Further data on the acute effect of intravenous steroids on canine CSF secretion and absorption.

Abstract:

:Considerable difference of opinion has arisen as to whether intravenously administered steroids affect cerebrospinal fluid (CSF) production in the acute laboratory animal undergoing ventriculocisternal perfusion. Our experiments with ventriculocisternal perfusion in dogs indicate that, when given intravenously, neither dexamethasone, methylprednisolone, hydrocortisone, nor aldosterone result in a significant, acute effect upon CSF production. Similarly, CSF absorption and outflow resistance mechanisms are not acutely affected by intravenous methylprednisolone, hydrocortisone, and aldosterone. Dexamethasone also probably does not produce an immediate effect upon CSF absorption.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Vela AR,Carey ME,Thompson BM

doi

10.3171/jns.1979.50.4.0477

subject

Has Abstract

pub_date

1979-04-01 00:00:00

pages

477-82

issue

4

eissn

0022-3085

issn

1933-0693

journal_volume

50

pub_type

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