Abstract：
:The blood schizontocidal activity of lumefantrine, monodesbutyl-benflumetol (DBB) and a 999:1 combination of both compounds has been investigated in 26 fresh isolates of Plasmodium falciparum from northwestern Thailand, using the WHO standard protocol Mark II for determining the inhibition of schizont maturation. The geometric mean cut-off concentrations of schizont maturation (GMCOC) were 943.2 nM for lumefantrine, 146.3 nM for DBB and 182.2 nM for the 999:1 combination of lumefantrine and DBB. The EC(50) values were 27.3 nM for lumefantrine, 5.7 nM for DBB, and 16.5 nM for the combination, and the EC(90) values 163.1 nM for lumefantrine, 44.1 nM for DBB, and 78.3 nM for the combination. Despite the very low concentration in the combination, DBB exerted significant synergistic activity with lumefantrine that was strongest at the EC(90) and EC(99) levels. Correlation analysis indicates that DBB is the leading determinant for the activity of the combination.
journal_name
Wien Klin Wochenschrjournal_title
Wiener klinische Wochenschriftauthors
Starzengruber P,Wernsdorfer G,Parizek M,Rojanawatsirivet C,Kollaritsch H,Wernsdorfer WHdoi
10.1007/s00508-007-0861-9subject
Has Abstractpub_date
2007-01-01 00:00:00pages
60-6issue
19-20 Suppl 3eissn
0043-5325issn
1613-7671journal_volume
119pub_type
杂志文章abstract：:Urological conditions of infancy and childhood account for the largest single disease group requiring either surgical or medical intervention. This makes early detection and classification of abnormalities mandatory. This study presents an analysis of the results of ultrasonic screening in 1000 patients. Ultrasonic ex...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1985-01-04 00:00:00
abstract：BACKGROUND:Down syndrome is the most commonly occurring chromosomal condition with a prevalence of 11.2-10000 life-births in Europe. The most important concern consists of various degrees of intellectual disability and sensory deficits. The overall prevalence of ophthalmologic abnormalities has been reported to be as h...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-015-0750-6
更新日期：2015-08-01 00:00:00
abstract：:Unstable coronary artery plaque is the most common underlying cause of acute coronary syndromes (ACS) and can manifest as unstable angina, non-ST segment elevation infarction (NSTE-ACS), and ST elevation myocardial infarction (STEMI), but can also manifest as sudden cardiac arrest due to ischaemia induced tachyarrhyth...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-014-0526-4
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Among patients with allergy to insect stings, double positivity in tests for IgE antibodies specific to honey bee and wasp venoms is a frequent diagnostic problem. True double sensitization and possible cross-reactivity of venom hyaluronidases and with carbohydrate determinants must be considered in such pat...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-009-1171-1
更新日期：2009-01-01 00:00:00
abstract：:The inscription on Paracelsus' epitaph in the cemetery of Saint Sebastian in Salzburg is critically reviewed with regard to an allusion to Job, Chapter 19. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1989-02-17 00:00:00
abstract：:We present a case of spontaneous recanalization of the internal carotid artery (ICA) that occurred in a 51-year-old male patient. The occlusion of the right ICA was asymptomatic and was detected incidentally during imaging of the opposite carotid artery. The patient underwent neuroradiologic analysis and a tapered, fl...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-010-1490-2
更新日期：2010-11-01 00:00:00
abstract：BACKGROUND:The increasing prevalence of overweight and obesity among children is often associated with motor deficits. Motor performance among children partly depends on modifiable factors, for example, weight status, electronic media use, sports club participation, and on nonmodifiable factors, for example, sex, age, ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-015-0887-3
更新日期：2016-01-01 00:00:00
abstract：:Transmission of Cryptosporidium sp. within the general public was studied. We were looking for a possible risk of infection associated with animal contacts. Investigation of the animal contacts of affected individuals led to the formulation of the hypothesis that animals are a source of cryptosporidiosis. The research...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/BF03040292
更新日期：2003-02-28 00:00:00
abstract：:Schönbauer's merits for the Society of Physicians in Vienna not only concern the renovation of its building after the Second World War but also his active scientific co-operation during four decades. His lectures are primarily devoted to abdominal surgery and neuro-surgery. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 传,历史文章,杂志文章
doi：
更新日期：1988-12-02 00:00:00
abstract：:IgM (Immunoglobin M) antibodies to the antigen T (Thomsen-Friedenreich antigen, transformation antigen) were detected by normal agglutination technique in the serum of 7 out of 73 newborn children. Neither the mother's anti-T titre, nor the quantity of IgM and IgG (Immunoglobulin G) in the sera of mother and child was...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1982-08-06 00:00:00
abstract：:Skin tests were performed and the specific IgE levels determined by means of the radio-allero-sorbent test (RAST) in fifty patients with allergic rhinitis/conjunctivitis and extrinsic bronchial asthma. An overall correlation between in vitro and in vivo diagnosis was found in 87% of cases. The results of this study in...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1975-10-17 00:00:00
abstract：:Midodrine, which is used in the treatment of hypotensive circulatory distrubances was investigated with respect to possible effects on carbohydrate and fat metabolism in 5 healthy subjects and 7 patients with disturbed glocuse tolerance. An i.v. glucose tolerance test was carried out on both groups and was repeated a ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1977-03-04 00:00:00
abstract：:From the 1st of April 1974 till the 30th of September 1979 a consecutive series of 123 couples with a history of recurrent abortion was studied cytogenetically with modern banding techniques. 8 chromosomal aberrations were detected (6.5%); 3 women were found to be balanced reciprocal translocation carriers; the karyot...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1980-08-29 00:00:00
abstract：BACKGROUND:Autologous hematopoietic stem cell transplantation (aHSCT) is the recommended standard upfront treatment for transplant eligible myeloma patients. Considering possible complications related to chemotherapy-cytokine mobilization, cytokine-alone mobilization is often used. We compared mobilization with filgras...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00508-017-1205-z
更新日期：2017-08-01 00:00:00
abstract：:An analysis of 28 cases of amanita phalloides poisoning serves as basis for a discussion of the clinical features and therapeutic problems involved. A critical review of recent experimental investigations in animals points to new possibilities in the treatment of amanita phalloides poisoning. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1979-08-10 00:00:00
abstract：:The Poison Control Centre in Vienna registered 4018 inquires regarding possible poisoning in children over a two-year period. The peak incidence occurred in the age group between 2 and 3 years and poisoning chiefly took place in the mornings and in the afternoons, the most frequently ingested substances being househol...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1978-01-06 00:00:00
abstract：:Correction: Wien Klin Wochenschr 2014 https://doi.org/10.1007/s00508-014-0571-z The disclosure needs to additionally mention the following:Erika von Mutius is listed as inventor on the following patents: Publication number EP 1411977: Composition containing bacterial antigens used for the prophylaxis …. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,已发布勘误
doi：10.1007/s00508-019-01546-3
更新日期：2019-09-01 00:00:00
abstract：PURPOSE:To determine which of the three surgical techniques for acute unilateral complete rupture of Achilles tendons in use at the University Clinical Centre Maribor gives the best short-term functional results. METHODS:In the retrospective analysis of the results of 3 surgical techniques, 262 patients of which 244 (...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-016-1158-7
更新日期：2017-03-01 00:00:00
abstract：:Cardiovascular diseases during pregnancy are the most common causes of pregnancy-associated mortality.Vaginal delivery is the preferred mode of birth in the majority of pregnancies.It is recommended that patients with modified World Health Organization (mWHO) class IV risk are counselled against pregnancy.Patients car...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：10.1007/s00508-019-1529-y
更新日期：2020-02-01 00:00:00
abstract：:The case is reported of a 16 year-old girl with arterial hypertension, generalized neurofibromatosis, coarctation of the abdominal aorta, bilateral renal artery stenosis, occlusion of the coeliac artery and superior mesenteric artery and kyphoscoliosis. ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1984-01-06 00:00:00
abstract：:Total oesophageal resection for cancer is a major procedure, involving surgery within the thoracic cage, the abdomen and the cervical mediastinum. Plastic restruction using a segment of colon which is placed retrosternally between the cervical oesophagus and the stomach, is an additional procedure of considerable diff...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1975-09-19 00:00:00
abstract：BACKGROUND:Arthroscopic reconstruction is a standard surgical procedure in cases of symptomatic knee instability due to rupture of the anterior cruciate ligament. Bone-tendon-bone and hamstring tendon grafts are both in use for anterior cruciate ligament reconstruction. There are no significant differences between the ...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00508-010-1340-2
更新日期：2010-05-01 00:00:00
abstract：:Sweden has been in the favorable situation of having limited antibiotic resistance and low antibiotic consumption. When pneumococci with reduced susceptibility to penicillin and methicillin-resistant Staphylococcus aureus emerged during the 1990s, professionals and relevant authorities called for extensive action plan...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：10.1007/s00508-008-0977-6
更新日期：2008-01-01 00:00:00
abstract：:Both IMP and HMPAO are lipophilic substances with high blood brain barrier permeability and sufficiently long constant retention in the brain parenchyma to enable SPECT to be carried out with a computer controlled Gamma camera. Both tracers are almost completely cleared from the blood during a single passage through t...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章,评审
doi：
更新日期：1988-06-10 00:00:00
abstract：:The stereoselective and saturable binding between receptor and ligand molecules plays an important role in many biological processes. Therefore ligand-receptor interactions have been increasingly studied in recent years by means of radionuclide labelled ligand molecules of high radiochemical purity and high specific a...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:We report the first documented case of human granulocytic ehrlichiosis (HGE) in Austria. The infection was acquired near Arzl in the surroundings of Innsbruck in northern Tyrol. Except for a biphasic course of illness, presentation in this 33-year-old female patient was comparable to clinical findings observed in othe...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/BF03040326
更新日期：2003-04-30 00:00:00
abstract：:We evaluated the overnight urinary excretion of 6-sulfatoxymelatonin in a group of 347 women (range: 18-69 years). 26 women (range 20-29 years) with normogonadotrophic, hypoestrogenemic amenorrhoea (WHO II) were selected and compared with a group of 26 women menstruating normally (range: 19-30 years) with respect to u...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1997-10-03 00:00:00
abstract：:The treatment of intractable pain, especially in cancer patients, often sets problems to patient and therapist. While epidural and intrathecal spinal administration of opiates is a routine treatment in pain with a sub-diaphragmatic topography it is almost ineffective in cervicocephalic or thoracic cancer. An alternati...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Norovirus is easily spread from person to person by the fecal-oral route and through aerosols or by vehicles such as contaminated food or water. The virus is able to survive in the environment for many days, which enables outbreaks to be prolonged. We describe a norovirus outbreak and its control measures in...
journal_title：Wiener klinische Wochenschrift
pub_type： 杂志文章
doi：10.1007/s00508-008-1135-x
更新日期：2009-01-01 00:00:00
abstract：:The article summarizes the first results of an attempt to reconstruct the destinies of the Jewish pediatricians of Vienna after the German occupation of Austria in March 1938. Traditionally pediatrics in Vienna were characterized by a high percentage of Jewish specialists. In 1938 they were confronted with abrupt humi...
journal_title：Wiener klinische Wochenschrift
pub_type： 历史文章,杂志文章
doi：
更新日期：1999-10-01 00:00:00
