Systemic gamma-interferon therapy for recurrent gliomas.

Abstract:

:Recombinant gamma-interferon (2 mg/sq m) was administered intravenously twice weekly in 8-week courses to 14 patients with recurrent gliomas. Computerized tomography (CT) evidence of response was seen in only one patient, and stabilization for 12 to 86 weeks was recorded in three. This was a disappointing result, particularly in a series of patients with relatively small initial tumor volumes (less than 50 cu mm on enhanced CT) and Karnofsky functional ratings of 70 or higher. In addition, several instances of toxicity potentially attributable to gamma-interferon were observed.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Mahaley MS Jr,Bertsch L,Cush S,Gillespie GY

doi

10.3171/jns.1988.69.6.0826

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

826-9

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

69

pub_type

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