Abstract:
PURPOSE:To quantify dynamic enhancement of breast lesions with echo-planar and conventional magnetic resonance (MR) imaging, to correlate these data with histologic findings and vessel density, and to evaluate MATERIALS AND METHODS:Twenty female patients with 22 breast lesions underwent conventional and MR echo-planar imaging T1 values, change in gadopentetate dimeglumine concentration, and extraction-flow products were calculated with echo-planar imaging data and were correlated with histologic findings and microvessel density. RESULTS:T1 values of cancers were not statistically significantly shorter. Cancers had more rapid uptake and higher extraction-flow products (P < .02). Sensitivity was 86% and specificity was 93% for diagnosis of malignancy. Microvessel density was higher for malignant lesions (P < .02) with an overall positive (not statistically significant) correlation between extraction-flow product and microvessel density. CONCLUSION:Echo-planar imaging appears promising for quantification of breast lesion enhancement. Microvessel data indicate that tumor angiogenesis affects enhancement.
journal_name
Radiologyjournal_title
Radiologyauthors
Hulka CA,Smith BL,Sgroi DC,Tan L,Edmister WB,Semple JP,Campbell T,Kopans DB,Brady TJ,Weisskoff RMdoi
10.1148/radiology.197.1.7568850subject
Has Abstractpub_date
1995-10-01 00:00:00pages
33-8issue
1eissn
0033-8419issn
1527-1315journal_volume
197pub_type
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