Principal component analysis in the evaluation of osteoarthritis.

Abstract:

OBJECTIVES:The purpose of this study is to demonstrate advantages of principal component analysis (PCA) as a standardized procedure in the evaluation of osteoarthritis (OA) in a skeletal series to: (1) compute aggregate scores for joint complexes that accurately capture pathological expression, (2) reveal which variables describe the most sample variation in OA, (3) enable inter- and intra-sample comparison of results, and (4) formulate predictive models from component-based arthritic scores. MATERIALS AND METHODS:The sample (144 males, 145 females) is drawn from a large skeletal cemetery collection of modern Europeans of known sex, age, and occupation. OA data was collected using standard ranked categorical scoring. PCA was conducted separately on lumbar spine, pelvis, and knee regions to generate composite OA scores from eigenequations of the first and second principal components (PC). RESULTS:Results demonstrate that as severity in OA increases, so does the distribution of OA within the joint surface. In each region, PCA produced the same general pattern with eburnation scoring driving significant changes in composite OA scores, representing earlier to later stages of cartilage degeneration. The distribution of arthritic traits determined by PCA produced an OA score that quantifies the expression of joint changes in varied biological joint structures from most moveable to least mobile, the final stage being joint fusion. OA scores are most highly variable in the lumbar region for both males and females, as compared to the pelvis and knee. CONCLUSIONS:PCA is a simple, non-parametric method of extracting relevant information from complex OA datasets and summarizes variation based on correlated multi-attributes to reveal a simplified structure of OA expression. Multivariate techniques like PCA should be used to describe discrete OA samples, and are useful to compute population-specific representative measurements for idiopathic joint OA in a skeletal sample.

journal_name

Am J Phys Anthropol

authors

Calce SE,Kurki HK,Weston DA,Gould L

doi

10.1002/ajpa.23130

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

476-490

issue

3

eissn

0002-9483

issn

1096-8644

journal_volume

162

pub_type

杂志文章
  • Linkage disequilibrium in Bougainville Island.

    abstract::Linkage disequilibria are estimated for three 2-locus systems in 18 samples from Bougainville Island, Solomon Islands. The systems are haptoglobin, acid phosphatase and MN blood group. The disequilibria are estimated two ways: by maximum likelihood (ML) and by the covariance between the non-alleles. Though seven of th...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330480305

    authors: Cadien JD,Hassett MJ,Friedlaender JS

    更新日期:1978-03-01 00:00:00

  • Evaluation of the auricular surface method for non-adult sex estimation on the Lisbon documented collection.

    abstract:OBJECTIVES:Sex is usually not estimated in skeletonized non-adult individuals because sexual dimorphism is considered minimal before puberty. In 2017, a new approach based on the shape of the auricular surface was proposed, showing that this anatomic area of the ilium is dimorphic. This study tests the reproducibility ...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.24012

    authors: Monge Calleja ÁM,Aranda CM,Santos AL,Luna LH

    更新日期:2020-07-01 00:00:00

  • Reliability of anthropometric methods and replicate measurements.

    abstract::The Spearman-Brown Prophesy formula, derived from psychometrics, may be used in anthropometric studies to describe the relationship between the intraclass reliability coefficient for a single measurement and the reliability resulting from the mean of replicate measurements. This theory may be applied to determine expe...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330790108

    authors: Himes JH

    更新日期:1989-05-01 00:00:00

  • Craniometric variation and population history of the prehistoric Tewa.

    abstract::Although the population history and social organization of the prehistoric Pueblo Indians of the American Southwest have received attention in the archaeological literature, little research on this topic has been conducted by biological anthropologists. Here, we examine postmarital residence at two ancestral Tewa Indi...

    journal_title:American journal of physical anthropology

    pub_type: 历史文章,杂志文章

    doi:10.1002/ajpa.20150

    authors: Schillaci MA,Stojanowski CM

    更新日期:2005-04-01 00:00:00

  • Brief communication: diachronic investigation of linear enamel hypoplasia in prehistoric skeletal samples from Trentino, Italy.

    abstract::Linear enamel hypoplasia was scored on Neolithic, Copper Age, and Early Bronze Age samples from the Trentino region, Italy, in order to compare the extent of growth disruption in different biocultural subsistence systems (foragers with little agriculture, to agriculturists and agropastoralists). The Early Bronze Age s...

    journal_title:American journal of physical anthropology

    pub_type: 历史文章,杂志文章

    doi:10.1002/ajpa.10135

    authors: Cucina A

    更新日期:2002-11-01 00:00:00

  • Evolution of postural diversity in primates as reflected by the size and shape of the medial tibial facet of the talus.

    abstract:OBJECTIVES:Comprehensive quantification of the shape and proportions of the medial tibial facet (MTF) of the talus (=astragalus) has been lacking for Primates and their closest relatives. In this study, aspects of MTF form were quantified and employed to test hypotheses about their functional and phylogenetic significa...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.22702

    authors: Boyer DM,Yapuncich GS,Butler JE,Dunn RH,Seiffert ER

    更新日期:2015-05-01 00:00:00

  • The phylogeny and ontogeny of humeral torsion.

    abstract::In a series of specimens extending from fossil material through recent vertebrates including man there occurs a gradual phylogenetic increase in the degree of humeral torsion. A further (ontogenetic) torsion is superimposed upon the phylogenetic one in man which increases from birth until the proximal epiphysial carti...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330450325

    authors: Krahl VE

    更新日期:1976-11-01 00:00:00

  • Detection of significant demographic differences between subpopulations of prehispanic Maya from Copan, Honduras, by survival analysis.

    abstract::Heterogeneity and small sample size are problems that affect many paleodemographic studies. The former can cause the overall distribution of age at death to be an amalgam that does not accurately reflect the distributions of any of the groups composing the heterogeneous population. The latter can make it difficult to ...

    journal_title:American journal of physical anthropology

    pub_type: 历史文章,杂志文章

    doi:10.1002/ajpa.1330850206

    authors: Whittington SL

    更新日期:1991-06-01 00:00:00

  • A Y-chromosomal comparison of the Madjars (Kazakhstan) and the Magyars (Hungary).

    abstract::The Madjars are a previously unstudied population from Kazakhstan who practice a form of local exogamy in which wives are brought in from neighboring tribes, but husbands are not, so the paternal lineages remain genetically isolated within the population. Their name bears a striking resemblance to the Magyars who have...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.20984

    authors: Bíró AZ,Zalán A,Völgyi A,Pamjav H

    更新日期:2009-07-01 00:00:00

  • Brief communication: effect of coca-leaf chewing on salivary progesterone assays.

    abstract::Although there is evidence for reduced fertility in Andean and Himalayan populations at higher altitudes, factors other than hypoxia may be primarily responsible. A valuable approach in the investigation of these fertility determinants is the use of salivary steroid assays. However, coca-leaf chewing--a ubiquitous pra...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330920410

    authors: Vitzthum VJ,von Dornum M,Ellison PT

    更新日期:1993-12-01 00:00:00

  • An outbreak of relapsing fever unmasked by microbial paleoserology, 16th century, France.

    abstract:OBJECTIVES:Depicting past epidemics currently relies on DNA-based detection of pathogens, an approach limited to pathogens with well-preserved DNA sequences. We used paleoserology as a complementary approach detecting specific antibodies under a mini line-blot format including positive and negative control antigens. M...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.24138

    authors: Oumarou Hama H,Barbieri R,Guirou J,Chenal T,Mayer A,Ardagna Y,Signoli M,Aboudharam G,Raoult D,Drancourt M

    更新日期:2020-12-01 00:00:00

  • Histological investigations on the Tyrolean Ice Man.

    abstract::The 5,200-year-old Tyrolean Ice Man discovered in 1991 in the Otztal Alps is the world's most ancient known human glacier mummy. Histological investigation was aimed at 1) optimizing specimen preparation and 2) documenting the preservation state of (sub)cellular components. Minute pieces of frozen tissue were removed ...

    journal_title:American journal of physical anthropology

    pub_type: 历史文章,杂志文章

    doi:10.1002/(SICI)1096-8644(199808)106:4<521::AID-AJPA

    authors: Hess MW,Klima G,Pfaller K,Künzel KH,Gaber O

    更新日期:1998-08-01 00:00:00

  • Technical note: a histological technique for detecting the cryptic preservation of erythrocytes and soft tissue in ancient human skeletonized remains.

    abstract::Bone samples from a Middle Bronze Age (ca., 1600-1300 BC) site were prepared for histological analysis. Preliminary results suggested that components of bone marrow remained preserved. To verify these findings and optimize the sample preparation procedure, we conducted experiments varying the type of acid used to deca...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.22375

    authors: Setzer TJ,Sundell IB,Dibbley SK,Les C

    更新日期:2013-12-01 00:00:00

  • Dietary and dental variations in the genus Lemur, with comments concerning dietary-dental correlations among Malagasy primates.

    abstract::Field studies of feeding in the lemur subspecies Lemur fulvus rufus and L. f. mayottensis have revealed that feeding patterns within a single species can be markedly different, both regionally and seasonally. Thus L. f. rufus is a dietary specialist (3 plant species accounting for 80-90% of feeding time), and is highl...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330490118

    authors: Kay RF,Sussman RW,Tattersall I

    更新日期:1978-07-01 00:00:00

  • Comparing Dirichlet normal surface energy of tooth crowns, a new technique of molar shape quantification for dietary inference, with previous methods in isolation and in combination.

    abstract::Inferred dietary preference is a major component of paleoecologies of extinct primates. Molar occlusal shape correlates with diet in living mammals, so teeth are a potentially useful structure from which to reconstruct diet in extinct taxa. We assess the efficacy of Dirichlet normal energy (DNE) calculated for molar t...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.21489

    authors: Bunn JM,Boyer DM,Lipman Y,St Clair EM,Jernvall J,Daubechies I

    更新日期:2011-06-01 00:00:00

  • An isotopic perspective on the transport of Byzantine mining camp laborers into southwestern Jordan.

    abstract::The Byzantine Empire managed a complex administrative network that controlled the mining and processing of natural resources from within its boundaries. Scholars relying upon archeological and textual evidence debate the level of imperial involvement in these ventures, particularly in the provinces. Ancient sources no...

    journal_title:American journal of physical anthropology

    pub_type: 历史文章,杂志文章

    doi:10.1002/ajpa.21085

    authors: Perry MA,Coleman DS,Dettman DL,al-Shiyab AH

    更新日期:2009-11-01 00:00:00

  • Modeling neolithic dispersal in central Europe: demographic implications.

    abstract::On the basis of new examination of ancient DNA and craniometric analyses, Neolithic dispersal in Central Europe has been recently explained as reflecting colonization or at least a major influx of near eastern farmers. Given the fact that Neolithic dispersal in Central Europe was very rapid and extended into a large a...

    journal_title:American journal of physical anthropology

    pub_type: 历史文章,杂志文章

    doi:10.1002/ajpa.21572

    authors: Galeta P,Sládek V,Sosna D,Bruzek J

    更新日期:2011-09-01 00:00:00

  • A case of marked bilateral asymmetry in the sacral alae of the Neandertal specimen Regourdou 1 (Périgord, France).

    abstract:OBJECTIVES:A marked asymmetry was previously reported in the sacral alae and S1-L5 facets orientation of the Neandertal individual Regourdou 1. Here, we provide a detailed description and quantification of the morphology and degree of asymmetry of this sacrum. MATERIAL AND METHODS:Regourdou 1 was compared to a modern ...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.23968

    authors: Rmoutilová R,Gómez-Olivencia A,Brůžek J,Holliday T,Ledevin R,Couture-Veschambre C,Madelaine S,Džupa V,Velemínská J,Maureille B

    更新日期:2020-02-01 00:00:00

  • Recognition of leukemia in skeletal remains: report and comparison of two cases.

    abstract::Recognition of disease in the archeologic record is facilitated by characterization of the skeletal impact of documented (in life) disease. The present study describes the osteological manifestations of leukemia as identified in the skeletons of two individuals diagnosed during life: a 3-year-old black girl with acute...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-8644(199704)102:4<481::AID-AJPA

    authors: Rothschild BM,Hershkovitz I,Dutour O,Latimer B,Rothschild C,Jellema LM

    更新日期:1997-04-01 00:00:00

  • Isolation by distance, linguistic similarity, and the genetic structure on Bougainville Island.

    abstract::Previous research has revealed extensive genetic variation among villages on Bougainville, in the Solomon Islands. Using previously published gene frequency data for seven loci, the role of isolation by distance in structuring genetic variation on Bougainville was reanalyzed. Newer methods of kinship estimation show t...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330660309

    authors: Relethford JH

    更新日期:1985-03-01 00:00:00

  • Socioeconomic variation in estimated growth velocity of schoolchildren from a rural, subsistence agricultural community in southern Mexico.

    abstract::Socioeconomic variation in estimated growth velocities (annual growth increments) of several anthropometric dimensions was considered in schoolchildren from a rural, subsistence agricultural community in the Valley of Oaxaca in southern Mexico. The children (114 males, 99 females), 6-13 years of age, were measured twi...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330760404

    authors: Little BB,Buschang PH,Malina RM

    更新日期:1988-08-01 00:00:00

  • Maxillary molar occlusal polygons in five human samples.

    abstract::Angular and linear measurements of maxillary first molar occlusal polygons are given for young San (Bushmen), Sotho, Asiatic Indians, Whites, and Papago Indians. Angular and linear measurements are inseparably related. Much greater variation occurs in widths than in lengths. Maximum variation occurs between San and Pa...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330700308

    authors: Morris DH

    更新日期:1986-07-01 00:00:00

  • Enamel thickness and growth rates in modern human permanent first molars over a 2000 year period in Britain.

    abstract:OBJECTIVES:This study explores variation and trends in first molar enamel thickness and daily enamel secretion rates over a 2000 year period in Britain. METHODS:Permanent first molars (n = 89) from the Roman, Anglo-Saxon, and Medieval periods, as well as modern-day Britain, were analyzed using standard histological me...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.24026

    authors: Aris C,Mahoney P,O'Hara MC,Deter C

    更新日期:2020-09-01 00:00:00

  • Bilateral absence of the lesser trochanter in a late Epigravettian skeleton from Arene Candide (Italy).

    abstract::A virtually complete skeleton recovered from excavations in a Late Upper Paleolithic context by Cardini between 1940 and 1942 at the Arene Candide cave (NW Italy) lacks the normal development of the left and right lesser trochanters. The specimen is a short-statured male about 25 years old and shows no other especiall...

    journal_title:American journal of physical anthropology

    pub_type: 历史文章,杂志文章

    doi:10.1002/ajpa.1330830404

    authors: Formicola V,Frayer DW,Heller JA

    更新日期:1990-12-01 00:00:00

  • Temporal aspects of biological distance: serial correlation and trend in a prehistoric skeletal lineage.

    abstract::A number of previous studies have examined biological variability within individual human skeletal samples, using internal chronology as an explanatory source for variation. In this paper time series and matrix comparison methods are used to examine temporal serial correlation and trend of biological characteristics w...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330820106

    authors: Konigsberg LW

    更新日期:1990-05-01 00:00:00

  • Patterns of variability in mineralization of the primate femoral diaphysis.

    abstract::The purpose of this research was to study intra- and interspecific variability in mineral density in the femoral diaphysis of nonhuman primates. Four hundred five sections were taken from five sites along the femoral diaphysis of 34 macaques (Macaca sp.), 24 squirrel monkeys (Saimirisciureus), and 23 tamarins (Saguinu...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330510209

    authors: Burr DB

    更新日期:1979-08-01 00:00:00

  • Optimal birthweights in Peruvian populations at high and low altitudes.

    abstract::This study tests the hypothesis that optimum birthweight for survival is lower among hospital-born infants in Puno, Peru (altitude 3860 m) than that among their counterparts at low altitude in Tacna, Peru (altitude 600 m). The data are derived from hospital birth records for 1971 and 1972 and municipal death records f...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.1330560302

    authors: Beall CM

    更新日期:1981-11-01 00:00:00

  • Testing the association between human mid-facial morphology and climate using autosomal, mitochondrial, Y chromosomal polymorphisms and cranial non-metrics.

    abstract:OBJECTIVES:To figure out which and how many systems of genetic markers should be used to control for the effects of shared population history in studies examining the association between morphology and climate and to test cranial non-metric traits as an additional source of neutral distances for such studies. MATERIAL...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.22894

    authors: Evteev AA,Movsesian AA

    更新日期:2016-03-01 00:00:00

  • Pleistocene-Holocene boundary in Southern Arabia from the perspective of human mtDNA variation.

    abstract::It is now known that several population movements have taken place at different times throughout southern Arabian prehistory. One of the principal questions under debate is if the Early Holocene peopling of southern Arabia was mainly due to input from the Levant during the Pre-Pottery Neolithic B, to the expansion of ...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.22131

    authors: Al-Abri A,Podgorná E,Rose JI,Pereira L,Mulligan CJ,Silva NM,Bayoumi R,Soares P,Cerný V

    更新日期:2012-10-01 00:00:00

  • Development of ecological competence in Sumatran orangutans.

    abstract::Data on orangutans (Pongo pygmaeus abelii) living in a Sumatran swamp forest yield an estimated median interbirth interval of at least 8 years, concurring with findings from other sites. This longest known mammalian interbirth interval appears due to maternal amenorrhea during the long exclusive dependence of the offs...

    journal_title:American journal of physical anthropology

    pub_type: 杂志文章

    doi:10.1002/ajpa.10426

    authors: van Noordwijk MA,van Schaik CP

    更新日期:2005-05-01 00:00:00