Abstract:
:A bacterium with a spiral shape and bipolar, single, sheathed flagella was isolated from the livers of mice with active, chronic hepatitis. The bacteria also colonized the cecal and colonic mucosae of mice. The bacterium grew at 37 degrees C under microaerophilic and anaerobic conditions, rapidly hydrolyzed urea, was catalase and oxidase positive, reduced nitrate to nitrite, and was resistant to cephalothin metronidazole. On the basis of 16S rRNA gene sequence analysis, the organism was classified as a novel helicobacter, Helicobacter hepaticus. This new helicobacter, like two other murine Helicobacter species, H. muridarum and "H. rappini," is an efficient colonizer of the gastrointestinal tract, but in addition, it has the pathogenic potential to elicit persistent hepatitis in mice.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Fox JG,Dewhirst FE,Tully JG,Paster BJ,Yan L,Taylor NS,Collins MJ Jr,Gorelick PL,Ward JMdoi
10.1128/JCM.32.5.1238-1245.1994subject
Has Abstractpub_date
1994-05-01 00:00:00pages
1238-45issue
5eissn
0095-1137issn
1098-660Xjournal_volume
32pub_type
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