Abstract:
:Significantly lower concentrations of norepinephrine were observed in whole brain and hypothalamus of pups exposed to ethanol pre- and post-natally as compared to controls. Dopamine levels were found to be unaltered in whole brain compared to controls although hypothalamus and corpus striatum demonstrated a decreased concentration in the experimental animals exposed to ethanol. The reduced levels of these neurotransmitters observed in the hypothalamus could reflect a direct damage to norepinephrine neurons by pre- or post-natal exposure to ethanol. However, depressed dopamine levels in the corpus striatum indicate additional injury to dopamine neurons. Alternatively, a modulatory interaction between norepinephrinergic and dopaminergic systems may be operative in these offspring. The changes observed in catecholamines could not be explained by a single and simple mode of ethanol action in the developing rat.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Detering N,Collins R,Hawkins RL,Ozand PT,Karahasan AMdoi
10.1007/978-1-4757-1419-7_75subject
Has Abstractpub_date
1980-01-01 00:00:00pages
721-7eissn
0065-2598issn
2214-8019journal_volume
132pub_type
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