Recruitment of unrelated persons as bone marrow donors. A preliminary experience.

Abstract:

:Seven hundred and sixty-three blood donors previously typed for HLA-A and B antigens were asked to consider donating bone marrow to unrelated patients for whom no HLA-matched sibling was available. Eighty-eight percent (668) indicated willingness to donate marrow, and of these, 615 (81%) participated in testing and 53 (7%) were unable to participate at the time of the request. Donors matched for HLA-A, B, C, and DR antigens and compatible in the mixed-leukocyte culture reaction were identified for 12 patients and eight transplants were performed. Engraftment was successful in all eight patients. In this article the factors considered in planning the program, the protocol eventually developed, the problems encountered, and critical issues of informed consent and donor confidentiality are reviewed.

journal_name

Transfusion

journal_title

Transfusion

authors

McElligott MC,Menitove JE,Aster RH

doi

10.1046/j.1537-2995.1986.26486262736.x

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

309-14

issue

4

eissn

0041-1132

issn

1537-2995

journal_volume

26

pub_type

杂志文章
  • Transfusion and component characteristics are not associated with allergic transfusion reactions to apheresis platelets.

    abstract:BACKGROUND:Transfusion-related characteristics have been hypothesized to cause allergic transfusion reactions (ATRs) but they have not been thoroughly studied. The primary objective of this study is to evaluate the associations of infusion rate, infusion volume, ABO mismatching, component age, and pretransfusion medica...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章

    doi:10.1111/trf.12852

    authors: Savage WJ,Tobian AA,Savage JH,Hamilton RG,Borge PD,Kaufman RM,Ness PM

    更新日期:2015-02-01 00:00:00

  • Impact of different hold time before addition of platelet additive solution on the in vitro quality of apheresis platelets.

    abstract:BACKGROUND:The quality of platelets (PLTs) stored in PLT additive solution (PAS) is dependent on the type and proportion of the used PAS. No data are available as to whether a different hold time before the addition of PAS to hyperconcentrated PLT suspensions has an impact on PLT quality. The in vitro quality between s...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2006.00826.x

    authors: Ringwald J,Haager B,Krex D,Zimmermann R,Strasser E,Antoon M,De Schrijver E,Eckstein R

    更新日期:2006-06-01 00:00:00

  • Temporal changes in blood product usage in preterm neonates born at less than 30 weeks' gestation in Canada.

    abstract:BACKGROUND:Knowledge of neonatal transfusion practices remains limited to local cohorts or survey-based studies. This study evaluated the pattern and temporal changes in the types and frequency of blood product use among preterm neonates born at less than 30 weeks' gestation in Canada. STUDY DESIGN AND METHODS:A retro...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/trf.12998

    authors: Keir AK,Yang J,Harrison A,Pelausa E,Shah PS,Canadian Neonatal Network.

    更新日期:2015-06-01 00:00:00

  • First Zika-positive donations in the continental United States.

    abstract:BACKGROUND:Zika virus (ZIKV) has spread in the Americas, including parts of the southern United States, and infection can be associated with serious complications, including congenital brain abnormalities. Probable transfusion transmission of ZIKV has been documented in Brazil. STUDY DESIGN AND METHODS:Preemptive test...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.14029

    authors: Galel SA,Williamson PC,Busch MP,Stanek D,Bakkour S,Stone M,Lu K,Jones S,Rossmann SN,Pate LL,cobas Zika IND Study Group.

    更新日期:2017-03-01 00:00:00

  • Recipients of blood from a donor with multiple HLA antibodies: a lookback study of transfusion-related acute lung injury.

    abstract:BACKGROUND:The effects of transfusion of HLA antibodies to patients with corresponding antigens are not well known. STUDY DESIGN AND METHODS:Records of patients who received blood from previous donations of a donor implicated in a case of transfusion-related acute lung injury (TRALI) were examined. The donor had multi...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.0041-1132.2004.04193.x

    authors: Toy P,Hollis-Perry KM,Jun J,Nakagawa M

    更新日期:2004-12-01 00:00:00

  • A randomized, double-blind comparison of donor tolerance of 400 mL, 200 mL, and sham red cell donation.

    abstract:BACKGROUND:Volume replacement could allow the safe collection of twice the normal amount of red cells in a standard donation. Studies in small numbers of donors have shown that a temporary decrease in red cell mass is well tolerated when donors give twice the usual amount (170-225 mL) of red cells in a standard 405- to...

    journal_title:Transfusion

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1537-2995.1996.36896374369.x

    authors: Smith KJ,James DS,Hunt WC,McDonough W,Quintana R

    更新日期:1996-08-01 00:00:00

  • Surveillance for Creutzfeldt-Jakob disease among persons with hemophilia.

    abstract:BACKGROUND:Although Creutzfeldt-Jakob disease (CJD) has been shown to be transmissible through blood components in rodent models, no human blood-to-blood transmission has been documented. If blood transmission were possible in humans, persons with hemophilia in the United States would be at higher risk of contracting C...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1998.38998409000.x

    authors: Evatt B,Austin H,Barnhart E,Schonberger L,Sharer L,Jones R,DeArmond S

    更新日期:1998-09-01 00:00:00

  • Removal of prion challenge from an immune globulin preparation by use of a size-exclusion filter.

    abstract:BACKGROUND:A size-exclusion filter (Viresolve 180, Millipore Corp.) was tested for its ability to remove transmissible spongiform encephalopathies prion protein from an immune globulin preparation during ultrafiltration. STUDY DESIGN AND METHODS:Hamster-adapted 263K scrapie brain homogenate (SBH) was spiked into Rh0(D...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2002.00160.x

    authors: Van Holten RW,Autenrieth S,Boose JA,Hsieh WT,Dolan S

    更新日期:2002-08-01 00:00:00

  • Immune hemolytic anemia associated with teicoplanin.

    abstract:BACKGROUND:Several drugs can cause immune hemolytic anemia. Here a patient who developed hemolytic anemia after treatment with teicoplanin is described. CASE REPORT:Owing to a two-vessel disease, a 68-year-old white man underwent coronary artery bypass grafting. He was readmitted for superficial sternal wound infectio...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.0041-1132.2003.00599.x

    authors: Coluccio E,Villa MA,Villa E,Morelati F,Revelli N,Paccapelo C,Garratty G,Rebulla P

    更新日期:2004-01-01 00:00:00

  • Time interval between antibody investigations among patients who demonstrate serial red cell antibody formation.

    abstract:BACKGROUND:Current national standards for pretransfusion testing do not address the frequency or optimal time interval to repeat antibody identification testing for patients in whom antibodies have been previously detected. STUDY DESIGN AND METHODS:A retrospective review was performed of patients with existing red blo...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15013

    authors: Dinh A,Eliason K,Dzik WS

    更新日期:2019-02-01 00:00:00

  • Influence of climate on donor deferrals.

    abstract::The purpose of this study was to ascertain the cause for seasonal variations of donor deferral. Deferred donors and monthly temperatures from 1981 to 1984 were tallied and analyzed. Temperatures were categorized at 10-degree intervals from 15 degrees F to 75 degrees F. Donors failing the hemoglobin screening then unde...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1988.28689059031.x

    authors: Lau P,Hansen M,Sererat M

    更新日期:1988-11-01 00:00:00

  • Diethylenetriaminopentaacetic acid is unsuitable for long-term preservation of RBCs.

    abstract:BACKGROUND:The addition of an appropriate metal chelator, such as diethylenetriaminopentaacetic acid (DTPA) to stored blood has been shown to be effective in a short-term (0-12 days) prevention of lipid peroxidation of stored RBCS: However, its long-term effectiveness has not been carefully evaluated. STUDY DESIGN AND...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2001.41040556.x

    authors: Liu TZ,Chiu DT,Stern A

    更新日期:2001-04-01 00:00:00

  • Effects of a multimodality blood conservation schema toward improvement of intraoperative hemoglobin levels and off-pump transfusions in coronary artery bypass graft surgery.

    abstract:BACKGROUND:Cardiothoracic surgery places significant demands on blood bank resources. Measures aimed at reducing intraoperative hemodilution were initiated as part of a blood conservation program. STUDY DESIGN AND METHODS:We initiated a series of measures aimed at reducing hemodilution volume: 1) reduction of intraven...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12745

    authors: Tran MH,Lin DM,Wilcox T,Schiro D,Cannesson M,Milliken J

    更新日期:2014-10-01 00:00:00

  • Estimating the incubation time distribution and expected number of cases of transfusion-associated acquired immune deficiency syndrome.

    abstract::The number of cases of transfusion-associated acquired immune deficiency syndrome (TA-AIDS) that will be seen over the next few years is difficult to estimate, because of the uncertainty about the number of persons infected with the human immunodeficiency virus (HIV) via blood transfusion and about the duration of the...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1989.29890020437.x

    authors: Kalbfleisch JD,Lawless JF

    更新日期:1989-10-01 00:00:00

  • Laboratory diagnosis of heparin-associated thrombocytopenia and comparison of platelet aggregation test, heparin-induced platelet activation test, and platelet factor 4/heparin enzyme-linked immunosorbent assay.

    abstract:BACKGROUND:As clinical diagnosis of heparin-associated thrombocytopenia (HAT) is often difficult, confirmation by sensitive laboratory assays is desirable. STUDY DESIGN AND METHODS:The sensitivity of the heparin-induced platelet activation (HIPA) test and the platelet aggregation test (PAT) was prospectively compared ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1994.34594249047.x

    authors: Greinacher A,Amiral J,Dummel V,Vissac A,Kiefel V,Mueller-Eckhardt C

    更新日期:1994-05-01 00:00:00

  • Issues in the quality of umbilical cord blood stem cells for transplantation.

    abstract:BACKGROUND:Because the frequency of umbilical cord blood (UCB) stem cell transplantation has increased, the quality of UCB available in banks is an important part of the success of UCB stem cell transplants. STUDY DESIGN AND METHODS:A quality assurance monitoring system was used to evaluate 268 UCB units provided to u...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2005.04265.x

    authors: McCullough J,McKenna D,Kadidlo D,Schierman T,Wagner J

    更新日期:2005-06-01 00:00:00

  • Coagulopathy after traumatic brain injury: incidence, pathogenesis, and treatment options.

    abstract::Coagulopathy after traumatic brain injury (TBI) is frequent and represents a powerful predictor related to outcome and prognosis. The complex pathophysiological mechanisms of the coagulopathy of TBI are multifactorial and remain still undefined. The nature of the coagulation abnormalities differs between severe TBI an...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.12033

    authors: Maegele M

    更新日期:2013-01-01 00:00:00

  • Emm. A red cell antigen of very high frequency.

    abstract::Anti-Emm, an antibody to a public red cell antigen, was found in the serums of four Emm-propositi and in the serum of the Emm-brother of one of them. Three of the propositi were men, and their antibodies, as well as that of the compatible brother, were believed to be "naturally occurring." Since there are two Emm-sibl...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1987.27487264738.x

    authors: Daniels GL,Taliano V,Klein MT,McCreary J

    更新日期:1987-07-01 00:00:00

  • Absence of transfusion-associated microchimerism in pediatric and adult recipients of leukoreduced and gamma-irradiated blood components.

    abstract:BACKGROUND:Transfusion-associated microchimerism (TA-MC), the persistence of significant levels of donor white blood cells (WBCs) in blood recipients for prolonged periods, has been demonstrated after nonleukoreduced and leukoreduced transfusion to patients with severe traumatic injury. Development of TA-MC has not bee...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03366.x

    authors: Sanchez R,Lee TH,Wen L,Montalvo L,Schechterly C,Colvin C,Alter HJ,Luban NL,Busch MP

    更新日期:2012-05-01 00:00:00

  • Conversion to low transfusion-related acute lung injury (TRALI)-risk plasma significantly reduces TRALI.

    abstract:BACKGROUND:Transfusion-related acute lung injury (TRALI) is an uncommon but serious transfusion reaction. Studies have shown that the transfusion of HLA and HNA antibodies in donor plasma can lead to TRALI. Female donors are more likely to have such antibodies due to alloantigen exposure during pregnancy. Many blood su...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2011.03403.x

    authors: Arinsburg SA,Skerrett DL,Karp JK,Ness PM,Jhang J,Padmanabhan A,Gibble J,Schwartz J,King KE,Cushing MM

    更新日期:2012-05-01 00:00:00

  • The evolving role of plerixafor in hematopoietic progenitor cell mobilization.

    abstract::The introduction of plerixafor as a peripheral blood stem cell mobilization agent has allowed more patients with multiple myeloma, non-Hodgkin's lymphoma, and Hodgkin's disease to mobilize sufficient hematopoietic progenitor cells (HPCs) to proceed to autologous transplantation. Because of the high cost of plerixafor,...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.12102

    authors: Tanhehco YC,Vogl DT,Stadtmauer EA,O'Doherty U

    更新日期:2013-10-01 00:00:00

  • Longitudinal monitoring of WBC subsets in packed RBC units after filtration: implications for transfusion transmission of infections.

    abstract:BACKGROUND:Specific subsets of peripheral blood WBCs are reservoirs for infectious agents, such as CMV and EBV, and can serve as vectors for transfusion transmission of these agents. While filter WBC reduction has been used to prevent transfusion transmission of infections, its effectiveness has not been documented for...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.2000.40050500.x

    authors: Roback JD,Bray RA,Hillyer CD

    更新日期:2000-05-01 00:00:00

  • Management of chronic myelocytic leukemia in pregnancy by cell pheresis.

    abstract::Cell pheresis was employed in the initial management of a pregnant patient with chronic myelocytic leukemia (CML). Reduction in circulating leukocyte and platelet counts was evident after two weeks of therapy. This technique is an effective mode of management of the pregnant patient with CML and may play an important ...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1046/j.1537-2995.1978.18178118555.x

    authors: Caplan SN,Coco FV,Berkman EM

    更新日期:1978-01-01 00:00:00

  • The effects of cryopreservation on red blood cell rheologic properties.

    abstract:BACKGROUND:In transfusion medicine, frozen red blood cells (RBCs) are an alternative for liquid-stored RBCs. Little is known about the rheologic properties (i.e., aggregability and deformability) of thawed RBCs. In this study the rheologic properties of high-glycerol frozen RBCs and postthaw stored in saline-adenine-gl...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/j.1537-2995.2010.02730.x

    authors: Henkelman S,Lagerberg JW,Graaff R,Rakhorst G,Van Oeveren W

    更新日期:2010-11-01 00:00:00

  • Additional red blood cell alloantibodies after blood transfusions in a nonhematologic alloimmunized patient cohort: is it time to take precautionary measures?

    abstract:BACKGROUND:Red blood cell (RBC) alloimmunization is common in transfused patients. Most studies report on the rate of alloimmunization in chronically transfused patients, which can be as high as 60 percent. Less is known on the incidence of clinically relevant antibodies in accidentally transfused patients. Because the...

    journal_title:Transfusion

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1537-2995.2006.00764.x

    authors: Schonewille H,van de Watering LM,Brand A

    更新日期:2006-04-01 00:00:00

  • Hemovigilance survey of pathogen-reduced blood components in the Warsaw Region in the 2009 to 2013 period.

    abstract:BACKGROUND:In 2009 the Mirasol Pathogen Reduction Technology (PRT) was introduced to the routine blood component production of the Regional Blood Transfusion Center in Warsaw (RBTCW). The goal of this study was to investigate the safety of Mirasol-treated blood components. STUDY DESIGN AND METHODS:The accumulated pass...

    journal_title:Transfusion

    pub_type: 杂志文章,评审

    doi:10.1111/trf.13330

    authors: Łętowska M,Przybylska Z,Piotrowski D,Lachert E,Rosiek A,Rzymkiewicz L,Cardoso M

    更新日期:2016-03-01 00:00:00

  • Donor-type fresh frozen plasma is effective in preventing hemolytic reaction in major ABO incompatible allogeneic stem cell transplant.

    abstract:BACKGROUND:Hemolysis at the time of graft infusion is one of the immediate complications in major ABO-incompatible allogeneic hematopoietic stem cell transplants (HSCTs). We conducted a retrospective analysis to evaluate the efficacy of donor-type fresh frozen plasma (FFP) in reducing isohemagglutinin titer and prevent...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.15053

    authors: Quek J,Lee JJ,Lim FL,Diong C,Goh YT,Gopalakrishnan S,Ho A,Hwang W,Koh M,Loh Y,Linn YC

    更新日期:2019-01-01 00:00:00

  • Assessing transfusion competency in junior doctors: a retrospective cohort study.

    abstract:BACKGROUND:There is scope to further improve the safety of transfusion practice within the United Kingdom. This study aims to identify the current role of junior doctors in the transfusion process and to assess their competency to appropriately prescribe blood and blood products to patients. STUDY DESIGN AND METHODS:T...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.12274

    authors: Graham J,Grant-Casey J,Alston R,Baker P,Pendry K

    更新日期:2014-01-01 00:00:00

  • Detection of dengue, chikungunya, and Zika RNA in blood donors from Southeast Asia.

    abstract:BACKGROUND:Chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses are of concern due to the potential of transfusion transmission in blood, especially in regions such as Southeast Asia where the viruses are endemic. The recent availability of nucleic acid testing (NAT) to screen blood donations on an automated pla...

    journal_title:Transfusion

    pub_type: 杂志文章

    doi:10.1111/trf.16110

    authors: Stanley J,Chongkolwatana V,Duong PT,Kitpoka P,Stramer SL,Dung NTT,Grimm KE,Pojanasingchod A,Suksomboonvong P,Galel SA

    更新日期:2020-10-07 00:00:00

  • An automated motivational interview promotes donation intention and self-efficacy among experienced whole blood donors.

    abstract:BACKGROUND:Interventions intended to motivate donors to return can be costly and time consuming. The current study examined the effect of a Web-based automated interview, informed by motivational interviewing and self-determination theory, on donor intention, motivation, and behavior in a sample of highly experienced d...

    journal_title:Transfusion

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/trf.15402

    authors: Livitz IE,France CR,France JL,Fox KR,Ankawi B,Slepian PM,Kessler DA,Rebosa M,Shaz BH

    更新日期:2019-09-01 00:00:00