki D,Akioka N,Kuwayama N,Kuroda S

    更新日期:2018-03-23 00:00:00

  • The surgical treatment of metastatic spinal tumors within the intradural extramedullary compartment.

    abstract::The authors retrospectively reviewed the surgical outcomes in 10 cases of symptomatic intradural extramedullary spinal metastases of nonneurogenic origin because the collective experience in treating this rare manifestation of systemic cancer is limited. Pain and weakness were the presenting complaints in 70% of the p...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1996.85.2.0225

    authors: Chow TS,McCutcheon IE

    更新日期:1996-08-01 00:00:00

  • Brain injury from a spent bullet descending vertically. Report of five cases.

    abstract::This is a report of five cases in which a bullet penetrated the vertex of the skull and brain, apparently during its vertical descent after having been fired into the air. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1971.34.2part1.0222

    authors: Hanieh A

    更新日期:1971-02-01 00:00:00

  • Long-term intrathecal baclofen infusion for treatment of spasticity.

    abstract::Seven patients with spasticity of spinal cord origin have been maintained for up to 2 years with continuous spinal intrathecal infusion of baclofen. Prior to treatment, all of the patients had severe rigidity in their lower limbs and most had frequent and extensive spontaneous spasms, all of which greatly interfered w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.66.2.0181

    authors: Penn RD,Kroin JS

    更新日期:1987-02-01 00:00:00

  • Striatal hyperintensity on T1-weighted magnetic resonance images and high-density signal on CT scans obtained in patients with hyperglycemia and no involuntary movement. Report of two cases.

    abstract::The authors report on two patients in whom an increased signal on T1-weighted magnetic resonance images and a high-density signal on computerized tomography scans of the striatum were demonstrated, both of which were associated with nonketotic hyperglycemia. Involuntary movements, which have been present in all previo...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2004.101.2.0343

    authors: Sorimachi T,Fujii Y,Tsuchiya N,Saito M

    更新日期:2004-08-01 00:00:00

  • Bilateral retro-auricular dermal sinus tracts with intradural extension. Case report.

    abstract::The authors describe a previously unreported malformation involving paired, bilaterally symmetrical dermal sinus tracts in the retro-auricular area, both of which passed through the asterion and posterior fossa dura mater to end intracranially. Cranial dermal sinus tracts are congenital lesions that virtually always o...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2003.99.1.0163

    authors: Nejat F,Dias MS,Eftekhar B,Roodsari NN,Hamidi S

    更新日期:2003-07-01 00:00:00

  • Symptomatic Arnold-Chiari malformation: review of experience with 22 cases.

    abstract::Twenty-two patients with closed myelomeningoceles, shunted hydrocephalus, and symptomatic Arnold-Chiari malformations were studied retrospectively. Seventeen of the 22 patients were aged 6 months or younger; five patients were aged 3 to 23 years. Patients in the younger group presented with stridor, apnea, and/or feed...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1987.66.6.0812

    authors: Bell WO,Charney EB,Bruce DA,Sutton LN,Schut L

    更新日期:1987-06-01 00:00:00

  • Intracranial and systemic effects of osmotic and oncotic therapy in experimental cerebral edema.

    abstract::Experiments were carried out to compare the effectiveness of oncotic and osmotic therapy in dogs with experimental cerebral edema caused by a left parietal cold lesion. Animals were divided into five groups and treated for 6 hours with either crystalloid (control group), or mannitol, albumin, furosemide, or albumin/fu...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1984.60.3.0481

    authors: Albright AL,Latchaw RE,Robinson AG

    更新日期:1984-03-01 00:00:00

  • Effect of intracisternal phentolamine on cerebral blood flow after subarachnoid injection of blood.

    abstract::The hydrogen clearance method was used to measure total and focal cerebral blood flow (CBF) in the monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). Some monkeys also received 0.2 to 1.0 mg/kg phentolamine intracisternally 3 hours after SAH. Results show that SAH did not change cerebrovasc...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1976.44.3.0353

    authors: Martins AN,Newby N,Doyle TF,Kobrine AI,Ramirez A

    更新日期:1976-03-01 00:00:00

  • High-dose glucocorticoid treatment improves neurological recovery in head-injured mice.

    abstract::The ability of a single large intravenous dose of the sodium succinate esters of the glucocorticoids methylprednisolone, prednisolone, or hydrocortisone to enhance early neurological recovery after moderate to severe blunt head injury was examined in male CF-1 mice. Unanesthetized mice were restrained and subjected to...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1985.62.6.0882

    authors: Hall ED

    更新日期:1985-06-01 00:00:00

  • The pineal gland: anatomy, physiology, and clinical significance.

    abstract::Since the discovery of melatonin approximately 25 years ago, there has been intense study regarding the details of the structure and function of the pineal gland. This work is reviewed, with particular emphasis on those aspects of importance to human physiology and disease. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,评审

    doi:10.3171/jns.1985.63.3.0321

    authors: Erlich SS,Apuzzo ML

    更新日期:1985-09-01 00:00:00

  • Transient cerebellar mutism caused by bilateral damage to the dentate nuclei after the second posterior fossa surgery. Case report.

    abstract::The authors report on the case of a 6-year-old boy who underwent resection of a midline cerebellar tumor. The boy was able to speak fluently after the operation. Magnetic resonance (MR) imaging showed that the right dentate nucleus had been partially removed along with the tumor, but that the left dentate nucleus rema...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.2006.104.2.329

    authors: Kusano Y,Tanaka Y,Takasuna H,Wada N,Tada T,Kakizawa Y,Hongo K

    更新日期:2006-02-01 00:00:00

  • Traumatic aneurysms and arteriovenous fistulas of intracranial vessels associated with penetrating head injuries occurring during war: principles and pitfalls in diagnosis and management. A survey of 31 cases and review of the literature.

    abstract::In the early days of the war between Iran and Iraq, reports of the sudden deaths of soldiers who previously had survived a penetrating head injury suggested the possibility that a late complication, traumatic aneurysm (TA), could be the cause of this catastrophe. In response, the authors planned a prospective study to...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1996.84.5.0769

    authors: Amirjamshidi A,Rahmat H,Abbassioun K

    更新日期:1996-05-01 00:00:00

  • Thalamic syndrome caused by unruptured cerebral aneurysm. Case report.

    abstract::A case is reported of a 63-year-old woman with thalamic syndrome as the presenting feature of an unruptured cerebral aneurysm. Unruptured aneurysm is a rare cause of thalamic syndrome; the possible mechanisms of production of the sensory disturbance are discussed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/jns.1995.82.2.0291

    authors: Stoodley MA,Warren JD,Oatey PE

    更新日期:1995-02-01 00:00:00

  • Hydroxyurea for treatment of unresectable and recurrent meningiomas. II. Decrease in the size of meningiomas in patients treated with hydroxyurea.

    abstract::In this paper the authors present the first evidence that meningiomas respond to treatment with hydroxyurea. Hydroxyurea was administered as an adjunct chemotherapeutic treatment in patients with recurrent and unresectable meningiomas. Hydroxyurea was used because experimental data demonstrated that it inhibits growth...

    journal_title:Journal of neurosurgery

    pub_type: 临床试验,杂志文章

    doi:10.3171/jns.1997.86.5.0840

    authors: Schrell UM,Rittig MG,Anders M,Koch UH,Marschalek R,Kiesewetter F,Fahlbusch R

    更新日期:1997-05-01 00:00:00

  • The first formulation of image-based stereotactic principles: the forgotten work of Gaston Contremoulins.

    abstract::Although image-based human stereotaxis began with Spiegel and Wycis in 1947, the major principles of radiographic stereotaxis were formulated 50 years earlier by the French scientific photographer Gaston Contremoulins. In 1897, frustrated by the high morbidity of bullet extraction from the brain, the Parisian surgeon ...

    journal_title:Journal of neurosurgery

    pub_type: 传,历史文章,杂志文章

    doi:10.3171/2016.10.JNS161966

    authors: Giller CA,Mornet P,Moreau JF

    更新日期:2017-12-01 00:00:00

  • Surgical management and outcome of schwannomas in the craniocervical region.

    abstract:OBJECT:Schwannomas occupying the craniocervical junction (CCJ) are rare and usually originate from the jugular foramen, hypoglossal nerves, and C-1 and C-2 nerves. Although they may have different origins, they may share the same symptoms, surgical approaches, and complications. An extension of these lesions along the ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2010.5.JNS0966

    authors: Cavalcanti DD,Martirosyan NL,Verma K,Safavi-Abbasi S,Porter RW,Theodore N,Sonntag VK,Dickman CA,Spetzler RF

    更新日期:2011-05-01 00:00:00

  • Intraocular pressure during neurosurgical procedures in context of head position and loss of cerebrospinal fluid.

    abstract:OBJECTIVE:Perioperative visual loss (POVL) is a rare but serious complication in surgical disciplines, especially in spine surgery. The exact pathophysiology of POVL remains unclear, but elevated intraocular pressure (IOP) is known to be part of it. As POVL is rarely described in patients undergoing intracranial or int...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章

    doi:10.3171/2018.3.JNS173098

    authors: Czorlich P,Krätzig T,Kluge N,Skevas C,Knospe V,Spitzer MS,Dreimann M,Mende KC,Westphal M,Eicker SO

    更新日期:2018-08-24 00:00:00