The clinical morphology of human atherosclerotic lesions. Lessons from the PDAY Study. Pathobiological Determinants of Atherosclerosis in Youth.

Abstract:

:The PDAY study addresses the role traditional risk factors play in the development and progression of arterial lesions in youth (15 to 34 years of age). This autopsy based study indicates that in the aorta and in the right coronary artery, atherosclerosis is positively associated with cholesterol (LDL+VLDL), glucose intolerance, smoking, hypertension, and obesity and negatively associated with HDL-cholesterol. When a high cholesterol group (> 240 mg/dl) is compared to a low cholesterol group (< 200 mg/dl) early fatty sudanophilic lesions decrease in the aorta from 35% to 29% (p < 0.03) surface area, while raised atherosclerotic lesions are lowered (from 5%) in the high cholesterol group (to 3%) in the low cholesterol group; p < 0.02). Clearly, risk factors particularly cholesterol levels, directly affect the development of atherosclerosis in the coronary arteries and the aorta of young people. The data presented suggest that risk factor modification would be beneficial in young people as from 15 years of age.

journal_name

Wien Klin Wochenschr

authors

Cornhill JF,Herderick EE,Vince DG

subject

Has Abstract

pub_date

1995-01-01 00:00:00

pages

540-3

issue

18

eissn

0043-5325

issn

1613-7671

journal_volume

107

pub_type

杂志文章
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    authors: Irsigler K,Kirtz H,Najemnik C,Freyler H

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    authors: Pilz P

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  • [Imaging of diseases of the thyroid gland in Austria].

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    authors: Czerny C,Hörmann M,Kurtaran A,Niederle B

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    authors: Moser M,Buchberger W

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  • [Automated exchange transfusion in premature and newborn infants with hyperbilirubinemia using a peripheral arteriovenous vascular access device].

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  • Treatment of partial thickness burns of the face with Acticoat7™ : A retrospective single center study.

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  • Chronic gastrointestinal symptoms in hemodialysis patients.

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    journal_title:Wiener klinische Wochenschrift

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    doi:

    authors: Hammer J,Oesterreicher C,Hammer K,Koch U,Traindl O,Kovarik J

    更新日期:1998-04-24 00:00:00

  • Doxycycline versus ceftriaxone for the treatment of patients with chronic Lyme borreliosis.

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  • [Postoperative imaging and evaluation of the electrode position and depth of insertion of multichannel cochlear implants by means of high-resolution computed tomography and conventional X-rays].

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    authors: Czerny C,Gstoettner W,Adunka O,Hamzavi J,Baumgartner WD

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  • Endovascular treatment of delayed hemorrhage developing after the pancreaticoduodenectomy procedure.

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  • [Diagnosis of chronic pancreatitis. Studies of duodenal juice after stimulation with the secretin-ceruletide test. Decision limits and evaluation of various parameters].

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  • [Familial thymoma].

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  • [Steroid receptor levels in human breast carcinomas in relation to serum hormone levels in postmenopausal patients (author's transl)].

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  • [Cardiogenic shock].

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  • [Mixed lymphocyte culture as a compatibility test for bone marrow transplantation].

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    doi:

    authors: Hajek-Rosenmayr A

    更新日期:1986-01-24 00:00:00

  • [Haemodynamic changes in acute myocardial infarction following high doses of furosemide (author's transl)].

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    authors: Szeless ST,Kleinberger G,Kotzaurek R,Pall H,Pichler M

    更新日期:1976-07-16 00:00:00

  • [Human atrial natriuretic peptide: a secretory product of the heart and its significance for physiology and clinical practice].

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    doi:

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    更新日期:1987-03-06 00:00:00

  • [Value of postoperative irradiation of cases of cervix cancer of histologic stage I/b with extensive infiltration (stage I/c)].

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    doi:

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