Enantiomeric separation of amide derivatives of some 2-arylpropionic acids by HPLC on a cellulose-based chiral stationary phase.

abstract：:A new method has been devised for the determination of diclofenac sodium in bulk and in pharmaceutical preparations using Eu3+ ions as the Fluorescent probe. The technique was built around the hypersensitive property of the transitions of the fluorescent probe ion, Eu3+, at 616 nm. This is normally a forbidden transit...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Carreira LA,Rizk M,el-Shabrawy Y,Zakhari NA,Toubar SS

更新日期：1995-10-01 00:00:00

abstract：:A validated stability indicating RP-HPLC assay of doxofylline was developed by separating its related substances and degradants on LichrocartC18 (250 mm × 4.6 mm; 5 μm) column using 10 mM ammonium acetate and acetonitrile as a mobile phase in a gradient mode of elution at a flow rate of 1.0 mL/min at 30 °C. The column...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Rao RN,Naidu ChG,Prasad KG,Santhakumar B,Saida S

更新日期：2013-05-05 00:00:00

abstract：:Quantitative analysis of metabolic mixtures by (1)H 1D NMR offers a limited potential for precise quantification of biomarkers, due to strong overlap between the peaks. Two-dimensional spectroscopy is a powerful tool to unambiguously and simultaneously measure a larger number of metabolite contributions. However, it i...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Martineau E,Giraudeau P,Tea I,Akoka S

更新日期：2011-01-05 00:00:00

abstract：:A liquid chromatographic method was developed for the simultaneous separation of curcumin, β-arteether, tetrahydrocurcumin and dihydroartemisinin based on the design of experiments and the design space methodology. The influence of the percentage of organic modifier, flow rate of the mobile phase and column temperatur...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Memvanga PB,Mbinze JK,Rozet E,Hubert P,Préat V,Marini RD

更新日期：2014-01-01 00:00:00

abstract：:The 60 MHz (1)H NMR spectra of racemic thiopental, 1, have been studied with the achiral shift reagent, tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato) europium(III), 2, and the chiral tris[3-(trifluoromethylhydroxymethylene)-d-camphorato] europium(III), 3, and tris[3-(heptafluoropropylhydroxymethylene)...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Eberhart ST,Hatzis A,Jimenez J,Rothchild R,Simons P

更新日期：1987-01-01 00:00:00

abstract：:Medicinal plant materials are not usually analysed for condensed tannins (CT). Thirty commercially available European medicinal plants and herbal products were screened for CT and fourteen CT samples were analysed in detail. This is also the first comprehensive CT analysis of pine buds, walnut leaves, heather flowers ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Ropiak HM,Ramsay A,Mueller-Harvey I

更新日期：2016-03-20 00:00:00

abstract：:A simple, selective and sensitive method has been developed to determine debrisoquine and 4-hydroxydebrisoquine in human urine. Separation of the analytes was obtained using a mobile phase of 0.1 M sodium dihydrogen phosphate-acetonitrile (87:13, v/v) and a muBondapak C18 column. The column effluent was monitored with...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bozkurt A,Basci NE,Isimer A,Kayaalp SO

更新日期：1993-08-01 00:00:00

abstract：:Two UV spectrophotometric methods have been validated for the analysis of hydrolyzed tinidazole solutions. The pH of the samples must be 5.00-7.00 for both methods. The multiwavelength method may be used for samples degraded at pH 6-12 if the amount of conserved 5-nitroimidazole species is at least 93 mol.% of the ori...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Salo JP,Salomies H

更新日期：2003-03-10 00:00:00

abstract：:A simple high-performance liquid chromatographic method was developed to study the pharmacokinetics of osthole in rat plasma. After addition of an internal standard (paeonol), plasma was deproteinized by acetonitrile for sample clean-up. The drugs were separated on a reversed-phase column and detected by UV absorption...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Tsai TH,Tsai TR,Chen CC,Chen CF

更新日期：1996-04-01 00:00:00

abstract：:A carbon paste electrode modified with poly(vinylpyrrolidone) (PVP) was developed for the determination of rutin. PVP enhances the adsorption of rutin on the electrode surface due to the presence of hydrogen bonding between the imide group in PVP and the hydroxyl group in rutin. The current responses in cyclic and lin...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Franzoi AC,Spinelli A,Vieira IC

更新日期：2008-08-05 00:00:00

abstract：:Enantiomers of various solutes including several basic drugs and alpha-amino acids were analyzed by capillary electrophoresis in diluted human serum, and chloroquine and tryptophan were found to be well enantioseparated. In order to specify the protein responsible for enantioseparation, these drug enantiomers were ana...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Taga A,Du Y,Suzuki S,Honda S

更新日期：2003-01-01 00:00:00

abstract：:Macrocyclic antibiotics are present in an increasing number of chiral separation applications. In this study, erythromycin and some derivatives, belonging to the group of macrolide antibiotics, were investigated for their potential as chiral selector. Erythromycin A itself and five related substances namely erythromyc...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Thanh Ha PT,Van Schepdael A,Roets E,Hoogmartens J

更新日期：2004-03-10 00:00:00

abstract：:A new multi-class method has been developed for the identification and quantification of the residues of 26 antibiotics from different classes (sulfonamides, macrolides, tetracyclines, penicillins, and quinolones) in milk and meat by ultra performance liquid chromatography coupled to hybrid quadrupole - high resolutio...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Cepurnieks G,Rjabova J,Zacs D,Bartkevics V

更新日期：2015-01-01 00:00:00

abstract：:DuP 937, an anthrapyrazole antitumour agent that is chemically unstable in aqueous solution, was shown, by absorption spectroscopy, to form an inclusion complex with heptakis(2,6-di-O-methyl)-beta-cyclodextrin (DM beta CD) in aqueous solution. Proton nuclear magnetic resonance spectroscopy was used to determine the st...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Raghavan K,Nemeth G,Gray D,Hussain MA

更新日期：1994-10-01 00:00:00

abstract：:Comparison is made between conventional liquid-liquid extraction and solid-phase extraction techniques using Extrelut-1, Extrelut-3 and C18-RP cartridges respectively for the screening of several beta-blockers in urine. Generally, using GC with nitrogen specific detection as the screening technique, liquid-liquid extr...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Delbeke FT,Debackere M,Desmet N,Maertens F

更新日期：1988-01-01 00:00:00

abstract：:Ruggedness tests were performed on the United States Pharmacopoeia assay for tetracycline.HCl to examine problems previously reported in the literature. The experiments were performed on nine different columns. The effects of four factors selected from the procedure were examined on qualitative responses by performing...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Heyden YV,Massart DL,Zhu Y,Hoogmartens J,De Beer J

更新日期：1996-06-01 00:00:00

abstract：:Reliable methods for the analysis of silicon are of great importance, because it seems that the silicate anion can reduce aluminum bioavailability in patients undergoing dialysis. Thus, a simple and sensitive spectrophotometric method is described for the determination of silicate traces in dialysis solutions. The met...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Raggi MA,Sabbioni C,Mandrioli R,Zini Q,Varani G

更新日期：1999-06-01 00:00:00

abstract：:Popularity of natural-based preparations supporting the sexual potency significantly increased in recent years, which also led to the increase of illegal use of phosphodiesterase type 5 inhibitor (PDE-5) in sexual performance enhancement products. In this study, a rapid U-HPLC‒HRMS/MS method has been developed to simu...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Jiru M,Stranska-Zachariasova M,Dzuman Z,Hurkova K,Tomaniova M,Stepan R,Cuhra P,Hajslova J

更新日期：2019-02-05 00:00:00

abstract：:The shelf-life of a drug is usually determined by fitting the assayed values of drug potency versus time to a linear least-squares model. In least-squares models, the parameters are estimated by minimizing the sum of squares of the residuals. Shelf-life is estimated as the time corresponding to the intersection point ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Roy T

更新日期：1993-09-01 00:00:00

abstract：:The solution-phase hydrolysis kinetics of the Aprepitant (Emend) prodrug, Fosaprepitant Dimeglumine, were investigated using an HPLC chromatographic reactor approach. The term 'chromatographic reactor' refers to the use of an analytical-scale column as both a flow-through reactor and, simultaneously, as separation med...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Skrdla PJ,Abrahim A,Wu Y

更新日期：2006-06-07 00:00:00

abstract：:The present work describes the development and validation of rapid, sensitive and accurate liquid chromatography method, coupled with tandem mass spectrometry detection, for quantification of tranexamic acid in human plasma using isotopically labeled internal standard (IS). A one-step plasma protein precipitation was ...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Delavenne X,Montbel A,Hodin S,Zufferey P,Basset T

更新日期：2014-03-01 00:00:00

abstract：:Diabetes mellitus is a typical heterogeneous metabolic disorder characterized by abnormal metabolism of carbohydrates, lipids and proteins. Genipin possesses a wide spectrum of biological activities including ameliorating effects on diabetes, but the definite mechanism of this effect remains unknown. To investigate th...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Shen XL,Liu H,Xiang H,Qin XM,Du GH,Tian JS

更新日期：2016-09-10 00:00:00

abstract：:The validation of an analytical method for the quantitative determination of erythromycin thiocyanate formulated in an antibiotic preparation for veterinary use was carried out. This method is based on the microbiological method described in the European Pharmacopoeia to analyze erythromycin thiocyanate as a raw mater...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bernabéu JA,Camacho MA,Gil-Alegre ME,Ruz V,Torres-Suárez AI

更新日期：1999-11-01 00:00:00

abstract：:A reversed-phase gradient elution system with methanol-triethylammonium phosphate buffer (83.3 mM, pH 6.0) as eluent on C(18)-bonded silica is described for the separation of 38 ribonucleotides, deoxynucleotides, cyclic nucleotides and deoxycyclic nucleotides in less than 33 min. The retention of the nucleotides can b...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Willis CL,Lim CK,Peters TJ

更新日期：1986-01-01 00:00:00

abstract：:A previously established method for the analysis of chlortetracycline by liquid chromatography using polystyrene-divinylbenzene stationary phases was examined in a multicentre study involving four laboratories and a total of 12 columns. Three chlortetracycline hydrochloride samples were analysed. The main component an...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Naidong W,De Beer J,Marcelis X,Derese P,Miller JH,Hoogmartens J

更新日期：1992-02-01 00:00:00

abstract：:The interactions between gemcitabine hydrochloride (GEM) and bovine serum albumin (BSA) or human serum albumin (HSA) have been studied by spectroscopic techniques. By the analysis of fluorescence spectrum and fluorescence intensity, it was observed that the GEM has a strong ability to quench the intrinsic fluorescence...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Kandagal PB,Ashoka S,Seetharamappa J,Shaikh SM,Jadegoud Y,Ijare OB

更新日期：2006-05-03 00:00:00

abstract：:A sensitive and rapid ultra performance liquid chromatography-tandem mass spectrometric (UPLC-MS/MS) method has been developed for the determination of 21-hydroxy deflazacort in human plasma using betamethasone as the internal standard (IS). After solid-phase extraction from 100 μL human plasma, the analyte and IS wer...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Patel DP,Sharma P,Patel BM,Sanyal M,Singhal P,Shrivastav PS

更新日期：2013-11-01 00:00:00

abstract：:The conditions of least squares deconvolution by linear combination have been investigated in three-component systems. The significant effects of the main factors, the lack of significant interactions and the linear relationship of absorbance with the concentration of each component were established by using a 2(3) fa...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Géher J,Szabó E

更新日期：1988-01-01 00:00:00

abstract：:In this paper a novel electrochemical sensor based on nickel carbide (Ni3C) nanoparticles as a new modifier was constructed. Ni3C nanoparticle was synthesized and characterized by scanning electron microscopy, X-ray diffraction and first-principles study. Electrochemical impedance spectroscopy (EIS) and cyclic voltamm...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Torkashvand M,Gholivand MB,Taherpour AA,Boochani A,Akhtar A

更新日期：2017-05-30 00:00:00

abstract：:Abiraterone acetate is administered as a prodrug to patients with metastatic, castration-resistant prostate cancer (mCRPC) and is readily metabolized into the potent 17a-hydroxylase/17,20-lyase (CYP17) enzyme inhibitor and androgen receptor inhibitor abiraterone and Δ(4)-abiraterone (D4A), respectively. To investigate...

journal_title：Journal of pharmaceutical and biomedical analysis

authors： Bhatnagar A,McKay MJ,Crumbaker M,Ahire K,Karuso P,Gurney H,Molloy MP

更新日期：2018-05-30 00:00:00