Iterative image reconstruction algorithms in coronary CT angiography improve the detection of lipid-core plaque--a comparison with histology.

Abstract:

OBJECTIVES:To evaluate whether iterative reconstruction algorithms improve the diagnostic accuracy of coronary CT angiography (CCTA) for detection of lipid-core plaque (LCP) compared to histology. METHODS AND MATERIALS:CCTA and histological data were acquired from three ex vivo hearts. CCTA images were reconstructed using filtered back projection (FBP), adaptive-statistical (ASIR) and model-based (MBIR) iterative algorithms. Vessel cross-sections were co-registered between FBP/ASIR/MBIR and histology. Plaque area <60 HU was semiautomatically quantified in CCTA. LCP was defined by histology as fibroatheroma with a large lipid/necrotic core. Area under the curve (AUC) was derived from logistic regression analysis as a measure of diagnostic accuracy. RESULTS:Overall, 173 CCTA triplets (FBP/ASIR/MBIR) were co-registered with histology. LCP was present in 26 cross-sections. Average measured plaque area <60 HU was significantly larger in LCP compared to non-LCP cross-sections (mm(2): 5.78 ± 2.29 vs. 3.39 ± 1.68 FBP; 5.92 ± 1.87 vs. 3.43 ± 1.62 ASIR; 6.40 ± 1.55 vs. 3.49 ± 1.50 MBIR; all p < 0.0001). AUC for detecting LCP was 0.803/0.850/0.903 for FBP/ASIR/MBIR and was significantly higher for MBIR compared to FBP (p = 0.01). MBIR increased sensitivity for detection of LCP by CCTA. CONCLUSION:Plaque area <60 HU in CCTA was associated with LCP in histology regardless of the reconstruction algorithm. However, MBIR demonstrated higher accuracy for detecting LCP, which may improve vulnerable plaque detection by CCTA. KEY POINTS:• A low attenuation plaque area is associated with the presence of lipid-core plaque • MBIR leads to higher diagnostic accuracy for detecting lipid-core plaque • The benefit of MBIR is mainly due to increased sensitivity at high specificities • Semiautomated CCTA assessment can detect vulnerable plaques non-invasively.

journal_name

Eur Radiol

journal_title

European radiology

authors

Puchner SB,Ferencik M,Maurovich-Horvat P,Nakano M,Otsuka F,Kauczor HU,Virmani R,Hoffmann U,Schlett CL

doi

10.1007/s00330-014-3404-6

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

15-23

issue

1

eissn

0938-7994

issn

1432-1084

journal_volume

25

pub_type

杂志文章
  • Deep learning-based image restoration algorithm for coronary CT angiography.

    abstract:OBJECTIVES:The purpose of this study was to compare the image quality of coronary computed tomography angiography (CTA) subjected to deep learning-based image restoration (DLR) method with images subjected to hybrid iterative reconstruction (IR). METHODS:We enrolled 30 patients (22 men, 8 women) who underwent coronary...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-019-06183-y

    authors: Tatsugami F,Higaki T,Nakamura Y,Yu Z,Zhou J,Lu Y,Fujioka C,Kitagawa T,Kihara Y,Iida M,Awai K

    更新日期:2019-10-01 00:00:00

  • 1H MR spectroscopy of mesial temporal lobe epilepsies treated with Gamma knife.

    abstract::Proton MR spectroscopy was used to observe long-term post-irradiation metabolic changes in epileptogenic tissue and in the contralateral parts of the brain which are not available with conventional imaging methods. We studied these changes in the temporal lobe in six patients, following radiosurgery on the amygdala an...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-002-1723-5

    authors: Hájek M,Dezortová M,Liscák R,Vymazal J,Vladyka V

    更新日期:2003-05-01 00:00:00

  • Haemodynamic and rheological effects of contrast media: the role of viscosity and osmolality.

    abstract::All currently available iodinated contrast media (CM) produce some form of haemodynamic or rheological change when injected. These effects are thought to be due primarily to the osmolality and viscosity of the CM. The new hexa-iodinated contrast agent Visipaque has the advantage of being iso-osmotic with blood at all ...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/BF02342566

    authors: Pugh ND

    更新日期:1996-01-01 00:00:00

  • The value of re-staging chest CT at first local recurrence of extremity and trunk soft tissue sarcoma.

    abstract:OBJECTIVE:To determine the prevalence of pulmonary metastases on re-staging chest CT at the time of first local recurrence (LR) of trunk or extremity soft tissue sarcoma (STS). MATERIALS AND METHODS:Retrospective review of all patients diagnosed with recurrent STS between May 2007 and April 2018. Data collected includ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-020-07366-8

    authors: Baig MS,Habib W,Attard V,Sharif B,Lindsay D,Upadhyay B,Saifuddin A

    更新日期:2020-10-10 00:00:00

  • Assessment of tumour invasion into the mandible: the value of different imaging techniques.

    abstract::In oral carcinomas close to the mandible, tumour invasion of the mandible is important in selecting segmental or marginal resection. Imaging may play a role in assessing tumour invasion. This study compares the accuracy of panoramic X-ray, CT and MR imaging in assessing invasion of the mandible in 29 patients. At hist...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050585

    authors: van den Brekel MW,Runne RW,Smeele LE,Tiwari RM,Snow GB,Castelijns JA

    更新日期:1998-01-01 00:00:00

  • Integrated imaging of non-small cell lung cancer recurrence: CT and PET-CT findings, possible pitfalls and risk of recurrence criteria.

    abstract:OBJECTIVES:To review the role of imaging in the diagnosis of recurrent disease in previously treated non-small cell lung cancer (NSCLC) and discuss the imaging pitfalls. METHODS:A comprehensive review of published literature on CT and PET imaging of NSCLC recurrence was performed. Diagnostic and prognostic values are ...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-011-2299-8

    authors: Caulo A,Mirsadraee S,Maggi F,Leccisotti L,van Beek EJ,Bonomo L

    更新日期:2012-03-01 00:00:00

  • MR-guided liver tumor ablation employing open high-field 1.0T MRI for image-guided brachytherapy.

    abstract:OBJECTIVE:To determine the feasibility and safety of image-guided brachytherapy employing a modified open high-field MR system. METHODS:This is a follow-up study of a development project enabling technologies for interventional use of 1.0T open MRI. Modifications included coils and in-bore visualization, fluoroscopic ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-010-1751-5

    authors: Ricke J,Thormann M,Ludewig M,Jungnickel K,Grosser O,Wybranski C,Peters N,Hass P,Bunke J,Fischbach F

    更新日期:2010-08-01 00:00:00

  • Initial clinical experience with oral manganese (CMC-001) for liver MR imaging.

    abstract::Recently, a new oral liver-specific manganese-based MR agent (CMC-001) has been introduced. This contrast medium is delivered to the liver in high concentrations in the portal vein and very low doses in the hepatic artery, as only small amounts of manganese enter the general circulation. It is taken up by the hepatocy...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-006-0336-9

    authors: Thomsen HS,Barentsz JO,Burcharth F,Chabanova E,Dekker HM,Moesgaard F,Moller JM,Leth-Espensen P,Logager V,Takahashi S

    更新日期:2007-01-01 00:00:00

  • Superficial femoral artery: current treatment options.

    abstract::Treatment of the superficial femoral artery (SFA) has been among the least effective of all endovascular procedures in terms of long-term patency. The relatively small vessel lumen, in conjunction with a high plaque burden, slow flow, and a high frequency of primary occlusions, contributes to a considerable rate of ac...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s00330-005-0111-3

    authors: Tepe G,Schmehl J,Heller S,Wiesinger B,Claussen CD,Duda SH

    更新日期:2006-06-01 00:00:00

  • A multifaceted approach to quality in the MRI-directed biopsy pathway for prostate cancer diagnosis.

    abstract:KEY POINTS:• Identify, assure, and measure major sources of variability affecting the MRI-directed biopsy pathway for prostate cancer diagnosis.• Develop strategies to control and minimize variations that impair pathway effectiveness including the performance of main players and team working.• Assure end-to-end quality...

    journal_title:European radiology

    pub_type: 社论

    doi:10.1007/s00330-020-07527-9

    authors: Padhani AR,Schoots IG,Turkbey B,Giannarini G,Barentsz JO

    更新日期:2020-11-25 00:00:00

  • High-resolution myocardial perfusion imaging at 3 T: comparison to 1.5 T in healthy volunteers.

    abstract::The purpose of this study was to evaluate high-resolution (HR) myocardial first-pass perfusion in healthy volunteers at 3 T compared to a typical clinical imaging protocol at 1.5 T, with respect to overall image quality and the presence of subendocardial dark rim artifacts. Myocardial first-pass rest perfusion studies...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-006-0560-3

    authors: Strach K,Meyer C,Thomas D,Naehle CP,Schmitz C,Litt H,Bernstein A,Cheng B,Schild H,Sommer T

    更新日期:2007-07-01 00:00:00

  • Differentiation of myocardial ischemia and infarction assessed by dynamic computed tomography perfusion imaging and comparison with cardiac magnetic resonance and single-photon emission computed tomography.

    abstract:OBJECTIVES:To evaluate the feasibility of myocardial blood flow (MBF) by computed tomography from dynamic CT perfusion (CTP) for detecting myocardial ischemia and infarction assessed by cardiac magnetic resonance (CMR) or single-photon emission computed tomography (SPECT). METHODS:Fifty-three patients who underwent st...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-016-4238-1

    authors: Tanabe Y,Kido T,Uetani T,Kurata A,Kono T,Ogimoto A,Miyagawa M,Soma T,Murase K,Iwaki H,Mochizuki T

    更新日期:2016-11-01 00:00:00

  • Feasibility of whole-body diffusion-weighted MRI for detection of primary tumour, nodal and distant metastases in women with cancer during pregnancy: a pilot study.

    abstract:OBJECTIVES:To evaluate the feasibility of whole-body diffusion-weighted MRI (WB-DWI/MRI) for detecting primary tumour, nodal and distant metastases in pregnant women with cancer. METHODS:Twenty pregnant patients underwent WB-DWI/MRI in additional to conventional imaging. Reproducibility of WB-DWI/MRI between two reade...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-5126-z

    authors: Han SN,Amant F,Michielsen K,De Keyzer F,Fieuws S,Van Calsteren K,Dresen RC,Gziri MM,Vandecaveye V

    更新日期:2018-05-01 00:00:00

  • Tracheal rupture caused by blunt chest trauma: radiological and clinical features.

    abstract::The aim of this study was to assess radiomorphologic and clinical features of tracheal rupture due to blunt chest trauma. From 1992 until 1998 the radiomorphologic and clinical key findings of all consecutive tracheal ruptures were retrospectively analyzed. The study included ten patients (7 men and 3 women; mean age ...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300050080

    authors: Kunisch-Hoppe M,Hoppe M,Rauber K,Popella C,Rau WS

    更新日期:2000-01-01 00:00:00

  • Diagnostic value of the stand-alone synthetic image in digital breast tomosynthesis examinations.

    abstract:OBJECTIVE:To demonstrate the non-inferiority of synthetic image (SI) mammography versus full-field digital mammography (FFDM) in breast tomosynthesis (DBT) examinations. METHODS:An observational, retrospective, single-centre, multireader blinded study was performed, using 2384 images to directly compare SI and FFDM ba...

    journal_title:European radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00330-017-4991-9

    authors: Garayoa J,Chevalier M,Castillo M,Mahillo-Fernández I,Amallal El Ouahabi N,Estrada C,Tejerina A,Benitez O,Valverde J

    更新日期:2018-02-01 00:00:00

  • Percutaneous cryoablation for perivascular hepatocellular carcinoma: Therapeutic efficacy and vascular complications.

    abstract:OBJECTIVES:To evaluate the therapeutic efficacy of and vascular complications associated with percutaneous cryoablation for the treatment of perivascular HCC. METHODS:Between August 2015 and September 2017, 58 consecutive patients (48 men, 10 women; mean age, 61.1 years; age range, 44-84 years) who underwent percutane...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-018-5617-6

    authors: Kim R,Kang TW,Cha DI,Song KD,Lee MW,Rhim H,Lim HK,Sinn DH

    更新日期:2019-02-01 00:00:00

  • Imaging of trabecular bone structure in osteoporosis.

    abstract::Osteoporosis is a metabolic bone disorder that is characterized by reduced bone mass and a deterioration of bone structure which results in an increased fracture risk. Since the disease is preventable, diagnostic techniques are of major importance. Standard techniques determine bone mineral density, whereas some of th...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s003300050922

    authors: Link TM,Majumdar S,Grampp S,Guglielmi G,van Kuijk C,Imhof H,Glueer C,Adams JE

    更新日期:1999-01-01 00:00:00

  • Clinical Feasibility of 3D Automated Coronary Atherosclerotic Plaque Quantification Algorithm on Coronary Computed Tomography Angiography: Comparison with Intravascular Ultrasound.

    abstract:OBJECTIVE:To evaluate the diagnostic performance of automated coronary atherosclerotic plaque quantification (QCT) by different users (expert/non-expert/automatic). METHODS:One hundred fifty coronary artery segments from 142 patients who underwent coronary computed tomography angiography (CCTA) and intravascular ultra...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-015-3698-z

    authors: Park HB,Lee BK,Shin S,Heo R,Arsanjani R,Kitslaar PH,Broersen A,Dijkstra J,Ahn SG,Min JK,Chang HJ,Hong MK,Jang Y,Chung N

    更新日期:2015-10-01 00:00:00

  • Comparison of transient severe motion in gadoxetate disodium and gadopentetate dimeglumine-enhanced MRI: effect of modified breath-holding method.

    abstract:OBJECTIVES:To compare the occurrence of transient severe motion (TSM) between gadoxetate disodium- and gadopentetate dimeglumine-enhanced MRI and between gadoxetate disodium-enhanced MRI scans obtained with and without the application of a modified breath-holding technique. METHODS:We reviewed 80 patients who underwen...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-5070-y

    authors: Song JS,Choi EJ,Park EH,Lee JH

    更新日期:2018-03-01 00:00:00

  • Radiofrequency ablation for non-spinal osteoid osteomas in 557 patients.

    abstract:OBJECTIVES:To present the results of biopsy and computed tomography (CT) guided radiofrequency ablation (RFA) for non-spinal osteoid osteomas, and compare the results before and after procedural modifications. METHODS:We retrospectively studied 557 patients with non-spinal osteoid osteomas treated with biopsy and CT-g...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-011-2240-1

    authors: Rimondi E,Mavrogenis AF,Rossi G,Ciminari R,Malaguti C,Tranfaglia C,Vanel D,Ruggieri P

    更新日期:2012-01-01 00:00:00

  • Magnetic resonance imaging protocols for examination of the neurocranium at 3 T.

    abstract::The increasing availability of high-field (3 T) MR scanners requires adapting and optimizing clinical imaging protocols to exploit the theoretically higher signal-to-noise ratio (SNR) of the higher field strength. Our aim was to establish reliable and stable protocols meeting the clinical demands for imaging the neuro...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-003-1984-7

    authors: Schwindt W,Kugel H,Bachmann R,Kloska S,Allkemper T,Maintz D,Pfleiderer B,Tombach B,Heindel W

    更新日期:2003-09-01 00:00:00

  • Tuberous sclerosis: diffusion MRI findings in the brain.

    abstract::Diffusion MRI has mainly been used for detection of acute ischemia, and for distinction of cytotoxic and vasogenic edema. We applied diffusion MRI in patients with tuberous sclerosis in order to evaluate diffusion imaging characteristics of parenchymal changes. Five children with known tuberous sclerosis were included...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300101029

    authors: Sener RN

    更新日期:2002-01-01 00:00:00

  • Percutaneous thrombectomy: a review.

    abstract::Percutaneous thrombectomy (PT) is an established technique for the removal of acute thrombus in occluded arteries, veins and vascular grafts. Percutaneous thrombectomy can be used as an adjunctive treatment to other methods of thrombus removal such as thrombolysis or as sole therapy. The two main methods are percutane...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s003300101014

    authors: Morgan R,Belli AM

    更新日期:2002-01-01 00:00:00

  • Cardiac MRI in pulmonary artery hypertension: correlations between morphological and functional parameters and invasive measurements.

    abstract:OBJECTIVE:To compare cardiac MRI with right heart catheterisation in patients with pulmonary hypertension (PH) and to evaluate its ability to assess PH severity. MATERIALS AND METHODS:Forty patients were included. MRI included cine and phase-contrast sequences, study of ventricular function, cardiac cavity areas and r...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-009-1664-3

    authors: Alunni JP,Degano B,Arnaud C,Tétu L,Blot-Soulétie N,Didier A,Otal P,Rousseau H,Chabbert V

    更新日期:2010-05-01 00:00:00

  • Quantitative parameters of CT texture analysis as potential markersfor early prediction of spontaneous intracranial hemorrhage enlargement.

    abstract:OBJECTIVE:To objectively quantify intracranial hematoma (ICH) enlargement by analysing the image texture of head CT scans and to provide objective and quantitative imaging parameters for predicting early hematoma enlargement. METHODS:We retrospectively studied 108 ICH patients with baseline non-contrast computed tomog...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-018-5364-8

    authors: Shen Q,Shan Y,Hu Z,Chen W,Yang B,Han J,Huang Y,Xu W,Feng Z

    更新日期:2018-10-01 00:00:00

  • Efficacy of contrast-enhanced FDG PET/CT in patients awaiting liver transplantation with rising alpha-fetoprotein after bridge therapy of hepatocellular carcinoma.

    abstract:OBJECTIVE:To assess the diagnostic accuracy and illustrate positive findings of contrast-enhanced fluorine-18 fluoro-D-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) image in patients awaiting liver transplantation (LT) with rising alpha-fetoprotein (AFP) after bridge therapy of hepatocellula...

    journal_title:European radiology

    pub_type: 杂志文章,多中心研究

    doi:10.1007/s00330-018-5425-z

    authors: Refaat R,Basha MAA,Hassan MS,Hussein RS,El Sammak AA,El Sammak DAEA,Radwan MHS,Awad NM,Saad El-Din SA,Elkholy E,Ibrahim DRD,Saleh SA,Montasser IF,Said H

    更新日期:2018-12-01 00:00:00

  • Effective dose in Albanian direct chest fluoroscopy.

    abstract::In the absence of reliable supplies of X-ray film, direct fluoroscopy is still extensively used in Albania, with chest radiology a particularly common application. This paper aims to quantify both patient skin dose and the risk-related quantity effective dose for direct fluoroscopy units based in seven different Alban...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s003300000462

    authors: Marshall NW,Shehu G,Marsh D,Faulkner K,Malone J,Dewhurst K

    更新日期:2001-01-01 00:00:00

  • MRI of the rectum: non-neoplastic disease.

    abstract::The rectum has become the most successful area of the gastrointestinal tract to be studied with MRI. Its anatomical location, fixed in the pelvic fat, and its lack of peristalsis, make it an ideal organ to be scanned with MRI. In addition, MRI allows a direct sagittal and coronal display, of key importance to colorect...

    journal_title:European radiology

    pub_type: 杂志文章,评审

    doi:10.1007/s003300050328

    authors: Paley MR,Ros PR

    更新日期:1998-01-01 00:00:00

  • Chemoembolisation for hepatocellular carcinoma with bile duct invasion: is preprocedural biliary drainage mandatory?

    abstract:PURPOSE:To determine the necessity of preprocedural biliary drainage prior to chemoembolisation for hepatocellular carcinoma (HCC) with bile duct invasion. MATERIALS AND METHODS:The study included 52 patients who received chemoembolisation for unresectable HCC invading bile duct and causing hyperbilirubinemia (>3 mg/d...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-017-5110-7

    authors: Park J,Kim HC,Lee JH,Cho E,Kim M,Hur S,Jae HJ,Lee M,Chung JW

    更新日期:2018-04-01 00:00:00

  • Assessment and treatment planning of lateral intracranial dural arteriovenous fistulas in 3 T MRI and DSA: A detailed analysis under consideration of time-resolved imaging of contrast kinetics (TRICKS) and ce-MRA sequences.

    abstract:OBJECTIVES:The current gold standard in the assessment of lateral intracranial dural arteriovenous fistulas (LDAVF) is digital subtraction angiography (DSA). However, magnetic resonance imaging (MRI) is a non-invasive emerging tool for the evaluation of such lesions. The aim of our study was to compare the DSA to our 3...

    journal_title:European radiology

    pub_type: 杂志文章

    doi:10.1007/s00330-016-4335-1

    authors: Ertl L,Brückmann H,Kunz M,Patzig M,Brem C,Forbrig R,Fesl G

    更新日期:2016-12-01 00:00:00