当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Patients with malignant or potentially malignant ventricular arrhythmias: opportunities and limitations of drug therapy in prevention of sudden death.

Patients with malignant or potentially malignant ventricular arrhythmias: opportunities and limitations of drug therapy in prevention of sudden death.

Abstract：

:Almost 90% of patients resuscitated from out of hospital cardiac arrest have coronary heart disease and can be categorized in one of three groups: acute myocardial infarction, ischemic event or primary arrhythmic event. The patients who have acute myocardial infarction have the best prognosis, and those with primary arrhythmic events have the worst. Recent studies show that ventricular arrhythmias after myocardial infarction are associated with mortality independent of any association with left ventricular dysfunction. Ventricular arrhythmias that have caused cardiac arrest or hemodynamic collapse, that is, malignant arrhythmias, should be treated aggressively and evaluated carefully with one of two methods that have high predictive accuracy for outcome: 1) the Holter recording/exercise test approach, or 2) the electrophysiologic approach. It is not yet known whether treating potentially malignant ventricular arrhythmias after myocardial infarction with class I or III antiarrhythmic drugs will reduce mortality, but two clinical trials are under way in the United States to address this question. Beta-adrenergic blocking drugs do reduce mortality, probably as a result of both antiischemic and antiarrhythmic effects. Calcium channel blocking agents, various antiplatelet drugs and alpha-adrenergic blocking drugs are under investigation to determine their value in secondary prevention of ventricular fibrillation.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Bigger JT Jr

doi

10.1016/s0735-1097(85)80521-0

subject

Has Abstract

pub_date

1985-06-01 00:00:00

pages

23B-26B

issue

6 Suppl

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(85)80521-0

journal_volume

5

pub_type

临床试验,杂志文章,评审

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • A randomized trial to evaluate the relative protection against post-percutaneous coronary intervention microvascular dysfunction, ischemia, and inflammation among antiplatelet and antithrombotic agents: the PROTECT-TIMI-30 trial.

    abstract：OBJECTIVES:The goal of this study was to evaluate glycoprotein IIb/IIIa inhibition with eptifibatide when administered with indirect thrombin inhibition as compared with monotherapy with direct thrombin inhibition with bivalirudin among patients with non-ST-segment elevation acute coronary syndromes (ACS). BACKGROUND:...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.jacc.2005.12.077

    authors： Gibson CM,Morrow DA,Murphy SA,Palabrica TM,Jennings LK,Stone PH,Lui HH,Bulle T,Lakkis N,Kovach R,Cohen DJ,Fish P,McCabe CH,Braunwald E,TIMI Study Group.

    更新日期：2006-06-20 00:00:00

  • Cell-mediated cytotoxicity in hearts with dilated cardiomyopathy: correlation with interstitial fibrosis and foci of activated T lymphocytes.

    abstract：OBJECTIVES:The purpose of this study was to investigate the expression of perforin and T-cell intracellular antigen-1, two crucial components of lymphocyte-mediated cytotoxicity, in endomyocardial biopsies from patients with idiopathic dilated cardiomyopathy. BACKGROUND:Previous reports have demonstrated the presence ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(96)00475-5

    authors： Badorff C,Noutsias M,Kühl U,Schultheiss HP

    更新日期：1997-02-01 00:00:00

  • Building Sustainable Capacity for Cardiovascular Care at a Public Hospital in Western Kenya.

    abstract：:Cardiovascular disease deaths are increasing in low- and middle-income countries and are exacerbated by health care systems that are ill-equipped to manage chronic diseases. Global health partnerships, which have stemmed the tide of infectious diseases in low- and middle-income countries, can be similarly applied to a...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2015.09.086

    authors： Binanay CA,Akwanalo CO,Aruasa W,Barasa FA,Corey GR,Crowe S,Esamai F,Einterz R,Foster MC,Gardner A,Kibosia J,Kimaiyo S,Koech M,Korir B,Lawrence JE,Lukas S,Manji I,Maritim P,Ogaro F,Park P,Pastakia SD,Sugut W,Ve

    更新日期：2015-12-08 00:00:00

  • Nonthoracotomy internal defibrillation in dogs: threshold reduction using a subcutaneous chest wall electrode with a transvenous catheter electrode.

    abstract：:The efficacy of truncated exponential waveform shocks using a cardioverter-defibrillator catheter with and without a 13.9 cm2 subcutaneous thoracic patch electrode was examined in 10 pentobarbital-anesthetized dogs. The cardioverter-defibrillator catheter was positioned through the external jugular vein with the dista...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80025-6

    authors： Wetherbee JN,Chapman PD,Klopfenstein HS,Bach SM Jr,Troup PJ

    更新日期：1987-08-01 00:00:00

  • Ambient Air Pollution and Mortality After Cardiac Transplantation.

    abstract：BACKGROUND:Heart transplant recipients are at high risk for mortality, with traditional risk scores performing modestly in predicting post-transplant survival, underscoring the importance of as yet unidentified factors in determining prognosis. In this analysis, the association between PM2.5 exposure levels and surviva...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2019.09.066

    authors： Al-Kindi SG,Sarode A,Zullo M,Brook J,Burnett R,Oliveira GH,Huang W,Brook R,Rajagopalan S

    更新日期：2019-12-17 00:00:00

  • Cardiac alternans: diverse mechanisms and clinical manifestations.

    abstract：OBJECTIVES:The purpose of this review is to assemble the widely dispersed information about cardiac alternans and to categorize the types and mechanisms of alternans, their clinical manifestations and possible therapeutic implications. BACKGROUND:The phenomena of mechanical and electrical alternans have been of contin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/0735-1097(92)90122-4

    authors： Surawicz B,Fisch C

    更新日期：1992-08-01 00:00:00

  • Cardiovascular Magnetic Resonance to Evaluate Aortic Regurgitation After Transcatheter Aortic Valve Replacement.

    abstract：BACKGROUND:Residual aortic regurgitation (AR) following transcatheter aortic valve replacement (TAVR) is associated with greater mortality; yet, determining AR severity post-TAVR using Doppler echocardiography remains challenging. Cardiovascular magnetic resonance (CMR) is purported as a more accurate means of quantify...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2016.05.059

    authors： Ribeiro HB,Orwat S,Hayek SS,Larose É,Babaliaros V,Dahou A,Le Ven F,Pasian S,Puri R,Abdul-Jawad Altisent O,Campelo-Parada F,Clavel MA,Pibarot P,Lerakis S,Baumgartner H,Rodés-Cabau J

    更新日期：2016-08-09 00:00:00

  • Characteristics and long-term outcomes of percutaneous revascularization of unprotected left main coronary artery stenosis in the United States: a report from the National Cardiovascular Data Registry, 2004 to 2008.

    abstract：OBJECTIVES:This study sought to assess percutaneous coronary intervention (PCI) for unprotected left main coronary artery (ULMCA) stenosis in routine U.S. clinical practice. BACKGROUND:Percutaneous coronary intervention for ULMCA stenosis is controversial; however, current use and outcomes of ULMCA PCI in routine U.S....

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2011.10.883

    authors： Brennan JM,Dai D,Patel MR,Rao SV,Armstrong EJ,Messenger JC,Curtis JP,Shunk KA,Anstrom KJ,Eisenstein EL,Weintraub WS,Peterson ED,Douglas PS,Hillegass WB

    更新日期：2012-02-14 00:00:00

  • Comparison between transcatheter and surgical closure of secundum atrial septal defect in children and adults: results of a multicenter nonrandomized trial.

    abstract：OBJECTIVES:This study sought to compare the safety, efficacy and clinical utility of the Amplatzer septal occluder (ASO) for closure of secundum atrial septal defect (ASD) with surgical closure. BACKGROUND:The clinical utility of a device such as the ASO can only be judged against the results of contemporaneous surger...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0735-1097(02)01862-4

    authors： Du ZD,Hijazi ZM,Kleinman CS,Silverman NH,Larntz K,Amplatzer Investigators.

    更新日期：2002-06-05 00:00:00

  • Effect of lesion characteristics on outcome of directional coronary atherectomy.

    abstract：:Directional coronary atherectomy, a new transluminal procedure for treatment of obstructive lesions in coronary arteries by excision and removal of tissue, was performed on 447 lesions in 382 procedures. Successful outcome, defined as a reduction of stenosis by greater than or equal to 20% with a less than 50% residua...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90840-6

    authors： Hinohara T,Rowe MH,Robertson GC,Selmon MR,Braden L,Leggett JH,Vetter JW,Simpson JB

    更新日期：1991-04-01 00:00:00

  • Heart rate variability before and after myocardial infarction in conscious dogs at high and low risk of sudden death.

    abstract：:Heart rate variability has been demonstrated both experimentally and clinically to be of prognostic importance in determining mortality after myocardial infarction. However, no paired studies have been reported to examine heart rate variability before and after myocardial infarction. The hypothesis was tested that low...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(10)80351-1

    authors： Hull SS Jr,Evans AR,Vanoli E,Adamson PB,Stramba-Badiale M,Albert DE,Foreman RD,Schwartz PJ

    更新日期：1990-10-01 00:00:00

  • ACC/AHA Versus ESC/ESH on Hypertension Guidelines: JACC Guideline Comparison.

    abstract：:This study compares the recommendations of the most recent American College of Cardiology (ACC)/American Heart Association (AHA) and European Society of Cardiology (ESC)/European Society of Hypertension (ESH) blood pressure guidelines. Both guidelines represent updates of previous guidelines and reinforce previous con...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2019.03.507

    authors： Bakris G,Ali W,Parati G

    更新日期：2019-06-18 00:00:00

  • Percutaneous transluminal coronary angioplasty after thrombolytic therapy: a prospective controlled randomized trial.

    abstract：:In 162 patients with acute transmural myocardial infarction, combined intravenous and intracoronary thrombolytic therapy with streptokinase was initiated. In vessels that remained occluded, mechanical recanalization was performed with a 3F recanalization catheter (group I, n = 79) or a 4F Grüntzig balloon catheter (gr...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0735-1097(86)80172-3

    authors： Erbel R,Pop T,Henrichs KJ,von Olshausen K,Schuster CJ,Rupprecht HJ,Steuernagel C,Meyer J

    更新日期：1986-09-01 00:00:00

  • Geographic Variation in the Treatment of U.S. Adult Heart Transplant Candidates.

    abstract：BACKGROUND:The current U.S. priority ranking for heart candidates is based on treatment intensity, not objective markers of severity of illness. This system may encourage centers to overtreat candidates. OBJECTIVES:This study sought to describe national variation in the intensity of treatment of adult heart transplant...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2018.02.030

    authors： Parker WF,Anderson AS,Hedeker D,Huang ES,Garrity ER Jr,Siegler M,Churpek MM

    更新日期：2018-04-24 00:00:00

  • Pheochromocytoma Is Characterized by Catecholamine-Mediated Myocarditis, Focal and Diffuse Myocardial Fibrosis, and Myocardial Dysfunction.

    abstract：BACKGROUND:Pheochromocytoma is associated with catecholamine-induced cardiac toxicity, but the extent and nature of cardiac involvement in clinical cohorts is not well-characterized. OBJECTIVES:This study characterized the cardiac phenotype in patients with pheochromocytoma using cardiac magnetic resonance (CMR). MET...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2016.03.543

    authors： Ferreira VM,Marcelino M,Piechnik SK,Marini C,Karamitsos TD,Ntusi NAB,Francis JM,Robson MD,Arnold JR,Mihai R,Thomas JDJ,Herincs M,Hassan-Smith ZK,Greiser A,Arlt W,Korbonits M,Karavitaki N,Grossman AB,Wass JAH,Neubaue

    更新日期：2016-05-24 00:00:00

  • The presence of infection-related antiphospholipid antibodies in infective endocarditis determines a major risk factor for embolic events.

    abstract：OBJECTIVES:The impact of infection-associated antiphospholipid antibodies (APA) on endothelial cell activation, blood coagulation and fibrinolysis was evaluated in patients with infective endocarditis with and without major embolic events. BACKGROUND:An embolic event is a common and severe complication of infective en...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00024-8

    authors： Kupferwasser LI,Hafner G,Mohr-Kahaly S,Erbel R,Meyer J,Darius H

    更新日期：1999-04-01 00:00:00

  • Appearance of abnormal Q waves early in the course of acute myocardial infarction: implications for efficacy of thrombolytic therapy.

    abstract：OBJECTIVES:The purpose of this study was to determine the time course of the appearance of abnormal Q waves on the electrocardiogram (ECG) over the first 6 h of symptoms of myocardial infarction and to determine what implications, if any, such Q waves have for the efficacy of thrombolytic therapy. BACKGROUND:Severe my...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0735-1097(94)00514-q

    authors： Raitt MH,Maynard C,Wagner GS,Cerqueira MD,Selvester RH,Weaver WD

    更新日期：1995-04-01 00:00:00

  • Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina.

    abstract：OBJECTIVES:The primary objective of the Monotherapy Assessment of Ranolazine In Stable Angina (MARISA) trial was to determine the dose-response relationship of ranolazine, a potentially new anti-anginal compound, on symptom-limited exercise duration. BACKGROUND:Fatty acids rise precipitously in response to stress, inc...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2003.11.045

    authors： Chaitman BR,Skettino SL,Parker JO,Hanley P,Meluzin J,Kuch J,Pepine CJ,Wang W,Nelson JJ,Hebert DA,Wolff AA,MARISA Investigators.

    更新日期：2004-04-21 00:00:00

  • Amiodarone therapy does not compromise subsequent heart transplantation.

    abstract：OBJECTIVES:The objective of this study was to determine the frequency of pulmonary complications, feasibility of early hospital discharge and requirements for postoperative inotropic and chronotropic support in patients receiving amiodarone therapy before heart transplantation. BACKGROUND:Although many patients waitin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0735-1097(92)90450-2

    authors： Chelimsky-Fallick C,Middlekauff HR,Stevenson WG,Kobashigawa J,Saxon LA,Moriguchi J,Brownfield ED,Hamilton MA,Drinkwater D,Laks H

    更新日期：1992-12-01 00:00:00

  • The implanted defibrillator: relation of defibrillating lead configuration and clinical variables to defibrillation threshold.

    abstract：:Forty-two defibrillating lead systems for the automatic implantable defibrillator were implanted and tested in 41 patients. Two basic lead configurations were used: 1) spring-patch, consisting of a transvenous superior vena cava spring electrode as the anode and an apical or left lateral ventricular patch electrode (e...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80219-9

    authors： Troup PJ,Chapman PD,Olinger GN,Kleinman LH

    更新日期：1985-12-01 00:00:00

  • Selective decrease in lysis of old thrombi after rapid administration of tissue-type plasminogen activator.

    abstract：:The safety of thrombolytic therapy of acute myocardial infarction could be improved if a method were developed to dissolve fresh occlusive coronary thrombus without simultaneously dissolving hemostatic thrombi outside the coronary arteries. This study is based on the assumption that, in a patient with evolving acute m...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(89)90441-5

    authors： Kanamasa K,Watanabe I,Cercek B,Yano J,Fishbein MC,Ganz W

    更新日期：1989-11-01 00:00:00

  • Prevalence of electrocardiographic anomalies in young individuals: relevance to a nationwide cardiac screening program.

    abstract：OBJECTIVES:This study sought to investigate the prevalence of potentially abnormal electrocardiographic (ECG) patterns in young individuals to assess the implications for a nationwide screening program for conditions causing sudden cardiac death (SCD). BACKGROUND:The Italian experience suggests that pre-participation ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.01.046

    authors： Chandra N,Bastiaenen R,Papadakis M,Panoulas VF,Ghani S,Duschl J,Foldes D,Raju H,Osborne R,Sharma S

    更新日期：2014-05-20 00:00:00

  • Lorcainide in patients with refractory ventricular tachyarrhythmia.

    abstract：:Lorcainide, a new antiarrhythmic agent with local anesthetic or membrane-stabilizing properties similar to those of quinidine, was tested in 76 patients with diverse types of heart disease and recurrent ventricular tachycardia or ventricular fibrillation. Lorcainide was administered for 72 to 96 hours in a dose rangin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80293-4

    authors： Chesnie B,Lampert S,Podrid P,Lown B

    更新日期：1984-06-01 00:00:00

  • Aspirin therapy in primary cardiovascular disease prevention: a position paper of the European Society of Cardiology working group on thrombosis.

    abstract：:Although the use of oral anticoagulants (vitamin K antagonists) has been abandoned in primary cardiovascular prevention due to lack of a favorable benefit-to-risk ratio, the indications for aspirin use in this setting continue to be a source of major debate, with major international guidelines providing conflicting re...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2014.03.049

    authors： Halvorsen S,Andreotti F,ten Berg JM,Cattaneo M,Coccheri S,Marchioli R,Morais J,Verheugt FW,De Caterina R

    更新日期：2014-07-22 00:00:00

  • Early revascularization improves survival in cardiogenic shock complicating acute myocardial infarction.

    abstract：:The effects of coronary revascularization by percutaneous transluminal coronary angioplasty or coronary bypass grafting, or both, on survival were evaluated in 81 patients with cardiogenic shock complicating acute myocardial infarction. Thirty-two patients had successful revascularization and 49 patients had unsuccess...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90269-s

    authors： Moosvi AR,Khaja F,Villanueva L,Gheorghiade M,Douthat L,Goldstein S

    更新日期：1992-04-01 00:00:00

  • Provocation of neurocardiogenic syncope by clomipramine administration during the head-up tilt test in vasovagal syndrome.

    abstract：OBJECTIVES:We sought to test the hypothesis that activation of the serotonergic system in patients with vasovagal syndrome during the head-up tilt test provokes syncope. BACKGROUND:Central serotonergic activation participates in the pathogenesis of neurocardiogenic syncope. Drugs increasing serotonin (5-HT) in the cen...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)00719-1

    authors： Theodorakis GN,Markianos M,Zarvalis E,Livanis EG,Flevari P,Kremastinos DT

    更新日期：2000-07-01 00:00:00

  • Potential role of mechanical stress in the etiology of pediatric heart disease: septal shear stress in subaortic stenosis.

    abstract：OBJECTIVES:The objective of this study was to show elevations in septal shear stress in response to morphologic abnormalities that have been associated with discrete subaortic stenosis (SAS) in children. Combined with the published data, this critical connection supports a four-stage etiology of SAS that is advanced in...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00048-x

    authors： Cape EG,Vanauker MD,Sigfússon G,Tacy TA,del Nido PJ

    更新日期：1997-07-01 00:00:00

  • Immune response factors in rheumatic heart disease: meta-analysis of HLA-DR associations and evaluation of additional class II alleles.

    abstract：OBJECTIVES:This study used a meta-analysis to examine HLA-DR frequencies in rheumatic heart disease and prospectively examined other class II allelic disease associations. BACKGROUND:Studies of rheumatic heart disease have reported HLA class II allelic associations, but these are inconsistent. METHODS:A meta-analysis...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/0735-1097(95)80022-9

    authors： Carlquist JF,Ward RH,Meyer KJ,Husebye D,Feolo M,Anderson JL

    更新日期：1995-08-01 00:00:00

  • Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial.

    abstract：OBJECTIVES:This trial examined the relative clinical efficacy, angiographic outcomes, and safety of zotarolimus-eluting coronary stents (ZES) with a phosphorylcholine polymer versus sirolimus-eluting stents (SES). BACKGROUND:Whether a cobalt-based alloy stent coated with the novel antiproliferative agent, zotarolimus,...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2006.08.035

    authors： Kandzari DE,Leon MB,Popma JJ,Fitzgerald PJ,O'Shaughnessy C,Ball MW,Turco M,Applegate RJ,Gurbel PA,Midei MG,Badre SS,Mauri L,Thompson KP,LeNarz LA,Kuntz RE,ENDEAVOR III Investigators.

    更新日期：2006-12-19 00:00:00

  • Application of appropriateness criteria to stress single-photon emission computed tomography sestamibi studies and stress echocardiograms in an academic medical center.

    abstract：OBJECTIVES:The purpose of this study was to apply published appropriateness criteria for single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in a single academic medical center. BACKGROUND:The American College of Cardiology Foundation (ACCF) and the American Society of Nuclear Cardiol...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.10.064

    authors： Gibbons RJ,Miller TD,Hodge D,Urban L,Araoz PA,Pellikka P,McCully RB

    更新日期：2008-04-01 00:00:00