Metronidazole v. cefoxitin in severe appendicitis--a trial to compare a single intraoperative dose of two antibiotics given intravenously.

Abstract:

:In severe appendicitis, the effect of a single intravenous dose of metronidazole (500 mg) was compared with cefoxitin (1 g). The antibiotics were given by random allocation once the diagnosis had been established at operation. In the metronidazole group, 5 out of 48 patients developed a wound infection whilst in hospital compared with 13 out of 48 in the cefoxitin group (P = 0.036). However, 57% of wound infections became apparent after the patient went home and the overall infection rates were similar. The mean length of postoperative hospital stay was 5.0 days in the metronidazole group and 6.8 days in the cefoxitin group (P = 0.052), but of those who did develop a wound infection, the length of stay was almost double in the cefoxitin group. Anaerobic organisms were cultured from the wound in 7 out of 15 patients who received cefoxitin but in none of 5 patients in the metronidazole group. Whilst metronidazole only delayed the discharge of pus from the wound, it did seem to reduce the severity of infection. Cefoxitin appeared to be less effective, given as a single intravenous injection at a dose of 1 g.

journal_name

Postgrad Med J

authors

Corder AP,Bates T,Prior JE,Harrison M,Donaldson PJ

doi

10.1136/pgmj.59.697.720

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

720-3

issue

697

eissn

0032-5473

issn

1469-0756

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验
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    journal_title:Postgraduate medical journal

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Church JJ

    更新日期:1983-01-01 00:00:00

  • Cerebral neoplastic angioendotheleosis complicated by hypercalcaemia.

    abstract::This is a case report of a 67 year old man who presented with a fluctuating level of consciousness and myoclonic jerks caused in part by hypercalcaemia. The diagnosis of cerebral neoplastic angioendotheleosis was only made later on brain biopsy and is the first report of the occurrence of hypercalcaemia in neoplastic ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.67.788.571

    authors: Wierzbicki AS,Gibbs JM,Lidov HG,Lolin Y,Thomas PK

    更新日期:1991-06-01 00:00:00

  • Primary meningococcal pericarditis with tamponade.

    abstract::A case of primary purulent meningococcal pericarditis presenting with chest pain, hypotension and cardiac tamponade followed by oliguric renal failure is reported. Treatment with antibiotics and surgical drainage was successful. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.722.1067

    authors: Ramsdale DR,Kaul TK,Coulshed N

    更新日期:1985-12-01 00:00:00

  • Prevalence and characteristics in coding, classification and diagnosis of diabetes in primary care.

    abstract:INTRODUCTION:Approximately 366 million people worldwide live with diabetes and this figure is expected to rise. Among the correct diagnosis, there will be errors in the diagnosis, classification and coding, resulting in adverse health and financial implications. AIM:To determine the prevalence and characteristics of d...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,多中心研究

    doi:10.1136/postgradmedj-2013-132068

    authors: Seidu S,Davies MJ,Mostafa S,de Lusignan S,Khunti K

    更新日期:2014-01-01 00:00:00

  • Improving residents' clinical approach to obesity: impact of a multidisciplinary didactic curriculum.

    abstract:BACKGROUND/OBJECTIVES:Obesity has been declared a 21st century pandemic by WHO. Yet surveys reveal physicians-in-training are uncomfortable managing obesity. One major barrier is the lack of residency education on obesity management. This study incorporates an obesity-specific didactic curriculum into an internal medic...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/postgradmedj-2014-132821

    authors: Acosta A,Azzalin A,Emmons CJ,Shuster JJ,Jay M,Lo MC

    更新日期:2014-11-01 00:00:00

  • Non-Hodgkin's lymphoma presenting as 'chronic active toxoplasmosis'.

    abstract::We report the case of a 58 year old man in whom an unusually prolonged infection with Toxoplasma gondii was the presenting feature of an underlying non-Hodgkin's lymphoma. This case demonstrates the particular usefulness of the IgM ELISA test in monitoring disease activity. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.64.757.883

    authors: Dudley NJ,Balfour AH

    更新日期:1988-11-01 00:00:00

  • An aggressive intrasinusoidal lymphoma presenting with marked systemic disturbance but normal imaging studies.

    abstract::A patient with an aggressive intrasinusoidal non-Hodgkins lymphoma, presenting with marked systemic disturbance but only a mildly raised alkaline phosphatase as a localising sign is described. All imaging studies of the liver were normal and the diagnosis was delayed until a percutaneous liver biopsy was performed. On...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.76.892.103

    authors: Camidge R,Ong E,Lucraft H

    更新日期:2000-02-01 00:00:00

  • Macrocytic anaemia due to copper deficiency in a patient with late onset hypogammaglobulinaemia.

    abstract::Very few cases of acquired severe copper deficiency have been described. The principal effects are haematological, but the precise abnormalities are uncertain due to the possible association of other deficiencies. A case of isolated severe copper deficiency associated with late onset hypogammaglobulinaemia is reported...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.63.737.205

    authors: Oppenheimer SM,Hoffbrand BI,Dormandy TL,Parker N,Wickens DG

    更新日期:1987-03-01 00:00:00

  • Strangulated femoral hernia: the persisting clinical trap.

    abstract::Five cases of strangulated femoral hernia, all with a delay in establishing the diagnosis, are reported here. These cases illustrate the continuing difficulties experienced, both in primary care and hospital practice, in making this diagnosis despite the clinical awareness of this condition. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.67.783.57

    authors: Heys SD,Brittenden J

    更新日期:1991-01-01 00:00:00

  • Investigation of cereal toxicity in coeliac disease.

    abstract::Coeliac disease is exacerbated by wheat gluten. A review of methods for the purification, identification and quantitation of wheat proteins to investigate coeliac disease is presented. Recent developments including amino acid sequencing and expression of wheat protein peptides in E. coli should permit characterization...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.63.743.767

    authors: Ciclitira PJ,Ellis HJ

    更新日期:1987-09-01 00:00:00

  • Bilateral superselective arterial microcoil embolisation in delayed post-traumatic high flow priapism.

    abstract::High flow arteriogenic priapism is uncommon and usually occurs after trauma to the genitoperineal area. The onset of prolonged erection can be delayed and is often relatively pain free. Arteriography in this case illustrated the causative bilateral arteriocavernosal fistulae and pseudoaneurysms. Treatment consisted of...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pmj.77.905.193

    authors: Gujral S,MacDonagh RP,Cavanagh PM

    更新日期:2001-03-01 00:00:00

  • Successful treatment with ketoconazole of Cushing's syndrome in pregnancy.

    abstract::Patients with Cushing's syndrome rarely become pregnant. This is a high risk situation both for the fetus and the mother, if untreated. We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.66.773.221

    authors: Amado JA,Pesquera C,Gonzalez EM,Otero M,Freijanes J,Alvarez A

    更新日期:1990-03-01 00:00:00

  • Pancreatic ketoacidosis: ketonemia associated with acute pancreatitis.

    abstract::Ketonaemia is well documented as a consequence of prolonged starvation, acute alcoholism, and uncontrolled diabetes mellitus. However, its occurrence in acute pancreatitis has not been described. In this report, three patients who manifested ketoacidosis at the time of presentation of acute pancreatitis are described....

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.71.831.32

    authors: Kabadi UM

    更新日期:1995-01-01 00:00:00

  • Views of specialist registrars on specialty care in the community: employment prospects and the need for additional training.

    abstract:AIM:To obtain the views of specialist registrars on specialty care in the community. METHOD:Specialist registrars from five Deaneries in England completed an online questionnaire about their views on employment prospects, the role of specialty care in the community, and the need for additional training in this area. ...

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    doi:10.1136/pgmj.2006.054320

    authors: Azam N,Moshkovska T,Mayberry JF

    更新日期:2007-01-01 00:00:00

  • Assessing the use of magnetic resonance imaging virtopsy as an alternative to autopsy: a systematic review and meta-analysis.

    abstract:BACKGROUND:The post mortem examination or autopsy is a trusted method of identifying the cause of death. Patients and their families may oppose an autopsy for a variety of reasons, including fear of mutilation or owing to religious and personal beliefs. Imaging alternatives to autopsy have been explored, which may prov...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,meta分析,评审

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    authors: Ahmad MU,Sharif KA,Qayyum H,Ehsanullah B,Balyasnikova S,Wale A,Shanmuganandan A,Siddiqui MRS,Athanasiou T,Kemp GJ

    更新日期:2017-11-01 00:00:00

  • Localized fibrous mesothelioma of the mediastinum devoid of pleural connections.

    abstract::Localized fibrous mesothelioma of the pleura is an uncommon neoplasm. Very rarely (there have been three previous cases) it may occur as an isolated mediastinal tumour. Such a tumour was present for at least 3 years in a 47 year old man, causing shortness of breath and superior vena cava syndrome. A mass weighing over...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.65.768.788

    authors: Balassiano M,Reichert N,Rosenman Y,Hertcheg E,Lieberman Y,Yellin A

    更新日期:1989-10-01 00:00:00

  • COVID-19 in patients with heart failure: the new and the old epidemic.

    abstract::Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has spread in nearly 200 countries in less than 4 months since its first identification; accordingly, the coronavirus disease 2019 (COVID 2019) has affirmed itself as a clinical challenge. The prevalence of pre-existing cardiovascular diseases in patients wi...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2020-138080

    authors: Sisti N,Valente S,Mandoli GE,Santoro C,Sciaccaluga C,Franchi F,Cameli P,Mondillo S,Cameli M

    更新日期:2020-07-30 00:00:00

  • Subconjunctival haemorrhage: a feature of acute severe asthma.

    abstract::Bilateral subconjunctival haemorrhage was observed on 5 separate occasions in 4 patients presenting a fulminant form of acute severe asthma. Four of these episodes required ventilatory support. All patients recovered from their asthma attack after treatment with bronchodilators, corticosteroids, and oxygen. The incide...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.61.717.579

    authors: Rodriguez-Roisin R,Torres A,Agustí AG,Ussetti P,Agustí-Vidal A

    更新日期:1985-07-01 00:00:00

  • COX-2 inhibitors and the heart: are all coxibs the same?

    abstract::The selective COX-2 inhibitors (coxibs) were originally developed to minimise the adverse effects of conventional non-steroidal anti-inflammatory drugs (NSAIDs) while maintaining the same analgesic and anti-inflammatory properties. Many large studies confirmed the improved gastric side effect profile of coxibs compare...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.2005.042234

    authors: Sooriakumaran P

    更新日期:2006-04-01 00:00:00

  • Cardiovascular complications of cirrhosis.

    abstract::Cardiovascular complications of cirrhosis include cardiac dysfunction and abnormalities in the central, splanchnic and peripheral circulation, and haemodynamic changes caused by humoral and nervous dysregulation. Cirrhotic cardiomyopathy implies systolic and diastolic dysfunction and electrophysiological abnormalities...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/gut.2006.112177

    authors: Møller S,Henriksen JH

    更新日期:2009-01-01 00:00:00

  • Therapy of fungal infections of the central nervous system.

    abstract::Fungal infections of the central nervous system present a considerable challenge to available chemotherapy and other forms of treatment. The particular difficulties are discussed here, after an account of the fungi involved and their sensitivity to antifungal agents. Cryptococcal, coccidioidal and candidal infections ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.55.647.615

    authors: Speller DC

    更新日期:1979-09-01 00:00:00

  • General practice and social service partnership for better clinical outcomes, patient self efficacy and lifestyle behaviours of diabetic care: randomised control trial of a chronic care model.

    abstract:BACKGROUND:The International Diabetes Attitudes, Wishes, and Needs (DAWN) programmes have shown the existence of a critical gap in self management support and access to the support system. This study aims to evaluate the effectiveness of the diabetes mellitus (DM) self management programme, with partnership between gen...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/pgmj.2011.118885

    authors: Lee A,Siu CF,Leung KT,Lau LC,Chan CC,Wong KK

    更新日期:2011-10-01 00:00:00

  • Community-acquired pneumonia: doctors do not follow national guidelines.

    abstract:OBJECTIVES:Appropriate assessment of community-acquired pneumonia (CAP) allows accurate severity scoring and hence optimal management, leading to reduced morbidity and mortality. British Thoracic Society (BTS) guidelines provide an appropriate score. Adherence to BTS guidelines was assessed in our medical assessment un...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.056556

    authors: Collini P,Beadsworth M,Anson J,Neal T,Burnham P,Deegan P,Beeching N,Miller A

    更新日期:2007-08-01 00:00:00

  • Mycobacteria as a cause of infective exacerbation in bronchiectasis.

    abstract::In 91 patients with bronchiectasis seen over 6 years, a positive mycobacterial culture was obtained in 12 cases (13%). The organisms isolated were Mycobacterium tuberculosis in nine cases, Mycobacterium avium in two cases and Mycobacterium tuberculosis and chelonei were obtained on separate occasions in one case. Comp...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.68.805.896

    authors: Chan CH,Ho AK,Chan RC,Cheung H,Cheng AF

    更新日期:1992-11-01 00:00:00

  • Lobar collapse demystified: the chest radiograph with CT correlation.

    abstract::Collapse of a lobe of a lung is an important indicator of a range of conditions, including malignancy. Clinical symptoms and signs may suggest a diagnosis of lobar collapse; however, it is often diagnosed, and always needs to be confirmed, with radiological examination. The radiological signs may be subtle, difficult ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/postgradmedj-2011-130213

    authors: Mullett R,Jain A,Kotugodella S,Curtis J

    更新日期:2012-06-01 00:00:00

  • Antibiotic prescription for patients referred to a specialist breast clinic.

    abstract::Hospital referral is indicated as an emergency for breast infections not settling with oral antibiotics. Referrals to a breast clinic over a period of 6 months were assessed for prior antibiotic prescription. A total of 1078 patients were seen during this period. 91 (8%) patients had been prescribed antibiotics, 71% o...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.049296

    authors: Twine C,Gateley CA

    更新日期:2006-11-01 00:00:00

  • Perceptions of medical school graduates and students regarding their academic preparation to teach.

    abstract:PURPOSE:How medical students learn and develop the characteristics associated with good teaching in medicine is not well known. Information about this process can improve the academic preparation of medical students for teaching responsibilities. The purpose of this study was to determine how different experiences cont...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.2006.045393

    authors: Henry BW,Haworth JG,Hering P

    更新日期:2006-09-01 00:00:00

  • Massive haematemesis and melaena from a Meckel's diverticulum.

    abstract::A case of Meckel's diverticulum in a middle-aged man presenting acutely with haematemesis and melaena is reported. Such a presentation has not to our knowledge been previously reported in this age group. ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.59.698.786

    authors: Shaunak S,O'Donohue J

    更新日期:1983-12-01 00:00:00

  • Coagulation problems in human pregnancy.

    abstract::Coagulation problems in pregnancy are primarily associated with overactivity of the intrinsic clotting system. This accounts for the increased incidence of thrombo-embolism during pregnancy. Where specific obstetric complications cause clotting problems the common underlying feature is usually placental pathology as i...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章,评审

    doi:10.1136/pgmj.55.643.367

    authors: Redman CW

    更新日期:1979-05-01 00:00:00

  • Bone dysplasias and mental functioning.

    abstract::Fourteen patients suffering from various degrees of bone dysplasia and mental handicap with superimposed neuroses or psychotic episodes are reported. Known biochemical and chromosomal causes are noted. Mental states associated with syndromes and mental malfunctioning or impairment because of skeletal defects or other ...

    journal_title:Postgraduate medical journal

    pub_type: 杂志文章

    doi:10.1136/pgmj.53.622.458

    authors: Jancar J

    更新日期:1977-08-01 00:00:00