Analysis of treatment failure after radiosurgery for arteriovenous malformations.


OBJECT:The aim of this study was to evaluate the causes of treatment failure in patients with arteriovenous malformations (AVMs) who underwent radiosurgery, which is increasingly used as a treatment method for selected, surgically high-risk AVMs. Unfortunately, radiosurgical treatment fails in a small but significant percentage of patients. In the time period covered in this study, 72 patients attained angiographically confirmed cures after radiosurgery and 36 were retreated after the initial radiosurgical treatment failed. METHODS:Using a computerized image fusion technique, the initial radiosurgical dosimetry plan was superimposed on the remaining AVM nidus at the time of retreatment. Twenty-six percent of the retreated cases were found to have AVM niduses outside the original treatment isodose line, which means that targeting error was a factor. The retreated group was also statistically compared with the cured group. CONCLUSIONS:Multivariate analysis revealed that the following factors were statistically significant predictors of treatment failure: increasing AVM size, decreasing treatment dose, and increasing Spetzler-Martin grade.


J Neurosurg


Journal of neurosurgery


Ellis TL,Friedman WA,Bova FJ,Kubilis PS,Buatti JM




Has Abstract


1998-07-01 00:00:00












  • The cerebral hemodynamics of normotensive hypovolemia during lower-body negative pressure.

    abstract::Although severe hypovolemia can lead to hypotension and neurological decline, many patients with neurosurgical disorders experience a significant hypovolemia while autonomic compensatory mechanisms maintain a normal blood pressure. To assess the effects of normotensive hypovolemia upon cerebral hemodynamics, transcran...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Giller CA,Levine BD,Meyer Y,Buckey JC,Lane LD,Borchers DJ

    更新日期:1992-06-01 00:00:00

  • Expression of platelet-derived growth factor and transforming growth factor and their correlation with cellular morphology in glial tumors.

    abstract::This study was undertaken to evaluate the role of two sets of growth factors, platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta), in the induction and maintenance of glial tumors and their phenotypic expression. Explants from eight malignant tumors, five benign tumors, and two nontumo...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Mapstone TB

    更新日期:1991-09-01 00:00:00

  • Alterations in endothelium-dependent responsiveness of the canine basilar artery subarachnoid hemorrhage.

    abstract::To investigate the alteration of endothelium-dependent responses in chronic vasospasm after subarachnoid hemorrhage (SAH), experiments were carried out in the double-hemorrhage canine model. After the presence of vasospasm was confirmed by cerebral angiography on Days 0 and 7, pharmacological studies on the basilar ar...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kim P,Sundt TM Jr,Vanhoutte PM

    更新日期:1988-08-01 00:00:00

  • Transcranial approach to the orbit: microsurgical anatomy.

    abstract::An anatomical study of three microsurgical intraorbital routes to the optic nerve and orbital apex, which can be reached through a fronto-orbital craniotomy, was conducted on cadaver specimens. The structures that could be exposed via the medial, central, or lateral approaches directed through the orbital roof were de...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Natori Y,Rhoton AL Jr

    更新日期:1994-07-01 00:00:00

  • Primary visual cortical thickness in correlation with visual field defects in patients with pituitary macroadenomas: a structural 7-Tesla retinotopic analysis.

    abstract:OBJECTIVE:Vision loss remains a debilitating complication of pituitary adenomas, although there is considerable variability in visual impairment before and after decompression surgery. Growing evidence suggests secondary damage to remote visual structures may contribute to vision loss in patients with chiasmatic compre...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Rutland JW,Delman BN,Huang KH,Verma G,Benson NC,Villavisanis DF,Lin HM,Bederson JB,Chelnis J,Shrivastava RK,Balchandani P

    更新日期:2019-10-18 00:00:00

  • Minimally invasive superficial temporal artery to middle cerebral artery bypass through an enlarged bur hole: the use of computed tomography angiography neuronavigation in surgical planning.

    abstract::The authors describe their minimally invasive technique for performing a superficial temporal artery (STA) to middle cerebral artery (MCA) bypass, which relies on an enlarged bur hole (2-2.5 cm) rather than the standard craniotomy. They perform this procedure in a minimally invasive fashion, using CT angiography for i...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Coppens JR,Cantando JD,Abdulrauf SI

    更新日期:2008-09-01 00:00:00

  • Prophylactic phenytoin in severe head injuries.

    abstract::We are reporting a retrospective study of 62 patients whose head injury was sufficiently severe to cause a high probability of posttraumatic epilepsy. Of 50 patients treated with phenytoin, 10% developed epilepsy of late onset. Twelve patients not treated with phenytoin but who had head injuries of equal magnitude had...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Wohns RN,Wyler AR

    更新日期:1979-10-01 00:00:00

  • The transfacet pedicle-sparing approach for thoracic disc removal: cadaveric morphometric analysis and preliminary clinical experience.

    abstract::A number of operative techniques have been described for the treatment of herniated thoracic discs. The transfacet pedicle-sparing approach allows for complete disc removal with limited spinal column disruption and soft-tissue dissection. Fifteen cadaveric spinal columns were used for evaluation of exposure, developme...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Stillerman CB,Chen TC,Day JD,Couldwell WT,Weiss MH

    更新日期:1995-12-01 00:00:00

  • MR imaging of CSF pulsatory flow and its relation to intracranial pressure.

    abstract::In a retrospective study of magnetic resonance (MR) images obtained in 289 neurosurgical patients, loss of signal intensity (signal-void phenomenon, SVP) of the cerebrospinal fluid (CSF) in the mesencephalic aqueduct was observed in 77 patients. This SVP was noted in the MR studies of 12 of 14 patients with communicat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Ohara S,Nagai H,Matsumoto T,Banno T

    更新日期:1988-11-01 00:00:00

  • Reoperation and readmission after clipping of an unruptured intracranial aneurysm: a National Surgical Quality Improvement Program analysis.

    abstract::OBJECTIVE Although reoperation and readmission have been used as quality metrics, there are limited data evaluating the rate of, reasons for, and predictors of reoperation and readmission after microsurgical clipping of unruptured aneurysms. METHODS Adult patients who underwent craniotomy for clipping of an unruptured...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Dasenbrock HH,Smith TR,Rudy RF,Gormley WB,Aziz-Sultan MA,Du R

    更新日期:2018-03-01 00:00:00

  • Acute occlusion of the posterior spinal vein. Experimental study in monkeys.

    abstract::The posterior spinal vein was occluded with silicone in seven rhesus monkeys, and locally resected in one. There were no neurological findings associated with acute venous obstruction of the cord. Follow-up arteriography revealed diversion of venous outflow into the anterior spinal venous system. Histology revealed gl...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Doppman JL,Girton M,Popovsky MA

    更新日期:1979-08-01 00:00:00

  • Pediatric spinal injury: review of 174 hospital admissions.

    abstract::Injury to the spinal column and spinal cord occurs relatively infrequently in the pediatric population. A review of 174 pediatric patients is presented, representing 5.4% of all patients admitted with spinal injury. Spinal cord injury was present in 45% of patients. A distinct injury profile, explained by anatomical a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Hamilton MG,Myles ST

    更新日期:1992-11-01 00:00:00

  • Calf enlargement from S-1 radiculopathy. Report of two cases.

    abstract::Two patients with painless hypertrophy of one calf had clinical and myelographic features compatible with an S-1 radiculopathy. Electromyographic studies revealed intermittent spontaneous discharges (bizarre repetitive potentials) in the affected extremity. Several patients have previously been described with S-1 radi...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Cooper WH,Ringel SP,Treihaft MM,Hall KA

    更新日期:1985-03-01 00:00:00

  • Moyamoya disease associated with aneurysm.

    abstract::Five cases of moyamoya disease associated with aneurysm are reported. In three cases, the aneurysms were located at the peripheral portion of the posterior choroidal artery, and in two at the basilar artery. Based on these cases, the symptoms and mechanisms of formation of aneurysms in moyamoya disease are discussed. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kodama N,Suzuki J

    更新日期:1978-04-01 00:00:00

  • A serrated suction tip for tumor removal. Technical note.

    abstract::A serrated suction tip with a variety of diameters and serrations has been developed for the microsurgical removal of tumors. These tips can dissect and aspirate tumor tissue, cerebrospinal fluid, or blood simultaneously, and the degree of suction can be controlled by the pressure of the tip against the tumor. ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Shibuya M,Suzuki Y,Nakane T

    更新日期:1988-07-01 00:00:00

  • Chronic motor cortex stimulation in patients with thalamic pain.

    abstract::Analysis of the authors' experience over the last 10 years has indicated that excellent pain control has rarely been obtained by thalamic relay nucleus stimulation in patients with thalamic pain. In the present study, 11 patients with thalamic pain were treated by chronic stimulation of the precentral gyrus. In eight ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tsubokawa T,Katayama Y,Yamamoto T,Hirayama T,Koyama S

    更新日期:1993-03-01 00:00:00

  • Response of malignant glioma cell lines to epidermal growth factor and platelet-derived growth factor in a serum-free medium.

    abstract::The use of a serum-free culture system for assessing the growth factor responsiveness of malignant glial cells is described. The mitogenic properties of epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) were examined in three human malignant glioma cell lines (T98G, U87, and U138). Each of the th...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Pollack IF,Randall MS,Kristofik MP,Kelly RH,Selker RG,Vertosick FT

    更新日期:1990-07-01 00:00:00

  • Effects of decompressive craniectomy on functional outcomes and death in poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.

    abstract::OBJECTIVE Patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH) (World Federation of Neurosurgical Societies Grade IV or V) are often considered for decompressive craniectomy (DC) as a rescue therapy for refractory intracranial hypertension. The authors performed a systematic review and meta-analysis to a...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章,meta分析


    authors: Alotaibi NM,Elkarim GA,Samuel N,Ayling OGS,Guha D,Fallah A,Aldakkan A,Jaja BNR,de Oliveira Manoel AL,Ibrahim GM,Macdonald RL

    更新日期:2017-12-01 00:00:00

  • Selective sacral rootlet neurectomy in the treatment of detrusor hyperreflexia. Technique and long-term results.

    abstract::Selective sacral neurectomy was performed in 12 patients with intractable urge incontinence of long duration (mean 12 years) caused by detrusor hyperreflexia. There was great variation in the innervation of the bladder, but resection of an S-3 root or rootlet was carried out in all patients. Six of the patients, who w...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Tørring J,Petersen T,Klemar B,Søgaard I

    更新日期:1988-02-01 00:00:00

  • Pediatric infratentorial subdural empyema: analysis of 14 cases.

    abstract:OBJECT:Pediatric cases of infratentorial subdural empyema (SDE) are both rare and associated with high rates of morbidity and mortality. The goal of this study was to report patient characteristics, treatment, and outcome in an exclusively pediatric series of SDE cases. METHODS:A series of 14 pediatric cases of infrat...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Venkatesh MS,Pandey P,Devi BI,Khanapure K,Satish S,Sampath S,Chandramouli BA,Sastry KV

    更新日期:2006-11-01 00:00:00

  • Effects of potassium channel-blocking agents on spontaneous discharges from neuromas in rats.

    abstract::Thirty-five Sprague-Dawley rats with saphenous neuromas underwent acute microfilament recording in the proximal nerve. The effect of the potassium channel-blocking agents, tetraethylammonium bromide (TEA) and 4-aminopyridine, on spontaneous activity in A fibers terminating in the neuroma was observed. The effects of g...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Burchiel KJ,Russell LC

    更新日期:1985-08-01 00:00:00

  • Radiotherapy for atypical meningiomas.

    abstract:OBJECT:The role of postoperative radiotherapy in patients undergoing first-time resection of WHO Grade II meningioma remains unclear as reflected by varied practices in published clinical studies and national professional surveys. Much of the relevant literature is based on pre-2000 WHO grading criteria for atypical me...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Mair R,Morris K,Scott I,Carroll TA

    更新日期:2011-10-01 00:00:00

  • Feeding artery pedicle aneurysms: association with parenchymal hemorrhage and arteriovenous malformation in the brain.

    abstract::The association between arteriovenous malformations (AVM's) and aneurysms is well documented in the literature. However, a specific type of aneurysm, termed a "pedicle" aneurysm, has received little attention despite its role as a primary source of hemorrhage. The authors report four recent cases of patients with cere...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Perata HJ,Tomsick TA,Tew JM Jr

    更新日期:1994-04-01 00:00:00

  • Changing central nervous system control following intercostal nerve transfer.

    abstract:OBJECT:The goal of this study was to find which central nervous system (CNS) pathways are involved in volitional control over reinnervated biceps or pectoral muscles. METHODS:Intercostal nerves (ICNs) were coapted to the musculocutaneous nerve (MCN) or the medial pectoral nerve (MPN) in 23 patients with root avulsions...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Malessy MJ,Thomeer RT,van Dijk JG

    更新日期:1998-10-01 00:00:00

  • Memory outcome following transsylvian selective amygdalohippocampectomy in 62 patients with hippocampal sclerosis.

    abstract:OBJECT:It remains unclear whether selective amygdalohippocampectomy, an operative technique developed for use in epilepsy surgery to spare unaffected brain tissue and thus minimize the cognitive consequences of temporal lobe surgery, actually leads to a better memory outcome. The present study was performed to determin...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Morino M,Ichinose T,Uda T,Kondo K,Ohfuji S,Ohata K

    更新日期:2009-06-01 00:00:00

  • Neurological and pathological effects of second lumbar spondylectomy and spinal column shortening in the dog.

    abstract::The second lumbar vertebra was surgically removed from 10 dogs, and the shortened vertebral column was stabilized by internal fixation with two types of plastic plates. Shortening of the spinal column was usually not associated with detectable loss of function or neurological deficit. Histological lesions, however, in...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Yturraspe DJ,Lumb WV,Young S,Gorman HA

    更新日期:1975-01-01 00:00:00

  • Comparison of techniques for ventriculoperitoneal shunting in 523 patients with subarachnoid hemorrhage.

    abstract:OBJECTIVE:It is common practice to use a new contralateral bur hole for ventriculoperitoneal shunt (VPS) placement in subarachnoid hemorrhage (SAH) patients with an existing ventriculostomy. At Thomas Jefferson University and Jefferson Hospital for Neuroscience, the authors have primarily used the ventriculostomy site ...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Chalouhi N,Whiting A,Anderson EC,Witte S,Zanaty M,Tjoumakaris S,Gonzalez LF,Hasan D,Starke RM,Hann S,Ghobrial GM,Rosenwasser R,Jabbour P

    更新日期:2014-10-01 00:00:00

  • Preservation of ejaculatory function by reconstruction of the canine hypogastric nerve.

    abstract:OBJECT:The hypogastric nerve (HGN) plays a crucial role in the primary functions of ejaculation: sperm transport through the vas deferens, secretion of prostatic fluid, and bladder neck closure. This study was undertaken to explore the possibility of restoring HGN function to the seminal tract and preserving its cross-...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Kihara K,Sato K,Ishizaka K,Oshima H

    更新日期:1998-04-01 00:00:00

  • Incidence patterns for ependymoma: a surveillance, epidemiology, and end results study.

    abstract:OBJECT:Previous small studies disagree about which clinical risk factors influence ependymoma incidence. The authors analyzed a large, population-based cancer registry to examine the relationship of incidence to patient age, sex, race, and tumor location, and to determine incidence trends over the past 3 decades. METH...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: McGuire CS,Sainani KL,Fisher PG

    更新日期:2009-04-01 00:00:00

  • Frontal sinus approach to the orbit. Technical note.

    abstract::The authors have previously advocated a supraorbital approach to tumors of the orbit. In this paper, they describe a technique in which they take advantage of a large frontal sinus as a means of entering the orbit without the necessity of intracranial exposure, as required by the more conventional supraorbital approac...

    journal_title:Journal of neurosurgery

    pub_type: 杂志文章


    authors: Colohan AR,Jane JA,Newman SA,Maggio WW

    更新日期:1985-11-01 00:00:00