Abstract：
:As a transcription factor mainly expressed in cardiovascular system, T-box 20 (TBX20) plays an important role in embryonic cardiovascular system development and adult heart function. Previous studies have identified associations of two SNPs in the T-box DNA-binding domain of TBX20 with congenital heart disease (CHD) in two Caucasian families, but the associations of TBX20 mutations underlying the more common populations with CHD remain to be uncovered. In this study, 25 unrelated Chinese Han neonates with CHD and 25 healthy children as controls were investigated for TBX20 mutations. SNP genotyping was performed by PCR-DNA sequencing. The selected SNPs were well genotyped and SNP rs3999941 was found to be strongly associated with CHD (p = 0.007). The minor allele of rs3999941 showed a high-risk factor for CHD (OR 4.24; 95 % CI 1.41-12.71). Besides, we found a new SNP site located at the 657th nucleotide of the exon 5 of TBX20 gene which may also be associated with CHD, c.657A>C. The frequency was significantly different between two groups (p = 0.011), the minor allele of SNP c.657A>C also showed a risk factor for CHD (OR 2.56; 95 % CI 1.02-6.46). These findings suggested that the TC genotype of SNP rs3999941 and AC genotype of the new SNP c.657A>C in the TBX20 gene may be risk factors for CHD and thus screening of these SNPs may have some implications in the prevention and treatment of CHD in Han Chinese children.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Chen J,Sun F,Fu J,Zhang Hdoi
10.1007/s00246-014-1073-5subject
Has Abstractpub_date
2015-04-01 00:00:00pages
737-42issue
4eissn
0172-0643issn
1432-1971journal_volume
36pub_type
杂志文章abstract：:The development of Leadless cardiac pacemakers avoids the inherent complications that may occur secondary to lead insertion. A large number of devices have been inserted in adult patients although data in pediatric patients are lacking. We aimed to assess our experience with the Leadless device in the pediatric popula...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02277-y
更新日期：2020-04-01 00:00:00
abstract：:A case report of a neonate with cardiac tumors in association with tuberous sclerosis is presented. The rare complication of pulmonary embolism and its successful treatment by anticoagulation and thrombolytic therapy is described. The treatment of these cardiac tumors is conservative, because the tumors regress sponta...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002460010247
更新日期：2001-07-01 00:00:00
abstract：:Atrioventricular block has been described in association with cases of long QT syndrome and mortality is increased in this subgroup. We describe an infant with congenital QT prolongation and atrioventricular block with normal cardiac function, leading to the initial diagnosis of long QT syndrome. She subsequently deve...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-1114-1
更新日期：2006-01-01 00:00:00
abstract：:We report a 4-month-old infant with torsade de pointes secondary to procainamide treatment. The infant presented with atrial flutter and converted to normal sinus rhythm with intravenous procainamide. Oral procainamide therapy was initiated as the infusion was tapered, and the patient subsequently developed incessant ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF00796823
更新日期：1995-03-01 00:00:00
abstract：:Interruption of the aortic arch and hypoplastic left heart syndrome in the same patient is exceptional. In the combined collections of the Registry of Cardiovascular Disease (St. Paul, Minnesota, U.S.A.) and the Registry of Congenital Heart Defects of the Rijksuniversiteit Gent (Gent, Belgium) three specimens were fou...
journal_title：Pediatric cardiology
pub_type： 杂志文章,评审
doi：10.1007/BF00798068
更新日期：1995-11-01 00:00:00
abstract：:This case report describes a boy who had Kawasaki disease (KD) at age 12 months and had a recurrence one year later. The coronary arteries were normal following the initial episode; however, during the second episode he developed coronary aneurysms. Gallium-67 radionuclide imaging, echocardiography, and angiography we...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/BF02310998
更新日期：1986-01-01 00:00:00
abstract：:We report a newborn with a congenital aneurysm of the muscular interventricular septum, a conduction system abnormality involving variable left and right bundle branch block, and an abnormality of the short arm of chromosome 20, This combination of anomalies has not been previously reported. To date, the infant has pr...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0928-6
更新日期：2007-01-01 00:00:00
abstract：:Despite improved outcomes following modifications to the Fontan technique, significant morbidity and mortality persist. We sought to determine if abnormal pre-Fontan catheterization hemodynamic data will predict postoperative prolonged hospital stay (PHLOS) and adverse post-discharge outcomes. This is a retrospective ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02430-y
更新日期：2020-12-01 00:00:00
abstract：:Surgical closure of the secundum type of atrial septal defect (ASD) in childhood leads to excellent survival. However, relevant morbidity has been reported. Transcatheter closure of these defects has now become an alternative approach. To compare the results of the two different interventions, reliable data are needed...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-0838-2
更新日期：2005-09-01 00:00:00
abstract：:Transcatheter closure of atrial septal defects (ASDs) has become a routine procedure in many countries of the world. It spares many patients cardiac surgery and has proven efficacy in long-term studies. Device improvements have resulted in a continuous reduction of complications and of residual shunt frequency. ASD cl...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-1011-7
更新日期：2005-05-01 00:00:00
abstract：:Coronary artery fistula (CAF) is a rare congenital anomaly that can be complicated by endocarditis, myocardial infarction, or coronary aneurysms. This article reviews the clinical characteristics and surgical outcome of 10 patients with CAF in Rajae Heart Center. From 1990 to 2000, 10 patients (age, 6 months to 15 yea...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-004-0656-y
更新日期：2005-07-01 00:00:00
abstract：:Thrombus formation in the native aortic root is a rare but potentially life-threatening complication in patients with hypoplastic left heart syndrome. The native aortic root in these patients serves as a conduit for the retrograde filling of the coronary arteries. Thrombus in this location could result in myocardial i...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-005-1274-z
更新日期：2006-05-01 00:00:00
abstract：:The aim of this study was to evaluate by Doppler echocardiography whether administration of transdermal nitroglycerin (NTG) to children with congestive heart failure could modify mitral flow velocity profile with redistribution of left ventricular filling to late diastole, suggesting preload reduction of the left vent...
journal_title：Pediatric cardiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002460010144
更新日期：2001-01-01 00:00:00
abstract：:Radiation exposure from pediatric cardiac catheterization may be substantial, although published estimates vary. We sought to report patient radiation dose across a range of diagnostic and interventional cases in a modern, high-volume pediatric catheterization laboratory. We retrospectively reviewed diagnostic and int...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-014-0869-7
更新日期：2014-06-01 00:00:00
abstract：:Non-invasive evaluation of right ventricular (RV) systolic function in neonates with pulmonary hypertension (PH) with traditional metrics including RV fractional area change (FAC) and tricuspid annular systolic plane excursion (TAPSE) has improved outcomes. Apical three-chamber (3C) RV-FAC, a novel tripartite assessme...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-020-02376-1
更新日期：2020-08-01 00:00:00
abstract：:The prevalence of obesity in long-term survivors with complex congenital heart disease may be increasing, and little is known about the timing and onset of weight gain and growth patterns in these high-risk patients. Prevalence rates of overweight/obesity and longitudinal changes in body mass index (BMI) with age were...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-015-1265-7
更新日期：2016-01-01 00:00:00
abstract：:We report hemodynamic findings in two patients with pulmonary atresia and intact ventricular septum (PAIVS) after "one-and-a-half ventricle repair" and placement of a bidirectional Glenn shunt using four-dimensional (4D) flow magnetic resonance imaging. Quantification of flow and analysis of flow patterns revealed the...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0288-6
更新日期：2013-02-01 00:00:00
abstract：:Kearns-Sayre syndrome (KSS) is a rare mitochondrial disorder characterized by large-scale deletions of mitochondrial DNA. Neuromuscular and cardiac conduction systems are most commonly involved in these patients. Here, we discuss a 10-year-old patient with diabetes mellitus who presented in complete heart block leadin...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-007-9040-z
更新日期：2008-05-01 00:00:00
abstract：:A 5-year-old boy born with a congenital heart defect had insertion of an epicardial pacemaker that was found on routine evaluation to have been displaced into the rectovesical pouch. He underwent transvenous insertion of another pacemaker, and the displaced pacemaker was successfully retrieved by laparoscopy without i...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-011-9972-1
更新日期：2011-12-01 00:00:00
abstract：:This case discusses a Shone's variant with small left ventricle and mitral valve, bicuspid aortic valve, coarctation of the aorta, an unusual arrangement of atrial appendages, and partially anomalous pulmonary venous drainage due to a deviated atrial septum. The left atrial appendage could be directly entered from the...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-006-1364-6
更新日期：2006-09-01 00:00:00
abstract：:The treatment of recurrent supraventricular tachycardia in a 3-week-old infant is described. Multiple doses of adenosine were used successfully to convert the dysrhythmia, without adverse effects or apparent tachyphylaxis. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900222
更新日期：1997-11-01 00:00:00
abstract：:This report describes the case of a 29-day-old infant with Kawasaki's disease who presented in extremis with multiple coronary aneurysms and coronary thromboses, myocardial ischemia, and congestive heart failure. The infant successfully underwent emergent coronary thrombolysis with tissue plasminogen activator. ...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-010-9781-y
更新日期：2010-11-01 00:00:00
abstract：:With improvements in technology and surgical technique, pediatric cardiologists are challenging surgeons to close symptomatic ventricular septal defects (VSDs) in ever smaller patients. Although delaying surgery may facilitate operative repair, early intervention decreases the period of time these patients require the...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-007-9016-z
更新日期：2008-01-01 00:00:00
abstract：:Ruptured sinus Valsalva aneurysm (SVA) in a patient with tetralogy of Fallot is a very rare cardiac complication. This report describes the case of a 10-year-old Hispanic girl who presented to her cardiologist for a routine transthoracic echocardiography (TTE), which showed a ruptured sinus of Valsalva, with left-to-r...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0457-7
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVES:The aim of this article is to examine the frequency, timing of formation of aneurysm of the ventricular membranous septum (AVMS), and prognosis in patients with a perimembranous ventricular septal defect (VSD). PATIENTS:One hundred forty-eight patients were diagnosed with a perimembranous VSD within 90 days...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0572-6
更新日期：2004-07-01 00:00:00
abstract：:Severe atrioventricular valve (AVV) or semilunar valve (SLV) regurgitation in the setting of a single ventricle physiology may proceed to valve replacement if repair strategies fail. Outcome data for these children are limited. We present transplant-free survival of a case series of children with single ventricle phys...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-019-02234-9
更新日期：2020-01-01 00:00:00
abstract：:Beta-blocker therapy is one of the principal therapies for congenital long-QT syndrome (LQTS). However, breakthrough cardiac events occur while being treated with beta-blockers. We sought to determine the frequency of and clinical correlates underlying beta-blocker therapy failures in genotyped, symptomatic LQTS proba...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-003-0567-3
更新日期：2004-09-01 00:00:00
abstract：:This study aimed to assess the impact of integrating a simulation-based education module into an extracorporeal membrane oxygenation (ECMO) curriculum on novice learners and to test the duration of time that skills obtained during this training exercise were retained. The authors hypothesized that multidisciplinary, s...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-012-0490-6
更新日期：2013-03-01 00:00:00
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journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s00246-016-1393-8
更新日期：2016-08-01 00:00:00
abstract：:A case of aneurysmal enlargement of the right atrium was found accidentally during a routine examination. The patient was asymptomatic and free of palpitations or proven rhythm disturbances. The results of echocardiography, magnetic resonance imaging, and cardiac catheterization excluded cardiac malformation, which co...
journal_title：Pediatric cardiology
pub_type： 杂志文章
doi：10.1007/s002469900341
更新日期：1998-09-01 00:00:00
