G-protein involvement in matrix-mediated motility and invasion of high and low experimental metastatic B16 melanoma clones.

abstract：:The existence of two subgroups of BRCA1-associated breast cancer (BC) families has been recently posited: the first with highly proliferating tumors, and the second composed of cases with a low proliferation rate. Our aim was to test whether the proliferation rate of BRCA1-associated breast cancers was affected by the...

journal_title：Cancer research

authors： Sobol H,Stoppa-Lyonnet D,Bressac-de-Paillerets B,Peyrat JP,Kerangueven F,Janin N,Noguchi T,Eisinger F,Guinebretiere JM,Jacquemier J,Birnbaum D

更新日期：1996-07-15 00:00:00

abstract：:Hemodynamic (blood flow rate, hematocrit, hemoglobin concentration, and blood viscosity) and pH responses to glucose (6 g/kg, i.p.) injections were studied in ten Walker 256 carcinoma tumors (0.5-1.8 g) grown in the "tissue-isolated" tumor preparation. A maximum blood flow reduction of 57 +/- 19% (SD) occurred concurr...

journal_title：Cancer research

authors： Sevick EM,Jain RK

更新日期：1988-03-01 00:00:00

abstract：:The rTSbeta protein has been hypothesized to synthesize signaling molecules that can down-regulate thymidylate synthase. These molecules share biological and chemical properties with acyl-homoserine lactones (AHL), suggesting some AHLs might act as rTS signaling mimics and down-regulate thymidylate synthase. We have d...

journal_title：Cancer research

authors： Dolnick R,Wu Q,Angelino NJ,Stephanie LV,Chow KC,Sufrin JR,Dolnick BJ

更新日期：2005-07-01 00:00:00

abstract：:The lung is an organ that is sensitive to mutations induced by chemicals in ambient air, and transgenic mice harboring guanine phosphoribosyltransferase (gpt) gene as a target gene are a well-established model system for assessing genotoxicity in vivo. Transcription factor Nrf2 mediates inducible and constitutive expr...

journal_title：Cancer research

authors： Aoki Y,Hashimoto AH,Amanuma K,Matsumoto M,Hiyoshi K,Takano H,Masumura K,Itoh K,Nohmi T,Yamamoto M

更新日期：2007-06-15 00:00:00

abstract：:2'-Deoxycoformycin (2'-dCF), a tight-binding inhibitor of adenosine deaminase, was administered to 26 pediatric patients with acute lymphoblastic leukemia in a Phase I study. Doses ranged from 0.25 to 1.0 mg/kg given i.v. for 3 consecutive days. Common toxicity included nausea, vomiting, diarrhea, hepatocellular enzym...

journal_title：Cancer research

authors： Poplack DG,Sallan SE,Rivera G,Holcenberg J,Murphy SB,Blatt J,Lipton JM,Venner P,Glaubiger DL,Ungerleider R,Johns D

更新日期：1981-09-01 00:00:00

abstract：:The aim of the present study was to establish screening biomarkers of exposure to antineoplastic drugs administered to 11 patients undergoing cancer chemotherapy. Among the anticancer drugs administered were cyclophosphamide (all), Adriamycin (5 of 11), methotrexate (3 of 11), 5-fluorouracil (4 of 11), vincristine (3 ...

journal_title：Cancer research

authors： Newman MA,Hee SQ,Schoeny R,Lowry L

更新日期：1990-06-01 00:00:00

abstract：:Macrophages play important roles in both physiologic and pathologic processes and arise from successive waves of embryonic and adult hematopoiesis. Monocyte-derived macrophages (MOMF) exert distinct functions under pathologic conditions, and leukemia-associated macrophages (LAM) show considerable diversities in activa...

journal_title：Cancer research

authors： Yang F,Feng W,Wang H,Wang L,Liu X,Wang R,Chen C,Yang X,Zhang D,Ren Q,Zheng G

更新日期：2020-09-01 00:00:00

abstract：:Despite the prevalence of KRAS mutations in human cancers, there remain no targeted therapies for treatment. The serine-threonine kinase STK33 has been proposed to be required for the survival of mutant KRAS-dependent cell lines, suggesting that small molecule kinase inhibitors of STK33 may be useful to treat KRAS-dep...

journal_title：Cancer research

authors： Babij C,Zhang Y,Kurzeja RJ,Munzli A,Shehabeldin A,Fernando M,Quon K,Kassner PD,Ruefli-Brasse AA,Watson VJ,Fajardo F,Jackson A,Zondlo J,Sun Y,Ellison AR,Plewa CA,San MT,Robinson J,McCarter J,Schwandner R,Judd T,C

更新日期：2011-09-01 00:00:00

abstract：:Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 case...

journal_title：Cancer research

authors： Wang M,Li Z,Chu H,Lv Q,Ye D,Ding Q,Xu C,Guo J,Du M,Chen J,Song Z,Yin C,Qin C,Gu C,Zhu Y,Xia G,Liu F,Zhang Z,Yuan L,Fu G,Hu Z,Tong N,Shen J,Liu K,Sun J,Sun Y,Li J,Li X,Shen H,Xu J,Shi Y,Zhang

更新日期：2016-06-01 00:00:00

abstract：:Microtubule inhibitors interfere with microtubule dynamics, causing cell cycle arrest and apoptosis. These effects are responsible for the chemotherapeutic activities of members of the taxane and Vinca alkaloid families in oncology. Unfortunately, a major side effect of the taxanes and Vinca alkaloids is the developme...

journal_title：Cancer research

authors： Wienecke A,Bacher G

更新日期：2009-01-01 00:00:00

abstract：:Thirteen patients with metastatic breast carcinoma were given injections of 50-1593 micrograms of 131I-monoclonal antibody (MAb) B6.2 immunoglobulin G and F(ab')2 for pharmacokinetic evaluation and radioimmunoimaging. Blood clearance of the 131I-MAb-B6.2 was biphasic. The mean half-times (t 1/2 alpha, t 1/2 beta) for ...

journal_title：Cancer research

authors： Hayes DF,Zalutsky MR,Kaplan W,Noska M,Thor A,Colcher D,Kufe DW

更新日期：1986-06-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immature myeloid cells that expand in tumor-bearing hosts in response to soluble factors produced by tumor and stromal cells. MDSC expansion has been linked to loss of immune effector cell function and reduced efficacy of immune-based cancer therapie...

journal_title：Cancer research

authors： Stiff A,Trikha P,Wesolowski R,Kendra K,Hsu V,Uppati S,McMichael E,Duggan M,Campbell A,Keller K,Landi I,Zhong Y,Dubovsky J,Howard JH,Yu L,Harrington B,Old M,Reiff S,Mace T,Tridandapani S,Muthusamy N,Caligiuri MA

更新日期：2016-04-15 00:00:00

abstract：:Mucin 1 (MUC1), a bound mucin glycoprotein, is overexpressed and aberrantly glycosylated in >80% of human ductal pancreatic carcinoma. Evidence suggests that MUC1 can be used as a tumor marker and is a potential target for immunotherapy of pancreatic cancer. However, vaccination with MUC1 peptides fails to stimulate t...

journal_title：Cancer research

authors： Deguchi T,Tanemura M,Miyoshi E,Nagano H,Machida T,Ohmura Y,Kobayashi S,Marubashi S,Eguchi H,Takeda Y,Ito T,Mori M,Doki Y,Sawa Y

更新日期：2010-07-01 00:00:00

abstract：:Expression of cyclooxygenase (COX)-2 protein in 4-nitroquinoline-1-oxide (4-NQO)-induced rat tongue lesions and the postinitiation chemopreventive potential of a selective COX-2 inhibitor, nimesulide (NIM), were examined in Fischer 344 male rats. NIM was administered in the diet at doses of 150, 300, and 600 ppm for 1...

journal_title：Cancer research

authors： Shiotani H,Denda A,Yamamoto K,Kitayama W,Endoh T,Sasaki Y,Tsutsumi N,Sugimura M,Konishi Y

更新日期：2001-02-15 00:00:00

abstract：:Evasion of apoptosis is a hallmark of chronic lymphocytic leukemia (CLL), calling for new strategies to bypass resistance. Here, we provide first evidence that small-molecule X-linked inhibitor of apoptosis (XIAP) inhibitors in combination with the death receptor ligand tumor necrosis factor-related apoptosis-inducing...

journal_title：Cancer research

authors： Loeder S,Zenz T,Schnaiter A,Mertens D,Winkler D,Döhner H,Debatin KM,Stilgenbauer S,Fulda S

更新日期：2009-12-01 00:00:00

abstract：:Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the tumor suppressor phosphatase and tensin homologue deleted from chromosome 10 or activating mutations of p110-alpha. These hotspot mutations result in oncogenic activity of the enzyme and cont...

journal_title：Cancer research

authors： Serra V,Markman B,Scaltriti M,Eichhorn PJ,Valero V,Guzman M,Botero ML,Llonch E,Atzori F,Di Cosimo S,Maira M,Garcia-Echeverria C,Parra JL,Arribas J,Baselga J

更新日期：2008-10-01 00:00:00

abstract：:We recently reported trophic response of transplantable mouse colon cancer cells (MC-26) to pentagastrin, in vivo, and demonstrated gastrin receptors on MC-26 cells, in vitro. In the present study, growth of MC-26 cells in mice, in response to pentagastrin, was studied in relation to binding kinetics and capacity of g...

journal_title：Cancer research

authors： Singh P,Walker JP,Townsend CM Jr,Thompson JC

更新日期：1986-04-01 00:00:00

abstract：:Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME). CD47 has been shown to mediate immune evasion, as the CD47-SIRPα axis prevents phagocytosis of tumor cells by macrophages and other myeloid cells....

journal_title：Cancer research

authors： Ma D,Liu S,Lal B,Wei S,Wang S,Zhan D,Zhang H,Lee RS,Gao P,Lopez-Bertoni H,Ying M,Li JJ,Laterra J,Wilson MA,Xia S

更新日期：2019-05-15 00:00:00

abstract：:Blood coagulation factor VII (fVII) is physiologically synthesized in the liver and released into the blood. Binding of fVII to tissue factor (TF) at sites of vascular injury triggers coagulation and hemostasis. TF/fVIIa complex formation on the surface of cancer cells plays important roles in cancer biology. Although...

journal_title：Cancer research

authors： Koizume S,Jin MS,Miyagi E,Hirahara F,Nakamura Y,Piao JH,Asai A,Yoshida A,Tsuchiya E,Ruf W,Miyagi Y

更新日期：2006-10-01 00:00:00

abstract：:Murine fibrosarcoma UV-2237MM cells were implanted into different organs of syngeneic C3H/HeN mice. The resultant tumors were treated by i.v. administration of Adriamycin (ADR). Despite the high sensitivity of the fibrosarcoma cells to ADR in vitro, the established tumors growing in vivo exhibited marked differences i...

journal_title：Cancer research

authors： Staroselsky AN,Fan D,O'Brian CA,Bucana CD,Gupta KP,Fidler IJ

更新日期：1990-12-15 00:00:00

abstract：:Fluence response relationships for the induction of DNA damage in the skin of UV-irradiated Xiphophorus fish were obtained by quantitative gel electrophoresis of unlabeled DNA following extraction and treatment with an enzyme preparation that makes single strand breaks next to cyclobutane pyrimidine dimers. A buffer c...

journal_title：Cancer research

authors： Ahmed FE,Setlow RB

更新日期：1993-05-15 00:00:00

abstract：:SR31747A is a sigma ligand with potent antiproliferative activity against tumor cells and for which three binding proteins have been identified to date: (a) SRBP-1 (also called sigma 1); (b) HIS; and (c) sigma 2. In this study, we characterized an additional SR31747A binding site, i.e., SRBP-2 (SR31747A-binding protei...

journal_title：Cancer research

authors： Vidal H,Mondesert G,Galiègue S,Carrière D,Dupuy PH,Carayon P,Combes T,Bribes E,Simony-Lafontaine J,Kramar A,Loison G,Casellas P

更新日期：2003-08-15 00:00:00

abstract：:(E)-2'-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier of radiation response in vitro on a human colon carcinoma cell line (WiDr), and the observed radiosensitization was confirm...

journal_title：Cancer research

authors： Coucke PA,Decosterd LA,Li YX,Cottin E,Chen X,Sun LQ,Stern S,Paschoud N,Denekamp J

更新日期：1999-10-15 00:00:00

abstract：:Acute endothelial cell apoptosis and microvascular compromise couple gastrointestinal tract irradiation to reproductive death of intestinal crypt stem cell clonogens (SCCs) following high-dose radiation. Genetic or pharmacologic inhibition of endothelial apoptosis prevents intestinal damage, but as the radiation dose ...

journal_title：Cancer research

authors： Rotolo JA,Mesicek J,Maj J,Truman JP,Haimovitz-Friedman A,Kolesnick R,Fuks Z

更新日期：2010-02-01 00:00:00

abstract：:Loss of hSNF5 function is usually observed in malignant rhabdoid tumor (MRT), a highly aggressive pediatric neoplasm. Previous studies have shown that reexpression of hSNF5 in MRT cell lines causes G1 cell cycle arrest with p16(INK4A), p21(CIP1/WAF1), and cyclin D1 playing key roles in MRT cell growth control. However...

journal_title：Cancer research

authors： Kuwahara Y,Charboneau A,Knudsen ES,Weissman BE

更新日期：2010-03-01 00:00:00

abstract：:The metabolism of both testosterone and dehydroepiandrosterone by 10 adenocarcinomas induced and grown in the presence of high prolactin (plasma prolactin greater than 220 ng/ml) was compared with the metabolism of 10 adenocarcinomas induced and grown in the presence of normal levels (plasma prolactin less than 60 ng/...

journal_title：Cancer research

authors： Miller WR

更新日期：1976-02-01 00:00:00

abstract：:Prior studies of fluorescence anisotropy (polarization) with diphenylhexatriene in normal and malignant cell populations have shown differences which have been attributed to an altered membrane lipid composition in cancer. We studied fresh tumor cells from patients with diverse lymphoid neoplasms and found a discrete ...

journal_title：Cancer research

authors： Spiegel RJ,Magrath IT,Shutta JA

更新日期：1981-02-01 00:00:00

abstract：:Neuroblastoma (NB), a common pediatric neoplasm, consists of two main cell populations: neuroblastic/ganglionic cells and Schwann cells. NB tumors with abundant Schwannian stroma display a more benign clinical behavior than stroma-poor tumors. Recent studies suggest that Schwann cells influence NB tumor growth via sec...

journal_title：Cancer research

authors： Chlenski A,Liu S,Crawford SE,Volpert OV,DeVries GH,Evangelista A,Yang Q,Salwen HR,Farrer R,Bray J,Cohn SL

更新日期：2002-12-15 00:00:00

abstract：:Tumor recurrence in prostate cancer has been attributed to the presence of CD44-expressing tumor-initiating cells. In this study, we report that miR-708 is a key negative regulator of this CD44(+) subpopulation of prostate cancer cells, with important implications for diagnosis and prognosis of this disease. miR-708 w...

journal_title：Cancer research

authors： Saini S,Majid S,Shahryari V,Arora S,Yamamura S,Chang I,Zaman MS,Deng G,Tanaka Y,Dahiya R

更新日期：2012-07-15 00:00:00

abstract：:SNAI2 overexpression appears to be associated with poor prognosis in breast cancer, yet it remains unclear in which breast cancer subtypes this occurs. Here we show that excess SNAI2 is associated with a poor prognosis of luminal B HER2+/ERBB2+ breast cancers in which SNAI2 expression in the stroma but not the epithel...

journal_title：Cancer research

authors： Blanco-Gómez A,Hontecillas-Prieto L,Corchado-Cobos R,García-Sancha N,Salvador N,Castellanos-Martín A,Sáez-Freire MDM,Mendiburu-Eliçabe M,Alonso-López D,De Las Rivas J,Lorente M,García-Casas A,Del Carmen S,Abad-Hernández MDM,C

更新日期：2020-12-01 00:00:00