Abstract:
:The discovery that metabolically active brown fat is present in humans throughout ontogeny raises new questions about the interactions between thermoregulatory, metabolic, and skeletal homeostasis. Brown adipose tissue (BAT) is distinct from white adipose tissue (WAT) for its ability to burn, rather than store, energy. BAT uniquely expresses uncoupling protein-1 (abbreviated as UCP1), which diverts the energy produced by cellular respiration to generate heat. While BAT is found in small mammals, hibernators, and newborns, this depot was thought to regress in humans during early postnatal life. Recent studies revealed that human BAT remains metabolically active throughout childhood and even in adulthood, particularly in response to cold exposure. In addition to the constitutive BAT depots present at birth, BAT cells can be induced within WAT depots under specific metabolic and climatic conditions. These cells, called inducible brown fat, "brite," or beige fat, are currently the focus of intense investigation as a possible treatment for obesity. Inducible brown fat is associated with higher bone mineral density, suggesting that brown fat interacts with bone growth in previously unrecognized ways. Finally, BAT may have contributed to climatic adaptation in hominins. Here, I review current findings on the role of BAT in thermoregulation, bone growth, and metabolism, describe the potential role of BAT in moderating the obesity epidemic, and outline possible functions of BAT across hominin evolutionary history.
journal_name
Am J Phys Anthropoljournal_title
American journal of physical anthropologyauthors
Devlin MJdoi
10.1002/ajpa.22661subject
Has Abstractpub_date
2015-02-01 00:00:00pages
98-115eissn
0002-9483issn
1096-8644journal_volume
156 Suppl 59pub_type
杂志文章,评审abstract::The use of tooth cementum annulations for age determination has been deemed promising, exhibiting high correlations with chronological age. Despite its apparent potential, to date, the tooth cementum annulations method has been used rarely for estimating ages in archaeological populations. Here we examine the readabil...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21136
更新日期:2009-11-01 00:00:00
abstract::In addition to being frugivorous, Cebus and Saimiri stand out among the New World primates of similar body size in being heavily dependent on animal matter for protein (faunivory). A detailed description of the morphology and behavior of the two genera is presented with the object of evaluating the interaction and res...
journal_title:American journal of physical anthropology
pub_type: 杂志文章,评审
doi:10.1002/ajpa.1330880405
更新日期:1992-08-01 00:00:00
abstract::Discovery of a previously unknown Bronze Age civilization (Oxus civilization) centered on the oases of Central Asia revealed the presence of large, preplanned urban centers immediately above sterile soil. Given the absence of local antecedents, the sudden appearance and proliferation of these Oxus civilization urban c...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199902)108:2<173::AID-AJPA
更新日期:1999-02-01 00:00:00
abstract::The wild bonobos (Pan paniscus) of Wamba, Zaire have an extremely high frequency of external abnormal traits. Out of 96 animals in a sample comprising all age and sex classes from two different natural groups, 46 individuals had at least one limb defect. The frequency of abnormalities was greater in males than in fema...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330630102
更新日期:1984-01-01 00:00:00
abstract:OBJECTIVES:The purpose of this study is to demonstrate advantages of principal component analysis (PCA) as a standardized procedure in the evaluation of osteoarthritis (OA) in a skeletal series to: (1) compute aggregate scores for joint complexes that accurately capture pathological expression, (2) reveal which variabl...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23130
更新日期:2017-03-01 00:00:00
abstract::In this paper we develop a model that examines fertility and childhood mortality patterns and their relationship to environmental variables. Interactions among environmental variables can account for different fertility patterns and different mixes of these variables can produce similar patterns of fertility. Our mode...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330770304
更新日期:1988-11-01 00:00:00
abstract::This paper presents the demographic changes that followed the transition from a hunting-gathering way of life (Natufian) to an agricultural, food-producing economy (Neolithic) in the southern Levant. The study is based on 217 Natufian (10,500-8,300 BC) skeletons and 262 Neolithic (8,300-5,500 BC) skeletons. Age and se...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.10332
更新日期:2004-08-01 00:00:00
abstract::It is well established that some observed patterns of force production in the primate masticatory system match those predicted by a simplified lever model. This model is also commonly invoked in adaptive explanations of craniodental diversity. However, systematic studies of the predictive power of this model are missi...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199904)108:4<483::AID-AJPA
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVES:War atrocities committed by the Spanish army in the Low Countries during the 16th century are so ingrained in the collective memory of Belgian and Dutch societies that they generally assume a signature of this history to be present in their genetic ancestry. Historians claim this assumption is a consequence ...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.23409
更新日期:2018-05-01 00:00:00
abstract::Although previous studies have characterized the genetic structure of populations from Haiti and Jamaica using classical and autosomal STR polymorphisms, the patrilineal influences that are present in these countries have yet to be explored. To address this lacuna, the current study aims to investigate, for the first ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22090
更新日期:2012-08-01 00:00:00
abstract::Correlations between ridge-counts on the ten fingers were compared by race and sex in 11 samples representing Negroes and Caucasians: five from subsaharan Africa, one American Black, three European, one American White and one from India. The samples of European ancestry showed no consistent sex difference in mean corr...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330460122
更新日期:1977-01-01 00:00:00
abstract::Because plants and animals consume or absorb different amounts of strontium and calcium, anthropologists are able to use strontium/calcium (Sr/Ca) ratios from archaeologically recovered human bone to estimate the relative contributions of meat and plants to paleodiets. Often females exhibit higher Sr/Ca ratios than ma...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330800205
更新日期:1989-10-01 00:00:00
abstract::The anatomic distribution of the Stafne static mandibular bone defect (SSBD) is extended with a description of a cavitation defect on the buccal ramus of the mandible. The anatomical placement of SSBD thus correlates precisely with the submandibular and parotid salivary glands, and gives further evidence that an incre...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(200003)111:3<425::AID-AJPA
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:Dental microwear is a promising tool to reconstruct animals' diet because it reflects the interplay between the enamel surface and the food items recently consumed. This study examines the sources of inter-individual variations in dietary habits in a free-ranging population of mandrills (Mandrillus sphinx) u...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23337
更新日期:2018-01-01 00:00:00
abstract::Hand radiograms for osseographic assessment of bone aging status were taken from more than 7,500 individuals residing in 31 different localities and belonging to 20 ethnic groups. Multiple regression analysis was used to evaluate possible associations between bone aging parameters and several climatic factors, to wit:...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199807)106:3<349::AID-AJPA
更新日期:1998-07-01 00:00:00
abstract::Many studies based on genetic diversity of North African populations have contributed to elucidate the modelling of the genetic landscape in this region. North Africa is considered as a distinct spatial-temporal entity on geographic, archaeological, and historical grounds, which has undergone the influence of differen...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22705
更新日期:2015-06-01 00:00:00
abstract::Modern humans, among extant hominoids, possess a unique projecting, external nose whose basic structure is reflected in a series of skeletal features including nasal bone convexity, an internasal angle, lateral nasal aperture eversion, prominence and anterior positioning of the anterior nasal spine, an acute angle of ...
journal_title:American journal of physical anthropology
pub_type: 历史文章,杂志文章
doi:10.1002/ajpa.1330750409
更新日期:1988-04-01 00:00:00
abstract::Primate molar shapes reflect developmental and ecological processes. Development may constrain as well as facilitate evolution of new tooth shapes, affecting how reliable dental characters are in phylogenetic studies. Much of the genetic machinery of development uses the same genes among different organs, including te...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/1096-8644(2000)43:31+<171::aid-ajpa6>3.0.c
更新日期:2000-01-01 00:00:00
abstract::This paper is one in a series which explores the possibility of using the non-destructive CT technique to identify patterns in tooth enamel distribution and structure of hominid molars from Plio-Pleistocene sites in South Africa, notably Swartkrans, Sterkfontein, and Kromdraai. Whereas previous investigators have emph...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330890202
更新日期:1992-10-01 00:00:00
abstract::The Nariokotome Homo erectus has an apparent disjunction of inferred age as judged by dental maturity, by epiphyseal closure and by stature, when compared to modern human norms. On this basis, it has been suggested that this fossil hominin differed in its pattern of growth and development from modern humans. In partic...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199909)110:1<81::AID-AJPA7
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:The use of dental metrics in phylogenetic reconstructions of fossil primates assumes variation in tooth size is highly heritable. Quantitative genetic studies in humans and baboons have estimated high heritabilities for dental traits, providing a preliminary view of the variability of dental trait heritabili...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23744
更新日期:2019-02-01 00:00:00
abstract::Mexican Americans are a numerous and fast growing ethnic population in the United States. Yet little is known about their genetic structure. Since they are a hybrid, it is of interest to identify their parental populations and to estimate the relative contributions of these groups. This information is relevant to hist...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330840204
更新日期:1991-02-01 00:00:00
abstract:OBJECTIVES:Many studies on subadult sex estimation focus on elements that express sexually dimorphic features in adults. In contrast, diaphyseal dimensions have been shown to display sex-specific differences prior to adolescence. The current study evaluates the use of diaphyseal dimensions in subadult sex estimation. ...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.23185
更新日期:2017-05-01 00:00:00
abstract::A method for estimating the general rate of nonpaternity in a population was validated using phenotype data on seven blood groups (A1A2BO, MNSs, Rh, Duffy, Lutheran, Kidd, and P) on 396 mother, child, and legal father trios from Nuevo León, Mexico. In all, 32 legal fathers were excluded as the possible father based on...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-8644(199907)109:3<281::AID-AJPA
更新日期:1999-07-01 00:00:00
abstract::Pliopithecinae and Crouzeliinae (Primates: Pliopithecidae) are distinguished dentally by the sharper crests, more compressed cusps, larger foveae, and narrower molars of the latter. Traditionally, such differences were qualitatively related to increased folivory in crouzeliines. This was subsequently disproved by micr...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22299
更新日期:2013-08-01 00:00:00
abstract::Treponemal disease is known to be associated with the compromised community health of permanent village settlement. This association explains its high visibility in the village-based, arguably chiefdom level, agriculturalist societies of late prehistoric (AD 1300-1600) North America. Within chiefdom-level societies, h...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.21381
更新日期:2011-02-01 00:00:00
abstract::The objective of this study is to present the characteristics of a collection of identified infants and young children housed in the Laboratory of Anthropology of the University of Granada, Spain. The sample, which is still being enlarged, is currently composed of 230 complete skeletons aged from 5 months of gestation...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22165
更新日期:2012-12-01 00:00:00
abstract::A previous study of passive joint mobility in patas monkeys (Erythrocebus patas) showed that laboratory-caged animals had significantly greater mobility in most joints than age/sex matched free-ranging monkeys. Passive joint mobility on 27 of the same animals was measured 6 months after the caged animals were released...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330670102
更新日期:1985-05-01 00:00:00
abstract::Sibling correlations for size attained in height, weight, sitting height, estimated leg length, the triceps skinfold, arm circumference, and estimated midarm muscle circumference were compared in 6- through 13-year-old schoolchildren grouped by household socioeconomic status. The children were residents of a Zapotec-s...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.1330710110
更新日期:1986-09-01 00:00:00
abstract:OBJECTIVES:One-male social systems are usually characterized by polygyny and reproductive exclusion by a single resident male. Sometimes, however, secondary males join these groups, and this may carry fitness costs and/or benefits to the resident male. In hamadryas baboons (Papio hamadryas hamadryas), which live in one...
journal_title:American journal of physical anthropology
pub_type: 杂志文章
doi:10.1002/ajpa.22804
更新日期:2015-11-01 00:00:00