Abstract:
:Previous models of the renal concentrating mechanism employ ideal approximations of solution thermodynamics for membrane transport calculation. In three-dimensional models of the renal medulla, predicted urine concentrations reach levels where these idealized approximations begin to break down. In this paper we derive equations that govern membrane transport for non-dilute solutions and use these equations in a three-dimensional model of the concentrating mechanism. New numerical methods were employed that are more stable than those employed previously. Compared to ideal solution models, the urea non-ideality tends to increase predicted osmolarities, whereas NaCl non-ideality decreases predictions.
journal_name
Bull Math Bioljournal_title
Bulletin of mathematical biologyauthors
Wang X,Wexler AS,Marsh DJdoi
10.1007/BF02460469subject
Has Abstractpub_date
1994-05-01 00:00:00pages
515-46issue
3eissn
0092-8240issn
1522-9602pii
S0092-8240(05)80287-3journal_volume
56pub_type
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