Analysis and measurement of some sources of variability in experimental spinal cord trauma.

Abstract:

:Experiments were performed on anesthetized cats to determine whether the variability that is common in experimental spinal cord injuries produced by the weight-drop technique can be reduced if a more accurate determination of the actual intensity of the insult to the cord is measured. In addition, determinations of the contribution of such variables as mass of drop-weight, impounder diameter, and animal weight to variability were made. It was found that of the three measures of intensity readily available from a strain gauge transducer, impulse (change in momentum of drop-weight) showed the highest correlation with the histologically determined extent of the lesion. It was shown that the mass of the drop-weight had a significant effect on lesion size even when the gram X centimeter quantification of the injury was constant. Animal weight and impounder diameter did not make a significant contribution to the variability of injury as determined by low-power microscopy.

journal_name

J Neurosurg

journal_title

Journal of neurosurgery

authors

Molt JT,Nelson LR,Poulos DA,Bourke RS

doi

10.3171/jns.1979.50.6.0784

subject

Has Abstract

pub_date

1979-06-01 00:00:00

pages

784-91

issue

6

eissn

0022-3085

issn

1933-0693

journal_volume

50

pub_type

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