Benign and malignant breast lesions: differentiation with echo-planar MR imaging.

Abstract:

PURPOSE:To quantify dynamic enhancement of breast lesions with echo-planar and conventional magnetic resonance (MR) imaging, to correlate these data with histologic findings and vessel density, and to evaluate MATERIALS AND METHODS:Twenty female patients with 22 breast lesions underwent conventional and MR echo-planar imaging T1 values, change in gadopentetate dimeglumine concentration, and extraction-flow products were calculated with echo-planar imaging data and were correlated with histologic findings and microvessel density. RESULTS:T1 values of cancers were not statistically significantly shorter. Cancers had more rapid uptake and higher extraction-flow products (P < .02). Sensitivity was 86% and specificity was 93% for diagnosis of malignancy. Microvessel density was higher for malignant lesions (P < .02) with an overall positive (not statistically significant) correlation between extraction-flow product and microvessel density. CONCLUSION:Echo-planar imaging appears promising for quantification of breast lesion enhancement. Microvessel data indicate that tumor angiogenesis affects enhancement.

journal_name

Radiology

journal_title

Radiology

authors

Hulka CA,Smith BL,Sgroi DC,Tan L,Edmister WB,Semple JP,Campbell T,Kopans DB,Brady TJ,Weisskoff RM

doi

10.1148/radiology.197.1.7568850

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

33-8

issue

1

eissn

0033-8419

issn

1527-1315

journal_volume

197

pub_type

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