Abstract:
:Previous reports have demonstrated that patients with hypertrophic cardiomyopathy (HCM) have prolonged isovolumic relaxation period (IRP) reflecting reduced rate of fall of left ventricular pressure. Eighty four patients with proven hypertrophic cardiomyopathy and 31 normal subjects were studied by simultaneous recordings of echocardiogram, apexcardiogram, phonocardiogram and ECG. In normal subjects the IRP value was 61 +/- 11 ms (mean +/- s.d.). In the 84 patients there was enormous variability of the IRP value from 0 to 160 ms reflecting abnormal and incoordinate (but not necessarily impaired) relaxation and it was possible to identify three subgroups among the patients: 60 patients in sinus rhythm who had prolonged IRP and significantly above the normal values, 9 patients in atrial fibrillation in whom the IRP was within the normal range and 15 patients with IRP values between 0-45 ms, with the mean (26 ms) below the normal range (mean +/- 2 s.d.). This group of patients with short IRP also had signs of outflow tract systolic pressure gradient, with partial mid-systolic closure of the aortic valve, systolic anterior motion of the anterior mitral valve leaflet and paradoxical splitting of the second heart sound. It is suggested that the short IRP is due to extremely delayed aortic valve closure and careful scrutiny of this subset with haemodynamic evaluation has shown that this non-invasive interval (A2-Mo) may not always be a valid measure of left ventricular relaxation.
journal_name
Postgrad Med Jjournal_title
Postgraduate medical journalauthors
Alvares RF,Goodwin JFdoi
10.1136/pgmj.62.728.545subject
Has Abstractpub_date
1986-06-01 00:00:00pages
545-51issue
728eissn
0032-5473issn
1469-0756journal_volume
62pub_type
杂志文章abstract:BACKGROUND:The post mortem examination or autopsy is a trusted method of identifying the cause of death. Patients and their families may oppose an autopsy for a variety of reasons, including fear of mutilation or owing to religious and personal beliefs. Imaging alternatives to autopsy have been explored, which may prov...
journal_title:Postgraduate medical journal
pub_type: 杂志文章,meta分析,评审
doi:10.1136/postgradmedj-2017-134945
更新日期:2017-11-01 00:00:00
abstract::The reported impact of human monoclonal IgM antibody (HA1A) on the mortality rate from Gram-negative bacteraemia aroused considerable interest in its use in Glasgow Royal Infirmary. However, the commercial preparation of HA1A was extremely expensive. With this in mind, the Infirmary's Drugs and Therapeutics Committee ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.71.832.86
更新日期:1995-02-01 00:00:00
abstract::Head injury from physical abuse is unfortunately a common occurrence in our society. It is a major cause of mortality and long-term physical and psychological disability in children. Diagnosis of non-accidental head injury may be difficult, as most infants present with non-specific clinical findings and without extern...
journal_title:Postgraduate medical journal
pub_type: 杂志文章,评审
doi:10.1136/pgmj.2010.103150
更新日期:2011-05-01 00:00:00
abstract::A patient who died in asystole less than 18 h after ingestion of 'Clovercide Extra', a combination hormonal weedkiller containing ioxynil and 4-chloro-2-methyl phenoxypropionic acid, is described. Previous reports describe coma as an early event following ingestion of these herbicides. In contrast our patient, althoug...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.64.755.681
更新日期:1988-09-01 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) has emerged worldwide as a significant and difficult-to-treat source of nosocomial infection, emphasizing the ever-present need for reliable and effective antisepsis. Betadine Solution (10% povidone-iodine; PVP-I) and Betadine Cream (5% povidone-iodine) are broad-spec...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
abstract::A female patient demonstrating a previously not reported constellation of polyglandular autoimmune syndrome type III (including autoimmune thyroiditis, Graves' ophthalmopathy, insulin-dependent diabetes mellitus and vitiligo), coeliac disease and sarcoidosis is described. This may be a random association but might als...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.69.807.72
更新日期:1993-01-01 00:00:00
abstract::Thirty-four varicella-zoster virus (VZV) seronegative nurses were vaccinated with the live varicella vaccine (Varilrix) and followed for periods of up to 36 months. No major vaccine reactions were observed. At 5 and 12 months, 94% of the nurses had seroconverted but at 3 years, only 64% retained antibody activity. How...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract:OBJECTIVE:To estimate the prevalence of, and implement a diagnostic strategy for, imported helminth infection in the gastroenterology clinic. DESIGN:A retrospective study of eosinophil count and probable tropical exposure (phase I) followed by a prospective study of parasitological investigation (phase II). SETTING:G...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.2010.003392rep
更新日期:2012-01-01 00:00:00
abstract::Sudden cardiac death is the leading cause of mortality among young athletes with an incidence of 1-2 per 100,000 athletes per annum. It is described as 'an event that is non-traumatic, non-violent, unexpected, and resulting from sudden cardiac arrest within six hours of previously witnessed normal health'. Most predis...
journal_title:Postgraduate medical journal
pub_type: 杂志文章,评审
doi:10.1136/postgradmedj-2011-130215
更新日期:2012-07-01 00:00:00
abstract::The clinical features of 62 cases of computerized axial tomography scan-proved cerebral haemorrhage and 81 cases of cerebral infarction in the carotid territory have been compared in a retrospective case note survey. The clinical features which can help in making the distinction between haemorrhage and infarction at t...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.56.659.629
更新日期:1980-09-01 00:00:00
abstract::A previously healthy 17 year old boy had Staphylococcus aureus endocarditis presenting as acute scrotal pain. There was no trauma or evidence of scrotal or epididymal infection. The pain subsided after therapy for endocarditis was started. ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.63.741.585
更新日期:1987-07-01 00:00:00
abstract::Fibrosing colonopathy is a recently described complication of cystic fibrosis, of unknown aetiology but possibly related to treatment with high-dose pancreatic enzyme supplements. We have used a whole gut perfusion technique to study subclinical gut inflammation in cystic fibrosis patients; concentrations of haemoglob...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract::Heart failure is a major problem worldwide; it is the leading cause of hospitalisation and is posing a huge financial burden. Advances in healthcare have contributed to increased life expectancy, with a resultant increase in the number of patients with chronic heart failure. For many patients who are still severely sy...
journal_title:Postgraduate medical journal
pub_type: 杂志文章,评审
doi:10.1136/postgradmedj-2015-133718
更新日期:2016-05-01 00:00:00
abstract::A 75 year old woman was treated for over three years with the somatostatin analogue, octreotide for an insulinoma. She had presented in a hypoglycaemic coma. C-peptide and insulin concentrations were both raised and an area of increased vascularity within the pancreas was shown by angiography. No lesion was found at l...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pmj.78.924.623
更新日期:2002-10-01 00:00:00
abstract::A previously undescribed type of congenital abdominal wall hernia is described. Presentation was with the symptoms and signs of subacute large bowel obstruction. The diagnosis was suggested by barium enema and confirmed at laparotomy. ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.65.760.112
更新日期:1989-02-01 00:00:00
abstract::Five patients with apparent adverse cardiovascular effects of disopyramide are reveiwed. Attention is drawn to the following problems. (1) A vagolytic effect may produce a sinus tachycardia with wide QRS complexes due to aberrant conduction or intraventricular block superficially resembling a ventricular tachycardia, ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.56.654.229
更新日期:1980-04-01 00:00:00
abstract::Stroke is a recognised complication of pregnancy, contributing to more than 12% of all maternal deaths. Estimated incidence rates vary considerably from 4.3 to 210 strokes per 100,000 deliveries. Atherosclerosis is rare in young adults, and so other causes of stroke become increasingly likely. Aetiological factors imp...
journal_title:Postgraduate medical journal
pub_type: 杂志文章,评审
doi:10.1136/pgmj.2007.066167
更新日期:2008-05-01 00:00:00
abstract::Weekly low dose methotrexate is an established treatment for rheumatoid arthritis, but its use in elderly people has not been adequately examined. The aim of this study was to evaluate its safety in elderly patients with rheumatoid arthritis. A retrospective review of the clinical records of rheumatoid arthritis patie...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pmj.76.902.787
更新日期:2000-12-01 00:00:00
abstract::Both the quality and the quantity of food ingested are relevant to the genesis of risk factors for coronary heart disease and the two are inseparable. Nevertheless they have a major common pathway through hypertension, which may well be the most important consequence of a high-protein, high-carbohydrate, high-fat, hig...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.54.629.171
更新日期:1978-03-01 00:00:00
abstract::Mathematical techniques are well suited to analysis of growth data. In the past there has been much emphasis on the mathematical description of shape and changes of shape as exemplified by the allometric equation. More recently these methods have been less popular and shape analysis has been handled largely by modern ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:
更新日期:1978-01-01 00:00:00
abstract::A case of primary purulent meningococcal pericarditis presenting with chest pain, hypotension and cardiac tamponade followed by oliguric renal failure is reported. Treatment with antibiotics and surgical drainage was successful. ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.61.722.1067
更新日期:1985-12-01 00:00:00
abstract::Obstructive sleep apnoea syndrome (OSAS) is a highly prevalent disease and is recognised as a major public health burden. Large-scale epidemiological studies have demonstrated an independent relationship between OSAS and various cardiovascular disorders. The pathogenesis of cardiovascular complications in OSAS is not ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/thx.2008.105577
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Essential Skills in the Management of Surgical Cases (ESMSC) is a novel 3-day international undergraduate surgical masterclass. Its current curriculum (Cores integrated for Research-Ci4R) is built on a tetracore, multiclustered architecture combining high-fidelity and low-fidelity simulation-based learning (...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/postgradmedj-2017-135479
更新日期:2018-05-01 00:00:00
abstract::We report the use of nivazol in a patient with Nelson's syndrome. Nivazol was highly effective in reducing ACTH secretion but, contrary to reports of its use in other primates, in our patient nivazol did have systemic glucocorticoid effects. ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.64.749.220
更新日期:1988-03-01 00:00:00
abstract::Altogether 42 million people worldwide have been infected with HIV, and 12 million have died over the last 20 years. Effective antiretroviral therapy has lead to sustained HIV viral suppression and immunological recovery in patients who have been infected with the virus. The incidence of AIDS has declined in the Weste...
journal_title:Postgraduate medical journal
pub_type: 杂志文章,评审
doi:10.1136/pmj.79.927.36
更新日期:2003-01-01 00:00:00
abstract::The characteristics of three combinations of thiopentone and etomidate [in the ratios of thiopentone (mg):etomidate (mg) of 5:1, 13:1 and 25:1] have been compared with the individual agents alone for the induction of anaesthesia. The incidence of pain on injection and abnormal movements was less with the combination c...
journal_title:Postgraduate medical journal
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/pgmj.66.777.539
更新日期:1990-07-01 00:00:00
abstract::Hypertension is the most common chronic disease in the West Indies, and is a major health problem today being among the 10 most common causes of death in the English-speaking territories of the region. Most patients have essential hypertension. Renal failure, stroke, and cardiac failure are the most common complicatio...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.59.696.616
更新日期:1983-10-01 00:00:00
abstract::Amniotic fluid embolism (AFE) associated with disseminated intravascular clotting (DIC) is usually fatal. Such a combination generally occurs at the term of pregnancy or in the immediate postpartum period. A case of AFE with DIC following a hypertonic-saline-induced abortion, is reported. The patient was in the midtri...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.59.688.127
更新日期:1983-02-01 00:00:00
abstract:PURPOSE OF THE STUDY:This study aims to describe all unsolicited electronic invitations received from potential predatory publishers or fraudulent conferences over a 12-month period following the first publication as a corresponding author of a junior academician. STUDY DESIGN:Unsolicited invitations received at an in...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/postgradmedj-2017-135097
更新日期:2018-02-01 00:00:00
abstract::Oral administration of 1 g of acetazolamide to 8 normal subjects studied at sea level and in normoxia caused an acute increase in cerebral blood flow (CBF). During the subsequent prolonged oral treatment with 1 g of acetazolamide daily, CBF returned to normal within 2 days. The alveolar CO2 tension decreased gradually...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
doi:10.1136/pgmj.63.737.185
更新日期:1987-03-01 00:00:00