Abstract:
:Seven hundred and sixty-three blood donors previously typed for HLA-A and B antigens were asked to consider donating bone marrow to unrelated patients for whom no HLA-matched sibling was available. Eighty-eight percent (668) indicated willingness to donate marrow, and of these, 615 (81%) participated in testing and 53 (7%) were unable to participate at the time of the request. Donors matched for HLA-A, B, C, and DR antigens and compatible in the mixed-leukocyte culture reaction were identified for 12 patients and eight transplants were performed. Engraftment was successful in all eight patients. In this article the factors considered in planning the program, the protocol eventually developed, the problems encountered, and critical issues of informed consent and donor confidentiality are reviewed.
journal_name
Transfusionjournal_title
Transfusionauthors
McElligott MC,Menitove JE,Aster RHdoi
10.1046/j.1537-2995.1986.26486262736.xsubject
Has Abstractpub_date
1986-07-01 00:00:00pages
309-14issue
4eissn
0041-1132issn
1537-2995journal_volume
26pub_type
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