Elevated urinary leukocyte esterase as a potential surrogate marker for HIV sexual transmission risks in men receiving antiretroviral therapy.

Abstract:

:Local genital tract inflammation stimulates leukocyte activity and causes HIV shedding, potentially increasing HIV sexual infectiousness. Although there are available clinical markers for genital tract inflammation, such as urinary leukocyte esterase, none have yet been examined in relation to HIV sexual risk behaviours. We sought to examine the association between urinary leukocyte esterase and sexual practices. Sexually active men living with HIV and receiving antiretroviral therapy (ART, N = 290) provided urine specimens and completed behavioural health assessments. HIV RNA tests and CD4 cell counts were abstracted from medical records. Urine specimens were analysed for leukocyte esterase using a standard point-of-care dipstick test. Thirty-one (10.6%) participants tested positive for leukocyte esterase. Logistic regression models did not indicate differences between men with elevated and un-elevated leukocyte activity on demographic, health, recent sexually transmitted infection symptoms and diagnoses or substance use. However, men with elevated leukocyte activity indicated significantly greater sexual behaviour in the previous three months, including more recent unprotected sexual intercourse. A simple over-the-counter urine test may serve as an indicator of sexual HIV infectiousness to inform further evaluation and treatment of genital tract inflammation, as well as condom use decisions during times of increased genital tract inflammation.

journal_name

Int J STD AIDS

authors

Kalichman SC,Washington C,Grebler T,Kalichman MO,Cherry C,Eaton L

doi

10.1177/0956462414536147

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

313-21

issue

5

eissn

0956-4624

issn

1758-1052

pii

0956462414536147

journal_volume

26

pub_type

杂志文章
  • The activity of candidate virucidal agents, low pH and genital secretions against HIV-1 in vitro.

    abstract::The effect of low pH, normally present in the female genital tract, on HIV viability was examined. HIV is more acid stable than previously reported with no substantial reduction in infectivity occurring until pH levels are reduced below 4.5. The virucidal activity of 3 topical spermicides and chlorhexidine was assesse...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/095646249500600409

    authors: O'Connor TJ,Kinchington D,Kangro HO,Jeffries DJ

    更新日期:1995-07-01 00:00:00

  • Phenytoin hypersensitivity syndrome masquerading as fever and systemic illness of unknown origin in an HIV-infected patient.

    abstract::A 32-year-old HIV-infected woman developed fever and systemic illness of unknown origin after being placed on phenytoin for seizures. Her clinical syndrome, skin biopsy findings, and clinical response to steroids were consistent with phenytoin hypersensitivity syndrome. ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/0956462053057648

    authors: Bedimo RJ,Geisler WM

    更新日期:2005-02-01 00:00:00

  • Management of sexually transmitted diseases in urban pharmacies in The Gambia.

    abstract::This study aimed to describe the quality and costs of sexually transmitted disease (STD) case management in urban pharmacies in The Gambia, and explore pharmacy workers' (PWs) willingness to improve the STD care they provide. PWs from 24 registered pharmacies were interviewed in order to collect information on their k...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/0956462011923471

    authors: Leiva A,Shaw M,Paine K,Manneh K,McAdam K,Mayaud P

    更新日期:2001-07-01 00:00:00

  • Causal links between binge drinking patterns, unsafe sex and HIV in South Africa: its time to intervene.

    abstract::South Africa has a massive burden of HIV and alcohol disease, and these pandemics are inextricably linked. Much evidence indicates that alcohol independently influences decisions around sex, and undermines skills for condom negotiation and correct use. Thus, not surprisingly, people with problem drinking in Africa hav...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,评审

    doi:10.1258/ijsa.2000.009432

    authors: Chersich MF,Rees HV

    更新日期:2010-01-01 00:00:00

  • Ritonavir- or cobicistat-boosted antiretroviral therapy and direct oral anticoagulants: A case for apixaban.

    abstract::The potential for drug-drug interactions (DDIs) between direct oral anticoagulants and antiretroviral therapy (ART) is vast. Ritonavir and cobicistat are used as pharmacokinetic enhancers with either concurrent protease inhibitors or the integrase strand transfer inhibitor, elvitegravir, to optimize therapeutic concen...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462419832099

    authors: Nisly SA,Stevens BN

    更新日期:2019-06-01 00:00:00

  • Joint effects of alcohol and stimulant use disorders on self-reported sexually transmitted infections in a prospective study of Cambodian female entertainment and sex workers.

    abstract::Female entertainment and sex workers (FESW) have high rates of alcohol and amphetamine-type stimulant (ATS) use, increasing risk for HIV/sexually transmitted infections (STI), and other negative outcomes. A prospective cohort of 1,198 FESW in a HIV/ATS use prevention intervention in Cambodia was assessed for alcohol a...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462420964647

    authors: Evans JL,Couture MC,Carrico A,Stein ES,Muth S,Phou M,Aynar L,Song N,Chhit S,Neak Y,Maher L,Page K

    更新日期:2020-12-13 00:00:00

  • Association of Trichomonas vaginalis with sociodemographic factors and other STDs among female inmates in Lisbon.

    abstract::A study on STDs was conducted among 211 female inmates in a prison in Lisbon, Portugal, in order to establish possible associations between Trichomonas vaginalis infection, sociodemographic factors and other STDs. T. vaginalis was found in 31.2% of the women, from whom only 65.1% presented symptoms. It was more freque...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/0956462041724235

    authors: Garcia A,Exposto F,Prieto E,Lopes M,Duarte A,Correia da Silva R

    更新日期:2004-09-01 00:00:00

  • PCR detection of Epstein-Barr virus, herpes simplex virus and human papillomavirus from the anal mucosa in HIV-seropositive and HIV-seronegative homosexual men.

    abstract::This study aimed to examine the prevalence of the Epstein-Barr virus (EBV), herpes simplex virus (HSV) and human papillomavirus (HPV) in the anal and oral mucosa of homosexual men with and without HIV infection and to correlate these findings to CD4+ count and anal cytology. Anal and oral cell samples from 20 HIV-infe...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/0956462991914762

    authors: Löwhagen GB,Bergbrant IM,Bergström T,Ryd W,Voog E

    更新日期:1999-09-01 00:00:00

  • Improved injection network ascertainment with supplementary elicitation techniques.

    abstract::Prior research indicates that injection drug users forget substantial proportions of their injection partners when asked to recall them. Such under-reporting hampers both ascertainment of the injection networks that underlie transmission of blood-borne pathogens and contact-tracing efforts for disease control. We repo...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/ijsa.2007.007167

    authors: Brewer DD,Hagan H,Hough ES

    更新日期:2008-03-01 00:00:00

  • Vaginal shedding of hepatitis C virus.

    abstract::A group of 14 women infected with hepatitis C virus (HCV) was evaluated for vaginal shedding of the virus. The HCV-RNA detection was performed in plasma, peripheral blood mononuclear cells (PBMC) and in supernatant and pellet of vaginal washings. HCV-RNA positive results were obtained in all plasma samples, in 57% of ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/0956462011924209

    authors: Gameiro R,Venneno T,Prieto E,Castro R,Carnall V,Canas-Ferreira W,Exposto F

    更新日期:2001-11-01 00:00:00

  • Validity of self-reported 'safe sex' among female sex workers in Mombasa, Kenya--PSA analysis.

    abstract::We assessed the validity of self-reported sex and condom use by comparing self-reports with prostate-specific antigen (PSA) detection in a prospective study of 210 female sex workers in Mombasa, Kenya. Participants were interviewed on recent sexual behaviours at baseline and 12-month follow-up visits. At both visits, ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/095646207779949899

    authors: Gallo MF,Behets FM,Steiner MJ,Thomsen SC,Ombidi W,Luchters S,Toroitich-Ruto C,Hobbs MM

    更新日期:2007-01-01 00:00:00

  • Audit of a network of sexually transmitted infections centred in South Wales.

    abstract::The aim of this article is to audit the distribution and frequency of sexually transmitted infections (STIs) within a sexual network centred in South Wales. After diagnosis of a new case of HIV in February 2007, partner notification, HIV and STI testing were undertaken. Those traced were given information regarding sa...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/ijsa.2009.009066

    authors: Knapper CM,Temple M,Roderick J,Smith J,Birley HD

    更新日期:2010-01-01 00:00:00

  • Uptake, retention, and outcomes in a demonstration project of pre-exposure prophylaxis among female sex workers in public health centers in Senegal.

    abstract::The Senegal pre-exposure prophylaxis (PrEP) Demonstration Project was an open-label cohort study assessing the delivery of daily oral PrEP to HIV-negative female sex workers (FSWs) in four Ministry of Health (MoH)-run clinics in Dakar, Senegal. We assessed uptake, retention in care, and adherence over up to 12 months ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462420943704

    authors: Sarr M,Gueye D,Mboup A,Diouf O,Bao MDB,Ndiaye AJ,Ndiaye BP,Hawes SE,Tousset E,Diallo A,Jones F,Kane CT,Thiam S,Ndour CT,Gottlieb GS,Mboup S

    更新日期:2020-10-01 00:00:00

  • Characteristics and geographic distribution of HIV-positive women diagnosed with cervical cancer in Dar es Salaam, Tanzania.

    abstract::Cervical cancer is the leading incident cancer and the main cause of cancer-related mortality among women in sub-Saharan Africa. Furthermore, HIV-infected women are at a higher risk of developing cervical cancer than HIV-negative women. The purpose of this study was to distinguish differences in characteristics of HIV...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462415606252

    authors: Lovgren K,Soliman AS,Ngoma T,Kahesa C,Meza J

    更新日期:2016-10-01 00:00:00

  • Incidence of sexually transmitted infections in HIV-infected and HIV-uninfected adolescents in the USA.

    abstract::Little is known about the incidence of bacterial sexually transmitted infections (STIs) among HIV-infected versus HIV-uninfected adolescents. This secondary analysis of a national, multisite study included adolescents aged 12-18 years who were behaviourally HIV-infected (n = 346) or HIV-uninfected but at-risk (n = 182...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462412472425

    authors: Mullins TL,Rudy BJ,Wilson CM,Sucharew H,Kahn JA

    更新日期:2013-02-01 00:00:00

  • Routine questioning about non-consenting sex: a survey of practice in Australasian sexual health clinics.

    abstract::The objectives of the study were, 1. To ascertain if sexual health physicians and practitioners believe a question concerning a past history of non-consensual sex should be asked routinely and are asking it. 2. To identify whether sexual health services have established protocols to integrate this question into practi...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/095646203321605530

    authors: Hurst C,MacDonald J,Say J,Read J

    更新日期:2003-05-01 00:00:00

  • Sexually transmitted diseases in lesbians.

    abstract::The limited published data support the assumption that lesbians are a low risk group for sexually transmitted diseases (STDs). However, there are virtually no contemporary data and the older papers do not take into account genital wart virus infection, now the third most prevalent STD in Britain. One of the dangers in...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/095646249000100304

    authors: Edwards A,Thin RN

    更新日期:1990-05-01 00:00:00

  • Women in community corrections in New York City: HIV infection and risks.

    abstract::Although the incidence of HIV among women on probation, parole and alternatives to incarceration programs is significant to public health, drivers of this concentrated epidemic among women under community corrections remain understudied. This study examined prevalence of HIV and sexually transmitted infections and the...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462416633624

    authors: El-Bassel N,Marotta PL,Shaw SA,Chang M,Ma X,Goddard-Eckrich D,Hunt T,Johnson K,Goodwin S,Almonte M,Gilbert L

    更新日期:2017-02-01 00:00:00

  • Direct observation therapy-highly active antiretroviral therapy in a resource-limited setting: the use of community treatment support can be effective.

    abstract::This study examines the use of various direct observation therapy-HAART treatment support modalities in Jos, Nigeria. A 12-month observational study enrolling 175 antiretroviral naïve patients into four arms of direct observation therapy-HAART (highly active antiretroviral therapy); daily observed therapy (DOT), twice...

    journal_title:International journal of STD & AIDS

    pub_type: 临床试验,杂志文章

    doi:10.1258/095646207782212252

    authors: Idoko JA,Agbaji O,Agaba P,Akolo C,Inuwa B,Hassan Z,Akintunde L,Badung B,Muazu M,Danang M,Imade G,Sankale JL,Kanki P

    更新日期:2007-11-01 00:00:00

  • Persistent genital arousal in women -- a new syndrome entity.

    abstract::The persistent sexual arousal syndrome (PSAS) is a newly described entity where women become involuntarily aroused genitally for extended periods in time in the absence of sexual desire. Genital vasoengorgement and oedema have been observed. These women are found to be usually very distressed. The cause of the syndrom...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章,评审

    doi:10.1258/095646206776253480

    authors: Goldmeier D,Leiblum SR

    更新日期:2006-04-01 00:00:00

  • Pneumocystis jirovecii prophylaxis discontinuation based upon total lymphocyte count in HIV-infected adults treated with antiretroviral therapy.

    abstract::Pneumocystis jirovecii pneumonia (PCP) prophylaxis may be discontinued when CD4 is > or =200 cells/mm(3) for three months in response to highly active antiretroviral therapy (HAART). Unlike CD4, the total lymphocyte count (TLC) is inexpensive and widely available in resource-constrained countries. Paired TLC and CD4 v...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/ijsa.2009.009090

    authors: Cheung C,Shuter J

    更新日期:2010-06-01 00:00:00

  • Anakinra in the treatment of protracted paradoxical inflammatory reactions in HIV-associated tuberculosis in the United Kingdom: a report of two cases.

    abstract::Paradoxical reactions, including immune reconstitution inflammatory syndrome (IRIS), are common in patients co-infected with human immunodeficiency virus (HIV) and tuberculosis (TB). Paradoxical reactions may confer substantial morbidity and mortality, especially in cases of central nervous system (CNS) TB, or through...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462420915394

    authors: Keeley AJ,Parkash V,Tunbridge A,Greig J,Collini P,McKane W,Tattersall RS

    更新日期:2020-07-01 00:00:00

  • Surveillance of an infectious syphilis outbreak in south London, UK: a comparison of reporting systems.

    abstract::Rising heterosexual syphilis in south London in 2002 prompted Local Enhanced Syphilis Surveillance (LESS) in five of the 10 genitourinary medicine clinics. LESS reported a fall in heterosexual infectious syphilis in 2004 that was corroborated by the National Enhanced Syphilis Surveillance (NESS). However, mandatory cl...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/ijsa.2008.008216

    authors: Menon-Johansson AS,Young Y,Maguire H,Trail P,Ward H

    更新日期:2009-03-01 00:00:00

  • Prevalence of Mycoplasma genitalium in asymptomatic men in Japan.

    abstract::We aim to clarify the prevalence of Mycoplasma genitalium in asymptomatic men in Japan. First-catch urine specimens were obtained from 187 asymptomatic Japanese men and examined for the presence of M. genitalium using a polymerase chain reaction (PCR)-based assay. Two (1.1%) of 187 first-catch urine specimens were pos...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/0956462971919877

    authors: Uno M,Deguchi T,Saito A,Yasuda M,Komeda H,Kawada Y

    更新日期:1997-04-01 00:00:00

  • Use of tablet-based kiosks in the emergency department to guide patient HIV self-testing with a point-of-care oral fluid test.

    abstract::Despite successes in efforts to integrate HIV testing into routine care in emergency departments, challenges remain. Kiosk-facilitated, directed HIV self-testing offers one novel approach to address logistical challenges. Emergency department patients, 18-64 years, were recruited to evaluate use of tablet-based-kiosks...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/0956462413487321

    authors: Gaydos CA,Solis M,Hsieh YH,Jett-Goheen M,Nour S,Rothman RE

    更新日期:2013-09-01 00:00:00

  • Seasonal variation in mortality of Pneumocystis jirovecii pneumonia in HIV-infected patients.

    abstract::A seasonal variation in the presentation of Pneumocystis jirovecii pneumonia (PCP) has been reported and a previous study from this centre noted a seasonal variation in mortality rates. This study examined seasonal influences (including climatic factors) within-host factors (clinical and laboratory-derived variables),...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/ijsa.2010.010148

    authors: Miller RF,Evans HE,Copas AJ,Huggett JF,Edwards SG,Walzer PD

    更新日期:2010-07-01 00:00:00

  • Feasibility of voluntary counselling and testing services for HIV among pregnant women presenting in labour in Pune, India.

    abstract::Factors affecting the eligibility and acceptability of voluntary counselling and rapid HIV testing (VCT) were examined among pregnant women presenting in labour in Pune, India. Of the 6702 total women appearing at the delivery room from April 2001 to March 2002, 4638 (69%) were admitted for normal delivery. The remain...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/0956462054679250

    authors: Bharucha KE,Sastry J,Shrotri A,Sutar S,Joshi A,Bhore AV,Phadke MA,Bollinger RC,Shankar AV

    更新日期:2005-08-01 00:00:00

  • Risk of Chlamydia trachomatis infection during pregnancy: effectiveness of guidelines-based screening in identifying cases.

    abstract::Our goal was to define the risk factors for Chlamydia trachomatis (CT) infection among pregnant women at a large urban medical centre. In a retrospective study, clinical records at a US maternity unit from July 2005 through February 2008 were reviewed. The study population included all pregnant women with a singleton ...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/ijsa.2010.009559

    authors: Silveira MF,Erbelding EJ,Ghanem KG,Johnson HL,Burke AE,Zenilman JM

    更新日期:2010-05-01 00:00:00

  • A dedicated clinic for HIV-positive individuals over 50 years of age: a multidisciplinary experience.

    abstract::The HIV-infected population is ageing. Issues including polypharmacy and co-morbidities led us to develop a dedicated clinic for HIV-infected individuals over 50. We describe our service evaluation after two years. The over 50 clinic commenced in January 2009. The team comprises a registrar, consultant, nurse practiti...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1258/ijsa.2012.011412

    authors: Waters L,Patterson B,Scourfield A,Hughes A,de Silva S,Gazzard B,Barton S,Asboe D,Pozniak A,Boffito M

    更新日期:2012-08-01 00:00:00

  • Molluscum contagiosum: a neglected sentinel infection.

    abstract::Perigenital molluscum contagiosum in adults is recognized as being a sexually transmitted infection. A retrospective casenote review was performed on patients attending a department of genitourinary medicine (GUM) who had been diagnosed as having molluscum. One or more co-existent sexually transmitted diseases (STD) w...

    journal_title:International journal of STD & AIDS

    pub_type: 杂志文章

    doi:10.1177/095646249100200604

    authors: Radcliffe KW,Daniels D,Evans BA

    更新日期:1991-11-01 00:00:00