Abstract:
:The 60 MHz (1)H NMR spectra of racemic thiopental, 1, have been studied with the achiral shift reagent, tris(6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionato) europium(III), 2, and the chiral tris[3-(trifluoromethylhydroxymethylene)-d-camphorato] europium(III), 3, and tris[3-(heptafluoropropylhydroxymethylene)-d-camphorato] europium(III), 4. Enantiomeric shift differences, DeltaDeltadelta, were clearly observed for all three methyl signals of 1 with 3 or 4, with larger values obtained using the former reagent. Thus, a 0.216 molal solution of 1 in CDCl(3) at 28 degrees C with a 3:1 molar ratio of 0.359 displayed DeltaDeltadelta values of about 17 Hz for the proximal methyl of the methylbutyl group (at the chiral centre), 13 Hz for the CH(3) of the ethyl group, and 6 Hz for the distal CH(3) of the methylbutyl group. Results are compared for those obtained with 2 and 3 using secobarbital, talbutal, butabarbital and pentobarbital.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Eberhart ST,Hatzis A,Jimenez J,Rothchild R,Simons Pdoi
10.1016/0731-7085(87)80027-4subject
Has Abstractpub_date
1987-01-01 00:00:00pages
233-45issue
3eissn
0731-7085issn
1873-264Xpii
0731-7085(87)80027-4journal_volume
5pub_type
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