Abstract：
:Experimental data suggesting that oxygen-derived free radicals may play a role in the myocardial injury associated with ischemia and reperfusion are presented. In several studies of prolonged global myocardial ischemia, the administration of free radical scavenging agents, such as superoxide dismutase, catalase, and mannitol, resulted in significantly better recovery of left ventricular function following reperfusion. In a region-at-risk model of localized myocardial ischemia, both superoxide dismutase and allopurinol significantly reduced the extent of myocardial necrosis that developed following reversible coronary arterial branch occlusion. The manner in which oxygen-derived free radicals may be harmful is examined. In particular, the possibility that these toxic species are involved in the exacerbation of the ischemic injury that develops upon reflow and reoxygenation is examined.
journal_name
Surgeryjournal_title
Surgeryauthors
Gardner TJ,Stewart JR,Casale AS,Downey JM,Chambers DEsubject
Has Abstractpub_date
1983-09-01 00:00:00pages
423-7issue
3eissn
0039-6060issn
1532-7361pii
0039-6060(83)90035-1journal_volume
94pub_type
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