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Intranasal dexmedetomidine premedication reduces the minimum alveolar concentration of sevoflurane for tracheal intubation in children: a randomized trial.

Abstract：

STUDY OBJECTIVE:To determine the effects of dexmedetomidine premedication on the minimum alveolar concentration of sevoflurane for tracheal intubation (MACTI) in children. DESIGN:Prospective, randomized, clinical comparison study. SETTING:Operating room of an academic hospital. PATIENTS:90 pediatric, ASA physical status 1 patients, aged 3 to 7 years, scheduled for minor elective surgery. INTERVENTIONS:Patients were randomized to three groups to receive placebo, dexmedetomidine 1 μg/kg, or dexmedetomidine 2 μg/kg approximately 60 minutes before anesthesia. Anesthesia was induced with sevoflurane. Each concentration of sevoflurane for which a tracheal intubation was attempted was predetermined according to modification of the Dixon's up-and-down method, with 0.25% as a step size and held constant for at least 15 minutes before tracheal intubation. All responses ("movement" or "no movement") to tracheal intubation were assessed. MEASUREMENTS AND MAIN RESULTS:The MACTI of sevoflurane was 2.82% ± 0.17% in the control group, 2.26% ± 0.18% in the 1 μg/kg dexmedetomidine group, and 1.83% ± 0.16% in the 2 μg/kg dexmedetomidine group. Dexmedetomidine premedication (1 and 2 μg/kg) decreased the MACTI of sevoflurane by 20% and 35%, respectively. There were no clinically significant episodes of hypotension or bradycardia in any patients. CONCLUSION:Intranasal dexmedetomidine premedication produces a dose-dependent decrease in the concentration of sevoflurane needed for tracheal intubation in children.

journal_name

J Clin Anesth

journal_title

Journal of clinical anesthesia

authors

Yao Y,Qian B,Chen Y,Zhou L,Liu J

doi

10.1016/j.jclinane.2013.12.012

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

309-14

issue

4

eissn

0952-8180

issn

1873-4529

pii

S0952-8180(14)00059-2

journal_volume

26

pub_type

杂志文章,随机对照试验

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