Correlation of in vitro activities of cephalothin and ceftazidime with their efficacies in the treatment of Staphylococcus aureus endocarditis in rabbits.

abstract：:Susceptibility tests using 7 antimicrobial agents (carbenicillin, chloramphenicol, clindamycin, penicillin, cephalothin, metronidazole, and tetracycline) were run against 35 anaerobes including Bacteroides fragilis (17), other gram-negative bacilli (7), clostridia (5), peptococci (4), and eubacteria (2). Results in tr...

journal_title：Antimicrobial agents and chemotherapy

authors： Rosenblatt JE,Murray PR,Sonnenwirth AC,Joyce JL

更新日期：1979-03-01 00:00:00

abstract：:We designed, synthesized, and characterized a novel nucleoside analog, (1S,3S,5S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-5-hydroxy-1-(hydroxymethyl)-2-methylene-cyclopentanecarbonitrile, or 4'-cyano-methylenecarbocyclic-2'-deoxyguanosine (CMCdG), and evaluated its anti-hepatitis B virus (anti-HBV) activity, safet...

journal_title：Antimicrobial agents and chemotherapy

authors： Higashi-Kuwata N,Hayashi S,Das D,Kohgo S,Murakami S,Hattori SI,Imoto S,Venzon DJ,Singh K,Sarafianos SG,Tanaka Y,Mitsuya H

更新日期：2019-03-27 00:00:00

abstract：:The microbicidal efficacies of two anionic surfactants, sodium lauryl sulfate (SLS) and n-lauroylsarcosine (LS), were evaluated in cultured cells and in a murine model of herpes simplex type 2 (HSV-2) intravaginal infection. In vitro studies showed that SLS and LS were potent inhibitors of the infectivity of HSV-2 str...

journal_title：Antimicrobial agents and chemotherapy

authors： Roy S,Gourde P,Piret J,Désormeaux A,Lamontagne J,Haineault C,Omar RF,Bergeron MG

更新日期：2001-06-01 00:00:00

abstract：:There is a high prevalence of beta-lactam- and macrolide-resistant Streptococcus pneumoniae in Taiwan. To understand the in vitro susceptibilities of recent isolates of S. pneumoniae to fluoroquinolones and telithromycin (which is not available in Taiwan), the MICs of 23 antimicrobial agents for 936 clinical isolates ...

journal_title：Antimicrobial agents and chemotherapy

authors： Hsueh PR,Teng LJ,Wu TL,Yang D,Huang WK,Shyr JM,Chuang YC,Wan JH,Yan JJ,Lu JJ,Wu JJ,Ko WC,Chang FY,Yang YC,Lau YJ,Liu YC,Lee CM,Leu HS,Liu CY,Luh KT,SMART Program 2001 Data.

更新日期：2003-07-01 00:00:00

abstract：:In this study, a chromosomally encoded putative drug efflux pump of the SMR family, named AbeS, from a multidrug-resistant strain of Acinetobacter baumannii was characterized to elucidate its role in antimicrobial resistance. Expression of the cloned abeS gene in hypersensitive Escherichia coli host KAM32 resulted in ...

journal_title：Antimicrobial agents and chemotherapy

authors： Srinivasan VB,Rajamohan G,Gebreyes WA

更新日期：2009-12-01 00:00:00

abstract：:Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae isolates have been increasingly reported worldwide, and therapeutic options to treat infections caused by these organisms are limited. We evaluated the activity of ceftazidime-avibactam and comparators against 456 Enterobacteriaceae isolates carryi...

journal_title：Antimicrobial agents and chemotherapy

authors： Castanheira M,Mendes RE,Sader HS

更新日期：2017-02-23 00:00:00

abstract：:Increases in community-acquired infections caused by extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae have important implications for hospital infection control and empirical antibiotic therapy protocols. We developed and validated a tool for identifying patients harboring these organisms at hospital ...

journal_title：Antimicrobial agents and chemotherapy

authors： Tumbarello M,Trecarichi EM,Bassetti M,De Rosa FG,Spanu T,Di Meco E,Losito AR,Parisini A,Pagani N,Cauda R

更新日期：2011-07-01 00:00:00

abstract：:The in vitro activities of ACH-702 and other antimicrobials against 30 Nocardia brasiliensis isolates were tested. The MIC(50) (MIC for 50% of the strains tested) and MIC(90) values of ACH-702 were 0.125 and 0.5 microg/ml. The same values for econazole were 2 and 4 microg/ml. The MIC(50) and MIC(90) values of imipenem...

journal_title：Antimicrobial agents and chemotherapy

authors： Vera-Cabrera L,Campos-Rivera MP,Escalante-Fuentes WG,Pucci MJ,Ocampo-Candiani J,Welsh O

更新日期：2010-05-01 00:00:00

abstract：:Given that tedizolid exhibits substantial lung penetration, we hypothesize that it could achieve good efficacy against Streptococcus pneumoniae lung infections. We evaluated the pharmacodynamics of tedizolid for treatment of S. pneumoniae lung infections and compared the efficacies of tedizolid human-simulated epithel...

journal_title：Antimicrobial agents and chemotherapy

authors： Abdelraouf K,Nicolau DP

更新日期：2016-12-27 00:00:00

abstract：:Miconazole, a broad-spectrum antimycotic agent with some antibacterial activity, has recently become available for experimental parenteral use in the United States. Its efficacy as an anticandidal drug was tested in adult Wistar rats. A previously established infectious dose of 5 x 10(6)Candida albicans was intravenou...

journal_title：Antimicrobial agents and chemotherapy

authors： Balk MW,Crumrine MH,Fischer GW

更新日期：1978-02-01 00:00:00

abstract：:A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Schoenknecht FD,Shadomy S,Sherris JC,Thornsberry C,Washington JA,Kammer RB

更新日期：1979-01-01 00:00:00

abstract：:The in vitro activities of extracts of Nigerian chewing sticks against Bacteroides gingivalis and B. melaninogenicus are presented. The greatest inhibitory action was produced by Serindeia werneckei, whereas Fagara zanthoxyloides produced no appreciable inhibitory effect. A generally good correlation was found between...

journal_title：Antimicrobial agents and chemotherapy

authors： Rotimi VO,Laughon BE,Bartlett JG,Mosadomi HA

更新日期：1988-04-01 00:00:00

abstract：:We passaged cells expressing TEM-1 and TEM-12 from a single plasmid through either ampicillin or ceftazidime. We found that the combined effects of recombination and selection removed the bla(TEM-1) allele from the bacterial population when it was passaged through ceftazidime or the bla(TEM-12) allele when cultures we...

journal_title：Antimicrobial agents and chemotherapy

authors： Mroczkowska JE,Barlow M

更新日期：2008-09-01 00:00:00

abstract：:Resistance to macrolides and ketolides occurs mainly via alterations in RNA moieties of the drug-binding site. Using an A2058G mutant of Mycobacterium smegmatis, additional telithromycin resistance was acquired via deletion of 15 residues from protein L22. Molecular modeling, based on the crystal structure of the larg...

journal_title：Antimicrobial agents and chemotherapy

authors： Berisio R,Corti N,Pfister P,Yonath A,Böttger EC

更新日期：2006-11-01 00:00:00

abstract：:The assembly of hepatitis B virus (HBV) core protein (HBc) into capsids represents a critical step of viral replication. HBc has multiple functions during the HBV life cycle, which makes it an attractive target for antiviral therapies. Capsid assembly modulators (CAMs) induce the formation of empty capsid or aberrant ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lahlali T,Berke JM,Vergauwen K,Foca A,Vandyck K,Pauwels F,Zoulim F,Durantel D

更新日期：2018-09-24 00:00:00

abstract：:The macrolide resistance gene erm(T) was identified for the first time in a porcine Erysipelothrix rhusiopathiae isolate from swine in China. The novel 3,749-bp small plasmid pER29, which carries erm(T), had a G+C content of 31% and four distinct open reading frames. The presence of pER29 increased by at least 128-fol...

journal_title：Antimicrobial agents and chemotherapy

authors： Xu CW,Zhang AY,Yang CM,Pan Y,Guan ZB,Lei CW,Peng LY,Li QZ,Wang HN

更新日期：2015-04-01 00:00:00

abstract：:A woman in her late 60s with disseminated histoplasmosis was treated with posaconazole because first-line therapies were not tolerated. She subsequently presented with decompensated heart failure, hypertension, and hypokalemia. Laboratory tests revealed low renin and aldosterone levels. A potential mechanism is inhibi...

journal_title：Antimicrobial agents and chemotherapy

authors： Kuriakose K,Nesbitt WJ,Greene M,Harris B

更新日期：2018-04-26 00:00:00

abstract：:Medicinal herbs may cause clinically relevant drug interactions with antiretroviral agents. Ginkgo biloba extract is a popular herbal product among HIV-infected patients because of its positive effects on cognitive function. Raltegravir, an HIV integrase inhibitor, is increasingly being used as part of combined antire...

journal_title：Antimicrobial agents and chemotherapy

authors： Blonk M,Colbers A,Poirters A,Schouwenberg B,Burger D

更新日期：2012-10-01 00:00:00

abstract：:The in vivo efficacy of ciprofloxacin or pefloxacin alone or in combination with fosfomycin was evaluated in experimental aortic valve endocarditis induced in 133 rabbits by a multidrug-susceptible or multidrug-resistant strain of Pseudomonas aeruginosa. Therapy was initiated early (12 h after infection), when bacteri...

journal_title：Antimicrobial agents and chemotherapy

authors： Xiong YQ,Potel G,Caillon J,Stephant G,Jehl F,Bugnon D,Le Conte P,Baron D,Drugeon H

更新日期：1995-02-01 00:00:00

abstract：:Mycobacterium simiae is a rare species of slow-growing nontuberculous mycobacteria (NTM). From 2002 to 2017, we conducted a retrospective study that included all patients with NTM-positive respiratory samples detected in two university hospitals of the French overseas department of Reunion Island. We recorded the prev...

journal_title：Antimicrobial agents and chemotherapy

authors： Coolen-Allou N,Touron T,Belmonte O,Gazaille V,Andre M,Allyn J,Picot S,Payet A,Veziris N

更新日期：2018-06-26 00:00:00

abstract：:We studied polymyxin B resistance in 10 pairs of clinical Acinetobacter baumannii isolates, two of which had developed polymyxin B resistance in vivo. All polymyxin B-resistant isolates had lower growth rates than and substitution mutations in the lpx or pmrB gene compared to their parent isolates. There were signific...

journal_title：Antimicrobial agents and chemotherapy

authors： Lim TP,Ong RT,Hon PY,Hawkey J,Holt KE,Koh TH,Leong ML,Teo JQ,Tan TY,Ng MM,Hsu LY

更新日期：2015-12-01 00:00:00

abstract：:Forty-one children <8 years of age treated for brucellosis with oral minocycline (2.5 mg/kg) twice daily for 3 weeks were recalled and examined to check for dental staining and defects. Dental staining and defects were found in 14 of 41 exposed children (34.1%) and in 30 of 82 matched controls (36.6%), respectively (P...

journal_title：Antimicrobial agents and chemotherapy

authors： Cascio A,Di Liberto C,D'Angelo M,Iaria C,Scarlata F,Titone L,Campisi G

更新日期：2004-07-01 00:00:00

abstract：:Treatment of Mycobacterium abscessus infections is extremely challenging due to its intrinsic resistance to most antibiotics, and research of pathogenesis is limited due to a lack of a practical in vivo model of infection. The objective of this study was to establish a simple in vivo model for M. abscessus infection, ...

journal_title：Antimicrobial agents and chemotherapy

authors： Meir M,Grosfeld T,Barkan D

更新日期：2018-03-27 00:00:00

abstract：:MICs of 25 Abiotrophia defectiva and 109 Granulicatella adiacens isolates were determined by broth microdilution. Using CLSI breakpoints, the susceptibilities of A. defectiva and G. adiacens isolates were, respectively, 24% and 34% to penicillin, 92% and 22% to ceftriaxone, 48% and 3% to cefepime, 72% and 87% to merop...

journal_title：Antimicrobial agents and chemotherapy

authors： Mushtaq A,Greenwood-Quaintance KE,Cole NC,Kohner PC,Ihde SM,Strand GJ,Harper LW,Virk A,Patel R

更新日期：2016-07-22 00:00:00

abstract：:The activities of sparfloxacin, azithromycin, temafloxacin, and rifapentine against two virulent strains of the Mycobacterium avium complex isolated from patients with AIDS were evaluated in a model of intracellular infection and were compared with that of clarithromycin. Human monocyte-derived macrophages were infect...

journal_title：Antimicrobial agents and chemotherapy

authors： Perronne C,Gikas A,Truffot-Pernot C,Grosset J,Vilde JL,Pocidalo JJ

更新日期：1991-07-01 00:00:00

abstract：:Lethal mutagenesis is an antiviral approach that consists in extinguishing a virus by an excess of mutations acquired during replication in the presence of a mutagenic agent, often a nucleotide analogue. One of its advantages is its broad spectrum nature that renders the strategy potentially effective against emergent...

journal_title：Antimicrobial agents and chemotherapy

authors： Gallego I,Soria ME,Gregori J,de Ávila AI,García-Crespo C,Moreno E,Gadea I,Esteban J,Fernández-Roblas R,Esteban JI,Gómez J,Quer J,Domingo E,Perales C

更新日期：2019-09-30 00:00:00

abstract：:BAL5788 is the water-soluble prodrug of BAL9141, a novel broad-spectrum cephalosporin with potent bactericidal activities against methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae. We investigated the safety and pharmacokinetics of BAL5788 in a double-blind, single-as...

journal_title：Antimicrobial agents and chemotherapy

authors： Schmitt-Hoffmann A,Roos B,Schleimer M,Sauer J,Man A,Nashed N,Brown T,Perez A,Weidekamm E,Kovács P

更新日期：2004-07-01 00:00:00

abstract：:The current voriconazole dosing recommendation in adolescents is based on limited efficacy and pharmacokinetic data. To confirm the appropriateness of dosing adolescents like adults, a pharmacokinetic study was conducted in 26 immunocompromised adolescents aged 12 to <17 years following intravenous (IV) voriconazole t...

journal_title：Antimicrobial agents and chemotherapy

authors： Driscoll TA,Frangoul H,Nemecek ER,Murphey DK,Yu LC,Blumer J,Krance RA,Baruch A,Liu P

更新日期：2011-12-01 00:00:00

abstract：:Azithromycin concentrations in the tonsils of 56 pediatric patients, treated with 10 or 20 mg of the drug per kg of body weight for 3 days, were compared. Azithromycin levels in plasma and tonsil samples were determined up to 8.5 days after the last dose. The 20-mg/kg regimen resulted in an improved tonsillar distribu...

journal_title：Antimicrobial agents and chemotherapy

authors： Blandizzi C,Malizia T,Batoni G,Ghelardi E,Baschiera F,Bruschini P,Senesi S,Campa M,Del Tacca M

更新日期：2002-05-01 00:00:00

abstract：:Novel antibiotics approved by noninferiority trials may become less effective over time in two scenarios: (i) the treatment effect in studies of novel antibiotics may be consistently worse than studies of older antibiotics; (ii) when a decreasingly effective control arm is used in a series of noninferiority trials. Ou...

journal_title：Antimicrobial agents and chemotherapy

authors： Bai AD,Komorowski AS,Lo CKL,Tandon P,Li XX,Mokashi V,Cvetkovic A,Findlater A,Liang L,Loeb M,Mertz D

更新日期：2020-10-20 00:00:00