The effect of solution non-ideality on membrane transport in three-dimensional models of the renal concentrating mechanism.

Abstract:

:Previous models of the renal concentrating mechanism employ ideal approximations of solution thermodynamics for membrane transport calculation. In three-dimensional models of the renal medulla, predicted urine concentrations reach levels where these idealized approximations begin to break down. In this paper we derive equations that govern membrane transport for non-dilute solutions and use these equations in a three-dimensional model of the concentrating mechanism. New numerical methods were employed that are more stable than those employed previously. Compared to ideal solution models, the urea non-ideality tends to increase predicted osmolarities, whereas NaCl non-ideality decreases predictions.

journal_name

Bull Math Biol

authors

Wang X,Wexler AS,Marsh DJ

doi

10.1007/BF02460469

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

515-46

issue

3

eissn

0092-8240

issn

1522-9602

pii

S0092-8240(05)80287-3

journal_volume

56

pub_type

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