Life-threatening complications of empiric ceftriaxone therapy for 'seronegative Lyme disease'.

Abstract:

:Lyme disease, now the most common tick-borne illness in the United States, has recently received much media attention, due in part to its potentially serious sequelae in untreated patients. Because a rare patient with late illness may lack antibodies to the etiologic agent, Borrelia burgdorferi, physicians may be tempted to give empiric antibiotics for illnesses that may not be Lyme disease. We have described a patient who, despite negative laboratory evidence for late Lyme disease, was treated for 3 weeks with intravenous ceftriaxone and sustained serious complications, including granulocytopenia, fever, hepatitis, and Clostridium difficile-associated diarrhea. We caution physicians to weight carefully the risks of empiric treatment for ill-defined medical problems, and to recognize the hazards of even "safe" medications.

journal_name

South Med J

journal_title

Southern medical journal

authors

Nadelman RB,Arlin Z,Wormser GP

doi

10.1097/00007611-199110000-00024

subject

Has Abstract

pub_date

1991-10-01 00:00:00

pages

1263-5

issue

10

eissn

0038-4348

issn

1541-8243

journal_volume

84

pub_type

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