Abstract:
:Etest is a new concept for MIC determinations for antimicrobial agents that is based on a predefined antibiotic gradient on a plastic strip calibrated with a continuous logarithmic MIC scale covering 15 twofold dilutions. Etest was compared with a reference agar dilution method for susceptibility testing of clinical isolates of Mycobacterium chelonae and M. fortuitum. Results read after 3 days showed good agreement between MICs obtained with Etest and those obtained with the reference method within +/- 2 dilutions for 90% of all test combinations. All but one of the strains were inhibited by low concentrations of ciprofloxacin or amikacin. Susceptibility to clarithromycin, erythromycin, imipenem, rifampin, doxycycline, and fusidic acid was variable, and all strains were resistant to ceftazidime and trimethoprim. The results suggest that Etest is well suited for studies of drug resistance in rapidly growing mycobacteria.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Hoffner SE,Klintz L,Olsson-Liljequist B,Bolmström Adoi
10.1128/JCM.32.8.1846-1849.1994subject
Has Abstractpub_date
1994-08-01 00:00:00pages
1846-9issue
8eissn
0095-1137issn
1098-660Xjournal_volume
32pub_type
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journal_title:Journal of clinical microbiology
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