Schistosoma mansoni: the effect of dexamethasone on the cercaria-schistosomulum transformation, in vivo.

Abstract:

:Treatment with dexamethasone (DMS) in the early phases of the experimental Schistosoma mansoni infection causes an indirect effect on the cercaria-schistosomulum transformation process. This is observed when naive albino mice are treated with that drug (50 mg/Kg, subcutaneously) and infected intraperitoneally 01 hour later with about 500 S. mansoni cercariae (LE strain). An inhibition in the host cell adhesion to the larvae, with a simultaneous delay in the cercaria-schistosomulum transformation, is observed. This effect is probably due to a blockade of the neutrophil migration to the peritoneal cavity of mice, by an impairment of the release of chemotactic substances. Such delay probably favors the killing of S. mansoni larvae, still in the transformation process, by the vertebrate host defenses, as the complement system.

authors

de Melo AL,Hermeto MV,Bicalho RS,Vargas AP,Favaretto FJ,Pereira LH

doi

10.1590/s0036-46651994000100014

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

89-93

issue

1

eissn

0036-4665

issn

1678-9946

journal_volume

36

pub_type

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