Abstract：
BACKGROUND AND OBJECTIVE:Endothelial dysfunction in diabetes mellitus (DM) is an important factor in the pathogenesis of micro and macrovascular complications. We aimed to measure soluble endothelial protein C receptor (sEPCR) and high sensitivity C reactive protein (hsCRP) levels as markers of endothelial damage in both types of diabetes mellitus and to determine if they can be used as predictors of vascular complications. METHODS:Fifty patients with DM, 20 with type 1 and 30 with type 2 as well as 30 healthy subjects were included. All were subjected to measurement of sEPCR and hsCRP by enzyme linked immunosorbent assay. RESULTS:sEPCR and hsCRP were significantly increased when compared to the control group in both types of DM. sEPCR was a significant predictor of macrovascular complications and thrombosis in type 1 p=0.02, and p=0.015, respectively. hsCRP was a significant predictor of macrovascular complications in type 2 p=0.04. CONCLUSION:Patients with type 1 and type 2 DM exhibit higher sEPCR and hsCRP levels compared to healthy controls which suggesting endothelial damage. sEPCR could be used as a predictor of macrovascular complications and thrombosis in type 1 DM, whereas, hsCRP might be used as a predictor of macrovascular complications in type 2 DM.
journal_name
Diabetes Res Clin Practjournal_title
Diabetes research and clinical practiceauthors
Zaghloul A,Al-Bukhari TA,Al-Pakistani HA,Shalaby M,Halawani SH,Bajuaifer N,Teama SHdoi
10.1016/j.diabres.2014.09.007subject
Has Abstractpub_date
2014-12-01 00:00:00pages
597-604issue
3eissn
0168-8227issn
1872-8227pii
S0168-8227(14)00407-0journal_volume
106pub_type
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journal_title：Diabetes research and clinical practice
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