Abstract:
:New pharmaceutical formulations must be proven as safe and effective before entering clinical trials. Also in the context of pulmonary drug delivery, preclinical models allow testing of novel antimicrobials, reducing risks and costs during their development. Such models allow reducing the complexity of the human lung, but still need to reflect relevant (patho-) physiological features. This review focuses on preclinical pulmonary models, mainly in vitro models, to assess drug safety and efficacy of antimicrobials. Furthermore, approaches to investigate common infectious diseases of the respiratory tract, are emphasized. Pneumonia, tuberculosis and infections occurring due to cystic fibrosis are in focus of this review. We conclude that especially in vitro models offer the chance of an efficient and detailed analysis of new antimicrobials, but also draw attention to the advantages and limitations of such currently available models and critically discuss the necessary steps for their future development.
journal_name
Adv Drug Deliv Revjournal_title
Advanced drug delivery reviewsauthors
Hittinger M,Juntke J,Kletting S,Schneider-Daum N,de Souza Carvalho C,Lehr CMdoi
10.1016/j.addr.2014.10.011subject
Has Abstractpub_date
2015-05-01 00:00:00pages
44-56eissn
0169-409Xissn
1872-8294pii
S0169-409X(14)00219-1journal_volume
85pub_type
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