Abstract：
:Smell and taste disorders can be challenging to diagnose because of the large number of potential etiologies. Patients are often unable to provide a clear history of symptoms, because they frequently cannot distinguish between difficulties with smell and taste. Standardized questionnaires may be helpful in diagnosis. Smell and taste dysfunction have been implicated in loss of appetite, unintended weight loss, malnutrition, and reduced quality of life. Taste dysfunction may be complete or partial, and affect one or more aspects of taste (sweetness, bitterness, sourness, saltiness, and umami [savory]). An estimated 95% of taste disorders are caused by impairment of smell rather than gustatory loss. The most common causes of olfactory dysfunction include allergic rhinitis, chronic rhinosinusitis (with or without sinonasal polyps), and upper respiratory infection. Other potential causes include head trauma, neurodegenerative diseases (including Parkinson disease and cognitive impairments), and medications. Examination of the nose, mouth, and oropharynx as well as neurologic examination (focusing on cranial nerves I, VII, IX, and X) is essential. Additional assessment such as cognitive testing, nasal endoscopy, computed tomography of the sinuses or nose, or brain magnetic resonance imaging may be indicated. Up to one-half of patients with olfactory dysfunction improve over time. Improvement in olfactory function is inversely correlated with severity and duration of loss, age, smoking, and male sex.
journal_name
Am Fam Physicianjournal_title
American family physicianauthors
Malaty J,Malaty IAsubject
Has Abstractpub_date
2013-12-15 00:00:00pages
852-9issue
12eissn
0002-838Xissn
1532-0650pii
d10555journal_volume
88pub_type
杂志文章,评审abstract：:Although herpes simplex virus is a recognized cause of esophagitis in immunocompromised patients, it may also be the etiologic agent in otherwise healthy individuals. Odynophagia and dysphagia are the major symptoms. The esophagogram may reveal ulcers in the distal esophagus and there may be motor disturbances as well...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1987-07-01 00:00:00
abstract：:Synovial cell sarcoma frequently presents as a painful periarticular mass in the lower extremity of a young male patient. The mass may appear encapsulated and is calcified in approximately 50 percent of cases. Surgery is the mainstay of therapy, with radical resection often necessary to prevent local recurrence. The m...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1990-04-01 00:00:00
abstract：:Frostbite can cause loss of life and limbs. Proper treatment and follow-up care are essential in reducing morbidity and mortality. Management of the frostbite patient consists of three stages. Initial care includes protection of the extremity from trauma or partial thawing. The second stage consists of rapid rewarming...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1984-12-01 00:00:00
abstract：:So many topical antifungal agents have been introduced that it has become very difficult to select the proper agent for a given infection. Nonspecific agents have been available for many years, and they are still effective in many situations. These agents include Whitfield's ointment, Castellani paint, gentian violet,...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Knee effusions may be the result of trauma, overuse or systemic disease. An understanding of knee pathoanatomy is an invaluable part of making the correct diagnosis and formulating a treatment plan. Taking a thorough medical history is the key component of the evaluation. The most common traumatic causes of knee effus...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2000-04-15 00:00:00
abstract：:Melanoma is an increasingly common malignancy, and it affects a younger population than most cancers. Risk factors for melanoma include white race, sun sensitivity, family history of melanoma, and melanocytic nevi. Sunburn and intermittent sun exposure appear to increase the risk of developing melanoma. The role of po...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2005-07-15 00:00:00
abstract：:Systemic lupus erythematosus, chronic cutaneous lupus erythematosus and subacute and acute cutaneous lupus erythematosus are associated with distinct cutaneous manifestations, and each disease has a particular clinical course and prognosis. Dermatomyositis, an immune-mediated disorder of unknown etiology that is often...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1996-04-01 00:00:00
abstract：:Alzheimer's disease accounts for about 60 percent of dementia cases. Misdiagnosis of the treatable dementias can have devastating results. Pseudodementia accompanying major depression and chronic cognitive dysfunction due to psychoactive drugs are among the most commonly missed diagnoses. Although cortical atrophy is ...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1987-11-01 00:00:00
abstract：:Common anorectal disorders can produce one or more of the following symptoms: pain, protrusion, pruritus, bleeding or discharge. The cause may be cryptitis, anal fissure, hemorrhoids, anorectal abscess, fistula in ano, neoplasm, condylomata acuminata, pilonidal cyst or inflammatory bowel disease. Each disorder is sugg...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1980-10-01 00:00:00
abstract：:Low-molecular-weight heparin is a relatively recent addition to the list of therapies for prophylaxis and treatment of deep venous thrombosis (DVT). As a prophylactic, low-molecular-weight heparin is as effective as standard heparin or warfarin and does not require monitoring of the activated partial thromboplastin ti...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1999-03-15 00:00:00
abstract：:Coxsackievirus B infection is common in children and young adults, usually causing mild symptoms in the gastrointestinal or upper respiratory tract. However, some patients develop pleurodynia, carditis or aseptic meningitis. This viral infection can be serious in the fetus and fatal in the newborn. Coxsackievirus B in...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1988-11-01 00:00:00
abstract：:Atypical moles can be distinguished visually by clinical features of size greater than 6 mm in diameter, color variegation, indistinct borders, and textured surface. All patients who have atypical moles should be counselled about sun avoidance, screening of family members, and regular skin checks at least once per yea...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2008-09-15 00:00:00
abstract：:Women experience depression twice as often as men. The diagnostic criteria for depression are the same for both sexes, but women with depression more frequently experience guilt, anxiety, increased appetite and sleep, weight gain and comorbid eating disorders. Women may achieve higher plasma concentrations of antidepr...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1999-07-01 00:00:00
abstract：:Patellofemoral pain syndrome (PFPS) is one of the most common causes of anterior knee pain encountered in the outpatient setting in adolescents and adults younger than 60 years. The incidence in the United States is between 3% and 6%. The cardinal feature of PFPS is pain in or around the anterior knee that intensifies...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2019-01-15 00:00:00
abstract：:Self-induced injury of one or more of the extremities may represent a distinct variety of Munchausen syndrome. The nature of the injury may be infectious, dermatologic or orthopedic. The mechanism may be secondary gain or another unconscious motivation that causes a craving for attention. In many cases, the underlying...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1988-06-01 00:00:00
abstract：:Finger fractures and dislocations are common injuries that are often managed by family physicians. A systematic physical examination is imperative to avoid complications and poor outcomes following these injuries. Radiography (commonly anteroposterior, true lateral, and oblique views) is required in the evaluation of ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2012-04-15 00:00:00
abstract：:Primary dysmenorrhea is menstrual pain that is not associated with pelvis pathology. It usually begins with the onset of ovulatory cycles, characteristically appearing in the year after menarche and increasing with time. The pain is associated with increased myometrial activity. Oral contraceptives and prostaglandin s...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1981-11-01 00:00:00
abstract：:Recognition of the allergic individual is facilitated by an awareness of certain characteristic actions and various facial lesions which may be clues to other allergic problems. A gaping expression, clearing of the throat and rubbing or mashing of the eyes and nose may indicate significant rhinitis. Dark circles and b...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
abstract：:Osteoporosis is characterized by low bone mineral density and a deterioration in the microarchitecture of bone that increases its susceptibility to fracture. The World Health Organization defines osteoporosis as a bone mineral density that is 2.5 standard deviations or more below the reference mean for healthy, young ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2004-10-01 00:00:00
abstract：:Parkinson's disease is a common neurodegenerative disorder that can cause significant disability and decreased quality of life. The cardinal physical signs of the disease are distal resting tremor, rigidity, bradykinesia, and asymmetric onset. Levodopa is the primary treatment for Parkinson's disease; however, its lon...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2006-12-15 00:00:00
abstract：:Myocardial infarction and congestive heart failure are associated with high morbidity and mortality rates. The results of recent clinical trials support a beneficial role for angiotensin-converting enzyme (ACE) inhibitors in attenuating mortality from myocardial infarction and left ventricular dysfunction. Large-scale...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1995-11-01 00:00:00
abstract：:"White coat" or "office" hypertension is often defined as the transient rise or elevation of blood pressure that occurs in the medical setting. Patients with these elevated readings have normal ambulatory pressures as determined by individual home blood pressure measurements or continuous 24-hour blood pressure monito...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1995-07-01 00:00:00
abstract：:Spinal cord compression from metastatic cancer is a medical emergency. Prompt intervention affords the best chance for successful recovery, while delay may result in devastating neurologic impairment. In the appropriate clinical setting, emergency myelography should be done to confirm the diagnosis of metastatic disea...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:Inflammatory breast cancer is a devastating disease with an extremely high rate of morbidity and mortality. Differentiating this disease from acute mastitis may be difficult on initial diagnosis. The expeditious diagnosis and treatment of inflammatory breast cancer has important ramifications for the patient's prognos...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1995-09-01 00:00:00
abstract：:Knee osteoarthritis is a common disabling condition that affects more than one-third of persons older than 65 years. Exercise, weight loss, physical therapy, intra-articular corticosteroid injections, and the use of nonsteroidal anti-inflammatory drugs and braces or heel wedges decrease pain and improve function. Acet...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2011-06-01 00:00:00
abstract：:Menstrual patterns can be an indicator of overall health and self-perception of well-being. Primary amenorrhea, defined as the lifelong absence of menses, requires evaluation if menarche has not occurred by 15 years of age or three years post-thelarche. Secondary amenorrhea is characterized by cessation of previously ...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2019-07-01 00:00:00
abstract：:This is a tenosynovitis of the abductor pollicis longus and extensor pollicis brevis tendons contained within the osseofibrous tunnel of the distal radius. Multiple tendons for the abductor pollicis longus and a separate, severely narrowed sheath for the extensor pollicis brevis make nonsurgical treatment difficult at...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：:Gas, bloating, and belching are associated with a variety of conditions but are most commonly caused by functional gastrointestinal disorders. These disorders are characterized by disordered motility and visceral hypersensitivity that are often worsened by psychological distress. An organized approach to the evaluatio...
journal_title：American family physician
pub_type： 杂志文章
doi：
更新日期：2019-03-01 00:00:00
abstract：:Antidepressant drugs are now an important component of the analgesic pharmacopeia. Their ability to relieve pain is independent of the presence of clinical depression, and their efficacy has been documented in the treatment of migraine and tension headaches, neuropathic pain and chronic pain syndromes, including those...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：1985-02-01 00:00:00
abstract：:Respiratory difficulty is a common presenting complaint in the outpatient primary care setting. Because patients may first seek care by calling their physician's office, telephone triage plays a role in the early management of dyspnea. Once the patient is in the office, the initial goal of assessment is to determine t...
journal_title：American family physician
pub_type： 杂志文章,评审
doi：
更新日期：2003-11-01 00:00:00
