Abstract:
:Oral administration of 1 g of acetazolamide to 8 normal subjects studied at sea level and in normoxia caused an acute increase in cerebral blood flow (CBF). During the subsequent prolonged oral treatment with 1 g of acetazolamide daily, CBF returned to normal within 2 days. The alveolar CO2 tension decreased gradually to 70% of the control value, indicating hyperventilation. At sea level hyperventilation will not increase brain oxygenation significantly in normal man, as the arterial oxygen content only increases minimally, while CBF is unchanged. At high altitude the beneficial effects of acetazolamide on the symptoms of acute mountain sickness may well be due to an improved oxygen supply to the brain, as hyperventilation will, at the low ambient PO2, cause a significant increase of the arterial oxygen content, while CBF presumably is unaffected by the drug. During hypoxia at high altitude the overall effect of prolonged acetazolamide treatment may thus be equivalent to a descent by several hundred metres.
journal_name
Postgrad Med Jjournal_title
Postgraduate medical journalauthors
Lassen NA,Friberg L,Kastrup J,Rizzi D,Jensen JJdoi
10.1136/pgmj.63.737.185subject
Has Abstractpub_date
1987-03-01 00:00:00pages
185-7issue
737eissn
0032-5473issn
1469-0756journal_volume
63pub_type
杂志文章abstract::Two cases of widespread cutaneous vasculitis are described in association with diltiazem, a recently introduced calcium antagonist. In both cases, spontaneous resolution occurred over several weeks following withdrawal of the drug. ...
journal_title:Postgraduate medical journal
pub_type: 杂志文章
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更新日期:1988-06-01 00:00:00
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journal_title:Postgraduate medical journal
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journal_title:Postgraduate medical journal
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更新日期:1979-01-01 00:00:00
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journal_title:Postgraduate medical journal
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pub_type: 杂志文章
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更新日期:1983-10-01 00:00:00
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更新日期:2004-12-01 00:00:00
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更新日期:1985-01-01 00:00:00
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更新日期:1996-06-01 00:00:00
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journal_title:Postgraduate medical journal
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