Comparative in vitro activity of cefbuperazone against anaerobic bacteria isolated from community hospitals.


:The activity of cefbuperazone against 266 strains of anaerobic bacteria was determined by the agar dilution method and compared with cefoxitin, moxalactam, piperacillin, and clindamycin. All strains were recent clinical isolates from community hospitals. All agents tested showed good activity against Bacteroides fragilis, Fusobacterium spp., Propionibacterium spp., Clostridium septicum, Clostridium perfringens, and the anaerobic, gram-positive cocci and gram-negative cocci. Cefbuperazone, cefoxitin, and moxalactam had poor activity against Bacteroides thetaiotaomicron, Bacteroides ovatus, and Bacteroides distasonis. The susceptibility of other Clostridium spp., Lactobacillus spp., and Eubacterium lentum was variable. Our community hospital isolates showed a difference in susceptibility patterns from those reported from university and research centers. This supports the recommendation that clinical microbiology laboratories, including those in community hospitals, need to perform susceptibility testing on representative clinical isolates.


Goldstein EJ,Citron DM




Has Abstract


1985-02-01 00:00:00












  • In vitro antimicrobial activities and spectra of U-100592 and U-100766, two novel fluorinated oxazolidinones.

    abstract::Two new fluorinated oxazolidinones, U-100592 and U-100766, were evaluated against more than 659 gram-positive and -negative organisms and compared with glycopeptides, erythromycin, clindamycin, clinafloxacin, and chloramphenicol. U-100592 and U-100766 were usually equally potent, but the MICs at which 90% of the isola...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jones RN,Johnson DM,Erwin ME

    更新日期:1996-03-01 00:00:00

  • Treatment of experimental Haemophilus influenzae type b meningitis with 1-oxa-beta-lactam (LY127935).

    abstract::1-Oxa-beta-lactam (LY127935) (Shionogi 6059-S) is a new type beta-lactam antibiotic having a broad spectrum of antibacterial activity. It is highly active against ampicillin-resistant strains of Haemophilus influenzae exhibiting minimal inhibitory concentrations as low as 0.06 microgram/ml. This compound also has the ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Cordera CS,Pekarek RS

    更新日期:1980-02-01 00:00:00

  • Impact of Morphological Sectors on Antifungal Susceptibility Testing and Virulence Studies.

    abstract::Morphological heterogeneity of Aspergillus terreus cultures was observed during continued cultivation of amphotericin B (AMB)-resistant isolates on drug-free medium. Outgrowth leads to the emergence of multiple sectors that might result from increased growth rates at drug-free conditions. We evaluated the differences ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Jukic E,Blatzer M,Binder U,Mayr L,Lass-Flörl C,Lackner M

    更新日期:2017-11-22 00:00:00

  • Genital tract, cord blood, and amniotic fluid exposures of seven antiretroviral drugs during and after pregnancy in human immunodeficiency virus type 1-infected women.

    abstract::The objective of the study was to measure antiretroviral exposures in four physiological compartments during pregnancy, delivery, and postpartum. This prospective, open-label, longitudinal study collected paired blood plasma (BP) and genital tract (GT) aspirates antepartum, at delivery, and up to 12 weeks postpartum. ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yeh RF,Rezk NL,Kashuba AD,Dumond JB,Tappouni HL,Tien HC,Chen YC,Vourvahis M,Horton AL,Fiscus SA,Patterson KB

    更新日期:2009-06-01 00:00:00

  • Ceftolozane-Tazobactam in the Treatment of Experimental Pseudomonas aeruginosa Pneumonia in Persistently Neutropenic Rabbits: Impact on Strains with Genetically Defined Mechanisms of Resistance.

    abstract::Ceftolozane-tazobactam (C/T) is a novel cephalosporin with in vitro activity against Pseudomonas aeruginosa that is resistant to extended-spectrum penicillins and antipseudomonal cephalosporins. In order to assess the antimicrobial effect of C/T in treatment of Pseudomonas pneumonia, we investigated the pharmacokineti...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Petraitis V,Petraitiene R,Naing E,Aung T,Thi WP,Kavaliauskas P,Win Maung BB,Michel AO,Ricart Arbona RJ,DeRyke AC,Culshaw DL,Nicolau DP,Satlin MJ,Walsh TJ

    更新日期:2019-08-23 00:00:00

  • Cefamandole bile levels in patients with hepatobiliary disease.

    abstract::Intraoperative biliary cefamandole concentrations were determined in 16 patients with hepatobiliary pathology. These included seven patients with cholelithiasis, five with acute cholecystitis, two with recurrent ascending cholangitis, and two with liver abscesses. Bile collected 0.5 to 2.5 h after the last antibiotic ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Uwaydah M,Kantarjian H,Osseiran M,Bal'a F

    更新日期:1982-12-01 00:00:00

  • Polycation binding to isolated lipopolysaccharide from antibiotic-hypersusceptible mutant strains of Escherichia coli.

    abstract::Lipopolysaccharide (LPS) samples isolated from a parent and two antibiotic-hypersusceptible mutant strains of Escherichia coli were analyzed for polycation affinity and level of binding. Purified salts of the LPSs from the parent strain, UB1005, and from one of the mutant strains, DC1, bound similar amounts of sodium ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Rocque WJ,Fesik SW,Haug A,McGroarty EJ

    更新日期:1988-03-01 00:00:00

  • Antimicrobial susceptibility among clinical Nocardia species identified by multilocus sequence analysis.

    abstract::Antimicrobial susceptibility patterns of 112 clinical isolates, 28 type strains, and 9 reference strains of Nocardia were determined using the Sensititre Rapmyco microdilution panel (Thermo Fisher, Inc.). Isolates were identified by highly discriminatory multilocus sequence analysis and were chosen to represent the di...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: McTaggart LR,Doucet J,Witkowska M,Richardson SE

    更新日期:2015-01-01 00:00:00

  • Action of a basic copolymer of ornithine and leucine on cells of Staphylococcus aureus.

    abstract::A basic, random copolymer of l-ornithine and l-leucine (OL; molar ratios 1:1) was bactericidal to a sensitive (S) strain of Staphylococcus aureus at low concentration. Resistant cells (R) were selected from the culture medium and, after serial transfers to solutions containing increasing amounts of the polymer, grew w...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Shenfeld A,Flowers HM,Katchalski E

    更新日期:1974-02-01 00:00:00

  • Pharmacokinetics of minocycline in renal failure.

    abstract::The pharmacokinetics of minocycline have been studied after single intravenous infusions and repeated oral doses to human subjects with varying degrees of renal impairment. There was no evidence of reduced drug clearance with reduced renal function after intravenous doses although there appeared to be an increase in t...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Welling PG,Shaw WR,Uman SJ,Tse FL,Craig WA

    更新日期:1975-11-01 00:00:00

  • Antimicrobial activity and spectrum of PPI-0903M (T-91825), a novel cephalosporin, tested against a worldwide collection of clinical strains.

    abstract::PPI-0903M is a novel N-phosphono-type cephalosporin active against oxacillin-resistant staphylococci and many other gram-positive organisms. This study evaluated the in vitro activity and spectrum of PPI-0903M against 1,478 recent clinical isolates collected from 80 medical centers (22 countries). PPI-0903M demonstrat...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Sader HS,Fritsche TR,Kaniga K,Ge Y,Jones RN

    更新日期:2005-08-01 00:00:00

  • Activities of high-dose daptomycin, vancomycin, and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm.

    abstract::Biofilm formation is an important virulence factor that allows bacteria to resist host responses and antibacterial agents. The aim of the study was to assess the in vitro activities of several antimicrobials alone or in combination against two Staphylococcus aureus isolates in a novel pharmacokinetic/pharmacodynamic (...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Parra-Ruiz J,Vidaillac C,Rose WE,Rybak MJ

    更新日期:2010-10-01 00:00:00

  • Induction of DnaK and GroEL heat shock proteins by fluoroquinolones in Escherichia coli.

    abstract::Various fluoroquinolones (norfloxacin, enoxacin, ofloxacin, levofloxacin, and sparfloxacin) induce DnaK and GroEL heat shock proteins in Escherichia coli. The induction is transient, consistent with the kinetics of cellular DNA relaxation. The concentrations of fluoroquinolones required for induction are similar to th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Mizushima T,Matsuo M,Sekimizu K

    更新日期:1997-01-01 00:00:00

  • Diazepam-mediated inhibition of human immunodeficiency virus type 1 expression in human brain cells.

    abstract::Treatment of acutely infected human brain cell and enriched microglial cell cultures with diazepam inhibited human immunodeficiency virus type 1 (HIV-1) p24 antigen expression. Similarly, diazepam suppressed HIV-1 expression in chronically infected promonocytic (U1) cells and acutely infected monocyte-derived macropha...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Lokensgard JR,Gekker G,Hu S,Arthur AF,Chao CC,Peterson PK

    更新日期:1997-11-01 00:00:00

  • Accelerated denaturation of hemoglobin and the antimalarial action of chloroquine.

    abstract::To study the antimalarial action of chloroquine, normal mouse erythrocytes were used as surrogates for erythrocytoid bodies. These bodies form in the endosomes of intraerythrocytic malaria parasites as they feed on their host and consist of erythrocyte cytoplasm enclosed in a vestige of the erythrocyte membrane. In su...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Fitch CD,Russell NV

    更新日期:2006-07-01 00:00:00

  • Monte Carlo simulations based on phase 1 studies predict target attainment of ceftobiprole in nosocomial pneumonia patients: a validation study.

    abstract::Monte Carlo simulation (MCS) of antimicrobial dosage regimens during drug development to derive predicted target attainment values is frequently used to choose the optimal dose for the treatment of patients in phase 2 and 3 studies. A criticism is that pharmacokinetic (PK) parameter estimates and variability in health...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Muller AE,Schmitt-Hoffmann AH,Punt N,Mouton JW

    更新日期:2013-05-01 00:00:00

  • Comparative efficacy of trovafloxacin in experimental endocarditis caused by ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus.

    abstract::The new fluoroquinolone trovafloxacin was tested against a ciprofloxacin-sensitive, methicillin-resistant Staphylococcus aureus strain in the rabbit model of endocarditis. Trovafloxacin was more effective than vancomycin (CFU/g of vegetation, 2.65 +/- 1.87 versus 4.54 +/- 2.80 [mean +/- standard deviation]; P < 0.05) ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Kim YS,Liu Q,Chow LL,Chambers HF,Täuber MG

    更新日期:1998-12-01 00:00:00

  • Bacterial Replication Rate Modulation in Combination with Antimicrobial Therapy: Turning the Microbe against Itself.

    abstract::A major clinical challenge for treating infectious diseases is the duration of antimicrobial therapy required to eradicate the pathogen. We hypothesized that modulation of the bacterial replication rate in the context of an antimicrobial exposure is coupled with the rate and extent of bactericidal effects. Herein we d...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Ambrose PG,VanScoy B,Conde H,McCauley J,Rubino CM,Bhavnani SM

    更新日期:2016-12-27 00:00:00

  • Prospective observational study comparing three different treatment regimes in patients with Clostridium difficile infection.

    abstract::In a hospital-based, prospective cohort study, the effects of the three standard treatment regimens for mild Clostridium difficile infection (CDI), oral (p.o.) metronidazole at 500 mg three times/day, intravenous (i.v.) metronidazole at 500 mg three times/day, and oral (p.o.) vancomycin at 250 mg four times/day, were ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wenisch JM,Schmid D,Kuo HW,Allerberger F,Michl V,Tesik P,Tucek G,Laferl H,Wenisch C

    更新日期:2012-04-01 00:00:00

  • Distribution of amoxicillin and clavulanic acid in infected animals and efficacy against experimental infections.

    abstract::The therapeutic effects produced by formulations of amoxicillin plus clavulanic acid (BRL 25 000A and BRL 25 000G) were compared with those of amoxicillin and clavulanic acid separately against a variety of infections produced by amoxicillin-susceptible and beta-lactamase-producing (amoxicillin-resistant) bacteria. Th...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Boon RJ,Beale AS,Comber KR,Pierce CV,Sutherland R

    更新日期:1982-09-01 00:00:00

  • Saccharomicins, novel heptadecaglycoside antibiotics produced by Saccharothrix espanaensis: antibacterial and mechanistic activities.

    abstract::Saccharomicins A and B, two new heptadecaglycoside antibiotics, were isolated from the fermentation broth of the rare actinomycete Saccharothrix espanaensis. They represent a novel class of bactericidal antibiotics that are active both in vitro and in vivo against bacteria and yeast (MICs: Staphylococcus aureus, <0.12...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Singh MP,Petersen PJ,Weiss WJ,Kong F,Greenstein M

    更新日期:2000-08-01 00:00:00

  • Evaluation of bactericidal activities of LY333328, vancomycin, teicoplanin, ampicillin-sulbactam, trovafloxacin, and RP59500 alone or in combination with rifampin or gentamicin against different strains of vancomycin-intermediate Staphylococcus aureus by

    abstract::This in vitro study evaluated the activities of vancomycin, LY333328, and teicoplanin alone and in combination with gentamicin, rifampin, and RP59500 against Staphylococcus aureus isolates with intermediate susceptibilities to vancomycin. Ampicillin-sulbactam and trovafloxacin were also evaluated. LY333328 and ampicil...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hershberger E,Aeschlimann JR,Moldovan T,Rybak MJ

    更新日期:1999-03-01 00:00:00

  • In vitro activities of penciclovir and acyclovir against herpes simplex virus types 1 and 2.

    abstract::Penciclovir (PCV) and acyclovir are acyclic guanine analogs which inhibit herpes simplex virus (HSV) DNA polymerase. Their 50% infective doses were 0.5 to 0.8 microgram/ml for clinical isolates of HSV-1 and 1.3 to 2.2 micrograms/ml for HSV-2. Furthermore, HSV-infected cultures receiving 2-h pulses of PCV had 2- to 50-...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Weinberg A,Bate BJ,Masters HB,Schneider SA,Clark JC,Wren CG,Allaman JA,Levin MJ

    更新日期:1992-09-01 00:00:00

  • Model-based approach for optimization of atazanavir dose recommendations for HIV-infected pediatric patients.

    abstract::Atazanavir (Reyataz; ATV) is a well-tolerated protease inhibitor (PI) that is indicated as a once-daily treatment for HIV infections. These features of ATV, combined with its virologic potency, make it particularly desirable for the treatment of HIV-infected pediatric patients. The objective of this study was to use a...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Hong Y,Kowalski KG,Zhang J,Zhu L,Horga M,Bertz R,Pfister M,Roy A

    更新日期:2011-12-01 00:00:00

  • Characterization of high-level quinolone resistance in Campylobacter jejuni.

    abstract::High-level resistance to quinolones has previously been shown to occur in Campylobacter spp. both in vitro and in patients treated with quinolones. We have selected isolates that are resistant to quinolones by plating cells from a susceptible C. jejuni strain, UA535, on medium containing nalidixic acid at 32 microgram...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Gootz TD,Martin BA

    更新日期:1991-05-01 00:00:00

  • Roxithromycin disposition in tonsils after single and repeated administrations.

    abstract::Levels of roxithromycin in serum and tissue were investigated in 29 subjects undergoing tonsillectomy. A total of 13 subjects received a single oral dose of 300 mg, and 16 received four oral doses 12 h apart as follows: a 300-mg loading dose followed by three 150-mg doses. Measurable levels of roxithromycin were prese...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Galioto GB,Ortisi G,Mevio E,Sassella D,Bartucci F,Privitera G

    更新日期:1988-09-01 00:00:00

  • Concentration-dependent synergy and antagonism within a triple antifungal drug combination against Aspergillus species: analysis by a new response surface model.

    abstract::Triple antifungal combinations are used against refractory invasive aspergillosis without an adequate understanding of their pharmacodynamic interactions. We initially studied the in vitro triple combination of voriconazole, amphotericin B, and caspofungin against Aspergillus fumigatus, A. flavus, and A. terreus by a ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Meletiadis J,Stergiopoulou T,O'Shaughnessy EM,Peter J,Walsh TJ

    更新日期:2007-06-01 00:00:00

  • Evolution of a 72-Kilobase Cointegrant, Conjugative Multiresistance Plasmid in Community-Associated Methicillin-Resistant Staphylococcus aureus Isolates from the Early 1990s.

    abstract::Horizontal transfer of plasmids encoding antimicrobial resistance and virulence determinants has been instrumental in Staphylococcus aureus evolution, including the emergence of community-associated methicillin-resistant S. aureus (CA-MRSA). In the early 1990s, the first CA-MRSA strain isolated in Western Australia (W...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Yui Eto K,Firth N,Davis AM,Kwong SM,Krysiak M,Lee YT,O'Brien FG,Grubb WB,Coombs GW,Bond CS,Ramsay JP

    更新日期:2019-10-22 00:00:00

  • Clinical evaluation of a dried blood spot assay for atazanavir.

    abstract::Current procedures for obtaining and measuring plasma concentrations of HIV protease inhibitors (PIs) are technically challenging. Dried blood spot (DBS) assays offer a way to overcome many of the obstacles. We sought to develop a DBS assay for quantitation of the PI atazanavir (ATV) and to compare this method with a ...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Van Schooneveld T,Swindells S,Nelson SR,Robbins BL,Moore R,Fletcher CV

    更新日期:2010-10-01 00:00:00

  • Effects of KPC Variant and Porin Genotype on the In Vitro Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae.

    abstract::Meropenem-vaborbactam is a new agent with the potential to treat carbapenem-resistant Enterobacteriaceae (CRE) infections. We describe the in vitro activity of meropenem-vaborbactam against representative CRE genotypes and laboratory-engineered Escherichia coli isolates harboring mutant blaKPC genes associated with ce...

    journal_title:Antimicrobial agents and chemotherapy

    pub_type: 杂志文章


    authors: Wilson WR,Kline EG,Jones CE,Morder KT,Mettus RT,Doi Y,Nguyen MH,Clancy CJ,Shields RK

    更新日期:2019-02-26 00:00:00