Abstract：
:(19)F MRI is emerging as a new imaging technique for cell tracking. It is particularly attractive because of its potential for direct and precise cell quantification. The most important challenge towards in vivo applications is the sensitivity of the technique, i.e. the detection limit in a reasonable imaging time. Optimal sensitivity can be achieved with dedicated (19)F compounds together with specifically adapted hardware and acquisition methods. In this paper we introduce the (19)F MRI technique focusing on these key sensitivity issues and review the state-of-the-art of (19)F MRI and developments towards its clinical use. We calculate (19)F detection limits reported in preclinical cell and clinical (19)F drug studies in terms of tissue concentration in a 1 cm(3) voxel, as an alternate way to compare detection limits. We estimate that a tissue concentration of a few millimoles per litre (mM) of (19)F is required for a human study at a resolution of 1 cm(3).
journal_name
Eur Radioljournal_title
European radiologyauthors
Amiri H,Srinivas M,Veltien A,van Uden MJ,de Vries IJ,Heerschap Adoi
10.1007/s00330-014-3474-5subject
Has Abstractpub_date
2015-03-01 00:00:00pages
726-35issue
3eissn
0938-7994issn
1432-1084journal_volume
25pub_type
杂志文章abstract：:In acute nonvariceal gastrointestinal (GI) bleeding, immediate arteriographic haemostasis is presently assumed to be a therapeutic advantage. This study assesses whether the risk of a delayed haemostasis, caused by arteriographic findings precluding embolization, might influence patient outcome. We performed a 5.5-yea...
journal_title：European radiology
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pub_type： 评论,社论
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