Abstract:
:In this study, we have compared a bioassay procedure with high-pressure liquid chromatography (HPLC) for the determination of metronidazole levels in serum and urine. Plasma and urine of volunteers with normal or impaired renal function were obtained at various intervals after a single intravenous dose of 500 mg metronidazole. In plasma of normal volunteers 30 hours after dosing, the bioassay gave results comparable to the total values of the parent compound plus metabolites. In patients with renal failure, the course of the plasma regression curve of metronidazole as measured by the bioassay procedure was intermediate between the values of metronidazole alone and the total values of parent compound plus metabolites. Recovery of metronidazole activity in urine, as determined by this bioassay method, was somewhat less than one half (in normal volunteers) to one quarter (in patients with renal failure) of metronidazole plus metabolites as measured by HPLC. These discrepancies might be explained by the lower antibacterial activity of the hydroxy (congruent to 40%) and acetic acid (congruent to 2%) metabolites as compared with that of the parent compound in the test system used.
journal_name
Surgeryjournal_title
Surgeryauthors
Turgeon PL,Dufresne LR,Ogilvie RI,Kreeft JHsubject
Has Abstractpub_date
1983-01-01 00:00:00pages
154-7issue
1 Pt 2eissn
0039-6060issn
1532-7361pii
0039-6060(83)90293-3journal_volume
93pub_type
杂志文章相关文献
SURGERY文献大全abstract::One hundred sixty patients had preoperative mediastinoscopy, resection of the primary tumor, and complete mediastinal lymphadenectomy for non-small-cell carcinoma of the lung. Minimum follow-up was 24 months (mean 40 months). Postoperative staging based on histologic examination of the specimen of the lung and mediast...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract::Complete axillary dissection was performed in 287 patients undergoing modified radical mastectomy between 1984 and 1987 to identify patterns of axillary node metastases, as well as discontinuous axillary node ("skip") metastases. Positive pathologic findings were compared with preoperative clinical examinations in 266...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1990-10-01 00:00:00
abstract::An evaluation of double isotope subtraction scanning with 201Tl and 99mTc was performed in 14 patients with primary hyperparathyroidism. Twelve of 13 adenomas and seven of seven hyperplastic glands were localized correctly by preoperative scanning. The technique appears useful for the identification of abnormal parath...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-12-01 00:00:00
abstract::Adrenal scintigraphy with 131I-6 beta-iodomethylnorcholesterol (NP-59) has been widely used to evaluate adrenal cortical tumors during the past 20 years. Unilateral visualization on the side of an adrenal tumor has been considered diagnostic of a benign adrenocortical adenoma in the patient with Cushing's syndrome. Bi...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract::A 5 MHz continuous-wave Doppler probe was used intraoperatively to evaluate 25 in situ saphenous vein bypass grafts. At least one arteriovenous fistula per case and five retained competent posterior valvular leaflets were identified before completion angiography. The Doppler was able to distinguish a retained valve fr...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Beta-cell destruction in type I diabetes mellitus results from a chronic autoimmune process. Exposure of thymic T cells to islet antigens during the prehyperglycemic phase of diabetes may alter the likelihood of autoimmune damage to beta cells in the native pancreas. Thus we evaluated whether prophylactic ma...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::In an experimental canine model of isolated and tandem arterial stenoses, noninvasive thigh and calf pressure measurements were evaluated against direct intra-arterial pressures. Under control circumstances, proximal iliac arterial stenosis, and high superficial femoral artery stenosis, the noninvasive measurements we...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::The inhibition of growth by adult human venous endothelial cells in culture forms the basis of a sensitive assay of glutaraldehyde (GA) concentration, valid between 0 and 5 parts per million. This cytotoxicity assay was used to measure residual (unbound) GA in commercial vascular prostheses of biologic origin followin...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract:BACKGROUND:Guidelines for management of small adrenal incidentalomas are mutually inconsistent. No cost-effectiveness analysis has been performed to evaluate rigorously the relative merits of these strategies. METHODS:We constructed a decision-analytic model to evaluate surveillance strategies for <4cm, nonfunctional,...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2017.07.030
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:In humans with chronic pancreatitis (CP), pancreatic interstitial pressure (IP) is elevated and pancreatic blood flow (PBF) is reduced. The efficacy of surgical decompression (SD) of the pancreatic duct (ie, pancreaticojejunostomy) is believed to be due to its ability to decrease IP and pancreatic vascular r...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-09-01 00:00:00
abstract:BACKGROUND:Gram-negative infections are a major cause of morbidity and death. Bactericidal permeability-increasing protein (BPI) is an endotoxin-neutralizing protein that also exhibits potent bactericidal activity. This study compared the efficacy of a 23 kd recombinant N-terminal fragment of BPI (rBPI23) with that of ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1993-08-01 00:00:00
abstract::Since 1966, 29 patients with recurrent carotid artery stenosis have been encountered. The mean (+/- SEM) internal between initial carotid endarterectomy and secondary presentation was 67.5 +/- 9.2 months (range 6 to 180 months). There was a disproportionate number of women with recurrent stenosis. The mean age at init...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-02-01 00:00:00
abstract:BACKGROUND:Lung injury in severe acute pancreatitis is mediated by infiltrating leukocytes. Our laboratory has previously demonstrated that acute lung injury in acute pancreatitis results in an up-regulation of vascular adhesion molecule-1 (VCAM-1) cell surface receptor expression on pulmonary vascular endothelium and ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2003.84
更新日期:2003-02-01 00:00:00
abstract::Studies on animals implicating reflux of bile salts in formation of "stress ulcer" often are suspect because of the inordinately high intragastric concentrations of bile salts used to induce experimental acute gastric mucosal damage. We studied reflux of bile salt in 11 patients after operation. Nine refluxed bile sal...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1976-07-01 00:00:00
abstract::Surgical trauma induces immunosuppression that may adversely influence survival. This study examined the effect of laparotomy on two different macrophage populations, peritoneal macrophages (PM phi) and Kupffer cells. Female, 6- to 8-week old, CFW/C3H-HeN mice (n = 160) were randomly allocated to one of three study gr...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1992-06-01 00:00:00
abstract::The multiple occurrence of squamous cell carcinoma is frequent in the upper aerodigestive tract (UADT). Risk factors not only for esophageal cancer, but also for multiple cancer in the UADT, were reviewed. Both cigarettes smoking and alcohol drinking are will known risk factors for esophageal cancer. The joint effect ...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:10.1067/msy.2002.119287
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Vocal cord paralysis is associated with extrathyroidal invasive malignancy. This study was performed to analyze the presentation of patients with invasive thyroid malignancy and to determine the preoperative symptomatic and radiographic correlates of vocal cord paralysis. METHODS:In a group of 365 consecuti...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.08.009
更新日期:2006-03-01 00:00:00
abstract::Oxygen delivery to random pattern and musculocutaneous flaps was investigated in a canine model. Oxygen tension was measured in the proximal and distal portions of each flap and in adjacent normal skin by means of a recently developed technique. The effect of delay techniques on tissue oxygen tension was also examined...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Liver resection is the only curative treatment offering a chance of long-term survival in patients with colorectal liver metastases (CRM). Recent data indicated that liver resection in patients with tumor progression while receiving chemotherapy was associated with poor outcome. The aim of the study was to i...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.02.004
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND:Although the effect of preoperative biliary drainage in patients with obstructive jaundice is controversial, bacterial or endotoxin translocation is one of the main postoperative problem in jaundiced patients. Failure in gut barrier functions causes bacterial translocation; homing and distribution of T lymph...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2004.02.001
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Identification of recurrent laryngeal nerve (RLN) has decreased the rates of permanent RLN palsy during thyroid operations; however, unexpected RLN palsy still occurs, even though the visual integrity was assured and most nerve injuries were not recognized intraoperatively. The aim of this study is to determ...
journal_title:Surgery
pub_type: 临床试验,杂志文章
doi:10.1016/j.surg.2008.02.006
更新日期:2008-06-01 00:00:00
abstract:BACKGROUND:The traditional tools to assess surgical capacity in low-income countries require significant amounts of time and resources, and have thus not been utilized systematically in this context. Proxy indicators have been suggested as a simpler tool to estimate surgical volume. The aim of this study was to assess ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2014.12.014
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:K-ras oncogene mutations have been identified in up to 95% of pancreatic cancers, implying their critical role in their molecular pathogenesis. However, the earliest stage in which K-ras mutations can be detected in potential precursor lesions of pancreatic cancer remains unclear. This study evaluates pancre...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(97)90181-1
更新日期:1997-01-01 00:00:00
abstract::Hypertriglyceridemia commonly accompanies clinical sepsis and may be caused by increased hepatic production or decreased clearance of triglyceride from the bloodstream. In contrast, enhanced lipid clearing capacity is usually seen after uncomplicated trauma. The purpose of the study was to determine the role of lipopr...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:The glial cell line-derived neurotrophic factor (GDNF) is a member of neurotrophic polypeptide family, which promotes survival and rescue of various neural cells in the central and peripheral nerve systems. We previously reported that GDNF promotes tumor cell invasion in pancreatic cancer cell lines. The pur...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.07.007
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:The existence of primary gastrinomas in lymph nodes continues to be controversial, because distinction from metastases from occult or regressed primary tumors may be difficult to exclude with certainty. If primary nodal gastrinomas do indeed occur, precursor neuroendocrine cells should be identifiable within...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(05)80100-x
更新日期:1995-12-01 00:00:00
abstract:BACKGROUND:The aim of the present study was to investigate whether the incidence of surgical site infection after pancreatoduodenectomy decreased after changing the prophylactic antibiotic to a third-generation cephalosporin in patients with unknown preoperative bile culture results after biliary drainage. METHODS:In ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.09.011
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:A laparoscopic approach to adrenalectomy has become the procedure of choice for most adrenal resections. We hypothesized that laparoscopic adrenalectomy is less likely to result in intensive care unit (ICU) level complications or death than open adrenalectomy, despite baseline comorbidity mix. METHODS:Using...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.08.020
更新日期:2012-12-01 00:00:00
abstract::Until recently, it was unclear whether calcium is more than a bystander in the development of acute pancreatitis. Now important evidence has been accumulated supporting a pivotal role of intracellular levels of calcium in the early pathogenesis of the disease. A sustained increase of cytosolic calcium concentrations, ...
journal_title:Surgery
pub_type: 杂志文章,评审
doi:10.1016/j.surg.2012.05.013
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:The "July phenomenon," a common belief in medical academia, refers to purported errors, inefficiency, and negative outcomes during the summertime transition of the house staff. We hypothesized that care in a trauma service is consistent throughout the year and that the July phenomenon therefore is a myth. M...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2001.116670
更新日期:2001-08-01 00:00:00