Scleroderma: developments from Osler to the present.

Abstract:

:The clinical entity of progressive systemic sclerosis (PSS, or scleroderma) has remained unchanged since Osler's first description in 1892. Several related or overlap syndromes have now been recognized, which may afford some insight into etiologic events in the development of PSS. As yet, the cause of PSS remains elusive. Abnormalities of collagen synthesis, the role of cellular and humoral immunity, and the relationship of these to vascular disease and hyperreactivity represent current areas of research. Few therapeutic advances of proven efficacy have been forthcoming over this period except for the use of vigorous antihypertensive therapy or early nephrectomy, dialysis, and transplantation in the control of malignant hypertension and progressive renal failure.

journal_name

South Med J

journal_title

Southern medical journal

authors

Cunningham PH,Andrews BS,Davis JS 4th

doi

10.1097/00007611-198006000-00027

subject

Has Abstract

pub_date

1980-06-01 00:00:00

pages

770-4

issue

6

eissn

0038-4348

issn

1541-8243

journal_volume

73

pub_type

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